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Erin Gordon, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-476-0752
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A. 2001Molecular Cell Biology
    University of Southern CaliforniaM.D.2005School of Medicine
    University of California, San DiegoInternal Medicine
    University of California, San FranciscoPulmonary and Critical Care Fellowship

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist with an interest in airway epithelial dysfunction in asthma. Specifically, my lab focuses on understanding how genetic risk variants that are associated with asthma at a population level, actually confer risk of disease at a molecular level. We use novel techniques such as conditionally reprogrammed primary airway epithelial cells, CRISPR gene deletion, and biospecimens from large numbers of human subjects to discover the function of genes associated with asthma and elucidate the causal single nucleotide polymorphism. These efforts are designed to uncover novel drug targets and define the subpopulation of asthmatics most likely to benefit from therapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding the Molecular Genetic Mechanisms of Asthma Risk Loci: IL33, IL1RL1, and GSDMB
    NIH/NIAID R01AI136962Jan 15, 2018 - Dec 31, 2022
    Role: Principal Investigator
    The function and regulation of IL-33 in the airway epithelium in asthma
    NIH/NHLBI K08HL114645Aug 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Periostin induces matrix stiffness and epithelial cell mesenchymal transition
    NIH/NHLBI F32HL107004Jan 1, 2011 - Dec 31, 2011
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 05 01; 199(9):1076-1085. PMID: 30888839.
      View in: PubMed
    2. Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV. Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov. 2018; 4:7. PMID: 29449961.
      View in: PubMed
    3. Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 03 01; 128(3):997-1009. PMID: 29400693.
      View in: PubMed
    4. Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA. Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clin Exp Allergy. 2017 Dec; 47(12):1534-1545. PMID: 28833774.
      View in: PubMed
    5. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 09 08; 1(14):e87871. PMID: 27699235.
      View in: PubMed
    6. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70. PMID: 27432971.
      View in: PubMed
    7. Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 05 01; 193(9):935-6. PMID: 27128698.
      View in: PubMed
    8. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 01; 139(1):72-81.e1. PMID: 27215490.
      View in: PubMed
    9. Erin D. Gordon, Cydney Urbanek, Shaopeng Yuan, Prescott Woodruff, John V. Fahy, Max A. Seibold. 98 Common genetic polymorphisms in the ST2 gene locus are associated with impaired soluble ST2 expression in the airway epithelium. Cytokine. 2013 Sep 1; 63(3):266.
      View in: Publisher Site
    10. Erin D. Gordon, Marrah Lachowicz-Scroggins, Cydney Urbanek, Max A. Seibold, John V. Fahy. 99 IL-33 splice variants are critical to its regulated secretion from airway epithelial cells. Cytokine. 2013 Sep 1; 63(3):266.
      View in: Publisher Site
    11. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55. PMID: 22093101.
      View in: PubMed
    12. Gordon E, Lazarus SC. Management of chronic obstructive pulmonary disease: moving beyond the asthma algorithm. J Allergy Clin Immunol. 2009 Nov; 124(5):873-80; quiz 881-2. PMID: 19895979.
      View in: PubMed
    13. Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S, Perkins DL, Finn PW. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14; 9:3. PMID: 18194569.
      View in: PubMed
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