Hyunil Jo, PhD

Title(s)Specialist, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South
San Francisco CA 94158
ORCID ORCID Icon0000-0002-4863-0779 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Seoul National UniversityB.S.2001Pharmacy
    Seoul National UniversityM.S.2003Pharmacy
    University of PennsylvaniaPh.D.2008Chemistry
    Collapse Awards and Honors
    Department of Defense2005  - 2008Predoctoral Training Award for Prostate Cancer

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dual antagonists of a5ß1/ avß1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 Sep 29; 127578. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395.
      View in: PubMed   Mentions:    Fields:    
    2. Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid. Blood. 2019 Nov 13; 134(Supplement_1):2344-2344. Karen Pei Yi Fong, Ismail A. Ahmed, Marco Mravic, Hyunil Jo, William F. DeGrado, Feng Gai, Joel S. Bennett. .
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    3. Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chem Commun (Camb). 2019 Apr 25; 55(35):5095-5098. Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. PMID: 30957824.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Glutamine Side Chain 13C-18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. J Am Chem Soc. 2019 05 08; 141(18):7320-7326. Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. PMID: 30998340.
      View in: PubMed   Mentions:    Fields:    
    5. 4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics. Molecules. 2019 Feb 08; 24(3). Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F. PMID: 30744004.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Cover Feature: Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle (ChemBioChem 9/2018). ChemBioChem. 2018 May 4; 19(9):892-892. Haifan Wu, Arusha Acharyya, Yibing Wu, Lijun Liu, Hyunil Jo, Feng Gai, William F. DeGrado. .
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    9. Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle. Chembiochem. 2018 05 04; 19(9):902-906. Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF. PMID: 29417711.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    10. Blue fluorescent amino acid for biological spectroscopy and microscopy. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):6005-6009. Hilaire MR, Ahmed IA, Lin CW, Jo H, DeGrado WF, Gai F. PMID: 28533371.
      View in: PubMed   Mentions: 7     Fields:    
    11. Water Distribution, Dynamics, and Interactions with Alzheimer's ß-Amyloid Fibrils Investigated by Solid-State NMR. J Am Chem Soc. 2017 05 03; 139(17):6242-6252. Wang T, Jo H, DeGrado WF, Hong M. PMID: 28406028.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    12. Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. PMID: 28278376.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Pharmacologic Blockade of avß1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    14. Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. Phys Chem Chem Phys. 2016 Oct 19; 18(41):28939-28950. Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F. PMID: 27725984.
      View in: PubMed   Mentions: 3     Fields:    
    16. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective avß1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. PMID: 27774126.
      View in: PubMed   Mentions:
    17. Structural Polymorphism of Alzheimer's ß-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. J Am Chem Soc. 2016 08 10; 138(31):9840-52. Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M. PMID: 27414264.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    18. Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorg Med Chem Lett. 2016 07 15; 26(14):3359-3363. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X. PMID: 27220724.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    19. The avß1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    20. Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule. Biophysical Journal. 2015 Jan 1; 108(2):350a. Michael P. Bokoch, Hyunil I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R. Coughlin. .
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    21. Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. J Am Chem Soc. 2014 Dec 31; 136(52):17987-95. Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. PMID: 25470189.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    22. Differential Stability of CaVß2a and CaVß3 in a CaV1.2 Calcium Channel Complex. Biophysical Journal. 2014 Jan 1; 106(2):136a. Marta Campiglio, Felix Findeisen, Hyunil Jo, William F. DeGrado, Daniel L. Minor, Bernhard E. Flucher. .
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    23. Assessment of local friction in protein folding dynamics using a helix cross-linker. J Phys Chem B. 2013 Nov 27; 117(47):14688-96. Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F. PMID: 24205975.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    24. Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. J Med Chem. 2013 Apr 11; 56(7):2804-12. Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. PMID: 23437766.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    25. Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. . 2012 Dec 13; 12(6):815-23. Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC. PMID: 23245326.
      View in: PubMed   Mentions:
    26. Erratum: Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nature Chemistry. 2012 Dec 1; 4(12):1050-1050. Amanda J. Reig, Marcos M. Pires, Rae Ana Snyder, Yibing Wu, Hyunil Jo, Daniel W. Kulp, Susan E. Butch, Jennifer R. Calhoun, Thomas Szyperski, Edward I. Solomon, William F. DeGrado. .
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    27. Development of a-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc. 2012 Oct 24; 134(42):17704-13. Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. PMID: 22998171.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    28. Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nat Chem. 2012 Nov; 4(11):900-6. Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Szyperski TG, Solomon EI, DeGrado WF. PMID: 23089864.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    29. Cysteine-linked aromatic nitriles as UV resonance Raman probes of protein structure. Journal of Raman Spectroscopy. 2012 Sep 1; 43(9):1244-1249. Colin L. Weeks, Hyunil Jo, Brandon Kier, William F. DeGrado, Thomas G. Spiro. .
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    30. Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in ß-sheet folding. J Am Chem Soc. 2012 May 16; 134(19):8026-9. Culik RM, Jo H, DeGrado WF, Gai F. PMID: 22540162.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    31. Inhibition of integrin a2ß1 ameliorates glomerular injury. J Am Soc Nephrol. 2012 Jun; 23(6):1027-38. Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. PMID: 22440900.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    32. Affinity of talin-1 for the ß3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):793-8. Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF. PMID: 22210111.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    33. Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. Biochemistry. 2010 Dec 14; 49(49):10354-6. Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F. PMID: 21077670.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    34. Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother. 2010 Sep; 54(9):3597-604. Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC. PMID: 20547797.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    35. An unusual pathway to cyclobutane formation via desulfurative intramolecular photocycloaddition of an enone benzothiazoline pair. Org Lett. 2009 Apr 16; 11(8):1685-7. Jo H, Fitzgerald ME, Winkler JD. PMID: 19301922.
      View in: PubMed   Mentions: 1     Fields:    
    36. Highly Stereoselective and Efficient Total Synthesis of (+)-Laurencin. ChemInform. 2005 May 17; 36(20). Seungyoup Beak, Hyunil Jo, Hansoo Kim, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim. .
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    37. Highly stereoselective and efficient total synthesis of (+)-laurencin. Org Lett. 2005 Jan 06; 7(1):75-7. Baek S, Jo H, Kim H, Kim H, Kim S, Kim D. PMID: 15624981.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    38. Efficient Construction of Bicyclic Systems by an Internal SN2' Enolate Alkylation/Ring-Closing Metathesis (RCM) Strategy: A Concise Synthesis of the trans-Hydrindane Nucleus. ChemInform. 2003 Dec 23; 34(51). Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim. .
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    39. Efficient construction of bicyclic systems by an internal SN2' enolate alkylation/ring-closing metathesis (RCM) strategy: a concise synthesis of the trans-hydrindane nucleus. Tetrahedron Letters. 2003 Sep 1; 44(37):7043-7044. Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim. .
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    40. ChemInform Abstract: Asymmetric Total Synthesis of (+)-Brefeldin A from (S)-Lactate by Triple Chirality Transfer Process and Nitrile Oxide Cycloaddition. ChemInform. 2002 Jul 30; 33(30):no-no. Deukjoon Kim, Jongkook Lee, Phil Jong Shim, Joong Inn Lim, Hyunil Jo, Sanghee Kim. .
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    41. Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition. J Org Chem. 2002 Feb 08; 67(3):764-71. Kim D, Lee J, Shim PJ, Lim JI, Jo H, Kim S. PMID: 11856018.
      View in: PubMed   Mentions: 4     Fields:    
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