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BIOL-11. THE ROLE OF ABERRANT EXPRESSION OF PRDM6 IN THE DEVELOPING CEREBELLUM AND IN GROUP 4 MEDULLOBLASTOMA. Neuro-Oncology. 2021 Jun 1; 23(Suppl 1):i5-i5.
Christin Schmidt, Annika Carlson, William Weiss, Bjoern Schwer. .
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OMIC-03. TRANSLATIONAL CONTROL IN MYC AND MYCN MEDULLOBLASTOMA. Neuro-Oncology. 2021 Jun 1; 23(Suppl 1):i37-i37.
Christin Schmidt, Albertas Navickas, Frederique Zindy, Dana Farmer, Davide Ruggero, Hani Goodarzi, Martine F Roussel, Bjoern Schwer, William Weiss. .
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TMOD-28. NEW APPROACHES FOR ELUCIDATING MEDULLOBLASTOMA DEVELOPMENT VIA HINDBRAIN BLASTOCYST COMPLEMENTATION. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii233-ii234.
Christin Schmidt, Annika Carlson, William Weiss, Bjoern Schwer. .
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Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 10; 15(10):3154-3181.
Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. PMID: 32778838.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 11; 563(7729):126-130.
Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. PMID: 30305734.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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DNA double-strand breaks as drivers of neural genomic change, function, and disease. DNA Repair (Amst). 2018 11; 71:158-163.
Alt FW, Schwer B. PMID: 30195640.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1919-1924.
Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. PMID: 29432181.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1564-1569.
Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. PMID: 29378963.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Editorial: DNA damage & immunity. Mech Ageing Dev. 2017 07; 165(Pt A):1-2.
Garinis GA, Schwer B, Schumacher B. PMID: 28445698.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer. Genome Editing in Neurosciences. 2017 Jan 1; 63-72.
Frederick W. Alt, Pei-Chi Wei, Bjoern Schwer. .
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Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2258-63.
Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. PMID: 26873106.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 2016 Feb 11; 164(4):644-55.
Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. PMID: 26871630.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2644-9.
Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. PMID: 24550291.
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PubMed Mentions:
18 Fields:
Translation:
Cells
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SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis. 2013 Jul; 34(7):1476-86.
Khongkow M, Olmos Y, Gong C, Gomes AR, Monteiro LJ, Yagüe E, Cavaco TB, Khongkow P, Man EP, Laohasinnarong S, Koo CY, Harada-Shoji N, Tsang JW, Coombes RC, Schwer B, Khoo US, Lam EW. PMID: 23514751.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013; 9(2):e1003298.
Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK. PMID: 23408915.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 2013 Jan 31; 152(3):417-29.
Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. PMID: 23374339.
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PubMed Mentions:
187 Fields:
Translation:
HumansAnimalsCells
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Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2234-9.
Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. PMID: 23345432.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8.
Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. PMID: 22308491.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60.
Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. PMID: 22308489.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012; 116:1-49.
Boboila C, Alt FW, Schwer B. PMID: 23063072.
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PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
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SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol. 2011; 76:267-77.
Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. PMID: 22114326.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90.
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. PMID: 21856199.
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PubMed Mentions:
287 Fields:
Translation:
HumansAnimalsCells
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The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011 Jun; 12(6):536-43.
Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. PMID: 21572431.
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PubMed Mentions:
149 Fields:
Translation:
AnimalsCells
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SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 01; 12(6):654-61.
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. PMID: 21109197.
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PubMed Mentions:
196 Fields:
Translation:
AnimalsCells
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Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21790-4.
Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. PMID: 21098266.
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PubMed Mentions:
80 Fields:
Translation:
AnimalsCells
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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5.
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. PMID: 20203611.
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PubMed Mentions:
630 Fields:
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HumansAnimalsCells
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Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 2009 Sep; 8(5):604-6.
Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. PMID: 19594485.
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PubMed Mentions:
119 Fields:
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HumansAnimalsCells
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Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans. 2009 Jun; 37(Pt 3):561-8.
Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW. PMID: 19442251.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2717-22.
Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. PMID: 19196992.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008 Feb; 263(2):128-41.
Lombard DB, Schwer B, Alt FW, Mostoslavsky R. PMID: 18226091.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008 Feb; 7(2):104-12.
Schwer B, Verdin E. PMID: 18249170.
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PubMed Mentions:
173 Fields:
Translation:
HumansAnimalsCells
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14.
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. PMID: 17923681.
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PubMed Mentions:
511 Fields:
Translation:
AnimalsCells
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Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007 Nov 16; 282(46):33583-33592.
Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. PMID: 17715127.
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PubMed Mentions:
143 Fields:
Translation:
HumansCells
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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10224-10229.
Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. PMID: 16788062.
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PubMed Mentions:
299 Fields:
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HumansAnimalsCells
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The Class III Protein Deacetylases. Histone Deacetylases. 2006 Jan 1; 237-268.
Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, Eric Verdin. .
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Preparation of enzymatically active recombinant class III protein deacetylases. Methods. 2005 Aug; 36(4):338-45.
North BJ, Schwer B, Ahuja N, Marshall B, Verdin E. PMID: 16091304.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004 Aug; 78(15):7958-68.
Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. PMID: 15254168.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol. 2002 Nov 15; 169(10):5531-7.
Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. PMID: 12421929.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57.
Schwer B, North BJ, Frye RA, Ott M, Verdin E. PMID: 12186850.
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PubMed Mentions:
240 Fields:
Translation:
HumansCells