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Bjoern Schwer, MD, PhD

Title(s)Assistant Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-476-6786
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Awards and Honors
    2013Martin D. Abeloff V Scholar, The V Foundation for Cancer Research
    2016Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair, UCSF
    2017Kimmel Scholar, Sidney Kimmel Foundation

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 Aug 10. Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. PMID: 32778838.
      View in: PubMed   Mentions:    Fields:    
    2. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 11; 563(7729):126-130. Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. PMID: 30305734.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    3. DNA double-strand breaks as drivers of neural genomic change, function, and disease. DNA Repair (Amst). 2018 11; 71:158-163. Alt FW, Schwer B. PMID: 30195640.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1919-1924. Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. PMID: 29432181.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1564-1569. Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. PMID: 29378963.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Editorial: DNA damage & immunity. Mech Ageing Dev. 2017 07; 165(Pt A):1-2. Garinis GA, Schwer B, Schumacher B. PMID: 28445698.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer. Genome Editing in Neurosciences. 2017 Jan 1; 63-72. Frederick W. Alt, Pei-Chi Wei, Bjoern Schwer. .
      View in: Publisher Site   Mentions:
    8. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2258-63. Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. PMID: 26873106.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 2016 Feb 11; 164(4):644-55. Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. PMID: 26871630.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    10. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2644-9. Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. PMID: 24550291.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    11. SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis. 2013 Jul; 34(7):1476-86. Khongkow M, Olmos Y, Gong C, Gomes AR, Monteiro LJ, Yagüe E, Cavaco TB, Khongkow P, Man EP, Laohasinnarong S, Koo CY, Harada-Shoji N, Tsang JW, Coombes RC, Schwer B, Khoo US, Lam EW. PMID: 23514751.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    12. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013; 9(2):e1003298. Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK. PMID: 23408915.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 2013 Jan 31; 152(3):417-29. Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. PMID: 23374339.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    14. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2234-9. Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. PMID: 23345432.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    15. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8. Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. PMID: 22308491.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    16. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60. Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. PMID: 22308489.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    17. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012; 116:1-49. Boboila C, Alt FW, Schwer B. PMID: 23063072.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    18. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol. 2011; 76:267-77. Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. PMID: 22114326.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    19. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. PMID: 21856199.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    20. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011 Jun; 12(6):536-43. Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. PMID: 21572431.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    21. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 01; 12(6):654-61. Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. PMID: 21109197.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    22. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21790-4. Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. PMID: 21098266.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    23. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. PMID: 20203611.
      View in: PubMed   Mentions: 542     Fields:    Translation:HumansAnimalsCells
    24. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 2009 Sep; 8(5):604-6. Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. PMID: 19594485.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    25. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans. 2009 Jun; 37(Pt 3):561-8. Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW. PMID: 19442251.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2717-22. Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. PMID: 19196992.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    27. SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008 Feb; 263(2):128-41. Lombard DB, Schwer B, Alt FW, Mostoslavsky R. PMID: 18226091.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    28. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008 Feb; 7(2):104-12. Schwer B, Verdin E. PMID: 18249170.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    29. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. PMID: 17923681.
      View in: PubMed   Mentions: 443     Fields:    Translation:AnimalsCells
    30. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007 Nov 16; 282(46):33583-92. Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. PMID: 17715127.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    31. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10224-10229. Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. PMID: 16788062.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansAnimalsCells
    32. The Class III Protein Deacetylases. Histone Deacetylases. 2006 Jan 1; 237-268. Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, Eric Verdin. .
      View in: Publisher Site   Mentions:
    33. Preparation of enzymatically active recombinant class III protein deacetylases. Methods. 2005 Aug; 36(4):338-45. North BJ, Schwer B, Ahuja N, Marshall B, Verdin E. PMID: 16091304.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    34. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004 Aug; 78(15):7958-68. Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. PMID: 15254168.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    35. Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol. 2002 Nov 15; 169(10):5531-7. Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. PMID: 12421929.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    36. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57. Schwer B, North BJ, Frye RA, Ott M, Verdin E. PMID: 12186850.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansCells
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