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Daniel Minor, JR, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-514-2836
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, Philadelphia, PAB.A. magna cum laude05/1989Biochemistry (Honors) Biophysics (Honors)
    Massachusetts Institute of Technology, Cambridge, MAPh.D.02/1996Biochemistry
    MRC Laboratory of Molecular Biology, Cambridge, UKpostdoc09/1996Ion channel structure
    University of California San Francisco, San Francisco, CApostdoc12/2000Ion channel structure and function

    Collapse Research 
    Collapse Research Activities and Funding
    Expanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo Probes
    NIH/NIMH R01MH116278Mar 1, 2018 - Jan 31, 2021
    Role: Co-Principal Investigator
    Genetic and chemical biological studies of K2P structure, function, and modulation
    NIH/NIMH R01MH093603Mar 1, 2011 - Feb 29, 2016
    Role: Principal Investigator
    Center for Structure of Membrane Proteins
    NIH/NIGMS U54GM094625Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    Structural studies of CaV alpha2delta subunits and interaction with anti-nocicept
    NIH/NINDS R21NS065448Sep 1, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Structural Studies of Ion Channel Assembly and Signaling Complexes
    NIH/NIDCD R01DC007664Jul 1, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Structure and function of voltage-gated calcium channels
    NIH/NHLBI R01HL080050May 1, 2005 - Mar 31, 2018
    Role: Principal Investigator
    Membrane Protein Expression Center
    NIH/NIGMS P50GM073210Sep 24, 2004 - Jul 31, 2009
    Role: Co-Investigator
    Discovery and characterization of ion channel modulators
    NIH/NINDS R01NS049272Jul 1, 2004 - May 31, 2010
    Role: Principal Investigator
    Eukaryotic Ion Channel Expression for Structural Study
    NIH/NINDS R21NS047299Jan 1, 2004 - Dec 31, 2006
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism. Cell Chem Biol. 2020 May 21; 27(5):511-524.e4. Pope L, Lolicato M, Minor DL. PMID: 32059793.
      View in: PubMed   Mentions:    Fields:    
    2. Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. Sci Adv. 2019 06; 5(6):eaax2650. Yen TJ, Lolicato M, Thomas-Tran R, Du Bois J, Minor DL. PMID: 31223657.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped ß-Sandwich Fold Important for SOCE Modulation. J Mol Biol. 2019 07 12; 431(15):2869-2883. Kimberlin CR, Meshcheriakova A, Palty R, Raveh A, Karbat I, Reuveny E, Minor DL. PMID: 31082439.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation. Neuron. 2019 03 20; 101(6):1134-1149.e3. Abderemane-Ali F, Findeisen F, Rossen ND, Minor DL. PMID: 30733149.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function. Neuron. 2018 02 21; 97(4):836-852.e6. Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL. PMID: 29429937.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Global versus local mechanisms of temperature sensing in ion channels. Pflugers Arch. 2018 05; 470(5):733-744. Arrigoni C, Minor DL. PMID: 29340775.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 02 06; 26(2):187-198.e4. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR. PMID: 29336885.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. PMID: 29236684.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    9. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 07 20; 547(7663):364-368. Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL. PMID: 28693035.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    10. Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. PMID: 28278376.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell. 2016 Feb 25; 164(5):922-36. Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL. PMID: 26919429.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    12. Let It Go and Open Up, an Ensemble of Ion Channel Active States. Cell. 2016 Feb 11; 164(4):597-8. Minor DL. PMID: 26871624.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. Neuron. 2014 Dec 17; 84(6):1198-212. Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL. PMID: 25500157.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. J Mol Biol. 2015 Jan 16; 427(1):3-30. Payandeh J, Minor DL. PMID: 25158094.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    15. Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. ACS Chem Neurosci. 2014 Sep 17; 5(9):812-22. Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL. PMID: 25028803.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron. 2013 Oct 30; 80(3):658-74. Isacoff EY, Jan LY, Minor DL. PMID: 24183018.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. J Mol Biol. 2014 Jan 23; 426(2):467-83. Shaya D, Findeisen F, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL. PMID: 24120938.
      View in: PubMed   Mentions: 50     Fields:    Translation:CellsPHPublic Health
    18. Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain. J Mol Biol. 2013 Sep 09; 425(17):3217-34. Findeisen F, Rumpf CH, Minor DL. PMID: 23811053.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    19. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. PMID: 23738709.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    20. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6352-7. Tien J, Lee HY, Minor DL, Jan YN, Jan LY. PMID: 23576756.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    21. Using yeast to study potassium channel function and interactions with small molecules. Methods Mol Biol. 2013; 995:31-42. Bagriantsev SN, Minor DL. PMID: 23494370.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. J Mol Biol. 2013 Jan 23; 425(2):378-94. Xu Q, Chang A, Tolia A, Minor DL. PMID: 23178170.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    23. Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains. EMBO J. 2012 Aug 01; 31(15):3297-308. Bagriantsev SN, Clark KA, Minor DL. PMID: 22728824.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    24. A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol. 2012 May 06; 19(6):633-41. Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL. PMID: 22562138.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Multiple modalities converge on a common gate to control K2P channel function. EMBO J. 2011 Jul 15; 30(17):3594-606. Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL. PMID: 21765396.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    26. Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12313-8. Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL. PMID: 21746903.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    27. Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Channels (Austin). 2011 Jul-Aug; 5(4):320-4. Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL. PMID: 21712653.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation. Structure. 2010 Dec 08; 18(12):1617-31. Findeisen F, Minor DL. PMID: 21134641.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    29. Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Channels (Austin). 2010 Nov-Dec; 4(6):459-74. Minor DL, Findeisen F. PMID: 21139419.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    30. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010 Dec 01; 29(23):3924-38. Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL. PMID: 20953164.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    31. Small molecule ion channel match making: a natural fit for new ASIC ligands. Neuron. 2010 Oct 06; 68(1):1-3. Bagriantsev SN, Minor DL. PMID: 20920784.
      View in: PubMed   Mentions: 3     Fields:    
    32. Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol. 2010 May; 6(5):369-75. Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY. PMID: 20364128.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    33. Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. PLoS One. 2009 Oct 16; 4(10):e7496. Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL. PMID: 19834614.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    34. Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Sci. 2009 Oct; 18(10):2100-14. Xu Q, Minor DL. PMID: 19693805.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    35. Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. Mol Biosyst. 2009 Aug; 5(8):802-10. Minor DL. PMID: 19603113.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    36. Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation. J Gen Physiol. 2009 Mar; 133(3):327-43. Findeisen F, Minor DL. PMID: 19237593.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    37. 2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. J Struct Funct Genomics. 2009 Apr; 10(2):193-208. Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W. PMID: 19148774.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    38. A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms. Protein Sci. 2009 Jan; 18(1):121-33. Hammon J, Palanivelu DV, Chen J, Patel C, Minor DL. PMID: 19177357.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    39. Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure. 2008 Oct 08; 16(10):1455-67. Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL. PMID: 18940602.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    40. X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. J Mol Biol. 2008 Nov 21; 383(4):854-70. Fujiwara Y, Minor DL. PMID: 18782578.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    41. Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation. Structure. 2008 Feb; 16(2):280-94. Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL. PMID: 18275819.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    42. Puzzle plugged by protein pore plasticity. Mol Cell. 2007 May 25; 26(4):459-60. Minor DL. PMID: 17531803.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    43. The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data. Neuron. 2007 May 24; 54(4):511-33. Minor DL. PMID: 17521566.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron. 2007 Mar 01; 53(5):663-75. Howard RJ, Clark KA, Holton JM, Minor DL. PMID: 17329207.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    45. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol. 2006 Nov; 13(11):987-95. Pioletti M, Findeisen F, Hura GL, Minor DL. PMID: 17057713.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    46. Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006 Jul 20; 51(2):201-12. Tsuruda PR, Julius D, Minor DL. PMID: 16846855.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    47. A sensitive channel family replete with sense and motion. Nat Struct Mol Biol. 2006 May; 13(5):388-90. Minor DL. PMID: 16738606.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    48. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol. 2005 Dec; 12(12):1108-15. Van Petegem F, Chatelain FC, Minor DL. PMID: 16299511.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansCells
    49. The pore helix dipole has a minor role in inward rectifier channel function. Neuron. 2005 Sep 15; 47(6):833-43. Chatelain FC, Alagem N, Xu Q, Pancaroglu R, Reuveny E, Minor DL. PMID: 16157278.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    50. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature. 2004 Jun 10; 429(6992):671-5. Van Petegem F, Clark KA, Chatelain FC, Minor DL. PMID: 15141227.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    51. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol Cell. 2003 Dec; 12(6):1427-37. Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA. PMID: 14690597.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
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