Barbara Panning, PhD

SchoolUCSF School of Medicine
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Role of SOX2 O-GIcNAcylation in pluripotency
    NIH/NIGMS R01GM114871Jun 6, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Investigation of X chromosome organization before the onset of X-inactivation
    NIH/NIGMS R01GM100341Jul 20, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Regulation of Xist RNA processing in embryonic stem cells
    NIH/NIGMS R01GM088506Aug 1, 2010 - Jul 31, 2014
    Role: Principal Investigator
    Investigation of the Tip60-p400 complex role in embryonic stem cell self-ren
    NIH/NIGMS R01GM085186Mar 1, 2009 - Feb 28, 2013
    Role: Principal Investigator
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Co-Investigator
    Xist RNA and Regulation of Chromatin Structure
    NIH/NIGMS R01GM063671Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12478-12483. PMID: 27738243.
      View in: PubMed
    2. Goodrich L, Panning B, Leung KN. Activators and repressors: A balancing act for X-inactivation. Semin Cell Dev Biol. 2016 08; 56:3-8. PMID: 27223409.
      View in: PubMed
    3. Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B. SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells. Elife. 2016 Mar 07; 5:e10647. PMID: 26949256; PMCID: PMC4841768.
    4. Panning B, Segal E. Editorial overview: Genome architecture and expression. Curr Opin Genet Dev. 2015 Apr; 31:v-vi. PMID: 26051228; PMCID: PMC4476266.
    5. Smith EA, McDermott G, Do M, Leung K, Panning B, Le Gros MA, Larabell CA. Quantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies. Biophys J. 2014 Oct 21; 107(8):1988-96. PMID: 25418180; PMCID: PMC4213715.
    6. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. PMID: 25307932; PMCID: PMC4253859.
    7. Leung KN, Panning B. X-inactivation: Xist RNA uses chromosome contacts to coat the X. Curr Biol. 2014 Jan 20; 24(2):R80-2. PMID: 24456982; PMCID: PMC4465072.
    8. Miri K, Latham K, Panning B, Zhong Z, Andersen A, Varmuza S. The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development. Development. 2013 Nov; 140(22):4480-9. PMID: 24154523; PMCID: PMC3817938.
    9. Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ. Quantitative genetic-interaction mapping in mammalian cells. Nat Methods. 2013 May; 10(5):432-7. PMID: 23407553; PMCID: PMC3641890.
    10. Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell. 2012 Jul 06; 11(1):91-9. PMID: 22770243; PMCID: PMC3396435.
    11. Myers SA, Panning B, Burlingame AL. Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9490-5. PMID: 21606357; PMCID: PMC3111310.
    12. Fazzio TG, Panning B. Control of embryonic stem cell identity by nucleosome remodeling enzymes. Curr Opin Genet Dev. 2010 Oct; 20(5):500-4. PMID: 20800472; PMCID: PMC3001349.
    13. Royce-Tolland ME, Andersen AA, Koyfman HR, Talbot DJ, Wutz A, Tonks ID, Kay GF, Panning B. The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation. Nat Struct Mol Biol. 2010 Aug; 17(8):948-54. PMID: 20657585; PMCID: PMC4336797.
    14. Fazzio TG, Panning B. Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. J Cell Biol. 2010 Feb 22; 188(4):491-503. PMID: 20176923; PMCID: PMC2828918.
    15. Eliuk SM, Maltby D, Panning B, Burlingame AL. High resolution electron transfer dissociation studies of unfractionated intact histones from murine embryonic stem cells using on-line capillary LC separation: determination of abundant histone isoforms and post-translational modifications. Mol Cell Proteomics. 2010 May; 9(5):824-37. PMID: 20133344; PMCID: PMC2871417.
    16. Panning B. Fine-tuning silencing. Cell Stem Cell. 2010 Jan 08; 6(1):3-4. PMID: 20085734; PMCID: PMC4512832.
    17. Worringer KA, Chu F, Panning B. The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels. BMC Mol Biol. 2009 Apr 22; 10:33. PMID: 19386123; PMCID: PMC2680859.
    18. Fazzio TG, Huff JT, Panning B. Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal. Cell Cycle. 2008 Nov 01; 7(21):3302-6. PMID: 18948739; PMCID: PMC4476248.
    19. Panning B. X-chromosome inactivation: the molecular basis of silencing. J Biol. 2008 Oct 27; 7(8):30. PMID: 18983701.
      View in: PubMed
    20. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science. 2008 Oct 03; 322(5898):43-4. PMID: 18832628; PMCID: PMC4479142.
    21. Panning B, Taatjes DJ. Transcriptional regulation: it takes a village. Mol Cell. 2008 Sep 05; 31(5):622-9. PMID: 18775322; PMCID: PMC4479147.
    22. Fazzio TG, Huff JT, Panning B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell. 2008 Jul 11; 134(1):162-74. PMID: 18614019; PMCID: PMC4308735.
    23. Nicodemi M, Panning B, Prisco A. The colocalization transition of homologous chromosomes at meiosis. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun; 77(6 Pt 1):061913. PMID: 18643306.
      View in: PubMed
    24. Nicodemi M, Panning B, Prisco A. A thermodynamic switch for chromosome colocalization. Genetics. 2008 May; 179(1):717-21. PMID: 18493085; PMCID: PMC2390650.
    25. Royce-Tolland M, Panning B. X-inactivation: it takes two to count. Curr Biol. 2008 Mar 25; 18(6):R255-6. PMID: 18364230.
      View in: PubMed
    26. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science. 2007 Nov 09; 318(5852):944-9. PMID: 17991856; PMCID: PMC3670588.
    27. Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B. Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed. J Cell Biol. 2007 Oct 22; 179(2):269-76. PMID: 17954609; PMCID: PMC2064763.
    28. Worringer KA, Panning B. Zinc finger protein Zn72D promotes productive splicing of the maleless transcript. Mol Cell Biol. 2007 Dec; 27(24):8760-9. PMID: 17923683; PMCID: PMC2169391.
    29. Nusinow DA, Sharp JA, Morris A, Salas S, Plath K, Panning B. The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome. J Mol Biol. 2007 Aug 03; 371(1):11-8. PMID: 17570398; PMCID: PMC2701898.
    30. de la Cruz CC, Kirmizis A, Simon MD, Isono K, Koseki H, Panning B. The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. Chromosome Res. 2007; 15(3):299-314. PMID: 17406994.
      View in: PubMed
    31. Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B. The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell. 2007 Mar 09; 128(5):977-89. PMID: 17350580.
      View in: PubMed
    32. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 2007 Mar 09; 128(5):1003-12. PMID: 17350582; PMCID: PMC2932701.
    33. Cohen HR, Panning B. XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1. Chromosoma. 2007 Aug; 116(4):373-83. PMID: 17333237.
      View in: PubMed
    34. Nusinow DA, Hernández-Muñoz I, Fazzio TG, Shah GM, Kraus WL, Panning B. Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome. J Biol Chem. 2007 Apr 27; 282(17):12851-9. PMID: 17322296.
      View in: PubMed
    35. Mlynarczyk-Evans S, Royce-Tolland M, Alexander MK, Andersen AA, Kalantry S, Gribnau J, Panning B. X chromosomes alternate between two states prior to random X-inactivation. PLoS Biol. 2006 Jun; 4(6):e159. PMID: 16669701; PMCID: PMC1457015.
    36. Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T. The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol. 2006 Feb; 8(2):195-202. PMID: 16415857; PMCID: PMC1400591.
    37. Alexander MK, Panning B. Counting chromosomes: not as easy as 1, 2, 3. Curr Biol. 2005 Oct 25; 15(20):R834-6. PMID: 16243022.
      View in: PubMed
    38. Chu F, Nusinow DA, Chalkley RJ, Plath K, Panning B, Burlingame AL. Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry. Mol Cell Proteomics. 2006 Jan; 5(1):194-203. PMID: 16210244.
      View in: PubMed
    39. de la Cruz CC, Fang J, Plath K, Worringer KA, Nusinow DA, Zhang Y, Panning B. Developmental regulation of Suz 12 localization. Chromosoma. 2005 Aug; 114(3):183-92. PMID: 15986205.
      View in: PubMed
    40. Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M. Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7635-40. PMID: 15897469; PMCID: PMC1140410.
    41. Nusinow DA, Panning B. Recognition and modification of seX chromosomes. Curr Opin Genet Dev. 2005 Apr; 15(2):206-13. PMID: 15797204.
      View in: PubMed
    42. Cohen HR, Royce-Tolland ME, Worringer KA, Panning B. Chromatin modifications on the inactive X chromosome. Prog Mol Subcell Biol. 2005; 38:91-122. PMID: 15881892.
      View in: PubMed
    43. Lucchesi JC, Kelly WG, Panning B. Chromatin remodeling in dosage compensation. Annu Rev Genet. 2005; 39:615-51. PMID: 16285873.
      View in: PubMed
    44. Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B. Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol. 2004 Dec 20; 167(6):1025-35. PMID: 15596546; PMCID: PMC2172612.
    45. Panning B. X inactivation in mouse ES cells: histone modifications and FISH. Methods Enzymol. 2004; 376:419-28. PMID: 14975322.
      View in: PubMed
    46. Andersen AA, Panning B. Epigenetic gene regulation by noncoding RNAs. Curr Opin Cell Biol. 2003 Jun; 15(3):281-9. PMID: 12787769.
      View in: PubMed
    47. Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y. Role of histone H3 lysine 27 methylation in X inactivation. Science. 2003 Apr 04; 300(5616):131-5. PMID: 12649488.
      View in: PubMed
    48. Plath K, Mlynarczyk-Evans S, Nusinow DA, Panning B. Xist RNA and the mechanism of X chromosome inactivation. Annu Rev Genet. 2002; 36:233-78. PMID: 12429693.
      View in: PubMed
    49. Hong B, Reeves P, Panning B, Swanson MS, Yang TP. Identification of an autoimmune serum containing antibodies against the Barr body. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8703-8. PMID: 11438711; PMCID: PMC37499.
    50. Mlynarczyk SK, Panning B. X inactivation: Tsix and Xist as yin and yang. Curr Biol. 2000 Dec 14-28; 10(24):R899-903. PMID: 11137025.
      View in: PubMed
    51. Rasmussen TP, Huang T, Mastrangelo MA, Loring J, Panning B, Jaenisch R. Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing. Nucleic Acids Res. 1999 Sep 15; 27(18):3685-9. PMID: 10471737; PMCID: PMC148623.
    52. Csankovszki G, Panning B, Bates B, Pehrson JR, Jaenisch R. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet. 1999 Aug; 22(4):323-4. PMID: 10431231.
      View in: PubMed
    53. Panning B, Jaenisch R. RNA and the epigenetic regulation of X chromosome inactivation. Cell. 1998 May 01; 93(3):305-8. PMID: 9590161.
      View in: PubMed
    54. Jaenisch R, Beard C, Lee J, Marahrens Y, Panning B. Mammalian X chromosome inactivation. Novartis Found Symp. 1998; 214:200-9; discussion 209-13, 228-32. PMID: 9601019.
      View in: PubMed
    55. Panning B, Dausman J, Jaenisch R. X chromosome inactivation is mediated by Xist RNA stabilization. Cell. 1997 Sep 05; 90(5):907-16. PMID: 9298902.
      View in: PubMed
    56. Cheung P, Panning B, Smiley JR. Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. J Virol. 1997 Mar; 71(3):1784-93. PMID: 9032307; PMCID: PMC191247.
    57. Marahrens Y, Panning B, Dausman J, Strauss W, Jaenisch R. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev. 1997 Jan 15; 11(2):156-66. PMID: 9009199.
      View in: PubMed
    58. Panning B, Jaenisch R. DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 1996 Aug 15; 10(16):1991-2002. PMID: 8769643.
      View in: PubMed
    59. Panning B, Smiley JR. Activation of expression of multiple subfamilies of human Alu elements by adenovirus type 5 and herpes simplex virus type 1. J Mol Biol. 1995 May 05; 248(3):513-24. PMID: 7752221.
      View in: PubMed
    60. Panning B, Smiley JR. Activation of RNA polymerase III transcription of human Alu elements by herpes simplex virus. Virology. 1994 Jul; 202(1):408-17. PMID: 8009851.
      View in: PubMed
    61. Panning B, Smiley JR. Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6. Mol Cell Biol. 1993 Jun; 13(6):3231-44. PMID: 7684492; PMCID: PMC359768.
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