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Hexamethylene Amiloride Binds the SARS-CoV-2 Envelope Protein at the Protein-Lipid Interface. Protein Sci. 2023 Aug 25; e4755.
Somberg NH, Medeiros-Silva J, Jo H, Wang J, DeGrado WF, Hong M. PMID: 37632140; PMCID: PMC10503410.
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1 Fields:
Translation:
HumansCells
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Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023 Aug 15.
Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. PMID: 37425793; PMCID: PMC10326967.
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A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Nat Commun. 2023 04 12; 14(1):2052.
Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH. PMID: 37045836; PMCID: PMC10090755.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology. bioRxiv. 2023 Feb 15.
Mravic M, He L, Kratochvil H, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF. PMID: 36824741; PMCID: PMC9949092.
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SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers. Biochemistry. 2022 11 01; 61(21):2280-2294.
Somberg NH, Wu WW, Medeiros-Silva J, Dregni AJ, Jo H, DeGrado WF, Hong M. PMID: 36219675; PMCID: PMC9583936.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. Proc Natl Acad Sci U S A. 2022 02 01; 119(5).
Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF. PMID: 35082148; PMCID: PMC8812518.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. J Clin Invest. 2021 06 15; 131(12).
Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. PMID: 33956668; PMCID: PMC8203456.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid. Biochemistry. 2021 06 01; 60(21):1722-1730.
Fong KP, Ahmed IA, Mravic M, Jo H, Kim OV, Litvinov RI, Weisel JW, DeGrado WF, Gai F, Bennett JS. PMID: 34010565.
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Translation:
Cells
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Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578.
Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395; PMCID: PMC7700746.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid. Blood. 2019 Nov 13; 134(Supplement_1):2344-2344.
Fong FK, Ahmed AI, Mravic MM, Jo JH, DeGrado DW, Gai GF, Bennett BJ. .
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Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chem Commun (Camb). 2019 Apr 25; 55(35):5095-5098.
Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. PMID: 30957824; PMCID: PMC6508085.
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9 Fields:
Translation:
HumansCells
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Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. J Am Chem Soc. 2019 05 08; 141(18):7320-7326.
Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. PMID: 30998340; PMCID: PMC6800148.
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6 Fields:
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4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics. Molecules. 2019 Feb 08; 24(3).
Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F. PMID: 30744004; PMCID: PMC6384856.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245.
Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032; PMCID: PMC6286348.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758.
Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523; PMCID: PMC6584023.
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12 Fields:
Translation:
HumansAnimalsCells
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Cover Feature: Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle (ChemBioChem 9/2018). ChemBioChem. 2018 May 4; 19(9):892-892.
Wu WH, Acharyya AA, Wu WY, Liu LL, Jo JH, Gai GF, DeGrado DW. .
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Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle. Chembiochem. 2018 05 04; 19(9):902-906.
Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF. PMID: 29417711; PMCID: PMC6512792.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Blue fluorescent amino acid for biological spectroscopy and microscopy. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):6005-6009.
Hilaire MR, Ahmed IA, Lin CW, Jo H, DeGrado WF, Gai F. PMID: 28533371; PMCID: PMC5468623.
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PubMed Mentions:
31 Fields:
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Water Distribution, Dynamics, and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR. J Am Chem Soc. 2017 05 03; 139(17):6242-6252.
Wang T, Jo H, DeGrado WF, Hong M. PMID: 28406028; PMCID: PMC5808936.
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PubMed Mentions:
39 Fields:
Translation:
Humans
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Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326.
Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. PMID: 28278376; PMCID: PMC5481814.
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18 Fields:
Translation:
HumansCells
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Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005.
Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032; PMCID: PMC5491273.
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PubMed Mentions:
24 Fields:
Translation:
Animals
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Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374.
Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306; PMCID: PMC5199700.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. Phys Chem Chem Phys. 2016 Oct 19; 18(41):28939-28950.
Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F. PMID: 27725984; PMCID: PMC5157935.
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8 Fields:
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Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907.
Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. PMID: 27774126; PMCID: PMC5066160.
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PubMed Mentions:
7
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Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. J Am Chem Soc. 2016 08 10; 138(31):9840-52.
Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M. PMID: 27414264; PMCID: PMC5149419.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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PubMed Mentions:
10 Fields:
Translation:
Cells
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The αvβ1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225; PMCID: PMC4461057.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule. Biophysical Journal. 2015 Jan 1; 108(2):350a.
Bokoch BM, Jo JH, Valcourt VJ, Srinivasan SY, Yasuhara YK, Pan PA, Dror DR, Shaw SD, DeGrado DW, Coughlin CS. .
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Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. J Am Chem Soc. 2014 Dec 31; 136(52):17987-95.
Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. PMID: 25470189; PMCID: PMC4286326.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Differential Stability of CaVß2a and CaVß3 in a CaV1.2 Calcium Channel Complex. Biophysical Journal. 2014 Jan 1; 106(2):136a.
Campiglio CM, Findeisen FF, Jo JH, DeGrado DW, Minor MD, Flucher FB. .
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Assessment of local friction in protein folding dynamics using a helix cross-linker. J Phys Chem B. 2013 Nov 27; 117(47):14688-96.
Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F. PMID: 24205975; PMCID: PMC3904762.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. J Med Chem. 2013 Apr 11; 56(7):2804-12.
Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. PMID: 23437766; PMCID: PMC4036227.
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PubMed Mentions:
43 Fields:
Translation:
Cells
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Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe. 2012 Dec 13; 12(6):815-23.
Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC. PMID: 23245326; PMCID: PMC3638032.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Erratum: Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nature Chemistry. 2012 Dec 1; 4(12):1050-1050.
Reig RA, Pires PM, Snyder SR, Wu WY, Jo JH, Kulp KD, Butch BS, Calhoun CJ, Szyperski ST, Solomon SE, DeGrado DW. .
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Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc. 2012 Oct 24; 134(42):17704-13.
Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. PMID: 22998171; PMCID: PMC3523126.
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PubMed Mentions:
75 Fields:
Translation:
Cells
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Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nat Chem. 2012 Nov; 4(11):900-6.
Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Szyperski TG, Solomon EI, DeGrado WF. PMID: 23089864; PMCID: PMC3568993.
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PubMed Mentions:
53 Fields:
Translation:
Cells
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Cysteine-linked aromatic nitriles as UV resonance Raman probes of protein structure. Journal of Raman Spectroscopy. 2012 Sep 1; 43(9):1244-1249.
Weeks WC, Jo JH, Kier KB, DeGrado DW, Spiro ST. .
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Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding. J Am Chem Soc. 2012 May 16; 134(19):8026-9.
Culik RM, Jo H, DeGrado WF, Gai F. PMID: 22540162; PMCID: PMC3354031.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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Inhibition of integrin α2β1 ameliorates glomerular injury. J Am Soc Nephrol. 2012 Jun; 23(6):1027-38.
Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. PMID: 22440900; PMCID: PMC3358756.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):793-8.
Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF. PMID: 22210111; PMCID: PMC3271903.
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PubMed Mentions:
41 Fields:
Translation:
Cells
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Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. Biochemistry. 2010 Dec 14; 49(49):10354-6.
Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F. PMID: 21077670; PMCID: PMC2999665.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother. 2010 Sep; 54(9):3597-604.
Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC. PMID: 20547797; PMCID: PMC2934977.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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An unusual pathway to cyclobutane formation via desulfurative intramolecular photocycloaddition of an enone benzothiazoline pair. Org Lett. 2009 Apr 16; 11(8):1685-7.
Jo H, Fitzgerald ME, Winkler JD. PMID: 19301922.
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PubMed Mentions:
1 Fields:
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Highly Stereoselective and Efficient Total Synthesis of (+)-Laurencin. ChemInform. 2005 May 17; 36(20).
Beak BS, Jo JH, Kim KH, Kim KH, Kim KS, Kim KD. .
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Highly stereoselective and efficient total synthesis of (+)-laurencin. Org Lett. 2005 Jan 06; 7(1):75-7.
Baek S, Jo H, Kim H, Kim H, Kim S, Kim D. PMID: 15624981.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Efficient Construction of Bicyclic Systems by an Internal SN2' Enolate Alkylation/Ring-Closing Metathesis (RCM) Strategy: A Concise Synthesis of the trans-Hydrindane Nucleus. ChemInform. 2003 Dec 23; 34(51).
Jo JH, Lee LJ, Kim KH, Kim KS, Kim KD. .
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Efficient construction of bicyclic systems by an internal SN2' enolate alkylation/ring-closing metathesis (RCM) strategy: a concise synthesis of the trans-hydrindane nucleus. Tetrahedron Letters. 2003 Sep 1; 44(37):7043-7044.
Jo JH, Lee LJ, Kim KH, Kim KS, Kim KD. .
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ChemInform Abstract: Asymmetric Total Synthesis of (+)-Brefeldin A from (S)-Lactate by Triple Chirality Transfer Process and Nitrile Oxide Cycloaddition. ChemInform. 2002 Jul 30; 33(30):no-no.
Kim KD, Lee LJ, Shim SP, Lim LJ, Jo JH, Kim KS. .
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Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition. J Org Chem. 2002 Feb 08; 67(3):764-71.
Kim D, Lee J, Shim PJ, Lim JI, Jo H, Kim S. PMID: 11856018.
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PubMed Mentions:
4 Fields: