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William Ryan, MD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentOtolaryngology
Address550 16th. Street
San Francisco CA 94158
Phone415-502-1877
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityM.D.2005School of Medicine
    Collapse Awards and Honors
    Wesleyan University1997Phi Beta Kappa

    Collapse Overview 
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    William R. Ryan, MD, FACS, is a board-certified fellowship-trained Associate Professor of Clinical Otolaryngology-Head and Neck Surgery in the divisions of Head and Neck Surgery Oncology, Salivary Gland Surgery and Sialendoscopy, Thyroid and Parathyroid Surgery in the Department of Otolaryngology – Head and Neck Surgery at the University of California, San Francisco. He received his medical degree from Stanford University and also completed both his internship and otolaryngology-head and neck surgery residency at Stanford University Medical Center, followed by an advanced head and neck oncologic surgery fellowship from UCSF.

    Clinically, Dr. Ryan is skilled in the care and management of patients with benign and malignant tumors of the head and neck and obstructive salivary disease with the appropriate application of robotic, endoscopic, minimally invasive, and traditional surgical techniques. He helps direct the Robotic Head and Neck Surgery program (for TORS: TransOral Robotic Surgery), the Thyroid and Parathyroid Surgery Center, and the Salivary Gland Surgery Center at UCSF. He has specific interests and expertise in thyroid and parathyroid surgery, sialendoscopy/salivary duct surgery, salivary tumor surgery, upper aerodigestive tract surgery (of the oral cavity, oropharynx, hypopharynx, larynx, upper esophagus, and trachea), skin cancer surgery, and regional facial, head and neck reconstruction.

    He is the co-director for following courses: the annual UCSF/Tripler Pacific Rim Otolaryngology-Head and Neck Surgery Update Course, in Honolulu, HI, and the UCSF Sialendoscopy/Salivary Duct Surgery Course, in San Francisco, CA. He is a regular lecturer at the UCSF School of Medicine and multiple regional and national courses. He is a lecture and proctor for the American College of Surgeons Thyroid and Parathyroid Ultrasound Course. He is a committee member in the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. He is a reviewer for the journals: Head and Neck, ORL (Otorhinolaryngology), and JAMA-Otolaryngology-Head and Neck Surgery. Also, he is a fellow of the American College of Surgeons.

    Specialty:
    Head and Neck Surgical Oncology, Salivary Gland and Duct Surgery and Sialendoscopy, Thyroid and Parathyroid Surgery

    Expertise:
    Head and Neck Surgical Oncology, Transoral Robotic Surgery, Surgeon-Performed Ultrasound, Salivary Gland and Duct Surgery and Sialendoscopy, Thyroid and Parathyroid Surgery

    Professional Interests:
    Head and Neck Tumors, transoral robotic surgery, surgeon-performed ultrasound, salivary surgery/sialoendoscopy, thyroid/parathyroid surgery, endoscopic sinus/skull base surgery, and facial reconstruction, outcomes research. salivary function in setting of oncologic treatments, head and neck surgery technique commonalities across the United States, the impact of sialendoscopy on patient symptoms, the benefits and drawbacks of head and neck cancer surveillance with radiology

    Education and Training:
    • Medical School: Stanford University, CA
    • Internship: Stanford University, CA – Head and Neck Surgery
    • Residency: Stanford University, CA – Otolaryngology-Head and Neck Surgery
    • Fellowship: University of California, San Francisco – Head and Neck Oncologic Surgery

    Awards and Honors:
    • 1997 Phi Beta Kappa, Wesleyan University
    • 2004, Best paper by a medical student award, 6th International Conference on Head and Neck Cancer, Washington D.C
    • 2009, Honorable Mention-Scientific Content Award, Stanford Otolaryngology Resident Research Symposium
    • 2011 University of California-San Francisco - Pinnacle Award- Highest Patient Satisfaction Award For A Clinical Division (Granted to the Division of Head and Neck Oncologic/Endocrine Surgery)
    • 2012 University of California-San Francisco - Pinnacle Award - Highest Patient Satisfaction Award For A Clinical Division at UCSF (Granted to the Division of Head and Neck Oncologic/Endocrine Surgery)
    • 2013 University of California-San Francisco - Pinnacle Award (Honorable Mention / 3rd Place) - Highest Patient Satisfaction Award For A Clinical Division at UCSF (Granted to the Division of Head and Neck Oncologic/Endocrine Surgery)


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Plonowska KA, Strohl MP, Wang SJ, Ha PK, George JR, Heaton CM, El-Sayed IH, Mallen-St Clair J, Ryan WR. Human Papillomavirus-Associated Oropharyngeal Cancer: Patterns of Nodal Disease. Otolaryngol Head Neck Surg. 2018 Oct 02; 194599818801907. PMID: 30274544.
      View in: PubMed
    2. Plonowska KA, Ha PK, Ryan WR. Advanced head and neck surgical techniques: A survey of US otolaryngology resident perspectives. Auris Nasus Larynx. 2018 Aug 28. PMID: 30170906.
      View in: PubMed
    3. Ryan WR, Plonowska KA, Gurman ZR, Aubin-Pouliot A, Chang JL. One-Year symptom outcomes after sialolithiasis treatment with sialendoscopy-assisted salivary duct surgery. Laryngoscope. 2018 Aug 27. PMID: 30151855.
      View in: PubMed
    4. Plonowska KA, Gurman ZR, Humphrey A, Chang JL, Ryan WR. One-year outcomes of sialendoscopic-assisted salivary duct surgery for sialadenitis without sialolithiasis. Laryngoscope. 2018 Aug 27. PMID: 30152080.
      View in: PubMed
    5. Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018 Jun 25. PMID: 29942093.
      View in: PubMed
    6. Formeister EJ, Sean Alemi A, El-Sayed I, George JR, Ha P, Daniel Knott P, Ryan WR, Seth R, Tamplen ML, Heaton CM. Shorter interval between radiation therapy and salvage laryngopharyngeal surgery increases complication rates following microvascular free tissue transfer. Am J Otolaryngol. 2018 Jun 06. PMID: 29908709.
      View in: PubMed
    7. Winchester D, Lehman J, Tello T, Chimato N, Hocker T, Kim S, Chang J, Markey J, Yom SS, Ryan W, Mully T, Hodge D, Otley C, Arron S. Undifferentiated Pleomorphic Sarcoma: Factors Predictive of Adverse Outcomes. J Am Acad Dermatol. 2018 May 19. PMID: 29787841.
      View in: PubMed
    8. Ryan WR, Plonowska K. Human Papillomavirus in the Mouth and Throat: More Widespread Than Expected? JAMA Otolaryngol Head Neck Surg. 2018 May 10. PMID: 29800955.
      View in: PubMed
    9. Chan CK, Han AY, Alonso JE, Xu MJ, Mallen-St Clair J, Heaton CM, Ryan WR, Kuan EC, St John MA. Squamous Cell Carcinoma of the Soft Palate in the United States: A Population-Based Study. Otolaryngol Head Neck Surg. 2018 May 01; 194599818771931. PMID: 29734872.
      View in: PubMed
    10. Windon MJ, D'Souza G, Rettig EM, Westra WH, van Zante A, Wang SJ, Ryan WR, Mydlarz WK, Ha PK, Miles BA, Koch W, Gourin C, Eisele DW, Fakhry C. Increasing prevalence of human papillomavirus-positive oropharyngeal cancers among older adults. Cancer. 2018 Apr 30. PMID: 29710393.
      View in: PubMed
    11. Xu MJ, Wu TJ, van Zante A, El-Sayed IH, Algazi AP, Ryan WR, Ha PK, Yom SS. Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma. J Otolaryngol Head Neck Surg. 2018 Apr 25; 47(1):28. PMID: 29695289.
      View in: PubMed
    12. Zheng M, Plonowska KA, Strohl MP, Ryan WR. Surgeon-performed ultrasound for the assessment of parotid masses. Am J Otolaryngol. 2018 Apr 16. PMID: 29778636.
      View in: PubMed
    13. Yin LX, D'Souza G, Westra WH, Wang SJ, van Zante A, Zhang Y, Rettig EM, Ryan WR, Ha PK, Wentz A, Koch W, Eisele DW, Fakhry C. Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas. Laryngoscope. 2018 Mar 14. PMID: 29536542.
      View in: PubMed
    14. Xu MJ, Lazar AA, Garsa AA, Arron ST, Ryan WR, El-Sayed IH, George JR, Algazi AP, Heaton CM, Ha PK, Yom SS. Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy. Head Neck. 2018 Mar 10. PMID: 29524273.
      View in: PubMed
    15. Garcia SM, Tamaki S, Lee S, Wong A, Jose A, Dreux J, Kouklis G, Sbitany H, Seth R, Knott PD, Heaton C, Ryan WR, Kim EA, Hansen SL, Hoffman WY, Pomerantz JH. High-Yield Purification, Preservation, and Serial Transplantation of Human Satellite Cells. Stem Cell Reports. 2018 Mar 13; 10(3):1160-1174. PMID: 29478895.
      View in: PubMed
    16. Alonso JE, Han AY, Kuan EC, Strohl M, Clair JM, St John MA, Ryan WR, Heaton CM. The survival impact of surgical therapy in squamous cell carcinoma of the hard palate. Laryngoscope. 2018 Feb 05. PMID: 29399797.
      View in: PubMed
    17. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 Jan 15. PMID: 29335337.
      View in: PubMed
    18. Zhou MJ, van Zante A, Lazar AA, Groppo ER, Garsa AA, Ryan WR, El-Sayed IH, Eisele DW, Yom SS. Squamous cell carcinoma of unknown primary of the head and neck: Favorable prognostic factors comparable to those in oropharyngeal cancer. Head Neck. 2017 Dec 06. PMID: 29210145.
      View in: PubMed
    19. Tamplen ML, Tamplen J, Shuman E, Heaton CM, George JR, Wang SJ, Ryan WR. Comparison of Output Volume Thresholds for Drain Removal After Selective Lateral Neck Dissection: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2017 Dec 01; 143(12):1195-1199. PMID: 28837725.
      View in: PubMed
    20. Strohl MP, Dewyer NA, Sckolnick J, Ryan WR. A Novel Approach to Oropharyngeal Foreign Body Removal. Otolaryngol Head Neck Surg. 2018 Jan; 158(1):194-196. PMID: 29039243.
      View in: PubMed
    21. Larson AR, Aubin-Pouliot A, Delagnes E, Zheng M, Chang JL, Ryan WR. Surgeon-Performed Ultrasound for Chronic Obstructive Sialadenitis Helps Predict Sialendoscopic Findings and Outcomes. Otolaryngol Head Neck Surg. 2017 Dec; 157(6):973-980. PMID: 28871894.
      View in: PubMed
    22. Puskas JD, Bavaria JE, Svensson LG, Blackstone EH, Griffith B, Gammie JS, Heimansohn DA, Sadowski J, Bartus K, Johnston DR, Rozanski J, Rosengart T, Girardi LN, Klodell CT, Mumtaz MA, Takayama H, Halkos M, Starnes V, Boateng P, Timek TA, Ryan W, Omer S, Smith CR. The COMMENCE trial: 2-year outcomes with an aortic bioprosthesis with RESILIA tissue. Eur J Cardiothorac Surg. 2017 Sep 01; 52(3):432-439. PMID: 28605428.
      View in: PubMed
    23. Delagnes EA, Zheng M, Aubin-Pouliot A, Chang JL, Ryan WR. Salivary duct stenosis: Short-term symptom outcomes after sialendoscopy-assisted salivary duct surgery. Laryngoscope. 2017 Dec; 127(12):2770-2776. PMID: 28714528.
      View in: PubMed
    24. Naunheim M, Wu X, Ryan WR, Wang SJ, Heaton CM. Volumetric Growth Rate of Recurrent Pleomorphic Adenoma. Ann Otol Rhinol Laryngol. 2017 Jul; 126(7):544-547. PMID: 28604082.
      View in: PubMed
    25. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 Jun 14; 7(1):3484. PMID: 28615711.
      View in: PubMed
    26. Markey JD, Morrel WG, Wang SJ, Ryan WR. The effect of submandibular gland preservation during level 1B neck dissection on postoperative xerostomia. Auris Nasus Larynx. 2018 Feb; 45(1):123-127. PMID: 28449980.
      View in: PubMed
    27. Ghosh P, Lazar AA, Ryan WR, Yom SS. A feasibility and efficacy trial of a hand-held humidification device in patients undergoing radiotherapy for head and neck cancer. Support Care Cancer. 2017 08; 25(8):2611-2618. PMID: 28353039.
      View in: PubMed
    28. Fakhry C, Westra WH, Wang SJ, van Zante A, Zhang Y, Rettig E, Yin LX, Ryan WR, Ha PK, Wentz A, Koch W, Richmon JD, Eisele DW, D'Souza G. The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer. Cancer. 2017 05 01; 123(9):1566-1575. PMID: 28241096.
      View in: PubMed
    29. Tamplen ML, Tamplen J, Torrecillas V, Seth R, Ricceri S, Hemmat S, Heaton C, Ryan WR, Knott PD. Does a Standalone Cancer Center Improve Head and Neck Microsurgical Outcomes? J Reconstr Microsurg. 2017 May; 33(4):252-256. PMID: 28061519.
      View in: PubMed
    30. Heaton CM, Ahmed SR, Ryan WR. Transoral robotic surgery (TORS) for excision of a retropharyngeal intramuscular lipoma. Auris Nasus Larynx. 2017 Dec; 44(6):742-744. PMID: 27956103.
      View in: PubMed
    31. D'Souza G, Westra WH, Wang SJ, van Zante A, Wentz A, Kluz N, Rettig E, Ryan WR, Ha PK, Kang H, Bishop J, Quon H, Kiess AP, Richmon JD, Eisele DW, Fakhry C. Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method. JAMA Oncol. 2016 Dec 08. PMID: 27930766.
      View in: PubMed
    32. Jáuregui E, Kiringoda R, Ryan WR, Eisele DW, Chang JL. Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. Laryngoscope. 2017 Jul; 127(7):1565-1570. PMID: 27861944.
      View in: PubMed
    33. Yu Y, Mabray M, Silveira W, Shen PY, Ryan WR, Uzelac A, Yom SS. Earlier and more specific detection of persistent neck disease with diffusion-weighted MRI versus subsequent PET/CT after definitive chemoradiation for oropharyngeal squamous cell carcinoma. Head Neck. 2017 Mar; 39(3):432-438. PMID: 27726241.
      View in: PubMed
    34. Delagnes EA, Aubin-Pouliot A, Zheng M, Chang JL, Ryan WR. Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. Laryngoscope. 2017 May; 127(5):1073-1079. PMID: 27701754.
      View in: PubMed
    35. Alemi AS, Heaton CM, Ryan WR, El-Sayed I, Wang SJ. Volumetric Growth of Cervical Schwannoma as a Predictor of Surgical Intervention. Otolaryngol Head Neck Surg. 2017 Jan; 156(1):152-155. PMID: 27625027.
      View in: PubMed
    36. Hemmat SM, Wang SJ, Ryan WR. Neck Dissection Technique Commonality and Variance: A Survey on Neck Dissection Technique Preferences among Head and Neck Oncologic Surgeons in the American Head and Neck Society. Int Arch Otorhinolaryngol. 2017 Jan; 21(1):8-16. PMID: 28050201.
      View in: PubMed
    37. Heaton CM, Yu K, Calkins S, George JR, Ryan WR, Wang SJ. Clinicopathologic characteristics and outcomes of recurrent oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 2016 Nov - Dec; 37(6):513-516. PMID: 27522438.
      View in: PubMed
    38. Hemmat S, Wang SJ, Ryan WR. How, when, and from whom neck dissection operative technique is learned: An international survey on neck dissection education among head and neck oncologic surgeons. Am J Otolaryngol. 2016 Sep-Oct; 37(5):431-5. PMID: 27221027.
      View in: PubMed
    39. Tamplen ML, Ricceri S, Hemmat S, Seth R, Ryan WR, Knott PD. Benefits of Immediate Extubation Following Free Tissue Transfer for Head and Neck Reconstruction. J Reconstr Microsurg. 2016 Sep; 32(7):533-9. PMID: 27110906.
      View in: PubMed
    40. Singer L, Calkins SM, Horvai AE, Ryan WR, Yom SS. Xanthogranuloma in the heavily irradiated low neck in a patient with head and neck cancer. J Otolaryngol Head Neck Surg. 2016 Mar 24; 45:20. PMID: 27009318; PMCID: PMC4806421.
    41. Aubin-Pouliot A, Delagnes EA, Chang JL, Ryan WR. Sialendoscopy-assisted surgery and the chronic obstructive sialadenitis symptoms questionnaire: A prospective study. Laryngoscope. 2016 06; 126(6):1343-8. PMID: 26972293.
      View in: PubMed
    42. Markey JD, Seth R, Wang SJ, Ryan WR, El-Sayed IH, Knott PD. Anterolateral Thigh Adipofascial Flap: A New Option for Scalp Reconstruction. J Reconstr Microsurg. 2016 Feb; 32(2):160-3. PMID: 26340759.
      View in: PubMed
    43. Aubin-Pouliot A, Delagnes EA, Eisele DW, Chang JL, Ryan WR. The Chronic Obstructive Sialadenitis Symptoms Questionnaire to assess sialendoscopy-assisted surgery. Laryngoscope. 2016 Jan; 126(1):93-9. PMID: 26256263.
      View in: PubMed
    44. Hemmat SM, Wang SJ, Uzelac A, Yom SS, Ryan WR. The Limitations of Routine Magnetic Resonance Imaging for Long-Term Post-Treatment Locoregional Surveillance of Salivary Carcinoma. ORL J Otorhinolaryngol Relat Spec. 2015; 77(3):132-40. PMID: 26022374.
      View in: PubMed
    45. Goepfert RP, Liu C, Ryan WR. Trans-oral robotic surgery and surgeon-performed trans-oral ultrasound for intraoperative location and excision of an isolated retropharyngeal lymph node metastasis of papillary thyroid carcinoma. Am J Otolaryngol. 2015 Sep-Oct; 36(5):710-4. PMID: 25964171.
      View in: PubMed
    46. Al-Shwaiheen FA, Wang SJ, Uzelac A, Yom SS, Ryan WR. The advantages and drawbacks of routine magnetic resonance imaging for long-term post-treatment locoregional surveillance of oral cavity squamous cell carcinoma. Am J Otolaryngol. 2015 May-Jun; 36(3):415-23. PMID: 25697087.
      View in: PubMed
    47. Goepfert RP, Yom SS, Ryan WR, Cheung SW. Development of a chemoradiation therapy toxicity staging system for oropharyngeal carcinoma. Laryngoscope. 2015 Apr; 125(4):869-76. PMID: 25388529.
      View in: PubMed
    48. Brinkman W, Herbert MA, O'Brien S, Filardo G, Prince S, Dewey T, Magee M, Ryan W, Mack M. Preoperative ß-blocker use in coronary artery bypass grafting surgery: national database analysis. JAMA Intern Med. 2014 Aug; 174(8):1320-7. PMID: 24934977.
      View in: PubMed
    49. Prendes BL, Aubin-Pouliot A, Egbert N, Ryan WR. Elective lymphadenectomy during salvage for locally recurrent head and neck squamous cell carcinoma after radiation. Otolaryngol Head Neck Surg. 2014 Sep; 151(3):462-7. PMID: 24894423.
      View in: PubMed
    50. Ryan WR, Chang JL, Eisele DW. Surgeon-performed ultrasound and transfacial sialoendoscopy for complete parotid duct stenosis. Laryngoscope. 2014 Feb; 124(2):418-20. PMID: 24130099.
      View in: PubMed
    51. Ryan WR, Orloff LA. Intraoperative tumor localization with surgeon-performed ultrasound-guided needle dye injection. Laryngoscope. 2011 Aug; 121(8):1651-5. PMID: 21660975.
      View in: PubMed
    52. Ryan WR, Ramachandra T, Hwang PH. Correlations between symptoms, nasal endoscopy, and in-office computed tomography in post-surgical chronic rhinosinusitis patients. Laryngoscope. 2011 Mar; 121(3):674-8. PMID: 21305550.
      View in: PubMed
    53. Ryan WR, Hwang PH. Safety of a preservative-free acidified saline nasal spray: a randomized, double-blind, placebo-controlled, crossover clinical trial. Arch Otolaryngol Head Neck Surg. 2010 Nov; 136(11):1099-103. PMID: 21079163.
      View in: PubMed
    54. Ryan WR, Most SP. A prospective evaluation of the efficacy of topical adhesive pads for the reduction of facial rhytids. Arch Facial Plast Surg. 2009 Jul-Aug; 11(4):252-6. PMID: 19620531.
      View in: PubMed
    55. Ryan WR, Fee WE. Long-term great auricular nerve morbidity after sacrifice during parotidectomy. Laryngoscope. 2009 Jun; 119(6):1140-6. PMID: 19399835.
      View in: PubMed
    56. Ryan WR, Fee WE. Great auricular nerve morbidity after nerve sacrifice during parotidectomy. Arch Otolaryngol Head Neck Surg. 2006 Jun; 132(6):642-9. PMID: 16785410.
      View in: PubMed
    57. Ryan WR, Fee WE, Le QT, Pinto HA. Positron-emission tomography for surveillance of head and neck cancer. Laryngoscope. 2005 Apr; 115(4):645-50. PMID: 15805874.
      View in: PubMed
    58. Ryan WR, Allan RN, Yamamoto T, Keighley MR. Crohn's disease patients who quit smoking have a reduced risk of reoperation for recurrence. Am J Surg. 2004 Feb; 187(2):219-25. PMID: 14769308.
      View in: PubMed
    59. Ryan WR, Ley C, Allan RN, Keighley MR. Patients with Crohn's disease are unaware of the risks that smoking has on their disease. J Gastrointest Surg. 2003 Jul-Aug; 7(5):706-11. PMID: 12850686.
      View in: PubMed
    60. Fisher RL, Ryan WR, Dugdale TW, Zimmermann GA. Arthroscopic ankle fusion. Conn Med. 1997 Oct; 61(10):643-6. PMID: 9375450.
      View in: PubMed
    61. Gibson JG, Tullis JL, Tinch RJ, Ryan WR, DiForte S. The post-thaw viability of red blood cells of ACD and CPD blood preserved in the frozen state with and without added adenine. Transfusion. 1972 May-Jun; 12(3):198-207. PMID: 5026173.
      View in: PubMed
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