Ian Seiple • UCSF Profiles

Ian Seiple, PhD

Title(s)	Associate Professor, Cardiovascular Research Inst
School	School of Medicine
Address	555 Mission Bay Blvd South, #452F San Francisco CA 94158
Phone	415-502-3623
vCard	Download vCard

Biography

Education and Training

UC Berkeley	BS	2006	Chemistry
The Scripps Research Institute	Ph.D.	2011	Chemistry
Harvard University	Postdoctoral	2015	Chemistry and Chemical Biology

Overview

Websites

Seiple Group Website

Research

Research Activities and Funding

Platforms for the Synthesis of Bacterial Protein Synthesis Inhibitors
NIH R35GM128656Aug 1, 2018 - Jul 31, 2023
Role: Principal Investigator

Preparation of a Solid-Phase Polyketide Synthase Mimic
NIH F32GM099233Sep 1, 2011 - Aug 31, 2014
Role: Principal Investigator

ORNG Applications

Academic Senate

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. bioRxiv. 2024 Mar 25. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS. PMID: 37398339; PMCID: PMC10312649.

View in: PubMed Mentions:
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022 12; 40(12):1834-1844. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. PMID: 35879364; PMCID: PMC9750872.

View in: PubMed Mentions: 4 Fields:
Bio Biotechnology
Translation:Humans Animals Cells
Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins. ACS Chem Biol. 2022 05 20; 17(5):1259-1268. Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA. PMID: 35481357.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Bio Biology
Translation:Cells
Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0005422. Prasad NK, Seiple IB, Cirz RT, Rosenberg OS. PMID: 35471042; PMCID: PMC9112940.

View in: PubMed Mentions: 22 Fields:
Ant Anti-Infective Agents
Translation:Humans Cells
Examining Gender Imbalance in Chemistry Authorship. ACS Chem Biol. 2021 11 19; 16(11):2042-2046. Cotton AD, Seiple IB. PMID: 34523912.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Bio Biology
Translation:Humans
Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules. ACS Chem Biol. 2021 Aug 19. Cotton AD, Wells JA, Seiple IB. PMID: 34410115.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Bio Biology
Label-retention expansion microscopy. J Cell Biol. 2021 09 06; 220(9). Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B. PMID: 34228783; PMCID: PMC8266563.

View in: PubMed Mentions: 19 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021 06; 7(24). Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S. PMID: 34117063; PMCID: PMC8195473.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Animals Cells
Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics. Acc Chem Res. 2021 04 20; 54(8):1891-1908. Cai L, Seiple IB, Li Q. PMID: 33792282; PMCID: PMC8214311.

View in: PubMed Mentions: 2 Fields:
Che Chemistry
Translation:Cells
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. J Am Chem Soc. 2021 01 20; 143(2):593-598. Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA. PMID: 33395526; PMCID: PMC8154509.

View in: PubMed Mentions: 80 Fields:
Che Chemistry
Translation:Humans Cells
Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. J Am Chem Soc. 2020 12 23; 142(51):21310-21321. Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB. PMID: 33301681; PMCID: PMC7790458.

View in: PubMed Mentions: 8 Fields:
Che Chemistry
Translation:Cells
Modular synthesis of streptogramin antibiotics. Synlett. 2021 Apr; 32(7):647-654. Li Q, Seiple IB. PMID: 34113063; PMCID: PMC8186492.

View in: PubMed Mentions:
Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395; PMCID: PMC7700746.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry
Translation:Animals Cells
Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature. 2020 10; 586(7827):145-150. Li Q, Pellegrino J, Lee DJ, Tran AA, Chaires HA, Wang R, Park JE, Ji K, Chow D, Zhang N, Brilot AF, Biel JT, van Zundert G, Borrelli K, Shinabarger D, Wolfe C, Murray B, Jacobson MP, Mühle E, Chesneau O, Fraser JS, Seiple IB. PMID: 32968273; PMCID: PMC7546582.

View in: PubMed Mentions: 26 Fields:
Sci Science
Translation:Animals Cells
Modular Approaches to Lankacidin Antibiotics. J Am Chem Soc. 2020 09 02; 142(35):15116-15126. Cai L, Yao Y, Yeon SK, Seiple IB. PMID: 32786797; PMCID: PMC8193914.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
Translation:Cells
Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes. Angew Chem Int Ed Engl. 2019 12 19; 58(52):18839-18843. Liu J, Cai L, Sun W, Cheng R, Wang N, Jin L, Rozovsky S, Seiple IB, Wang L. PMID: 31644827; PMCID: PMC6917869.

View in: PubMed Mentions: 13 Fields:
Che Chemistry
A concise route to virginiamycin M2. Tetrahedron. 2019 Jun 14; 75(24):3309-3318. Li Q, Seiple IB. PMID: 32764837; PMCID: PMC7405890.

View in: PubMed Mentions: 8 Fields:
Che Chemistry
Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B. Angew Chem Int Ed Engl. 2018 10 08; 57(41):13551-13554. Yao Y, Cai L, Seiple IB. PMID: 30133094; PMCID: PMC6494672.

View in: PubMed Mentions: 2 Fields:
Che Chemistry
Translation:Cells
Modular, Scalable Synthesis of Group A Streptogramin Antibiotics. J Am Chem Soc. 2017 09 27; 139(38):13304-13307. Li Q, Seiple IB. PMID: 28902996.

View in: PubMed Mentions: 16 Fields:
Che Chemistry
Translation:Cells
A platform for the discovery of new macrolide antibiotics. Nature. 2016 05 19; 533(7603):338-45. Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, Kitamura Y, Zhou X, Condakes ML, Szczypinski FT, Green WD, Myers AG. PMID: 27193679; PMCID: PMC6526944.

View in: PubMed Mentions: 94 Fields:
Sci Science
Translation:Humans Cells
Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxybutan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics. Synlett. 2015; 1(27):57-60. Seiple, I. B.; Hog, D. T.; Myers, A. G.
The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8840-69. Wright PM, Seiple IB, Myers AG. PMID: 24990531; PMCID: PMC4536949.

View in: PubMed Mentions: 101 Fields:
Che Chemistry
Stereocontrolled synthesis of syn-β-Hydroxy-α-amino acids by direct aldolization of pseudoephenamine glycinamide. Angew Chem Int Ed Engl. 2014 Apr 25; 53(18):4642-7. Seiple IB, Mercer JA, Sussman RJ, Zhang Z, Myers AG. PMID: 24692320; PMCID: PMC4191905.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Translation:Cells
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome. J Nat Prod. 2012 May 25; 75(5):980-5. Lansdell TA, Hewlett NM, Skoumbourdis AP, Fodor MD, Seiple IB, Su S, Baran PS, Feldman KS, Tepe JJ. PMID: 22591513; PMCID: PMC3367325.

View in: PubMed Mentions: 9 Fields:
Pha Pharmacology
Translation:Humans Cells
Configurational analysis of tetracyclic dimeric pyrrole-imidazole alkaloids using a floating chirality approach. J Nat Prod. 2012 Feb 24; 75(2):127-30. Köck M, Schmidt G, Seiple IB, Baran PS. PMID: 22332969; PMCID: PMC3315375.

View in: PubMed Mentions: 4 Fields:
Pha Pharmacology
Translation:Cells
Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc. 2011 Sep 21; 133(37):14710-26. Seiple IB, Su S, Young IS, Nakamura A, Yamaguchi J, Jørgensen L, Rodriguez RA, O'Malley DP, Gaich T, Köck M, Baran PS. PMID: 21861522; PMCID: PMC3173569.

View in: PubMed Mentions: 34 Fields:
Che Chemistry
Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14411-5. Ji Y, Brueckl T, Baxter RD, Fujiwara Y, Seiple IB, Su S, Blackmond DG, Baran PS. PMID: 21844378; PMCID: PMC3167544.

View in: PubMed Mentions: 105 Fields:
Sci Science
Translation:Cells
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc. 2011 Mar 16; 133(10):3292-5. Fujiwara Y, Domingo V, Seiple IB, Gianatassio R, Del Bel M, Baran PS. PMID: 21341741; PMCID: PMC3964812.

View in: PubMed Mentions: 43 Fields:
Che Chemistry
Translation:Cells
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc. 2010 Sep 29; 132(38):13194-6. Seiple IB, Su S, Rodriguez RA, Gianatassio R, Fujiwara Y, Sobel AL, Baran PS. PMID: 20812741; PMCID: PMC2946225.

View in: PubMed Mentions: 85 Fields:
Che Chemistry
Total synthesis of palau'amine. Angew Chem Int Ed Engl. 2010 Feb 01; 49(6):1095-8. Seiple IB, Su S, Young IS, Lewis CA, Yamaguchi J, Baran PS. PMID: 20041464; PMCID: PMC3367661.

View in: PubMed Mentions: 42 Fields:
Che Chemistry
Translation:Cells
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc. 2008 Dec 10; 130(49):16490-1. Su S, Seiple IB, Young IS, Baran PS. PMID: 19049446; PMCID: PMC2913575.

View in: PubMed Mentions: 32 Fields:
Che Chemistry
Translation:Cells
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl. 2008; 47(19):3581-3. O'Malley DP, Yamaguchi J, Young IS, Seiple IB, Baran PS. PMID: 18357612.

View in: PubMed Mentions: 33 Fields:
Che Chemistry
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl. 2008; 47(19):3578-80. Yamaguchi J, Seiple IB, Young IS, O'Malley DP, Maue M, Baran PS. PMID: 18357598.

View in: PubMed Mentions: 30 Fields:
Che Chemistry
The pursuit of palau'amine. Angew Chem Int Ed Engl. 2007; 46(35):6586-94. Köck M, Grube A, Seiple IB, Baran PS. PMID: 17724780.

View in: PubMed Mentions: 48 Fields:
Che Chemistry
Translation:Cells
Synthesis of taiwaniaquinoids via Nazarov triflation. J Am Chem Soc. 2006 Aug 30; 128(34):11022-3. Liang G, Xu Y, Seiple IB, Trauner D. PMID: 16925409.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Translation:Cells
Stereoselective syntheses of the bioactive polypropionates aureothin, N-acetylaureothamine, and aureonitrile. Org Lett. 2005 Jul 07; 7(14):2837-9. Liang G, Seiple IB, Trauner D. PMID: 15987149.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells