Maya Kotas, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #201
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CAFellowship2018Pulmonary & Critical Care
    New York Presbyterian-Columbia University Medical Center, New York, NYResidency2015Internal Medicine
    Yale University, New Haven, CTPh.D.2013Immunobiology
    Yale School of Medicine, New Haven, CTM.D.2013Medicine
    Yale University, New Haven, CTBA2005Biomedical Engineering
    University of California, San Francisco, CA2020Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Dr. Kotas is an Assistant Professor in the Division of Pulmonary, Critical Care, Sleep, Allergy and Sleep Medicine. She received her BA, MD and PhD from Yale University. After completing residency training in Internal Medicine at New York Presbyterian - Columbia University, she completed a fellowship in Pulmonary & Critical Care Medicine at UCSF. She serves as an attending physician in the intensive care units at UCSF.

    Dr. Kotas's research focuses on the role of the innate immune system in regulating the biology of the airway epithelium. Her work utilizes mouse modeling and patient samples to better understand how the immune system reshapes the cells that line the airway during allergic diseases. The goal of this work is to discover new targets for treatment of allergic airway diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Defining the role of tuft cells in allergic airway disease
    Francis Family Foundation not assignedJul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator
    Understanding the Role of Airway Tuft Cells in Mucociliary Clearance in Cystic Fibrosis
    Nina Ireland Program in Lung Health not assignedJan 4, 2022 - Jan 3, 2024
    Role: Principal Investigator
    Characterization of the type 2 immune circuit that regulates airway epithelial remodeling
    A.P. Giannini Foundation not assignedJul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Role of ILC2s in lung maintenance and repair
    NIH F32HL140868Jan 1, 2018 - Dec 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. PMID: 37163060; PMCID: PMC10168323.
      View in: PubMed   Mentions:
    2. IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis. J Allergy Clin Immunol. 2023 05; 151(5):1277-1285. Kotas ME, Patel NN, Cope EK, Gurrola JG, Goldberg AN, Pletcher SD, Seibold MA, Moore CM, Gordon ED. PMID: 36736797; PMCID: PMC10243183.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage. Annu Rev Pathol. 2023 01 24; 18:311-335. Kotas ME, O'Leary CE, Locksley RM. PMID: 36351364; PMCID: PMC10443898.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair. Elife. 2022 09 08; 11. Barr J, Gentile ME, Lee S, Kotas ME, Fernanda de Mello Costa M, Holcomb NP, Jaquish A, Palashikar G, Soewignjo M, McDaniel M, Matsumoto I, Margolskee R, Von Moltke J, Cohen NA, Sun X, Vaughan AE. PMID: 36073526; PMCID: PMC9553214.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity. 2022 10 11; 55(10):1891-1908.e12. Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM. PMID: 36044899; PMCID: PMC9561030.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. JCI Insight. 2022 07 08; 7(13). Kotas ME, Moore CM, Gurrola JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. PMID: 35608904; PMCID: PMC9310525.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    7. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. The Journal of Immunology. 2022 May 1; 208(1_Supplement):50.39-50.39. Ricardo-Gonzalez RR, Kotas KM, O’Leary OC, Tenvooren TI, Marquez MD, Singh SK, Damsky DW, Liao LC, Schroeder SA, Cohen CJ, Fassett FM, Lee LJ, Daniel DS, Bittinger BK, Diaz DR, Fraser FJ, Ansel AK, Spitzer SM, Liang LH, Locksley LR. .
      View in: Publisher Site   Mentions:
    8. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 03 04; 7(69):eabj1080. O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. PMID: 35245089; PMCID: PMC9166270.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Toward Optimal Acute Respiratory Distress Syndrome Outcomes: Recognizing the Syndrome and Identifying Its Causes. Crit Care Clin. 2021 Oct; 37(4):733-748. Kotas ME, Thompson BT. PMID: 34548131; PMCID: PMC8449137.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. Mucosal Immunol. 2021 11; 14(6):1295-1305. Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM. PMID: 34290377; PMCID: PMC8528700.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    11. A role for IL-33-activated ILC2s in eosinophilic vasculitis. JCI Insight. 2021 06 22; 6(12). Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B. PMID: 33974563; PMCID: PMC8262498.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Why Innate Lymphoid Cells? Immunity. 2018 06 19; 48(6):1081-1090. Kotas ME, Locksley RM. PMID: 29924974; PMCID: PMC6145487.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    13. Mesenchymal stromal cells and macrophages in sepsis: new insights. Eur Respir J. 2018 04; 51(4). Kotas ME, Matthay MA. PMID: 29700107.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis. Cell Metab. 2015 May 05; 21(5):692-705. McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL, Kotas ME, Potthoff MJ, Richerson GB, Gillum MP. PMID: 25955206; PMCID: PMC4565052.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    15. Homeostasis, inflammation, and disease susceptibility. Cell. 2015 Feb 26; 160(5):816-827. Kotas ME, Medzhitov R. PMID: 25723161; PMCID: PMC4369762.
      View in: PubMed   Mentions: 404     Fields:    Translation:Humans
    16. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis. J Biol Chem. 2013 May 31; 288(22):16167-76. Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP. PMID: 23595987; PMCID: PMC3668772.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Sirtuin-1 is a nutrient-dependent modulator of inflammation. Adipocyte. 2013 Apr 01; 2(2):113-8. Kotas ME, Gorecki MC, Gillum MP. PMID: 23805409; PMCID: PMC3661114.
      View in: PubMed   Mentions: 21     Fields:    
    18. Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4810-5. Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R. PMID: 23487794; PMCID: PMC3607017.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    19. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. PMID: 22110092; PMCID: PMC3219953.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    20. Impact of CD1d deficiency on metabolism. PLoS One. 2011; 6(9):e25478. Kotas ME, Lee HY, Gillum MP, Annicelli C, Guigni BA, Shulman GI, Medzhitov R. PMID: 21980475; PMCID: PMC3183002.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    21. Comparative Evaluation of Methods Used for Sampling Malaria Vectors in the Kilombero Valley, South Eastern Tanzania. The Open Tropical Medicine Journal. 2008 Sep 26; 1(1):51-55. Okumu OF, Kotas KM, Kihonda KJ, Mathenge ME, Killeen KG, Moore MS. .
      View in: Publisher Site   Mentions:
    22. Replacement of bone marrow by bone in rat femurs: the bone bioreactor. Tissue Eng Part A. 2008 Feb; 14(2):237-46. Zhang Q, Cuartas E, Mehta N, Gilligan J, Ke HZ, Saltzman WM, Kotas M, Ma M, Rajan S, Chalouni C, Carlson J, Vignery A. PMID: 18333776.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    23. Replacement of Bone Marrow by Bone in Rat Femurs: The Bone Bioreactor. Tissue Engineering. 2008 Jan 9; 110306233438005. Zhang ZQ, Cuartas CE, Mehta MN, Gilligan GJ, Ke KH, Saltzman SW, Kotas KM, Ma MM, Rajan RS, Chalouni CC, Carlson CJ, Vignery VA. .
      View in: Publisher Site   Mentions:
    24. Cost-sharing strategies combining targeted public subsidies with private-sector delivery achieve high bednet coverage and reduced malaria transmission in Kilombero Valley, southern Tanzania. BMC Infect Dis. 2007 Oct 25; 7:121. Killeen GF, Tami A, Kihonda J, Okumu FO, Kotas ME, Grundmann H, Kasigudi N, Ngonyani H, Mayagaya V, Nathan R, Abdulla S, Charlwood JD, Smith TA, Lengeler C. PMID: 17961211; PMCID: PMC2211306.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsPHPublic Health
    25. Quantifying behavioural interactions between humans and mosquitoes: evaluating the protective efficacy of insecticidal nets against malaria transmission in rural Tanzania. BMC Infect Dis. 2006 Nov 10; 6:161. Killeen GF, Kihonda J, Lyimo E, Oketch FR, Kotas ME, Mathenge E, Schellenberg JA, Lengeler C, Smith TA, Drakeley CJ. PMID: 17096840; PMCID: PMC1657018.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsPHPublic Health
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