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    Daniel Minor, JR, PhD

    Address555 Mission Bay Blvd South
    San Francisco CA 94158
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL. Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell. 2016 Feb 25; 164(5):922-36. PMID: 26919429.
        View in: PubMed
      2. Minor DL. Let It Go and Open Up, an Ensemble of Ion Channel Active States. Cell. 2016 Feb 11; 164(4):597-8. PMID: 26871624.
        View in: PubMed
      3. Gaudet R, Roux B, Minor DL. Insights into the molecular foundations of electrical excitation. J Mol Biol. 2015 Jan 16; 427(1):1-2. PMID: 25542854.
        View in: PubMed
      4. Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL. Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. Neuron. 2014 Dec 17; 84(6):1198-212. PMID: 25500157; PMCID: PMC4270892 [Available on 12/17/15].
      5. Payandeh J, Minor DL. Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. J Mol Biol. 2015 Jan 16; 427(1):3-30. PMID: 25158094; PMCID: PMC4277928 [Available on 01/16/16].
      6. Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL. Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. ACS Chem Neurosci. 2014 Sep 17; 5(9):812-22. PMID: 25028803; PMCID: PMC4176385.
      7. Isacoff EY, Jan LY, Minor DL. Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron. 2013 Oct 30; 80(3):658-74. PMID: 24183018; PMCID: PMC3867263.
      8. Shaya D, Findeisen F, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL. Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. J Mol Biol. 2014 Jan 23; 426(2):467-83. PMID: 24120938; PMCID: PMC3947372.
      9. Findeisen F, Rumpf CH, Minor DL. Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain. J Mol Biol. 2013 Sep 9; 425(17):3217-34. PMID: 23811053; PMCID: PMC3839849.
      10. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. PMID: 23738709; PMCID: PMC3747594.
      11. Petrov E, Palanivelu D, Constantine M, Rohde PR, Cox CD, Nomura T, Minor DL, Martinac B. Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi. Biophys J. 2013 Apr 2; 104(7):1426-34. PMID: 23561519; PMCID: PMC3617418.
      12. Tien J, Lee HY, Minor DL, Jan YN, Jan LY. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6352-7. PMID: 23576756; PMCID: PMC3631655.
      13. Bagriantsev SN, Minor DL. Using yeast to study potassium channel function and interactions with small molecules. Methods Mol Biol. 2013; 995:31-42. PMID: 23494370; PMCID: PMC3950311.
      14. Xu Q, Chang A, Tolia A, Minor DL. Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. J Mol Biol. 2013 Jan 23; 425(2):378-94. PMID: 23178170; PMCID: PMC3540129.
      15. Bagriantsev SN, Clark KA, Minor DL. Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains. EMBO J. 2012 Aug 1; 31(15):3297-308. PMID: 22728824; PMCID: PMC3411076.
      16. Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL. A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol. 2012 Jun; 19(6):633-41. PMID: 22562138; PMCID: PMC3529583.
      17. Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK. Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol. 2012 Feb; 8(2):144-6. PMID: 22179068; PMCID: PMC3262069.
      18. Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL. Multiple modalities converge on a common gate to control K2P channel function. EMBO J. 2011 Aug 31; 30(17):3594-606. PMID: 21765396; PMCID: PMC3181481.
      19. Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL. Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12313-8. PMID: 21746903; PMCID: PMC3145705.
      20. Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL. Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Channels (Austin). 2011 Jul-Aug; 5(4):320-4. PMID: 21712653; PMCID: PMC3225732.
      21. Findeisen F, Minor DL. Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation. Structure. 2010 Dec 8; 18(12):1617-31. PMID: 21134641; PMCID: PMC3033571.
      22. Minor DL, Findeisen F. Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Channels (Austin). 2010 Nov-Dec; 4(6):459-74. PMID: 21139419; PMCID: PMC3018750.
      23. Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010 Dec 1; 29(23):3924-38. PMID: 20953164; PMCID: PMC3020648.
      24. Bagriantsev SN, Minor DL. Small molecule ion channel match making: a natural fit for new ASIC ligands. Neuron. 2010 Oct 6; 68(1):1-3. PMID: 20920784; PMCID: PMC2981581.
      25. Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY. Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol. 2010 May; 6(5):369-75. PMID: 20364128; PMCID: PMC2857593.
      26. Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL. Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. PLoS One. 2009; 4(10):e7496. PMID: 19834614; PMCID: PMC2759520.
      27. Xu Q, Minor DL. Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Sci. 2009 Oct; 18(10):2100-14. PMID: 19693805; PMCID: PMC2786974.
      28. Minor DL. Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. Mol Biosyst. 2009 Aug; 5(8):802-10. PMID: 19603113; PMCID: PMC3016960.
      29. Findeisen F, Minor DL. Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation. J Gen Physiol. 2009 Mar; 133(3):327-43. PMID: 19237593; PMCID: PMC2654080.
      30. Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W. 2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. J Struct Funct Genomics. 2009 Apr; 10(2):193-208. PMID: 19148774; PMCID: PMC2705707.
      31. Hammon J, Palanivelu DV, Chen J, Patel C, Minor DL. A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms. Protein Sci. 2009 Jan; 18(1):121-33. PMID: 19177357; PMCID: PMC2708023.
      32. Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL. Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure. 2008 Oct 8; 16(10):1455-67. PMID: 18940602; PMCID: PMC2701236.
      33. Fujiwara Y, Minor DL. X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. J Mol Biol. 2008 Nov 21; 383(4):854-70. PMID: 18782578; PMCID: PMC2630241.
      34. Balss J, Papatheodorou P, Mehmel M, Baumeister D, Hertel B, Delaroque N, Chatelain FC, Minor DL, Van Etten JL, Rassow J, Moroni A, Thiel G. Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12313-8. PMID: 18719119; PMCID: PMC2518832.
      35. Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL. Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation. Structure. 2008 Feb; 16(2):280-94. PMID: 18275819; PMCID: PMC3018278.
      36. Minor DL. Puzzle plugged by protein pore plasticity. Mol Cell. 2007 May 25; 26(4):459-60. PMID: 17531803.
        View in: PubMed
      37. Minor DL. The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data. Neuron. 2007 May 24; 54(4):511-33. PMID: 17521566; PMCID: PMC3011226.
      38. Howard RJ, Clark KA, Holton JM, Minor DL. Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron. 2007 Mar 1; 53(5):663-75. PMID: 17329207; PMCID: PMC3011230.
      39. Van Petegem F, Minor DL. The structural biology of voltage-gated calcium channel function and regulation. Biochem Soc Trans. 2006 Nov; 34(Pt 5):887-93. PMID: 17052221; PMCID: PMC3010275.
      40. Pioletti M, Findeisen F, Hura GL, Minor DL. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol. 2006 Nov; 13(11):987-95. PMID: 17057713; PMCID: PMC3018330.
      41. Tsuruda PR, Julius D, Minor DL. Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006 Jul 20; 51(2):201-12. PMID: 16846855; PMCID: PMC3014052.
      42. Minor DL. Wanting contact: how to pick up a channel. Nat Chem Biol. 2006 Jun; 2(6):298-9. PMID: 16710336.
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      43. Michelsen K, Mrowiec T, Duderstadt KE, Frey S, Minor DL, Mayer MP, Schwappach B. A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Traffic. 2006 Jul; 7(7):903-16. PMID: 16734667.
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      44. Minor DL. A sensitive channel family replete with sense and motion. Nat Struct Mol Biol. 2006 May; 13(5):388-90. PMID: 16738606.
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      45. Van Petegem F, Chatelain FC, Minor DL. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol. 2005 Dec; 12(12):1108-15. PMID: 16299511; PMCID: PMC3020901.
      46. Chatelain FC, Alagem N, Xu Q, Pancaroglu R, Reuveny E, Minor DL. The pore helix dipole has a minor role in inward rectifier channel function. Neuron. 2005 Sep 15; 47(6):833-43. PMID: 16157278; PMCID: PMC3017504.
      47. Minor DL. Bend to open? Structure. 2005 Aug; 13(8):1094-5. PMID: 16084381.
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      48. Van Petegem F, Clark KA, Chatelain FC, Minor DL. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature. 2004 Jun 10; 429(6992):671-5. PMID: 15141227; PMCID: PMC3076333.
      49. Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol Cell. 2003 Dec; 12(6):1427-37. PMID: 14690597.
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      50. Mosavi LK, Minor DL, Peng ZY. Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16029-34. PMID: 12461176; PMCID: PMC138559.
      51. Yi BA, Minor DL, Lin YF, Jan YN, Jan LY. Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11016-23. PMID: 11572962; PMCID: PMC58676.
      52. Minor DL. Potassium channels: life in the post-structural world. Curr Opin Struct Biol. 2001 Aug; 11(4):408-14. PMID: 11495731.
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      53. Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell. 2000 Sep 1; 102(5):657-70. PMID: 11007484.
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      54. Minor DL, Masseling SJ, Jan YN, Jan LY. Transmembrane structure of an inwardly rectifying potassium channel. Cell. 1999 Mar 19; 96(6):879-91. PMID: 10102275.
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      55. Minor DL, Kim PS. Context-dependent secondary structure formation of a designed protein sequence. Nature. 1996 Apr 25; 380(6576):730-4. PMID: 8614471.
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      56. Schumacher TN, Mayr LM, Minor DL, Milhollen MA, Burgess MW, Kim PS. Identification of D-peptide ligands through mirror-image phage display. Science. 1996 Mar 29; 271(5257):1854-7. PMID: 8596952.
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      57. Minor DL, Wyrick SD, Charifson PS, Watts VJ, Nichols DE, Mailman RB. Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists. J Med Chem. 1994 Dec 9; 37(25):4317-28. PMID: 7996543.
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      58. Minor DL, Kim PS. Context is a major determinant of beta-sheet propensity. Nature. 1994 Sep 15; 371(6494):264-7. PMID: 8078589.
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