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Hyunil Jo, PhD

Title(s)Specialist, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Phone215-913-7838
ORCID ORCID Icon0000-0002-4863-0779 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Seoul National UniversityB.S.2001Pharmacy
    Seoul National UniversityM.S.2003Pharmacy
    University of PennsylvaniaPh.D.2008Chemistry
    Collapse Awards and Honors
    Department of Defense2005  - 2008Predoctoral Training Award for Prostate Cancer

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chem Commun (Camb). 2019 Apr 25; 55(35):5095-5098. PMID: 30957824.
      View in: PubMed
    2. Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. Glutamine Side Chain 13C-18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. J Am Chem Soc. 2019 May 08; 141(18):7320-7326. PMID: 30998340.
      View in: PubMed
    3. Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F. 4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics. Molecules. 2019 Feb 08; 24(3). PMID: 30744004.
      View in: PubMed
    4. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. PMID: 30532032.
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    5. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. PMID: 30102523.
      View in: PubMed
    6. Haifan Wu, Arusha Acharyya, Yibing Wu, Lijun Liu, Hyunil Jo, Feng Gai, William F. DeGrado. Cover Feature: Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle (ChemBioChem 9/2018). ChemBioChem. 2018 May 4; 19(9):892-892.
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    7. Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF. Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle. Chembiochem. 2018 05 04; 19(9):902-906. PMID: 29417711.
      View in: PubMed
    8. Hilaire MR, Ahmed IA, Lin CW, Jo H, DeGrado WF, Gai F. Blue fluorescent amino acid for biological spectroscopy and microscopy. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):6005-6009. PMID: 28533371.
      View in: PubMed
    9. Wang T, Jo H, DeGrado WF, Hong M. Water Distribution, Dynamics, and Interactions with Alzheimer's ß-Amyloid Fibrils Investigated by Solid-State NMR. J Am Chem Soc. 2017 05 03; 139(17):6242-6252. PMID: 28406028.
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    10. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326. PMID: 28278376.
      View in: PubMed
    11. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. Pharmacologic Blockade of avß1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005. PMID: 28220032.
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    12. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374. PMID: 27918306.
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    13. Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F. Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. Phys Chem Chem Phys. 2016 Oct 19; 18(41):28939-28950. PMID: 27725984.
      View in: PubMed
    14. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective avß1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907. PMID: 27774126.
      View in: PubMed
    15. Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M. Structural Polymorphism of Alzheimer's ß-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. J Am Chem Soc. 2016 08 10; 138(31):9840-52. PMID: 27414264.
      View in: PubMed
    16. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X. Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorg Med Chem Lett. 2016 07 15; 26(14):3359-3363. PMID: 27220724.
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    17. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. The avß1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79. PMID: 25995225.
      View in: PubMed
    18. Michael P. Bokoch, Hyunil I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R. Coughlin. Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule. Biophysical Journal. 2015 Jan 1; 108(2):350a.
      View in: Publisher Site
    19. Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. J Am Chem Soc. 2014 Dec 31; 136(52):17987-95. PMID: 25470189.
      View in: PubMed
    20. Marta Campiglio, Felix Findeisen, Hyunil Jo, William F. DeGrado, Daniel L. Minor, Bernhard E. Flucher. Differential Stability of CaVß2a and CaVß3 in a CaV1.2 Calcium Channel Complex. Biophysical Journal. 2014 Jan 1; 106(2):136a.
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    21. Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F. Assessment of local friction in protein folding dynamics using a helix cross-linker. J Phys Chem B. 2013 Nov 27; 117(47):14688-96. PMID: 24205975.
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    22. Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. J Med Chem. 2013 Apr 11; 56(7):2804-12. PMID: 23437766.
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    23. Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC. Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe. 2012 Dec 13; 12(6):815-23. PMID: 23245326.
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    24. Amanda J. Reig, Marcos M. Pires, Rae Ana Snyder, Yibing Wu, Hyunil Jo, Daniel W. Kulp, Susan E. Butch, Jennifer R. Calhoun, Thomas Szyperski, Edward I. Solomon, William F. DeGrado. Erratum: Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nature Chemistry. 2012 Dec 1; 4(12):1050-1050.
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    25. Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. Development of a-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc. 2012 Oct 24; 134(42):17704-13. PMID: 22998171.
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    26. Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Szyperski TG, Solomon EI, DeGrado WF. Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nat Chem. 2012 Nov; 4(11):900-6. PMID: 23089864.
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    27. Colin L. Weeks, Hyunil Jo, Brandon Kier, William F. DeGrado, Thomas G. Spiro. Cysteine-linked aromatic nitriles as UV resonance Raman probes of protein structure. Journal of Raman Spectroscopy. 2012 Sep 1; 43(9):1244-1249.
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    28. Culik RM, Jo H, DeGrado WF, Gai F. Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in ß-sheet folding. J Am Chem Soc. 2012 May 16; 134(19):8026-9. PMID: 22540162.
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    29. Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. Inhibition of integrin a2ß1 ameliorates glomerular injury. J Am Soc Nephrol. 2012 Jun; 23(6):1027-38. PMID: 22440900.
      View in: PubMed
    30. Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF. Affinity of talin-1 for the ß3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):793-8. PMID: 22210111.
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    31. Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F. Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. Biochemistry. 2010 Dec 14; 49(49):10354-6. PMID: 21077670.
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    32. Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC. Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother. 2010 Sep; 54(9):3597-604. PMID: 20547797.
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    33. Jo H, Fitzgerald ME, Winkler JD. An unusual pathway to cyclobutane formation via desulfurative intramolecular photocycloaddition of an enone benzothiazoline pair. Org Lett. 2009 Apr 16; 11(8):1685-7. PMID: 19301922.
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    34. Seungyoup Beak, Hyunil Jo, Hansoo Kim, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim. Highly Stereoselective and Efficient Total Synthesis of (+)-Laurencin. ChemInform. 2005 May 17; 36(20).
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    35. Baek S, Jo H, Kim H, Kim H, Kim S, Kim D. Highly stereoselective and efficient total synthesis of (+)-laurencin. Org Lett. 2005 Jan 06; 7(1):75-7. PMID: 15624981.
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    36. Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim. Efficient Construction of Bicyclic Systems by an Internal SN2' Enolate Alkylation/Ring-Closing Metathesis (RCM) Strategy: A Concise Synthesis of the trans-Hydrindane Nucleus. ChemInform. 2003 Dec 23; 34(51).
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    37. Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim. Efficient construction of bicyclic systems by an internal SN2' enolate alkylation/ring-closing metathesis (RCM) strategy: a concise synthesis of the trans-hydrindane nucleus. Tetrahedron Letters. 2003 Sep 1; 44(37):7043-7044.
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    38. Deukjoon Kim, Jongkook Lee, Phil Jong Shim, Joong Inn Lim, Hyunil Jo, Sanghee Kim. ChemInform Abstract: Asymmetric Total Synthesis of (+)-Brefeldin A from (S)-Lactate by Triple Chirality Transfer Process and Nitrile Oxide Cycloaddition. ChemInform. 2002 Jul 30; 33(30):no-no.
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    39. Kim D, Lee J, Shim PJ, Lim JI, Jo H, Kim S. Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition. J Org Chem. 2002 Feb 08; 67(3):764-71. PMID: 11856018.
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