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Ian Seiple, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-502-3623
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    Collapse Biography 
    Collapse Education and Training
    UC BerkeleyBS2006Chemistry
    The Scripps Research InstitutePh.D.2011Chemistry
    Harvard UniversityPostdoctoral2015Chemistry and Chemical Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Preparation of a Solid-Phase Polyketide Synthase Mimic
    NIH/NIGMS F32GM099233Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, Kitamura Y, Zhou X, Condakes ML, Szczypinski FT, Green WD, Myers AG. A platform for the discovery of new macrolide antibiotics. Nature. 2016 May 19; 533(7603):338-45. PMID: 27193679.
      View in: PubMed
    2. Seiple, I. B.; Hog, D. T.; Myers, A. G. Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxybutan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics. Synlett. 2015; 1(27):57-60.
    3. Wright PM, Seiple IB, Myers AG. The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8840-69. PMID: 24990531; PMCID: PMC4536949.
    4. Seiple IB, Mercer JA, Sussman RJ, Zhang Z, Myers AG. Stereocontrolled synthesis of syn-ß-Hydroxy-a-amino acids by direct aldolization of pseudoephenamine glycinamide. Angew Chem Int Ed Engl. 2014 Apr 25; 53(18):4642-7. PMID: 24692320; PMCID: PMC4191905.
    5. Lansdell TA, Hewlett NM, Skoumbourdis AP, Fodor MD, Seiple IB, Su S, Baran PS, Feldman KS, Tepe JJ. Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome. J Nat Prod. 2012 May 25; 75(5):980-5. PMID: 22591513; PMCID: PMC3367325.
    6. Köck M, Schmidt G, Seiple IB, Baran PS. Configurational analysis of tetracyclic dimeric pyrrole-imidazole alkaloids using a floating chirality approach. J Nat Prod. 2012 Feb 24; 75(2):127-30. PMID: 22332969; PMCID: PMC3315375.
    7. Seiple IB, Su S, Young IS, Nakamura A, Yamaguchi J, Jørgensen L, Rodriguez RA, O'Malley DP, Gaich T, Köck M, Baran PS. Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc. 2011 Sep 21; 133(37):14710-26. PMID: 21861522; PMCID: PMC3173569.
    8. Ji Y, Brueckl T, Baxter RD, Fujiwara Y, Seiple IB, Su S, Blackmond DG, Baran PS. Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14411-5. PMID: 21844378; PMCID: PMC3167544.
    9. Fujiwara Y, Domingo V, Seiple IB, Gianatassio R, Del Bel M, Baran PS. Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc. 2011 Mar 16; 133(10):3292-5. PMID: 21341741; PMCID: PMC3964812.
    10. Seiple IB, Su S, Rodriguez RA, Gianatassio R, Fujiwara Y, Sobel AL, Baran PS. Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc. 2010 Sep 29; 132(38):13194-6. PMID: 20812741; PMCID: PMC2946225.
    11. Seiple IB, Su S, Young IS, Lewis CA, Yamaguchi J, Baran PS. Total synthesis of palau'amine. Angew Chem Int Ed Engl. 2010 Feb 1; 49(6):1095-8. PMID: 20041464; PMCID: PMC3367661.
    12. Su S, Seiple IB, Young IS, Baran PS. Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc. 2008 Dec 10; 130(49):16490-1. PMID: 19049446; PMCID: PMC2913575.
    13. O'Malley DP, Yamaguchi J, Young IS, Seiple IB, Baran PS. Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl. 2008; 47(19):3581-3. PMID: 18357612.
      View in: PubMed
    14. Yamaguchi J, Seiple IB, Young IS, O'Malley DP, Maue M, Baran PS. Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl. 2008; 47(19):3578-80. PMID: 18357598.
      View in: PubMed
    15. Köck M, Grube A, Seiple IB, Baran PS. The pursuit of palau'amine. Angew Chem Int Ed Engl. 2007; 46(35):6586-94. PMID: 17724780.
      View in: PubMed
    16. Liang G, Xu Y, Seiple IB, Trauner D. Synthesis of taiwaniaquinoids via Nazarov triflation. J Am Chem Soc. 2006 Aug 30; 128(34):11022-3. PMID: 16925409.
      View in: PubMed
    17. Liang G, Seiple IB, Trauner D. Stereoselective syntheses of the bioactive polypropionates aureothin, N-acetylaureothamine, and aureonitrile. Org Lett. 2005 Jul 7; 7(14):2837-9. PMID: 15987149.
      View in: PubMed
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