James Smith, MD, MS

Title(s)Associate Professor, Urology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A.1996Molecular Biology
    UC Berkeley, UCSF Joint Medical ProgramM.S.2000Public Health, Medicine
    University of California, San FranciscoM.D.2002Medicine
    University of UtahUrology Residency2007Urology
    University of California, San FranciscoMale Reproductive and Sexual Medicine Fellowship2009Urology

    Collapse Overview 
    Collapse Overview
    Dr. Smith is Director of the UCSF Male Reproductive Health practice dedicated to providing outstanding reproductive clinical care, conducting cutting edge research, and improving access to reproductive care. His research program is dedicated to helping men and boys with cancer become fathers after surviving cancer treatment. He and his partners conduct basic science investigations of sperm physiology, sperm stem cells, and semen physiology; translational research focused on fertility restoration by means of testicular and stem cell transplantation; and clinical research into reproductive effects of targeted cancer therapies such as tyrosine kinase inhibitors and MTOR inhibitors., Clinically, Dr. Smith treats men with fertility problems, need for fertility preservation, erectile dysfunction, orchalgia, and hypogonadism in the Center for Reproductive Health. Dr. Smith specializes in the use of minimally invasive vasectomy, microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval techniques, spermatic cord denervation, and varicocelectomy.

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular identity of human sperm potassium channel and its role in male fertility
    NIH/NIGMS R01GM111802Apr 1, 2015 - Mar 31, 2020
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, Zhang H, Santoro N. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. J Urol. 2019 Mar 05; 101097JU0000000000000205. PMID: 30835629.
      View in: PubMed
    2. Smith BM, Duncan FE, Ataman L, Smith K, Quinn GP, Chang RJ, Finlayson C, Orwig K, Valli-Pulaski H, Moravek MB, Zelinski MB, Irene Su H, Vitek W, Smith JF, Jeruss JS, Gracia C, Coutifaris C, Shah D, Nahata L, Gomez-Lobo V, Appiah LC, Brannigan RE, Gillis V, Gradishar W, Javed A, Rhoton-Vlasak AS, Kondapalli LA, Neuber E, Ginsberg JP, Muller CH, Hirshfeld-Cytron J, Kutteh WH, Lindheim SR, Cherven B, Meacham LR, Rao P, Torno L, Sender LS, Vadaparampil ST, Skiles JL, Schafer-Kalkhoff T, Frias OJ, Byrne J, Westphal LM, Schust DJ, Klosky JL, McCracken KA, Ting A, Khan Z, Granberg C, Lockart B, Scoccia B, Laronda MM, Mersereau JE, Marsh C, Pavone ME, Woodruff TK. The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond. Future Oncol. 2018 Dec; 14(29):3059-3072. PMID: 30474429.
      View in: PubMed
    3. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 Oct 30; 25(5):1346-1358. PMID: 30380423.
      View in: PubMed
    4. Adeleye AJ, Reid G, Kao CN, Mok-Lin E, Smith JF. Semen Parameters Among Transgender Women With a History of Hormonal Treatment. Urology. 2019 Feb; 124:136-141. PMID: 30312673.
      View in: PubMed
    5. Gilbert K, Nangia AK, Dupree JM, Smith JF, Mehta A. Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology? Urol Oncol. 2018 03; 36(3):92.e1-92.e9. PMID: 29169844.
      View in: PubMed
    6. Ramstein JJ, Tsai KK, Smith JF. Tyrosine Kinase Inhibitors and Male Reproductive Health. Clin Pharmacol Ther. 2017 Nov; 102(5):754-756. PMID: 28791688.
      View in: PubMed
    7. Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC. Semen amyloids participate in spermatozoa selection and clearance. Elife. 2017 06 27; 6. PMID: 28653619.
      View in: PubMed
    8. Ho JR, Hoffman JR, Aghajanova L, Smith JF, Cardenas M, Herndon CN. Demographic analysis of a low resource, socioculturally diverse urban community presenting for infertility care in a United States public hospital. Contracept Reprod Med. 2017; 2:17. PMID: 29201422.
      View in: PubMed
    9. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 02; 13(2):e1006163. PMID: 28207890.
      View in: PubMed
    10. Hussein AA, Yango P, Ezz Y, Smith JF, Tran ND. Fertility preservation options for prepubertal boys facing gonadotoxic therapies. Minerva Ginecol. 2016 Dec; 68(6):668-74. PMID: 27619261.
      View in: PubMed
    11. Winkelman WD, Katz PP, Smith JF, Rowen TS. The Sexual Impact of Infertility Among Women Seeking Fertility Care. Sex Med. 2016 Sep; 4(3):e190-7. PMID: 27165191.
      View in: PubMed
    12. Mehta A, Nangia AK, Dupree JM, Smith JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016 05; 105(5):1128-1137. PMID: 27054307.
      View in: PubMed
    13. Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29; 352(6285):555-9. PMID: 26989199.
      View in: PubMed
    14. Smith JF, Tran ND. Freezing and thawing testicular cells may not affect growth of cultured testicular cells. Fertil Steril. 2015 Nov; 104(5):1129. PMID: 26342245.
      View in: PubMed
    15. Hussein AA, Tran ND, Smith JF. Fertility preservation for boys and adolescents facing sterilizing medical therapy. Transl Androl Urol. 2014 Dec; 3(4):382-90. PMID: 26816794; PMCID: PMC4708141.
    16. Yango P, Altman E, Smith JF, Klatsky PC, Tran ND. Optimizing cryopreservation of human spermatogonial stem cells: comparing the effectiveness of testicular tissue and single cell suspension cryopreservation. Fertil Steril. 2014 Nov; 102(5):1491-1498.e1. PMID: 25241367; PMCID: PMC4608674.
    17. Smith JF, Yango P, Altman E, Choudhry S, Poelzl A, Zamah AM, Rosen M, Klatsky PC, Tran ND. Testicular niche required for human spermatogonial stem cell expansion. Stem Cells Transl Med. 2014 Sep; 3(9):1043-54. PMID: 25038247; PMCID: PMC4149303.
    18. Altman E, Yango P, Moustafa R, Smith JF, Klatsky PC, Tran ND. Characterization of human spermatogonial stem cell markers in fetal, pediatric, and adult testicular tissues. Reproduction. 2014 Oct; 148(4):417-27. PMID: 25030892; PMCID: PMC4599365.
    19. Odisho AY, Nangia AK, Katz PP, Smith JF. Temporal and geospatial trends in male factor infertility with assisted reproductive technology in the United States from 1999-2010. Fertil Steril. 2014 Aug; 102(2):469-75. PMID: 24931206.
      View in: PubMed
    20. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34. PMID: 24741080; PMCID: PMC4054457.
    21. Mannowetz N, Naidoo NM, Choo SA, Smith JF, Lishko PV. Slo1 is the principal potassium channel of human spermatozoa. Elife. 2013 Oct 08; 2:e01009. PMID: 24137539; PMCID: PMC3789364.
    22. Wu AK, Odisho AY, Washington SL, Katz PP, Smith JF. Out-of-pocket fertility patient expense: data from a multicenter prospective infertility cohort. J Urol. 2014 Feb; 191(2):427-32. PMID: 24018235.
      View in: PubMed
    23. Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, Lishko PV. Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6823-8. PMID: 23530196; PMCID: PMC3637729.
    24. Wu AK, Elliott P, Katz PP, Smith JF. Time costs of fertility care: the hidden hardship of building a family. Fertil Steril. 2013 Jun; 99(7):2025-30. PMID: 23454007; PMCID: PMC3736984.
    25. Letourneau JM, Smith JF, Ebbel EE, Craig A, Katz PP, Cedars MI, Rosen MP. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 2012 Sep 15; 118(18):4579-88. PMID: 22451228; PMCID: PMC3387319.
    26. Smith JF, Breyer BN, Shindel AW. Predictors of sexual bother in a population of male North American medical students. J Sex Med. 2011 Dec; 8(12):3363-9. PMID: 21951580; PMCID: PMC3565616.
    27. Nangia AK, Luke B, Smith JF, Mak W, Stern JE. National study of factors influencing assisted reproductive technology outcomes with male factor infertility. Fertil Steril. 2011 Sep; 96(3):609-14. PMID: 21733503.
      View in: PubMed
    28. Weiss DA, Harris CR, Smith JF. The use of complementary and alternative fertility treatments. Curr Opin Obstet Gynecol. 2011 Jun; 23(3):195-9. PMID: 21415747.
      View in: PubMed
    29. Smith JF, Eisenberg ML, Glidden D, Millstein SG, Cedars M, Walsh TJ, Showstack J, Pasch LA, Adler N, Katz PP. Socioeconomic disparities in the use and success of fertility treatments: analysis of data from a prospective cohort in the United States. Fertil Steril. 2011 Jul; 96(1):95-101. PMID: 21616487; PMCID: PMC3129357.
    30. Shindel AW, Horberg MA, Smith JF, Breyer BN. Sexual dysfunction, HIV, and AIDS in men who have sex with men. AIDS Patient Care STDS. 2011 Jun; 25(6):341-9. PMID: 21501095; PMCID: PMC3101920.
    31. Breyer BN, Van den Eeden SK, Horberg MA, Eisenberg ML, Deng DY, Smith JF, Shindel AW. HIV status is an independent risk factor for reporting lower urinary tract symptoms. J Urol. 2011 May; 185(5):1710-5. PMID: 21420120; PMCID: PMC3565615.
    32. Katz P, Showstack J, Smith JF, Nachtigall RD, Millstein SG, Wing H, Eisenberg ML, Pasch LA, Croughan MS, Adler N. Costs of infertility treatment: results from an 18-month prospective cohort study. Fertil Steril. 2011 Mar 01; 95(3):915-21. PMID: 21130988; PMCID: PMC3043157.
    33. Smith JF, Shindel AW, Huang YC, Clavijo RI, Flechner L, Breyer BN, Eisenberg ML, Lue TF. Pentoxifylline treatment and penile calcifications in men with Peyronie's disease. Asian J Androl. 2011 Mar; 13(2):322-5. PMID: 21102473; PMCID: PMC3565600.
    34. Rowen TS, Smith JF, Eisenberg ML, Breyer BN, Drey EA, Shindel AW. Contraceptive usage patterns in North American medical students. Contraception. 2011 May; 83(5):459-65. PMID: 21477690; PMCID: PMC3607662.
    35. Smith JF, Breyer BN, Eisenberg ML, Sharlip ID, Shindel AW. Sexual function and depressive symptoms among male North American medical students. J Sex Med. 2010 Dec; 7(12):3909-17. PMID: 21059174; PMCID: PMC3565609.
    36. Shindel AW, Eisenberg ML, Breyer BN, Sharlip ID, Smith JF. Sexual function and depressive symptoms among female North American medical students. J Sex Med. 2011 Feb; 8(2):391-9. PMID: 21054793.
      View in: PubMed
    37. Hotaling JM, Smith JF, Rosen M, Muller CH, Walsh TJ. The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis. Fertil Steril. 2011 Mar 01; 95(3):1141-5. PMID: 21030014.
      View in: PubMed
    38. Brant WO, Myers JB, Carrell DT, Smith JF. Male athletic activities and their effects on semen and hormonal parameters. Phys Sportsmed. 2010 Oct; 38(3):114-20. PMID: 20959704.
      View in: PubMed
    39. Eisenberg ML, Smith JF, Shindel AW, Lue TF. Tunica-sparing ossified Peyronie's plaque excision. BJU Int. 2011 Feb; 107(4):622-5. PMID: 20804484.
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    40. Smith JF. The professional imperative for obstetrician-gynecologists to discontinue newborn male circumcision. Am J Perinatol. 2011 Feb; 28(2):125-8. PMID: 20700861.
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    41. Shindel AW, Ando KA, Nelson CJ, Breyer BN, Lue TF, Smith JF. Medical student sexuality: how sexual experience and sexuality training impact U.S. and Canadian medical students' comfort in dealing with patients' sexuality in clinical practice. Acad Med. 2010 Aug; 85(8):1321-30. PMID: 20671459.
      View in: PubMed
    42. Smith JF, Eisenberg ML, Millstein SG, Nachtigall RD, Sadetsky N, Cedars MI, Katz PP. Fertility treatments and outcomes among couples seeking fertility care: data from a prospective fertility cohort in the United States. Fertil Steril. 2011 Jan; 95(1):79-84. PMID: 20659733; PMCID: PMC2966858.
    43. Breyer BN, Smith JF, Shindel AW, Sharlip ID, Eisenberg ML. The impact of infertility on family size in the USA: data from the National Survey of Family Growth. Hum Reprod. 2010 Sep; 25(9):2360-5. PMID: 20601679.
      View in: PubMed
    44. Eisenberg ML, Smith JF, Millstein SG, Nachtigall RD, Adler NE, Pasch LA, Katz PP. Predictors of not pursuing infertility treatment after an infertility diagnosis: examination of a prospective U.S. cohort. Fertil Steril. 2010 Nov; 94(6):2369-71. PMID: 20471010; PMCID: PMC2946977.
    45. Walsh TJ, Schembri M, Turek PJ, Chan JM, Carroll PR, Smith JF, Eisenberg ML, Van Den Eeden SK, Croughan MS. Increased risk of high-grade prostate cancer among infertile men. Cancer. 2010 May 01; 116(9):2140-7. PMID: 20309846; PMCID: PMC2893877.
    46. Breyer BN, Smith JF, Eisenberg ML, Ando KA, Rowen TS, Shindel AW. The impact of sexual orientation on sexuality and sexual practices in North American medical students. J Sex Med. 2010 Jul; 7(7):2391-400. PMID: 20384941; PMCID: PMC3607668.
    47. Smith JF, Eisenberg ML, Millstein SG, Nachtigall RD, Shindel AW, Wing H, Cedars M, Pasch L, Katz PP. The use of complementary and alternative fertility treatment in couples seeking fertility care: data from a prospective cohort in the United States. Fertil Steril. 2010 May 01; 93(7):2169-74. PMID: 20338559; PMCID: PMC2860047.
    48. Breyer BN, Shindel AW, Huang YC, Eisenberg ML, Weiss DA, Lue TF, Smith JF. Are sonographic characteristics associated with progression to surgery in men with Peyronie's disease? J Urol. 2010 Apr; 183(4):1484-8. PMID: 20171694; PMCID: PMC3565595.
    49. Smith JF, Caan BJ, Sternfeld B, Haque R, Quesenberry CP, Quinn VP, Shan J, Walsh TJ, Lue TF, Jacobsen SJ, Van den Eeden SK. Racial disparities in erectile dysfunction among participants in the California Men's Health Study. J Sex Med. 2009 Dec; 6(12):3433-9. PMID: 19796017.
      View in: PubMed
    50. Eisenberg ML, Shindel AW, Smith JF, Breyer BN, Lipshultz LI. Socioeconomic, anthropomorphic, and demographic predictors of adult sexual activity in the United States: data from the national survey of family growth. J Sex Med. 2010 Jan; 7(1 Pt 1):50-8. PMID: 19796014; PMCID: PMC4081028.
    51. Eisenberg ML, Henderson JT, Amory JK, Smith JF, Walsh TJ. Racial differences in vasectomy utilization in the United States: data from the national survey of family growth. Urology. 2009 Nov; 74(5):1020-4. PMID: 19773036; PMCID: PMC2784091.
    52. Smith JF, Brant WO, Fradet V, Shindel AW, Vittinghoff E, Chi T, Huang YC, Davis CB, Conti S, Lue TF. Penile sonographic and clinical characteristics in men with Peyronie's disease. J Sex Med. 2009 Oct; 6(10):2858-67. PMID: 19732312.
      View in: PubMed
    53. Smith JF, Walsh TJ, Shindel AW, Turek PJ, Wing H, Pasch L, Katz PP. Sexual, marital, and social impact of a man's perceived infertility diagnosis. J Sex Med. 2009 Sep; 6(9):2505-15. PMID: 19619144; PMCID: PMC2888139.
    54. Eisenberg ML, Smith JF, Millstein SG, Walsh TJ, Breyer BN, Katz PP. Perceived negative consequences of donor gametes from male and female members of infertile couples. Fertil Steril. 2010 Aug; 94(3):921-6. PMID: 19523614; PMCID: PMC2888643.
    55. Eisenberg ML, Shindel AW, Smith JF, Lue TF, Walsh TJ. Who is the 40-year-old virgin and where did he/she come from? Data from the National Survey of Family Growth. J Sex Med. 2009 Aug; 6(8):2154-61. PMID: 19493289.
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    56. Brant WO, Lue TF, Smith JF. Does bicycling contribute to erectile dysfunction? Examining the evidence. Phys Sportsmed. 2009 Apr; 37(1):44-53. PMID: 20048487.
      View in: PubMed
    57. Aaronson DS, Walsh TJ, Smith JF, Davies BJ, Hsieh MH, Konety BR. Meta-analysis: does lidocaine gel before flexible cystoscopy provide pain relief? BJU Int. 2009 Aug; 104(4):506-9; discussion 509-10. PMID: 19239453.
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    58. Saperston K, Smith J, Putman S, Matern R, Foot L, Wallis C, deVries C, Snow B, Cartwright P. Endoscopic subureteral injection is not less expensive than outpatient open reimplantation for unilateral vesicoureteral reflux. J Urol. 2008 Oct; 180(4 Suppl):1626-9; discussion 1629-30. PMID: 18715586.
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    59. Smith JF, Walsh TJ, Conti SL, Turek P, Lue T. Risk factors for emotional and relationship problems in Peyronie's disease. J Sex Med. 2008 Sep; 5(9):2179-84. PMID: 18638001; PMCID: PMC2881678.
    60. Smith JF, Walsh TJ, Turek PJ. Ejaculatory duct obstruction. Urol Clin North Am. 2008 May; 35(2):221-7, viii. PMID: 18423242.
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    61. Opitz JM, Smith JF, Santoro L. The FG syndromes (Online Mendelian Inheritance in Man 305450): perspective in 2008. Adv Pediatr. 2008; 55:123-70. PMID: 19048730.
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    62. Smith JF, Wayment RO, Cartwright PC, Snow BW, Opitz JM. Genitourinary anomalies of pediatric FG syndrome. J Urol. 2007 Aug; 178(2):656-9. PMID: 17574621.
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