Michael Peters, MD
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Title(s) | Assistant Professor, Medicine |
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School | School of Medicine |
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Address | 505 Parnassus Avenue San Francisco CA 94117
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Phone | 415-476-0735 |
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vCard | Download vCard |
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Biography Emory University | BA | 2002 | Economics | State University of New York, Stony Brook | MD | 2007 | Medicine | University of Colorado | Internal Medicine | 2010 | Medicine | University of California, San Francisco | Pulmonary/Critical Care | 2014 | Medicine | University of California, San Francisco | MAS | 2015 | Epidemiology |
| 2015
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| 2018 | Parker B. Francis Fellow | | 2014 | | ATS Scientific Abstract Award | | 2015 | | ATS Abstract Scholarship |
Overview Dr. Peters is an Assistant Professor of Medicine in the Division of Pulmonary and Critical Care Medicine and the Department of Medicine at UCSF.
Many asthma patients respond well to traditional asthma medications including inhaled corticosteroids. However, a significant subgroup of asthmatics (many of whom are older and obese) has severe disease that causes frequent exacerbations and significant disability. The Peters lab studies the pathobiology that results in certain patients developing steroid resistant asthma. To date, we find that patients with measures of obesity associated metabolic dysfunction, including high rates of hypertension and obesity, and elevations in plasma IL-6 levels are significantly more likely to develop asthma exacerbations despite treatment with high doses of inhaled corticosteroids. Furthermore, we find that obese asthma patients demonstrate lower airway gene expression measures of CD8+ T-cells when compared to non obese asthma patients suggesting that obesity may impair airway host defense. The Peters lab is working to identify treatments to restore airway host defense in asthma with the goal of decreasing the frequency and severity of asthma exacerbations.
Clinically, Dr. Peters works in the UCSF Severe Asthma Clinic and he is an attending in the UCSF Critical Care Units.
Research ORNG Applications Bibliographic
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TEMPORARY REMOVAL: The association of plasma IL-6 with measures of asthma morbidity in a moderate-severe pediatric cohort aged 6-18 years. J Allergy Clin Immunol Pract. 2021 Mar 23.
Permaul P, Peters MC, Petty CR, Cardet JC, Ly NP, Ramratnam SK, Ross K, Fitzpatrick A, Israel E, Bacharier LB, Phipatanakul W, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators . PMID: 33771493.
View in: PubMed Mentions: Fields:
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PrecISE: Precision Medicine in Severe Asthma An Adaptive Platform Trial with Biomarker Ascertainment. J Allergy Clin Immunol. 2021 Mar 02.
Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. PMID: 33667479.
View in: PubMed Mentions: Fields:
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QCT-based Measures Of Airway Narrowing And Shape Changes Associated With Endobronchial Biopsy Tissue Measures of Airway Remodeling And Clinical Outcomes In Asthma. Journal of Allergy and Clinical Immunology. 2021 Feb 1; 147(2):ab150.
Jiwoong Choi, Jonathan Boomer, In Kyu Lee, Fred Shi, Stephanie Christenson, Jenna Nguyen, Leonard Bacharier, Prescott Woodruff, Michael Peters, Sanghun Choi, Ching-Long Lin, Mario Castro. .
View in: Publisher Site Mentions:
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Erratum: COVID-19-related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids. Am J Respir Crit Care Med. 2020 12 15; 202(12):1744-1746.
Peters MC, Fahy JV. PMID: 33320072.
View in: PubMed Mentions: Fields:
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Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma. Am J Respir Crit Care Med. 2020 Dec 08.
Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Levy BD, Meyers DA, Ross K, Teague WG, Wenzel SE, Woodruff PG, Zein J, Jarjour NN, Mauger DT, Israel E. PMID: 33290668.
View in: PubMed Mentions: Fields:
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Reply to Nannini and to Lipworth et al. Am J Respir Crit Care Med. 2020 11 01; 202(9):1325-1326.
Peters MC, Fahy JV, Denlinger LC. PMID: 32687407.
View in: PubMed Mentions: Fields: Translation: Humans
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Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency. Am J Respir Crit Care Med. 2020 10 01; 202(7):973-982.
Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC. PMID: 32479111.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. J Biopharm Stat. 2020 Sep 17; 1-12.
Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR. PMID: 32941098.
View in: PubMed Mentions: Fields:
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An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells. Clin Exp Allergy. 2020 Aug; 50(8):904-914.
Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV. PMID: 32542913.
View in: PubMed Mentions: 1 Fields:
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COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. Am J Respir Crit Care Med. 2020 07 01; 202(1):83-90.
Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV. PMID: 32348692.
View in: PubMed Mentions: 40 Fields: Translation: HumansCellsPHPublic Health
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Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma. Lancet. 2020 02 01; 395(10221):371-383.
Peters MC, Wenzel SE. PMID: 32007172.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Diagnosis and Management of T2-High Asthma. J Allergy Clin Immunol Pract. 2020 02; 8(2):442-450.
Coverstone AM, Seibold MA, Peters MC. PMID: 32037108.
View in: PubMed Mentions: 2 Fields:
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Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care. 2020 01; 43(1):5-12.
Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. PMID: 31753960.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling. J Clin Invest. 2019 11 01; 129(11):4979-4991.
Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, Altemeier WA, Larmore M, Frevert CW, Mulligan MS, Ziegler SF, Debley JS, Peters MC, Hallstrand TS. PMID: 31437129.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma. J Allergy Clin Immunol. 2020 01; 145(1):430-433.
Li X, Hastie AT, Peters MC, Hawkins GA, Phipatanakul W, Li H, Moore WC, Busse WW, Castro M, Erzurum SC, Gaston B, Israel E, Jarjour NN, Levy BD, Wenzel SE, Meyers DA, Fahy JV, Bleecker ER. PMID: 31513878.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 05 01; 199(9):1076-1085.
Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. PMID: 30888839.
View in: PubMed Mentions: 20 Fields: Translation: HumansCells
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Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives. Am J Respir Crit Care Med. 2019 04 01; 199(7):823-829.
Siddiqui S, Denlinger LC, Fowler SJ, Akuthota P, Shaw DE, Heaney LG, Brown L, Castro M, Winders TA, Kraft M, Wagers S, Peters MC, Pavord ID, Walker S, Jarjour NN. PMID: 30726120.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma. Am J Respir Crit Care Med. 2019 02 15; 199(4):465-477.
Peters MC, Ringel L, Dyjack N, Herrin R, Woodruff PG, Rios C, O'Connor B, Fahy JV, Seibold MA. PMID: 30371106.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 03 22; 3(6).
Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. PMID: 29563345.
View in: PubMed Mentions: 3 Fields:
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Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol. 2019 01; 143(1):104-113.e14.
Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV. PMID: 29524537.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 03 01; 128(3):997-1009.
Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV, . PMID: 29400693.
View in: PubMed Mentions: 33 Fields: Translation: Humans
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Sputum Mast Cells and Eosinophils Identify Asthmatics with Lower Lung Function and Proneness to Exacerbations. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab196.
Merritt L. Fajt, Michael Peters, Eugene R. Bleecker, Juan Carlos Cardet, Mario Castro, Suzy Comhair, Andrea Coverstone, Loren C. Denlinger, Serpil C. Erzurum, Annette T. Hastie, Elliot Israel, Nizar N. Jarjour, Mats W. Johansson, Bruce D. Levy, David M. Mauger, Stephen P. Peters, Brenda R. Phillips, Wanda Phipatanakul, Kristie R. Ross, Sima K. Ramratnam, John V. Fahy, Sally Wenzel. .
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Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2018 02; 153(2):378-386.
Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC. PMID: 29080709.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):545-554.e4.
Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. PMID: 28866107.
View in: PubMed Mentions: 37 Fields: Translation: Humans
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ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14).
Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD, . PMID: 28724795.
View in: PubMed Mentions: 5 Fields:
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Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9).
Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. PMID: 28783702.
View in: PubMed Mentions: 13 Fields:
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Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 02 01; 195(3):302-313.
Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN, . PMID: 27556234.
View in: PubMed Mentions: 66 Fields: Translation: HumansCellsCTClinical Trials
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Biomarkers of Airway Type-2 Inflammation and Integrating Complex Phenotypes to Endotypes in Asthma. Curr Allergy Asthma Rep. 2016 10; 16(10):71.
Peters MC, Nguyen ML, Dunican EM. PMID: 27613654.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 09 08; 1(14):e87871.
Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. PMID: 27699235.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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Metabolic consequences of obesity as an "outside in" mechanism of disease severity in asthma. Eur Respir J. 2016 08; 48(2):291-3.
Peters MC, Fahy JV. PMID: 27478182.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70.
Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. PMID: 27432971.
View in: PubMed Mentions: 36 Fields: Translation: HumansCells
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Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 07; 4(7):574-584.
Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV, . PMID: 27283230.
View in: PubMed Mentions: 61 Fields: Translation: Humans
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Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1005-7.
Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV. PMID: 24735037.
View in: PubMed Mentions: 11 Fields: Translation: HumansCells
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Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb; 133(2):388-94.
Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. PMID: 24075231.
View in: PubMed Mentions: 72 Fields: Translation: HumansCells
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Type 2 immune responses in obese individuals with asthma. Am J Respir Crit Care Med. 2013 Sep 15; 188(6):633-4.
Peters MC, Fahy JV. PMID: 24032378.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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New-onset asthma among soldiers serving in Iraq and Afghanistan. Allergy Asthma Proc. 2010 Sep-Oct; 31(5):67-71.
Szema AM, Peters MC, Weissinger KM, Gagliano CA, Chen JJ. PMID: 20929596.
View in: PubMed Mentions: 23 Fields: Translation: Humans
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CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells. J Immunol. 2002 Jul 15; 169(2):693-701.
Miller JD, Peters M, Oran AE, Beresford GW, Harrington L, Boss JM, Altman JD. PMID: 12097371.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Year | Publications |
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2002 | 1 | 2010 | 1 | 2013 | 2 | 2014 | 1 | 2016 | 5 | 2017 | 5 | 2018 | 4 | 2019 | 6 | 2020 | 9 | 2021 | 3 |
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