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    Nerissa Ko, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address505 Parnassus Avenue
    San Francisco CA 94117
    Phone415-353-8897
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      Dr. Nerissa Ko is neurointensivist, a neurologist with specialized training in the care of patients in the intensive care unit with neurological diseases. She also has specialty training to care for patients with cerebrovascular diseases. Dr. Ko earned her medical degree at John A. Burns School of Medicine at the University of Hawaii, and completed a residency in neurology, followed by fellowships in neurocritical care and vascular neurology at UCSF. She is board certified in both vascular neurology and neurocritical care. In 2002, she joined the UCSF Neurovascular Service, where she is now assistant director and a principle attending at Moffitt-Long hospitals.

      Dr. Ko sees patients for consultation on an outpatient basis as well for stroke and complex vascular diseases such as brain aneurysms and arteriovenous malformations.

      Dr. Ko's research interests include:

      * Clinical outcome following subarachnoid hemorrhage
      * Cerebral blood flow measurement using radioactive Xenon
      * Quantitative perfusion imaging for cerebrovascular diseases


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, Baas AF, Blankensteijn JD, Böttinger EP, Bown MJ, Broderick J, Bijlenga P, Carrell DS, Crawford DC, Crosslin DR, Ebeling C, Eriksson JG, Fornage M, Foroud T, von Und Zu Fraunberg M, Friedrich CM, Gaál EI, Gottesman O, Guo DC, Harrison SC, Hernesniemi J, Hofman A, Inoue I, Jääskeläinen JE, Jones GT, Kiemeney LA, Kivisaari R, Ko N, Koskinen S, Kubo M, Kullo IJ, Kuivaniemi H, Kurki MI, Laakso A, Lai D, Leal SM, Lehto H, LeMaire SA, Low SK, Malinowski J, McCarty CA, Milewicz DM, Mosley TH, Nakamura Y, Nakaoka H, Niemelä M, Pacheco J, Peissig PL, Pera J, Rasmussen-Torvik L, Ritchie MD, Rivadeneira F, van Rij AM, Santos-Cortez RL, Saratzis A, Slowik A, Takahashi A, Tromp G, Uitterlinden AG, Verma SS, Vermeulen SH, Wang GT, Han B, Rinkel GJ, de Bakker PI. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc. 2016; 5(7). PMID: 27418160.
        View in: PubMed
      2. Zhu C, Haraldsson H, Tian B, Meisel K, Ko N, Lawton M, Grinstead J, Ahn S, Laub G, Hess C, Saloner D. High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI. MAGMA. 2016 Jun; 29(3):559-70. PMID: 26946509.
        View in: PubMed
      3. Edwards NJ, Grill MF, Choi HA, Ko NU. Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. Cerebrovasc Dis. 2016; 41(3-4):170-6. PMID: 26751784.
        View in: PubMed
      4. Chow FC, Boscardin WJ, Mills C, Ko N, Carroll C, Price RW, Deeks S, Sorond FA, Hsue PY. Cerebral vasoreactivity is impaired in treated, virally suppressed HIV-infected individuals. AIDS. 2016 Jan 2; 30(1):45-55. PMID: 26372478.
        View in: PubMed
      5. Smith WS, Browne JL, Ko NU. Cranial Accelerometry Can Detect Cerebral Vasospasm Caused by Subarachnoid Hemorrhage. Neurocrit Care. 2015 Dec; 23(3):364-9. PMID: 25761424.
        View in: PubMed
      6. Farlow JL, Lin H, Sauerbeck L, Lai D, Koller DL, Pugh E, Hetrick K, Ling H, Kleinloog R, van der Vlies P, Deelen P, Swertz MA, Verweij BH, Regli L, Rinkel GJ, Ruigrok YM, Doheny K, Liu Y, Broderick J, Foroud T. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. PLoS One. 2015; 10(3):e0121104. PMID: 25803036; PMCID: PMC4372548.
      7. Moftakhar P, Cooke DL, Fullerton HJ, Ko NU, Amans MR, Narvid JA, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Extent of collateralization predicting symptomatic cerebral vasospasm among pediatric patients: correlations among angiography, transcranial Doppler ultrasonography, and clinical findings. J Neurosurg Pediatr. 2015 Mar; 15(3):282-90. PMID: 25555113.
        View in: PubMed
      8. Choi JC, Oh YH, Kim JG, Kim HJ, Kong MH, Paeng DG, Ko NU, Easton JD. Spontaneous echo-contrast in the internal jugular veins of patients with ischemic stroke. J Clin Ultrasound. 2015 Sep; 43(7):431-7. PMID: 25346199.
        View in: PubMed
      9. Foroud T, Lai D, Koller D, Van't Hof F, Kurki MI, Anderson CS, Brown RD, Connolly ES, Eriksson JG, Flaherty M, Fornage M, von Und Zu Fraunberg M, Gaál EI, Laakso A, Hernesniemi J, Huston J, Jääskeläinen JE, Kiemeney LA, Kivisaari R, Kleindorfer D, Ko N, Lehto H, Mackey J, Meissner I, Moomaw CJ, Mosley TH, Moskala M, Niemelä M, Palotie A, Pera J, Rinkel G, Ripke S, Rouleau G, Ruigrok Y, Sauerbeck L, Slowik A, Vermeulen SH, Woo D, Worrall BB, Broderick J. Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. Stroke. 2014 Nov; 45(11):3194-9. PMID: 25256182; PMCID: PMC4213281.
      10. Rutledge WC, Ko NU, Lawton MT, Kim H. Hemorrhage rates and risk factors in the natural history course of brain arteriovenous malformations. Transl Stroke Res. 2014 Oct; 5(5):538-42. PMID: 24930128; PMCID: PMC4139097.
      11. Smith A, Wu AH, Lynch KL, Ko N, Grenache DG. Multi-wavelength spectrophotometric analysis for detection of xanthochromia in cerebrospinal fluid and accuracy for the diagnosis of subarachnoid hemorrhage. Clin Chim Acta. 2013 Sep 23; 424:231-6. PMID: 23800427.
        View in: PubMed
      12. Moftakhar P, Hetts SW, Ko NU. Vascular myelopathies. Semin Neurol. 2012 Apr; 32(2):146-53. PMID: 22961189.
        View in: PubMed
      13. Foroud T, Koller DL, Lai D, Sauerbeck L, Anderson C, Ko N, Deka R, Mosley TH, Fornage M, Woo D, Moomaw CJ, Hornung R, Huston J, Meissner I, Bailey-Wilson JE, Langefeld C, Rouleau G, Connolly ES, Worrall BB, Kleindorfer D, Flaherty ML, Martini S, Mackey J, De Los Rios La Rosa F, Brown RD, Broderick JP. Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke. 2012 Nov; 43(11):2846-52. PMID: 22961961; PMCID: PMC3752852.
      14. Kishore S, Ko N, Soares BP, Higashida RT, Tong E, Bhogal S, Bredno J, Cheng SC, Wintermark M. Perfusion-CT assessment of blood-brain barrier permeability in patients with aneurysmal subarachnoid hemorrhage. J Neuroradiol. 2012 Dec; 39(5):317-25. PMID: 22197406.
        View in: PubMed
      15. Weinsheimer SM, Xu H, Achrol AS, Stamova B, McCulloch CE, Pawlikowska L, Tian Y, Ko NU, Lawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL. Gene expression profiling of blood in brain arteriovenous malformation patients. Transl Stroke Res. 2011 Dec 1; 2(4):575-87. PMID: 22184505; PMCID: PMC3241209.
      16. Taub PR, Fields JD, Wu AH, Miss JC, Lawton MT, Smith WS, Young WL, Zaroff JG, Ko NU. Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2011 Aug; 15(1):13-8. PMID: 21479679; PMCID: PMC3133817.
      17. Kamel H, Navi BB, Nakagawa K, Hemphill JC, Ko NU. Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials. Crit Care Med. 2011 Mar; 39(3):554-9. PMID: 21242790.
        View in: PubMed
      18. Johnson EC, West TW, Ko NU, Strober JB. A 41-year-old man with new headache and altered mental status. Neurohospitalist. 2011 Jan; 1(1):48-54. PMID: 23983837; PMCID: PMC3726099.
      19. Jun P, Ko NU, English JD, Dowd CF, Halbach VV, Higashida RT, Lawton MT, Hetts SW. Endovascular treatment of medically refractory cerebral vasospasm following aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2010 Nov; 31(10):1911-6. PMID: 20616179; PMCID: PMC4067264.
      20. Josephson SA, Douglas VC, Lawton MT, English JD, Smith WS, Ko NU. Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-management. J Neurosurg. 2010 Mar; 112(3):626-30. PMID: 19731990.
        View in: PubMed
      21. Gabriel RA, Kim H, Sidney S, McCulloch CE, Singh V, Johnston SC, Ko NU, Achrol AS, Zaroff JG, Young WL. Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population. Stroke. 2010 Jan; 41(1):21-6. PMID: 19926839; PMCID: PMC2847493.
      22. Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff JG, Sidney S, Ko NU, Achrol AS, Lawton MT, McCulloch CE, Kwok PY, Young WL. Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Cerebrovasc Dis. 2009; 27(2):176-82. PMID: 19092239; PMCID: PMC2649796.
      23. Wintermark M, Dillon WP, Smith WS, Lau BC, Chaudhary S, Liu S, Yu M, Fitch M, Chien JD, Higashida RT, Ko NU. Visual grading system for vasospasm based on perfusion CT imaging: comparisons with conventional angiography and quantitative perfusion CT. Cerebrovasc Dis. 2008; 26(2):163-70. PMID: 18560220.
        View in: PubMed
      24. Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL. Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2008 Apr; 39(4):1103-8. PMID: 18309169; PMCID: PMC2650384.
      25. Chaudhary SR, Ko N, Dillon WP, Yu MB, Liu S, Criqui GI, Higashida RT, Smith WS, Wintermark M. Prospective evaluation of multidetector-row CT angiography for the diagnosis of vasospasm following subarachnoid hemorrhage: a comparison with digital subtraction angiography. Cerebrovasc Dis. 2008; 25(1-2):144-50. PMID: 18073468.
        View in: PubMed
      26. Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU, Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL. Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery. 2007 Oct; 61(4):731-9; discussion 740. PMID: 17986934.
        View in: PubMed
      27. Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, Ko NU, Achrol AS, Lawton MT, Higashida RT, Young WL. Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients. Stroke. 2007 Sep; 38(9):2430-7. PMID: 17673729.
        View in: PubMed
      28. Dispensa BP, Saloner DA, Acevedo-Bolton G, Achrol AS, Jou LD, McCulloch CE, Johnston SC, Higashida RT, Dowd CF, Halbach VV, Ko NU, Lawton MT, Martin AJ, Quinnine N, Young WL. Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging. J Magn Reson Imaging. 2007 Jul; 26(1):177-83. PMID: 17659544.
        View in: PubMed
      29. Zaroff JG, Pawlikowska L, Miss JC, Yarlagadda S, Ha C, Achrol A, Kwok PY, McCulloch CE, Lawton MT, Ko N, Smith W, Young WL. Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage. Stroke. 2006 Jul; 37(7):1680-5. PMID: 16728691.
        View in: PubMed
      30. Pawlikowska L, Poon KY, Achrol AS, McCulloch CE, Ha C, Lum K, Zaroff JG, Ko NU, Johnston SC, Sidney S, Marchuk DA, Lawton MT, Kwok PY, Young WL. Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformations. Neurosurgery. 2006 May; 58(5):838-43; discussion 838-43. PMID: 16639317.
        View in: PubMed
      31. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Neurocrit Care. 2006; 5(3):180-5. PMID: 17290085.
        View in: PubMed
      32. Yarlagadda S, Rajendran P, Miss JC, Banki NM, Kopelnik A, Wu AH, Ko N, Gelb AW, Lawton MT, Smith WS, Young WL, Zaroff JG. Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhage. Neurocrit Care. 2006; 5(2):102-7. PMID: 17099255.
        View in: PubMed
      33. Kothavale A, Banki NM, Kopelnik A, Yarlagadda S, Lawton MT, Ko N, Smith WS, Drew B, Foster E, Zaroff JG. Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhage. Neurocrit Care. 2006; 4(3):199-205. PMID: 16757824.
        View in: PubMed
      34. Wintermark M, Ko NU, Smith WS, Liu S, Higashida RT, Dillon WP. Vasospasm after subarachnoid hemorrhage: utility of perfusion CT and CT angiography on diagnosis and management. AJNR Am J Neuroradiol. 2006 Jan; 27(1):26-34. PMID: 16418351.
        View in: PubMed
      35. Tung PP, Olmsted E, Kopelnik A, Banki NM, Drew BJ, Ko N, Lawton MT, Smith W, Foster E, Young WL, Zaroff JG. Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhage. Stroke. 2005 Jul; 36(7):1567-9. PMID: 15947264.
        View in: PubMed
      36. Yu W, Smith WS, Singh V, Ko NU, Cullen SP, Dowd CF, Halbach VV, Higashida RT. Long-term outcome of endovascular stenting for symptomatic basilar artery stenosis. Neurology. 2005 Mar 22; 64(6):1055-7. PMID: 15781826.
        View in: PubMed
      37. Ko NU, Achrol AS, Chopra M, Saha M, Gupta D, Smith WS, Higashida RT, Young WL. Cerebral blood flow changes after endovascular treatment of cerebrovascular stenoses. AJNR Am J Neuroradiol. 2005 Mar; 26(3):538-42. PMID: 15760862.
        View in: PubMed
      38. Ko NU, Achrol AS, Martin AJ, Chopra M, Saloner DA, Higashida RT, Young WL. Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting. Stroke. 2005 Mar; 36(3):676-8. PMID: 15692113.
        View in: PubMed
      39. Wintermark M, Fischbein NJ, Smith WS, Ko NU, Quist M, Dillon WP. Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke. AJNR Am J Neuroradiol. 2005 Jan; 26(1):104-12. PMID: 15661711.
        View in: PubMed
      40. Kopelnik A, Fisher L, Miss JC, Banki N, Tung P, Lawton MT, Ko N, Smith WS, Drew B, Foster E, Zaroff J. Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhage. Neurocrit Care. 2005; 3(2):132-8. PMID: 16174882.
        View in: PubMed
      41. Smith WS, Dowd CF, Johnston SC, Ko NU, DeArmond SJ, Dillon WP, Setty D, Lawton MT, Young WL, Higashida RT, Halbach VV. Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2004 Nov; 35(11):2518-22. PMID: 15472097.
        View in: PubMed
      42. Wintermark M, Smith WS, Ko NU, Quist M, Schnyder P, Dillon WP. Dynamic perfusion CT: optimizing the temporal resolution and contrast volume for calculation of perfusion CT parameters in stroke patients. AJNR Am J Neuroradiol. 2004 May; 25(5):720-9. PMID: 15140710.
        View in: PubMed
      43. Tung P, Kopelnik A, Banki N, Ong K, Ko N, Lawton MT, Gress D, Drew B, Foster E, Parmley W, Zaroff J. Predictors of neurocardiogenic injury after subarachnoid hemorrhage. Stroke. 2004 Feb; 35(2):548-51. PMID: 14739408.
        View in: PubMed
      44. Ko NU, Johnston SC, Young WL, Singh V, Klatsky AL. Distinguishing intracerebral hemorrhages caused by arteriovenous malformations. Cerebrovasc Dis. 2003; 15(3):206-9. PMID: 12646781.
        View in: PubMed
      45. Kim HS, Shibata Y, Ko N, Ikemoto N, Ishizuka Y, Murakami N, Sugimoto M, Kobayashi M, Wataya Y. Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. Parasitol Int. 2000 Jan; 48(3):271-4. PMID: 11227768.
        View in: PubMed
      46. Pleasure SJ, Abosch A, Friedman J, Ko NU, Barbaro N, Dillon W, Fishman RA, Poncelet AN. Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression. Neurology. 1998 Jun; 50(6):1854-7. PMID: 9633740.
        View in: PubMed
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