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Michael Grabe, PhD

Photo of Michael Grabe, PhD
Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
AddressSan Francisco CA 94158
Phone415-502-2874
ORCID ORCID Icon0000-0003-3509-5997 Additional info
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    Collapse Biography 
    Collapse education and training
    University of California, San Francisco07/2021Diversity, Equity, and Inclusion Champion Training
    Collapse awards and honors
    Oakland Planning and Development Corporation, Pittsburgh, PA2012Shining Star Award (for community service)
    University of Pittsburgh2011Senior Vice Chancellor's Research Seminar
    NSF2009  - 2014CAREER Award
    Sloan Foundation2009  - 2011Alfred P. Sloan Research Fellow in Molecular Biology
    University of California, Berkeley1997  - 1998Outstanding Graduate Student Instructor

    Collapse Overview 
    Collapse overview
    The Grabe lab uses computational methods to understand biological phenomena. We are primarily interested in ion and small molecule transport across cellular membranes. We wish to understand the molecular workings of ion channels and transporters as well as how these proteins work together to regulate ion homeostasis in excitable cells and intracellular organelles such as the lysosome. We are also interested in the role that membrane proteins play in controlling the intrinsic shape of organelles.
    Collapse Academic Senate

    Collapse Research 
    Collapse research activities and funding
    Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins
    NIH R01GM137109Jan 1, 2021 - Nov 30, 2024
    Role: Principal Investigator
    Computer simulations of lysosomal and osteoclast microphysiology
    NIH R21GM100224Sep 1, 2012 - Jul 31, 2015
    Role: Principal Investigator
    Computational studies of sodium symporters
    NIH R01GM089740Sep 30, 2011 - May 31, 2021
    Role: Principal Investigator
    High Performance Computing for Biomedical Research
    NIH P41RR006009Sep 1, 1990 - Jul 31, 2013
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response. Elife. 2025 Sep 17; 14. San Felipe CJ, Batra J, Muralidharan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS. PMID: 40960494; PMCID: PMC12443476.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Detection of Cytosolic Ion Concentrations by the Trans-Golgi Network/Early Endosome is Important for Salt Tolerance. bioRxiv. 2025 Aug 17. McKay D, Lupanga U, Perez MU, Krebs M, Wege S, Grabe M, Schumacher K. PMID: 40832346; PMCID: PMC12363952.
      View in: PubMed   Mentions:
    3. Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove. Elife. 2025 Aug 06; 14. Stephens CA, van Hilten N, Zheng L, Grabe M. PMID: 40768244; PMCID: PMC12327946.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response. bioRxiv. 2025 Aug 01. Felipe CS, Batra J, Muralidharaan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS. PMID: 40027672; PMCID: PMC11870501.
      View in: PubMed   Mentions:
    5. A Cooperative Model for Symmetric Ligand Binding to Protein Fibrils. Biochemistry. 2025 Aug 05; 64(15):3382-3392. Smith MS, DeGrado WF, Grabe M, Shoichet BK. PMID: 40700656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site. Nat Struct Mol Biol. 2025 Jul; 32(7):1318. Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL. PMID: 40234720.
      View in: PubMed   Mentions:    Fields:    
    7. A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane. bioRxiv. 2025 Jun 27. Teo CF, Tuomivaara ST, van Hilten N, Crottès D, Jan YN, Grabe M, Jan LY. PMID: 40667283; PMCID: PMC12262486.
      View in: PubMed   Mentions:
    8. Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2. Nat Struct Mol Biol. 2025 Aug; 32(8):1479-1487. Li F, Eriksen J, Oses-Prieto JA, Gomez YK, Xu H, Hareendranath S, Das P, Finer-Moore J, Nguyen P, Bowen A, Nelson A, Burlingame A, Grabe M, Stroud RM, Edwards RH. PMID: 40461871.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Deep learning-guided design of dynamic proteins. Science. 2025 May 22; 388(6749):eadr7094. Guo AB, Akpinaroglu D, Stephens CA, Grabe M, Smith CA, Kelly MJS, Kortemme T. PMID: 40403060.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    10. Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove. bioRxiv. 2025 Mar 29. Stephens CA, van Hilten N, Zheng L, Grabe M. PMID: 39386458; PMCID: PMC11463437.
      View in: PubMed   Mentions:
    11. Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site. Nat Struct Mol Biol. 2025 Jul; 32(7):1154-1166. Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL. PMID: 40011746.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. A Cooperative Model for Symmetric Ligand Binding to Protein Fibrils. bioRxiv. 2025 Jan 30. Smith MS, DeGrado WF, Grabe M, Shoichet BK. PMID: 39975185; PMCID: PMC11838254.
      View in: PubMed   Mentions:
    13. Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A. Elife. 2024 Aug 16; 13. Lincoff J, Helsell CVM, Marcoline FV, Natale AM, Grabe M. PMID: 39150863; PMCID: PMC11383528.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Remodelling of the translatome controls diet and its impact on tumorigenesis. Nature. 2024 Sep; 633(8028):189-197. Yang H, Zingaro VA, Lincoff J, Tom H, Oikawa S, Oses-Prieto JA, Edmondson Q, Seiple I, Shah H, Kajimura S, Burlingame AL, Grabe M, Ruggero D. PMID: 39143206; PMCID: PMC12147720.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    15. Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site. bioRxiv. 2024 Jun 27. Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL. PMID: 38979306; PMCID: PMC11230452.
      View in: PubMed   Mentions: 1  
    16. Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT. Nat Commun. 2023 11 18; 14(1):7511. Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, Althoff T, Ermolova N, Wright EM, Hubbell WL, Grabe M, Abramson J. PMID: 37980423; PMCID: PMC10657379.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    17. Brominated lipid probes expose structural asymmetries in constricted membranes. Nat Struct Mol Biol. 2023 02; 30(2):167-175. Moss FR, Lincoff J, Tucker M, Mohammed A, Grabe M, Frost A. PMID: 36624348; PMCID: PMC9935397.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    18. Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching. Nature. 2022 11; 611(7937):827-834. Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D. PMID: 36418452; PMCID: PMC11212661.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 2022 06; 29(6):537-548. Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL. PMID: 35655098; PMCID: PMC9809158.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    20. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 2022 06; 606(7912):180-187. Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. PMID: 35614225; PMCID: PMC9646675.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    21. Berkeley Madonna Version 10-A simulation package for solving mathematical models. CPT Pharmacometrics Syst Pharmacol. 2022 03; 11(3):290-301. Marcoline FV, Furth J, Nayak S, Grabe M, Macey RI. PMID: 35064965; PMCID: PMC8923725.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    22. Taking the Monte-Carlo gamble: How not to buckle under the pressure! J Comput Chem. 2022 03 05; 43(6):431-434. Gomez YK, Natale AM, Lincoff J, Wolgemuth CW, Rosenberg JM, Grabe M. PMID: 34921560; PMCID: PMC8776593.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    23. Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). Fong LK, Chalkley MJ, Tan SK, Grabe M, DeGrado WF. PMID: 34155106; PMCID: PMC8256006.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    24. Inroads into Membrane Physiology through Transport Nanomachines. J Mol Biol. 2021 08 06; 433(16):167101. Stockbridge RB, Gaudet R, Grabe M, Minor DL. PMID: 34119492; PMCID: PMC9633016.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    25. Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. ACS Sens. 2021 06 25; 6(6):2168-2180. Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. PMID: 34102054; PMCID: PMC8240087.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    26. Allosteric cooperation in a de novo-designed two-domain protein. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33246-33253. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. PMID: 33318174; PMCID: PMC7776816.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    27. K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv. 2020 10; 6(44). Lolicato M, Natale AM, Abderemane-Ali F, Crottès D, Capponi S, Duman R, Wagner A, Rosenberg JM, Grabe M, Minor DL. PMID: 33127683; PMCID: PMC7608817.
      View in: PubMed   Mentions: 49     Fields:    
    28. A Computational Model of Protein Induced Membrane Morphology with Geodesic Curvature Driven Protein-Membrane Interface. J Comput Phys. 2020 Dec 01; 422. Zhou YC, Argudo D, Marcoline F, Grabe M. PMID: 32921806; PMCID: PMC7480790.
      View in: PubMed   Mentions: 2  
    29. A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms. PLoS Comput Biol. 2020 07; 16(7):e1007884. George A, Bisignano P, Rosenberg JM, Grabe M, Zuckerman DM. PMID: 32614821; PMCID: PMC7331975.
      View in: PubMed   Mentions: 10     Fields:    
    30. A kinetic mechanism for enhanced selectivity of membrane transport. PLoS Comput Biol. 2020 07; 16(7):e1007789. Bisignano P, Lee MA, George A, Zuckerman DM, Grabe M, Rosenberg JM. PMID: 32614861; PMCID: PMC7331977.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. EmrE reminds us to expect the unexpected in membrane transport. J Gen Physiol. 2020 01 06; 152(1). Grabe M, Zuckerman DM, Rosenberg JM. PMID: 31816640; PMCID: PMC7034101.
      View in: PubMed   Mentions: 7     Fields:    
    32. Protons in small spaces: Discrete simulations of vesicle acidification. PLoS Comput Biol. 2019 12; 15(12):e1007539. Singh A, Marcoline FV, Veshaguri S, Kao AW, Bruchez M, Mindell JA, Stamou D, Grabe M. PMID: 31869334; PMCID: PMC6946529.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    33. Biophysics at the coffee shop: lessons learned working with George Oster. Mol Biol Cell. 2019 07 22; 30(16):1882-1889. Igoshin OA, Chen J, Xing J, Liu J, Elston TC, Grabe M, Kim KS, Nirody JA, Rangamani P, Sun SX, Wang H, Wolgemuth C. PMID: 31322997; PMCID: PMC6727762.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    34. Harmonizing Experimental Data with Modeling to Predict Membrane Protein Insertion in Yeast. Biophys J. 2019 08 20; 117(4):668-678. Guerriero CJ, Gomez YK, Daskivich GJ, Reutter KR, Augustine AA, Weiberth KF, Nakatsukasa K, Grabe M, Brodsky JL. PMID: 31399214; PMCID: PMC6712491.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    35. A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel. J Gen Physiol. 2019 03 04; 151(3):316-327. Argudo D, Capponi S, Bethel NP, Grabe M. PMID: 30728217; PMCID: PMC6400526.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    36. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. PMID: 30622179; PMCID: PMC6347726.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    37. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032; PMCID: PMC6286348.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    38. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5. Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. PMID: 30340023; PMCID: PMC6503851.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    39. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523; PMCID: PMC6584023.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    40. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nat Commun. 2018 05 01; 9(1):1753. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. PMID: 29717135; PMCID: PMC5931594.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    41. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. PMID: 29507231; PMCID: PMC5866573.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    42. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 03 07; 97(5):1063-1077.e4. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. PMID: 29478917; PMCID: PMC5860880.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    43. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E172-E179. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. PMID: 29279396; PMCID: PMC5777057.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    44. Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell. 2017 Jul 15; 28(15):2076-2090. Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL. PMID: 28539401; PMCID: PMC5509421.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    45. New Continuum Approaches for Determining Protein-Induced Membrane Deformations. Biophys J. 2017 May 23; 112(10):2159-2172. Argudo D, Bethel NP, Marcoline FV, Wolgemuth CW, Grabe M. PMID: 28538153; PMCID: PMC5448241.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    46. Atomistic insight into lipid translocation by a TMEM16 scramblase. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):14049-14054. Bethel NP, Grabe M. PMID: 27872308; PMCID: PMC5150362.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    47. A mathematical model of osteoclast acidification during bone resorption. Bone. 2016 12; 93:167-180. Marcoline FV, Ishida Y, Mindell JA, Nayak S, Grabe M. PMID: 27650914; PMCID: PMC5077641.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    48. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. PMID: 27325773; PMCID: PMC4941443.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    49. Direct observation of proton pumping by a eukaryotic P-type ATPase. Science. 2016 Mar 25; 351(6280):1469-73. Veshaguri S, Christensen SM, Kemmer GC, Ghale G, Møller MP, Lohr C, Christensen AL, Justesen BH, Jørgensen IL, Schiller J, Hatzakis NS, Grabe M, Pomorski TG, Stamou D. PMID: 27013734; PMCID: PMC5023152.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    50. Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models. Biochim Biophys Acta. 2016 Jul; 1858(7 Pt B):1619-34. Argudo D, Bethel NP, Marcoline FV, Grabe M. PMID: 26853937; PMCID: PMC4877259.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    51. Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations. Structure. 2015 Aug 04; 23(8):1526-1537. Marcoline FV, Bethel N, Guerriero CJ, Brodsky JL, Grabe M. PMID: 26118532; PMCID: PMC4527966.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    52. Simulating Current-Voltage Relationships for a Narrow Ion Channel Using the Weighted Ensemble Method. J Chem Theory Comput. 2015 Apr 14; 11(4):1907-18. Adelman JL, Grabe M. PMID: 26392816; PMCID: PMC4573566.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    53. WESTPA: an interoperable, highly scalable software package for weighted ensemble simulation and analysis. J Chem Theory Comput. 2015 Feb 10; 11(2):800-9. Zwier MC, Adelman JL, Kaus JW, Pratt AJ, Wong KF, Rego NB, Suárez E, Lettieri S, Wang DW, Grabe M, Zuckerman DM, Chong LT. PMID: 26392815; PMCID: PMC4573570.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
    54. De novo design of a transmembrane Zn²⁺-transporting four-helix bundle. Science. 2014 Dec 19; 346(6216):1520-4. Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. PMID: 25525248; PMCID: PMC4400864.
      View in: PubMed   Mentions: 146     Fields:    Translation:Cells
    55. Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. Nat Struct Mol Biol. 2014 Jul; 21(7):626-32. Choudhary OP, Paz A, Adelman JL, Colletier JP, Abramson J, Grabe M. PMID: 24908397; PMCID: PMC4157756.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    56. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med. 2014 Jun; 20(6):624-32. Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM. PMID: 24836577; PMCID: PMC4048325.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    57. Continuum approaches to understanding ion and peptide interactions with the membrane. J Membr Biol. 2014 May; 247(5):395-408. Latorraca NR, Callenberg KM, Boyle JP, Grabe M. PMID: 24652510; PMCID: PMC4096575.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    58. Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J. 2014 Mar 18; 106(6):1280-9. Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. PMID: 24655503; PMCID: PMC3984995.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    59. Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature. 2014 Jan 02; 505(7481):103-7. Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV. PMID: 24256734; PMCID: PMC4160023.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    60. A model of lysosomal pH regulation. J Gen Physiol. 2013 Jun; 141(6):705-20. Ishida Y, Nayak S, Mindell JA, Grabe M. PMID: 23712550; PMCID: PMC3664703.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    61. Simulating rare events using a weighted ensemble-based string method. J Chem Phys. 2013 Jan 28; 138(4):044105. Adelman JL, Grabe M. PMID: 23387566; PMCID: PMC3568092.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    62. Membrane bending is critical for the stability of voltage sensor segments in the membrane. J Gen Physiol. 2012 Jul; 140(1):55-68. Callenberg KM, Latorraca NR, Grabe M. PMID: 22732310; PMCID: PMC3382720.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    63. Simulations of the alternating access mechanism of the sodium symporter Mhp1. Biophys J. 2011 Nov 16; 101(10):2399-407. Adelman JL, Dale AL, Zwier MC, Bhatt D, Chong LT, Zuckerman DM, Grabe M. PMID: 22098738; PMCID: PMC3218348.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    64. Raw sewage harbors diverse viral populations. mBio. 2011; 2(5). Cantalupo PG, Calgua B, Zhao G, Hundesa A, Wier AD, Katz JP, Grabe M, Hendrix RW, Girones R, Wang D, Pipas JM. PMID: 21972239; PMCID: PMC3187576.
      View in: PubMed   Mentions: 121     Fields:    Translation:Cells
    65. The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010 Dec 16; 468(7326):988-91. Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. PMID: 21131949; PMCID: PMC3736980.
      View in: PubMed   Mentions: 119     Fields:    Translation:Cells
    66. Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases. J Biol Chem. 2011 Jan 07; 286(1):649-60. Kashlan OB, Adelman JL, Okumura S, Blobner BM, Zuzek Z, Hughey RP, Kleyman TR, Grabe M. PMID: 20974852; PMCID: PMC3013024.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    67. Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J. 2010 Oct 06; 99(7):L56-8. Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. PMID: 20923633; PMCID: PMC3042592.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    68. APBSmem: a graphical interface for electrostatic calculations at the membrane. PLoS One. 2010 Sep 29; 5(9). Callenberg KM, Choudhary OP, de Forest GL, Gohara DW, Baker NA, Grabe M. PMID: 20949122; PMCID: PMC2947494.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    69. Characterization of the PCMBS-dependent modification of KCa3.1 channel gating. J Gen Physiol. 2010 Oct; 136(4):367-87. Bailey MA, Grabe M, Devor DC. PMID: 20837673; PMCID: PMC2947057.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    70. Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. J Biol Chem. 2010 Nov 05; 285(45):35216-23. Kashlan OB, Boyd CR, Argyropoulos C, Okumura S, Hughey RP, Grabe M, Kleyman TR. PMID: 20817728; PMCID: PMC2966135.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    71. The electrostatics of VDAC: implications for selectivity and gating. J Mol Biol. 2010 Feb 26; 396(3):580-92. Choudhary OP, Ujwal R, Kowallis W, Coalson R, Abramson J, Grabe M. PMID: 20005234; PMCID: PMC3736979.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    72. Conformational dynamics of the inner pore helix of voltage-gated potassium channels. J Chem Phys. 2009 Jun 07; 130(21):215103. Choe S, Grabe M. PMID: 19508102.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    73. A continuum method for determining membrane protein insertion energies and the problem of charged residues. J Gen Physiol. 2008 Jun; 131(6):563-73. Choe S, Hecht KA, Grabe M. PMID: 18474636; PMCID: PMC2391250.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    74. Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem. 2008 Jan 25; 283(4):2078-87. Krzysiak TC, Grabe M, Gilbert SP. PMID: 18037705; PMCID: PMC2265775.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    75. Structure prediction for the down state of a potassium channel voltage sensor. Nature. 2007 Feb 01; 445(7127):550-3. Grabe M, Lai HC, Jain M, Jan YN, Jan LY. PMID: 17187053.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    76. K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14361-6. Grabe M, Bichet D, Qian X, Jan YN, Jan LY. PMID: 16983068; PMCID: PMC1570128.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    77. Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14355-60. Bichet D, Grabe M, Jan YN, Jan LY. PMID: 16983069; PMCID: PMC1570129.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    78. Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis. Ann Intern Med. 2006 Jun 06; 144(11):832-41. Nayak S, Olkin I, Liu H, Grabe M, Gould MK, Allen IE, Owens DK, Bravata DM. PMID: 16754925.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    79. The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron. 2005 Aug 04; 47(3):395-406. Lai HC, Grabe M, Jan YN, Jan LY. PMID: 16055063.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    80. A quantitative assessment of models for voltage-dependent gating of ion channels. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17640-5. Grabe M, Lecar H, Jan YN, Jan LY. PMID: 15591352; PMCID: PMC539724.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    81. Electrostatic model of S4 motion in voltage-gated ion channels. Biophys J. 2003 Nov; 85(5):2854-64. Lecar H, Larsson HP, Grabe M. PMID: 14581190; PMCID: PMC1303566.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    82. Answers and questions from the KvAP structures. Neuron. 2003 Jul 31; 39(3):395-400. Cohen BE, Grabe M, Jan LY. PMID: 12895415.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    83. Protein interactions and membrane geometry. Biophys J. 2003 Feb; 84(2 Pt 1):854-68. Grabe M, Neu J, Oster G, Nollert P. PMID: 12547769; PMCID: PMC1302665.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    84. Biosynthesis and secretion of pituitary hormones: dynamics and regulation. Arch Physiol Biochem. 2002 Apr; 110(1-2):16-25. Moore HP, Andresen JM, Eaton BA, Grabe M, Haugwitz M, Wu MM, Machen TE. PMID: 11935396.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    85. Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells. Am J Physiol Cell Physiol. 2001 Sep; 281(3):C908-21. Chandy G, Grabe M, Moore HP, Machen TE. PMID: 11502568.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    86. Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH. JOP. 2001 Jul; 2(4 Suppl):229-36. Machen TE, Chandy G, Wu M, Grabe M, Moore HP. PMID: 11875264.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    87. Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem. 2001 Aug 31; 276(35):33027-35. Wu MM, Grabe M, Adams S, Tsien RY, Moore HP, Machen TE. PMID: 11402049.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    88. Regulation of organelle acidity. J Gen Physiol. 2001 Apr; 117(4):329-44. Grabe M, Oster G. PMID: 11279253; PMCID: PMC2217256.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    89. The mechanochemistry of V-ATPase proton pumps. Biophys J. 2000 Jun; 78(6):2798-813. Grabe M, Wang H, Oster G. PMID: 10827963; PMCID: PMC1300868.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    90. How Fo-ATPase generates rotary torque. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):523-8. Oster G, Wang H, Grabe M. PMID: 10836505; PMCID: PMC1692753.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    91. Energy transduction in the sodium F-ATPase of Propionigenium modestum. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):4924-9. Dimroth P, Wang H, Grabe M, Oster G. PMID: 10220395; PMCID: PMC21793.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    92. Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. J Bioenerg Biomembr. 1995 Jun; 27(3):285-93. Curry WB, Grabe MD, Kurnikov IV, Skourtis SS, Beratan DN, Regan JJ, Aquino AJ, Beroza P, Onuchic JN. PMID: 8847342.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
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