Daniel Minor, JR, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #452P
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, Philadelphia, PAB.A. magna cum laude05/1989Biochemistry (Honors) Biophysics (Honors)
    Massachusetts Institute of Technology, Cambridge, MAPh.D.02/1996Biochemistry
    MRC Laboratory of Molecular Biology, Cambridge, UKpostdoc09/1996Ion channel structure
    University of California San Francisco, San Francisco, CApostdoc12/2000Ion channel structure and function

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Expanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo Probes
    NIH R01MH116278Mar 1, 2018 - Jan 31, 2021
    Role: Co-Principal Investigator
    Genetic and chemical biological studies of K2P structure, function, and modulation
    NIH R01MH093603Mar 1, 2011 - Feb 28, 2021
    Role: Principal Investigator
    Center for Structure of Membrane Proteins
    NIH U54GM094625Sep 30, 2010 - Jun 30, 2016
    Role: Co-Investigator
    Structural studies of CaV alpha2delta subunits and interaction with anti-nocicept
    NIH R21NS065448Sep 1, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Structural Studies of Ion Channel Assembly and Signaling Complexes
    NIH R01DC007664Jul 1, 2005 - Jan 31, 2022
    Role: Principal Investigator
    Structure and function of voltage-gated calcium channels
    NIH R01HL080050May 1, 2005 - Mar 31, 2024
    Role: Principal Investigator
    Membrane Protein Expression Center
    NIH P50GM073210Sep 24, 2004 - Aug 31, 2015
    Role: Co-Investigator
    Discovery and characterization of ion channel modulators
    NIH R01NS049272Jul 1, 2004 - May 31, 2010
    Role: Principal Investigator
    Eukaryotic Ion Channel Expression for Structural Study
    NIH R21NS047299Jan 1, 2004 - Dec 31, 2006
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Expression, purification, and characterization of anuran saxiphilins using thermofluor, fluorescence polarization, and isothermal titration calorimetry. STAR Protoc. 2024 Mar 15; 5(1):102792. Chen Z, Zakrzewska S, Hajare HS, Du Bois J, Minor DL. PMID: 38133955; PMCID: PMC10776646.
      View in: PubMed   Mentions:    Fields:    
    2. Development of covalent chemogenetic K2P channel activators. bioRxiv. 2023 Oct 18. Deal PE, Lee H, Mondal A, Lolicato M, de Mendonca PRF, Black H, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL. PMID: 37905049; PMCID: PMC10614804.
      View in: PubMed   Mentions:
    3. EMC chaperone-CaV structure reveals an ion channel assembly intermediate. Nature. 2023 Jul; 619(7969):410-419. Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL. PMID: 37196677; PMCID: PMC10896479.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Structural basis for CaVα2δ:gabapentin binding. Nat Struct Mol Biol. 2023 06; 30(6):735-739. Chen Z, Mondal A, Minor DL. PMID: 36973510; PMCID: PMC10896480.
      View in: PubMed   Mentions: 5     Fields:    
    5. Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody. Nat Commun. 2022 Dec 09; 13(1):7556. Morgenstern TJ, Nirwan N, Hernández-Ochoa EO, Bibollet H, Choudhury P, Laloudakis YD, Ben Johny M, Bannister RA, Schneider MF, Minor DL, Colecraft HM. PMID: 36494348; PMCID: PMC9734117.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210114119. Chen Z, Zakrzewska S, Hajare HS, Alvarez-Buylla A, Abderemane-Ali F, Bogan M, Ramirez D, O'Connell LA, Du Bois J, Minor DL. PMID: 36279441; PMCID: PMC9636910.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 2022 06; 29(6):537-548. Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL. PMID: 35655098.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    8. Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation. Cell Chem Biol. 2022 04 21; 29(4):615-624.e5. MacKenzie TMG, Abderemane-Ali F, Garrison CE, Minor DL, Bois JD. PMID: 34963066; PMCID: PMC9035044.
      View in: PubMed   Mentions: 3     Fields:    
    9. Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins. J Gen Physiol. 2021 09 06; 153(9). Abderemane-Ali F, Rossen ND, Kobiela ME, Craig RA, Garrison CE, Chen Z, Colleran CM, O'Connell LA, Du Bois J, Dumbacher JP, Minor DL. PMID: 34351379; PMCID: PMC8348241.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    10. Inroads into Membrane Physiology through Transport Nanomachines. J Mol Biol. 2021 08 06; 433(16):167101. Stockbridge RB, Gaudet R, Grabe M, Minor DL. PMID: 34119492; PMCID: PMC9633016.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Ion Channels: Intersection of Structure, Function, and Pharmacology. J Mol Biol. 2021 08 20; 433(17):167102. Moiseenkova-Bell V, Delemotte L, Minor DL. PMID: 34119491.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels. J Mol Biol. 2021 08 20; 433(17):166995. Natale AM, Deal PE, Minor DL. PMID: 33887333; PMCID: PMC8436263.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    13. Production of K2P2.1 (TREK-1) for structural studies. Methods Enzymol. 2021; 653:151-188. Lee H, Lolicato M, Arrigoni C, Minor DL. PMID: 34099170.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. Preface. Methods Enzymol. 2021; 653:xv-xvi. Minor DL, Colecraft HM. PMID: 34099184.
      View in: PubMed   Mentions:    Fields:    
    15. Preface. Methods Enzymol. 2021; 652:xv-xvi. Minor DL, Colecraft HM. PMID: 34059292.
      View in: PubMed   Mentions:    Fields:    
    16. Preface. Methods Enzymol. 2021; 654:xvii-xviii. Minor DL, Colecraft HM. PMID: 34120727.
      View in: PubMed   Mentions:    Fields:    
    17. The Polysite Pharmacology of TREK K2P Channels. Adv Exp Med Biol. 2021; 1349:51-65. Pope L, Minor DL. PMID: 35138610; PMCID: PMC8887811.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv. 2020 10; 6(44). Lolicato M, Natale AM, Abderemane-Ali F, Crottès D, Capponi S, Duman R, Wagner A, Rosenberg JM, Grabe M, Minor DL. PMID: 33127683; PMCID: PMC7608817.
      View in: PubMed   Mentions: 25     Fields:    
    19. Polynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism. Cell Chem Biol. 2020 05 21; 27(5):511-524.e4. Pope L, Lolicato M, Minor DL. PMID: 32059793; PMCID: PMC7245552.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    20. Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. Sci Adv. 2019 06; 5(6):eaax2650. Yen TJ, Lolicato M, Thomas-Tran R, Du Bois J, Minor DL. PMID: 31223657; PMCID: PMC6584486.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation. J Mol Biol. 2019 07 12; 431(15):2869-2883. Kimberlin CR, Meshcheriakova A, Palty R, Raveh A, Karbat I, Reuveny E, Minor DL. PMID: 31082439; PMCID: PMC6599547.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation. Neuron. 2019 03 20; 101(6):1134-1149.e3. Abderemane-Ali F, Findeisen F, Rossen ND, Minor DL. PMID: 30733149; PMCID: PMC8878153.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    23. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels. ACS Chem Neurosci. 2018 12 19; 9(12):3153-3165. Pope L, Arrigoni C, Lou H, Bryant C, Gallardo-Godoy A, Renslo AR, Minor DL. PMID: 30089357; PMCID: PMC6302903.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function. Neuron. 2018 02 21; 97(4):836-852.e6. Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL. PMID: 29429937; PMCID: PMC5823783.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    25. Global versus local mechanisms of temperature sensing in ion channels. Pflugers Arch. 2018 05; 470(5):733-744. Arrigoni C, Minor DL. PMID: 29340775; PMCID: PMC5945320.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 02 06; 26(2):187-198.e4. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR. PMID: 29336885; PMCID: PMC5803430.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. PMID: 29236684; PMCID: PMC5750132.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    28. Channel surfing uncovers a dual-use transporter. EMBO J. 2017 11 15; 36(22):3272-3273. Minor DL. PMID: 29051229; PMCID: PMC5686543.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 07 20; 547(7663):364-368. Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL. PMID: 28693035; PMCID: PMC5778891.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    30. Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. PMID: 28278376; PMCID: PMC5481814.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell. 2016 Feb 25; 164(5):922-36. Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL. PMID: 26919429; PMCID: PMC4769381.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    32. Let It Go and Open Up, an Ensemble of Ion Channel Active States. Cell. 2016 Feb 11; 164(4):597-8. Minor DL. PMID: 26871624.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    33. Insights into the molecular foundations of electrical excitation. J Mol Biol. 2015 Jan 16; 427(1):1-2. Gaudet R, Roux B, Minor DL. PMID: 25542854; PMCID: PMC5544904.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    34. Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. Neuron. 2014 Dec 17; 84(6):1198-212. Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL. PMID: 25500157; PMCID: PMC4270892.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    35. Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. J Mol Biol. 2015 Jan 16; 427(1):3-30. Payandeh J, Minor DL. PMID: 25158094; PMCID: PMC4277928.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    36. Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. ACS Chem Neurosci. 2014 Sep 17; 5(9):812-22. Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL. PMID: 25028803; PMCID: PMC4176385.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron. 2013 Oct 30; 80(3):658-74. Isacoff EY, Jan LY, Minor DL. PMID: 24183018; PMCID: PMC3867263.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    38. Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. J Mol Biol. 2014 Jan 23; 426(2):467-83. Shaya D, Findeisen F, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL. PMID: 24120938; PMCID: PMC3947372.
      View in: PubMed   Mentions: 78     Fields:    Translation:CellsPHPublic Health
    39. Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain. J Mol Biol. 2013 Sep 09; 425(17):3217-34. Findeisen F, Rumpf CH, Minor DL. PMID: 23811053; PMCID: PMC3839849.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    40. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. PMID: 23738709; PMCID: PMC3747594.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    41. Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi. Biophys J. 2013 Apr 02; 104(7):1426-34. Petrov E, Palanivelu D, Constantine M, Rohde PR, Cox CD, Nomura T, Minor DL, Martinac B. PMID: 23561519; PMCID: PMC3617418.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    42. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6352-7. Tien J, Lee HY, Minor DL, Jan YN, Jan LY. PMID: 23576756; PMCID: PMC3631655.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    43. Using yeast to study potassium channel function and interactions with small molecules. Methods Mol Biol. 2013; 995:31-42. Bagriantsev SN, Minor DL. PMID: 23494370; PMCID: PMC3950311.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. J Mol Biol. 2013 Jan 23; 425(2):378-94. Xu Q, Chang A, Tolia A, Minor DL. PMID: 23178170; PMCID: PMC3540129.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    45. Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains. EMBO J. 2012 Aug 01; 31(15):3297-308. Bagriantsev SN, Clark KA, Minor DL. PMID: 22728824; PMCID: PMC3411076.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    46. A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol. 2012 May 06; 19(6):633-41. Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL. PMID: 22562138; PMCID: PMC3529583.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    47. Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol. 2011 Dec 18; 8(2):144-6. Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK. PMID: 22179068; PMCID: PMC3262069.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    48. Multiple modalities converge on a common gate to control K2P channel function. EMBO J. 2011 Jul 15; 30(17):3594-606. Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL. PMID: 21765396; PMCID: PMC3181481.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    49. Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12313-8. Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL. PMID: 21746903; PMCID: PMC3145705.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    50. Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Channels (Austin). 2011 Jul-Aug; 5(4):320-4. Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL. PMID: 21712653; PMCID: PMC3225732.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    51. Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation. Structure. 2010 Dec 08; 18(12):1617-31. Findeisen F, Minor DL. PMID: 21134641; PMCID: PMC3033571.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    52. Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Channels (Austin). 2010 Nov-Dec; 4(6):459-74. Minor DL, Findeisen F. PMID: 21139419; PMCID: PMC3018750.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    53. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010 Dec 01; 29(23):3924-38. Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL. PMID: 20953164; PMCID: PMC3020648.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    54. Small molecule ion channel match making: a natural fit for new ASIC ligands. Neuron. 2010 Oct 06; 68(1):1-3. Bagriantsev SN, Minor DL. PMID: 20920784; PMCID: PMC2981581.
      View in: PubMed   Mentions: 3     Fields:    
    55. Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol. 2010 May; 6(5):369-75. Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY. PMID: 20364128; PMCID: PMC2857593.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    56. Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. PLoS One. 2009 Oct 16; 4(10):e7496. Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL. PMID: 19834614; PMCID: PMC2759520.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Sci. 2009 Oct; 18(10):2100-14. Xu Q, Minor DL. PMID: 19693805; PMCID: PMC2786974.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    58. Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. Mol Biosyst. 2009 Aug; 5(8):802-10. Minor DL. PMID: 19603113; PMCID: PMC3016960.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    59. Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation. J Gen Physiol. 2009 Mar; 133(3):327-43. Findeisen F, Minor DL. PMID: 19237593; PMCID: PMC2654080.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    60. 2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. J Struct Funct Genomics. 2009 Apr; 10(2):193-208. Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W. PMID: 19148774; PMCID: PMC2705707.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    61. A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms. Protein Sci. 2009 Jan; 18(1):121-33. Hammon J, Palanivelu DV, Chen J, Patel C, Minor DL. PMID: 19177357; PMCID: PMC2708023.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    62. Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure. 2008 Oct 08; 16(10):1455-67. Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL. PMID: 18940602; PMCID: PMC2701236.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    63. X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. J Mol Biol. 2008 Nov 21; 383(4):854-70. Fujiwara Y, Minor DL. PMID: 18782578; PMCID: PMC2630241.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    64. Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12313-8. Balss J, Papatheodorou P, Mehmel M, Baumeister D, Hertel B, Delaroque N, Chatelain FC, Minor DL, Van Etten JL, Rassow J, Moroni A, Thiel G. PMID: 18719119; PMCID: PMC2518832.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    65. Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation. Structure. 2008 Feb; 16(2):280-94. Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL. PMID: 18275819; PMCID: PMC3018278.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    66. Puzzle plugged by protein pore plasticity. Mol Cell. 2007 May 25; 26(4):459-60. Minor DL. PMID: 17531803.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    67. The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data. Neuron. 2007 May 24; 54(4):511-33. Minor DL. PMID: 17521566; PMCID: PMC3011226.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    68. Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron. 2007 Mar 01; 53(5):663-75. Howard RJ, Clark KA, Holton JM, Minor DL. PMID: 17329207; PMCID: PMC3011230.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    69. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol. 2006 Nov; 13(11):987-95. Pioletti M, Findeisen F, Hura GL, Minor DL. PMID: 17057713; PMCID: PMC3018330.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    70. Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006 Jul 20; 51(2):201-12. Tsuruda PR, Julius D, Minor DL. PMID: 16846855; PMCID: PMC3014052.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    71. Wanting contact: how to pick up a channel. Nat Chem Biol. 2006 Jun; 2(6):298-9. Minor DL. PMID: 16710336.
      View in: PubMed   Mentions:    Fields:    
    72. A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Traffic. 2006 Jul; 7(7):903-16. Michelsen K, Mrowiec T, Duderstadt KE, Frey S, Minor DL, Mayer MP, Schwappach B. PMID: 16734667.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    73. A sensitive channel family replete with sense and motion. Nat Struct Mol Biol. 2006 May; 13(5):388-90. Minor DL. PMID: 16738606.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    74. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol. 2005 Dec; 12(12):1108-15. Van Petegem F, Chatelain FC, Minor DL. PMID: 16299511; PMCID: PMC3020901.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    75. The pore helix dipole has a minor role in inward rectifier channel function. Neuron. 2005 Sep 15; 47(6):833-43. Chatelain FC, Alagem N, Xu Q, Pancaroglu R, Reuveny E, Minor DL. PMID: 16157278; PMCID: PMC3017504.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    76. Bend to open? Structure. 2005 Aug; 13(8):1094-5. Minor DL. PMID: 16084381.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    77. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature. 2004 Jun 10; 429(6992):671-5. Van Petegem F, Clark KA, Chatelain FC, Minor DL. PMID: 15141227; PMCID: PMC3076333.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    78. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol Cell. 2003 Dec; 12(6):1427-37. Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA. PMID: 14690597.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    79. Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16029-34. Mosavi LK, Minor DL, Peng ZY. PMID: 12461176; PMCID: PMC138559.
      View in: PubMed   Mentions: 145     Fields:    Translation:Cells
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