Dr. Peters is an Assistant Professor of Medicine in the Division of Pulmonary and Critical Care Medicine and the Department of Medicine at UCSF.
Many asthma patients respond well to traditional asthma medications including inhaled corticosteroids. However, a significant subgroup of asthmatics (many of whom are older and obese) has severe disease that causes frequent exacerbations and significant disability. The Peters lab studies the pathobiology that results in certain patients developing steroid resistant asthma. To date, we find that patients with measures of obesity associated metabolic dysfunction, including high rates of hypertension and obesity, and elevations in plasma IL-6 levels are significantly more likely to develop asthma exacerbations despite treatment with high doses of inhaled corticosteroids. Furthermore, we find that obese asthma patients demonstrate lower airway gene expression measures of CD8+ T-cells when compared to non obese asthma patients suggesting that obesity may impair airway host defense. The Peters lab is working to identify treatments to restore airway host defense in asthma with the goal of decreasing the frequency and severity of asthma exacerbations.
Clinically, Dr. Peters works in the UCSF Severe Asthma Clinic and he is an attending in the UCSF Critical Care Units.