Bjoern Schwer, MD, PhD

Title(s)Associate Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-476-6786
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Collapse Awards and Honors
    2013Martin D. Abeloff V Scholar, The V Foundation for Cancer Research
    2016Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair, UCSF
    2017Kimmel Scholar, Sidney Kimmel Foundation
    2021Carol and Gene Ludwig Award for Early Career Research

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Relationships between genome-wide R-loop distribution and classes of recurrent DNA breaks in neural stem/progenitor cells. Sci Rep. 2022 08 04; 12(1):13373. Thongthip S, Carlson A, Crossley MP, Schwer B. PMID: 35927309; PMCID: PMC9352722.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Editorial: Genomic Instability and Neurodegeneration. Front Aging Neurosci. 2022; 14:940459. Fuchs J, Schwer B, El-Khamisy SF. PMID: 35754964; PMCID: PMC9214212.
      View in: PubMed   Mentions:
    3. A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis. bioRxiv. 2022 Feb 22. Dorman LC, Nguyen PT, Escoubas CC, Vainchtein ID, Xiao Y, Lidsky PV, Nakajo H, Silva NJ, Lagares-Linares C, Wang EY, Taloma SE, Cuevas B, Nakao-Inoue H, Rivera BM, Schwer B, Condello C, Andino R, Nowakowski TJ, Molofsky AV. PMID: 35233577; PMCID: PMC8887080.
      View in: PubMed   Mentions:
    4. Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice. Neuro Oncol. 2022 02 01; 24(2):259-272. Chuntova P, Hou Y, Naka R, Yamamichi A, Chen T, Goretsky Y, Hatae R, Nejo T, Kohanbash G, Mende AL, Montoya M, Downey KM, Diebold D, Skinner J, Liang HE, Schwer B, Okada H. PMID: 34347086; PMCID: PMC8804899.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Rep. 2021 09 07; 36(10):109666. Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, Ivanis J, Huebner EA, Arvanites A, Oza V, Davidow L, Maeda R, Sakuma M, Grantham A, Wang Q, Chang AN, Pfaff K, Costigan M, Coppola G, Rubin LL, Schwer B, Alt FW, Woolf CJ. PMID: 34496254; PMCID: PMC8462619.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. BIOL-11. THE ROLE OF ABERRANT EXPRESSION OF PRDM6 IN THE DEVELOPING CEREBELLUM AND IN GROUP 4 MEDULLOBLASTOMA. Neuro-Oncology. 2021 Jun 1; 23(Suppl 1):i5-i5. Schmidt SC, Carlson CA, Weiss WW, Schwer SB. .
      View in: Publisher Site   Mentions:
    7. OMIC-03. TRANSLATIONAL CONTROL IN MYC AND MYCN MEDULLOBLASTOMA. Neuro-Oncology. 2021 Jun 1; 23(Suppl 1):i37-i37. Schmidt SC, Navickas NA, Zindy ZF, Farmer FD, Ruggero RD, Goodarzi GH, Roussel RM, Schwer SB, Weiss WW. .
      View in: Publisher Site   Mentions:
    8. TMOD-28. NEW APPROACHES FOR ELUCIDATING MEDULLOBLASTOMA DEVELOPMENT VIA HINDBRAIN BLASTOCYST COMPLEMENTATION. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii233-ii234. Schmidt SC, Carlson CA, Weiss WW, Schwer SB. .
      View in: Publisher Site   Mentions:
    9. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 10; 15(10):3154-3181. Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. PMID: 32778838; PMCID: PMC7685531.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 11; 563(7729):126-130. Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. PMID: 30305734; PMCID: PMC6588192.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. DNA double-strand breaks as drivers of neural genomic change, function, and disease. DNA Repair (Amst). 2018 11; 71:158-163. Alt FW, Schwer B. PMID: 30195640; PMCID: PMC6340756.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    12. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1919-1924. Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. PMID: 29432181; PMCID: PMC5828622.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    13. Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1564-1569. Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. PMID: 29378963; PMCID: PMC5816209.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    14. Editorial: DNA damage & immunity. Mech Ageing Dev. 2017 07; 165(Pt A):1-2. Garinis GA, Schwer B, Schumacher B. PMID: 28445698; PMCID: PMC5544113.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer. Genome Editing in Neurosciences. 2017 Jan 1; 63-72. Alt AF, Wei WP, Schwer SB. .
      View in: Publisher Site   Mentions:
    16. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2258-63. Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. PMID: 26873106; PMCID: PMC4776469.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    17. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 2016 Feb 11; 164(4):644-55. Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. PMID: 26871630; PMCID: PMC4752721.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    18. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2644-9. Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. PMID: 24550291; PMCID: PMC3932927.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    19. SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis. 2013 Jul; 34(7):1476-86. Khongkow M, Olmos Y, Gong C, Gomes AR, Monteiro LJ, Yag?e E, Cavaco TB, Khongkow P, Man EP, Laohasinnarong S, Koo CY, Harada-Shoji N, Tsang JW, Coombes RC, Schwer B, Khoo US, Lam EW. PMID: 23514751.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    20. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013; 9(2):e1003298. Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK. PMID: 23408915; PMCID: PMC3567186.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 2013 Jan 31; 152(3):417-29. Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. PMID: 23374339; PMCID: PMC4382911.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    22. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2234-9. Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. PMID: 23345432; PMCID: PMC3568359.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    23. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8. Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. PMID: 22308491; PMCID: PMC3289296.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    24. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60. Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. PMID: 22308489; PMCID: PMC3289340.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    25. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012; 116:1-49. Boboila C, Alt FW, Schwer B. PMID: 23063072.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    26. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol. 2011; 76:267-77. Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. PMID: 22114326.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    27. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stanc?kov? A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. PMID: 21856199; PMCID: PMC3563434.
      View in: PubMed   Mentions: 356     Fields:    Translation:HumansAnimalsCells
    28. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011 Jun; 12(6):536-43. Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. PMID: 21572431; PMCID: PMC3117275.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    29. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 01; 12(6):654-61. Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. PMID: 21109197; PMCID: PMC3310379.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    30. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21790-4. Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. PMID: 21098266; PMCID: PMC3003110.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    31. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. PMID: 20203611; PMCID: PMC2841477.
      View in: PubMed   Mentions: 767     Fields:    Translation:HumansAnimalsCells
    32. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 2009 Sep; 8(5):604-6. Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. PMID: 19594485; PMCID: PMC2752488.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    33. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans. 2009 Jun; 37(Pt 3):561-8. Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW. PMID: 19442251; PMCID: PMC3540414.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2717-22. Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. PMID: 19196992; PMCID: PMC2650332.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    35. SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008 Feb; 263(2):128-41. Lombard DB, Schwer B, Alt FW, Mostoslavsky R. PMID: 18226091; PMCID: PMC2486832.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    36. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008 Feb; 7(2):104-12. Schwer B, Verdin E. PMID: 18249170.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    37. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. PMID: 17923681; PMCID: PMC2169418.
      View in: PubMed   Mentions: 604     Fields:    Translation:AnimalsCells
    38. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007 Nov 16; 282(46):33583-33592. Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. PMID: 17715127.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCells
    39. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10224-10229. Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. PMID: 16788062; PMCID: PMC1502439.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimalsCells
    40. The Class III Protein Deacetylases. Histone Deacetylases. 2006 Jan 1; 237-268. Schwer SB, North NB, Ahuja AN, Marshall MB, Verdin VE. .
      View in: Publisher Site   Mentions:
    41. Preparation of enzymatically active recombinant class III protein deacetylases. Methods. 2005 Aug; 36(4):338-45. North BJ, Schwer B, Ahuja N, Marshall B, Verdin E. PMID: 16091304.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    42. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004 Aug; 78(15):7958-68. Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. PMID: 15254168; PMCID: PMC446112.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    43. Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol. 2002 Nov 15; 169(10):5531-7. Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. PMID: 12421929.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    44. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57. Schwer B, North BJ, Frye RA, Ott M, Verdin E. PMID: 12186850; PMCID: PMC2174009.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansCells
    45. Functional and physical interaction between the yeast splicing factors Slu7 and Prp18. Nucleic Acids Res. 1997 Jun 01; 25(11):2146-52. Zhang X, Schwer B. PMID: 9153314; PMCID: PMC146706.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
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