Erin Gordon, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-0735
ORCID ORCID Icon0000-0001-7723-2297 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A. 2001Molecular Cell Biology
    University of Southern CaliforniaM.D.2005School of Medicine
    University of California, San DiegoInternal Medicine
    University of California, San FranciscoPulmonary and Critical Care Fellowship

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist with an interest in airway epithelial dysfunction in asthma. Specifically, my lab focuses on understanding how genetic risk variants that are associated with asthma at a population level, actually confer risk of disease at a molecular level. We use novel techniques such as conditionally reprogrammed primary airway epithelial cells, CRISPR gene deletion, and biospecimens from large numbers of human subjects to discover the function of genes associated with asthma and elucidate the causal single nucleotide polymorphism. These efforts are designed to uncover novel drug targets and define the subpopulation of asthmatics most likely to benefit from therapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding the Molecular Genetic Mechanisms of Asthma Risk Loci: IL33, IL1RL1, and GSDMB
    NIH R01AI136962Jan 15, 2018 - Dec 31, 2022
    Role: Principal Investigator
    The function and regulation of IL-33 in the airway epithelium in asthma
    NIH K08HL114645Aug 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Periostin induces matrix stiffness and epithelial cell mesenchymal transition
    NIH F32HL107004Jan 1, 2011 - Dec 31, 2011
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. JCI Insight. 2022 Jul 08; 7(13). Kotas ME, Moore CM, Gurrola JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. PMID: 35608904; PMCID: PMC9310525.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. Front Immunol. 2021; 12:704172. Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. PMID: 34691018; PMCID: PMC8528961.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection. Cell Rep Med. 2020 07 21; 1(4). Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR. PMID: 32754722; PMCID: PMC7402593.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 05 01; 199(9):1076-1085. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. PMID: 30888839; PMCID: PMC6515873.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    5. Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov. 2018; 4:7. Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV. PMID: 29449961; PMCID: PMC5809386.
      View in: PubMed   Mentions: 6  
    6. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 03 01; 128(3):997-1009. Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV, National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP). PMID: 29400693; PMCID: PMC5824874.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    7. Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clin Exp Allergy. 2017 Dec; 47(12):1534-1545. Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA. PMID: 28833774.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    8. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 09 08; 1(14):e87871. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. PMID: 27699235; PMCID: PMC5033813.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    9. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. PMID: 27432971; PMCID: PMC4978244.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    10. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 05 01; 193(9):935-6. Gordon ED, Locksley RM, Fahy JV. PMID: 27128698; PMCID: PMC4872659.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 01; 139(1):72-81.e1. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. PMID: 27215490; PMCID: PMC5073041.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    12. 98 Common genetic polymorphisms in the ST2 gene locus are associated with impaired soluble ST2 expression in the airway epithelium. Cytokine. 2013 Sep 1; 63(3):266. Gordon GE, Urbanek UC, Yuan YS, Woodruff WP, Fahy FJ, Seibold SM. .
      View in: Publisher Site   Mentions:
    13. 99 IL-33 splice variants are critical to its regulated secretion from airway epithelial cells. Cytokine. 2013 Sep 1; 63(3):266. Gordon GE, Lachowicz-Scroggins LM, Urbanek UC, Seibold SM, Fahy FJ. .
      View in: Publisher Site   Mentions:
    14. A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. PMID: 22093101; PMCID: PMC3271792.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    15. Management of chronic obstructive pulmonary disease: moving beyond the asthma algorithm. J Allergy Clin Immunol. 2009 Nov; 124(5):873-80; quiz 881-2. Gordon E, Lazarus SC. PMID: 19895979.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14; 9:3. Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S, Perkins DL, Finn PW. PMID: 18194569; PMCID: PMC2253534.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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