Mallar Bhattacharya, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
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    Collapse Education and Training
    Harvard UniversityB.A.
    Oxford UniversityM.Sc.
    Harvard UniversityM.D.
    Johns Hopkins HospitalResidencyInternal Medicine
    University of California, San FranciscoFellowshipPulmonary and Critical Care
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Dr. Bhattacharya is an attending ICU physician at UCSF Medical Center and directs a research laboratory at the Parnassus Heights campus. His lab focuses on lung injury and fibrosis, both major health problems for which effective therapies are limited, and is developing novel approaches to the study of cell-cell interactions in the lung--for example, between immune and structural cells. These interactions drive the development of scarring and progressive loss of lung function and therefore represent an opportunity for discovery of novel therapies.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting ATP Receptor P2RX4 for Pulmonary Fibrosis
    DOD W81XWH2110417Jul 1, 2021 - Jun 30, 2025
    Role: Principal Investigator
    The Regulation of RhoA Activation in Airway Smooth Muscle
    NIH R01HL131560May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    IQGAP1 In Vascular Barrier Regulation During Acute Lung Injury
    NIH K08HL114641Sep 1, 2012 - Jun 30, 2018
    Role: Principal Investigator
    Regulation of Endothelial Permeability by Integrin alpha-v beta-3
    NIH F32HL099026Jan 1, 2011 - Dec 31, 2011
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis. J Pathol. 2024 05; 263(1):22-31. Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD. PMID: 38332723; PMCID: PMC10987276.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Hard CiDRE revs up macrophage infectivity in COVID-19. Immunity. 2023 08 08; 56(8):1706-1708. Bhattacharya M. PMID: 37557078.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Immunology of human fibrosis. Nat Immunol. 2023 09; 24(9):1423-1433. Bhattacharya M, Ramachandran P. PMID: 37474654.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19. Am J Respir Cell Mol Biol. 2022 Nov; 67(5):520-527. Bhattacharya M. PMID: 35675555; PMCID: PMC9651197.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. PMID: 35634278; PMCID: PMC9134074.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. IL10 trains macrophage profibrotic function after lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 03 01; 322(3):L495-L502. Bhattacharyya A, Boostanpour K, Bouzidi M, Magee L, Chen TY, Wolters R, Torre P, Pillai SK, Bhattacharya M. PMID: 35107021; PMCID: PMC8917922.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    7. Molecular programs of fibrotic change in aging human lung. Nat Commun. 2021 11 02; 12(1):6309. Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, Bhattacharya M. PMID: 34728633; PMCID: PMC8563941.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    8. Invariant Natural Killer T cells coordinate removal of senescent cells. Med (N Y). 2021 08 13; 2(8):938-950. Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A. PMID: 34617070; PMCID: PMC8491998.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    9. Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages. Cell Rep. 2020 06 30; 31(13):107825. Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M. PMID: 32610126; PMCID: PMC8944937.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Fibroblast Gap-closure Assay-Microscopy-based in vitro Assay Measuring the Migration of Murine Fibroblasts. Bio Protoc. 2019 Aug 20; 9(16). Looney AP, Bhattacharya M. PMID: 31531389; PMCID: PMC6748635.
      View in: PubMed   Mentions: 1  
    11. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019 02; 20(2):163-172. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M. PMID: 30643263; PMCID: PMC6340744.
      View in: PubMed   Mentions: 1328     Fields:    Translation:HumansAnimalsCells
    12. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 11 02; 3(21). Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. PMID: 30385725; PMCID: PMC6238747.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. Could a coffee a day keep the inflammasome away? Sci Transl Med. 2017 02 08; 9(376). Bhattacharya M. PMID: 28179502.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Mesenchymal metamorphosis. Sci Transl Med. 2016 12 21; 8(370):370ec202. Bhattacharya M. PMID: 28003541.
      View in: PubMed   Mentions: 1     Fields:    
    15. Macrophages build a wall and the host pays for it. Science Translational Medicine. 2016 Nov 9; 8(364). Bhattacharya BM. .
      View in: Publisher Site   Mentions:
    16. Stiff discipline for cells in pulmonary hypertension. Science Translational Medicine. 2016 Sep 28; 8(358):358ec154-358ec154. Bhattacharya BM. .
      View in: Publisher Site   Mentions:
    17. Airway architect Adam33 in asthma. Science Translational Medicine. 2016 Aug 17; 8(352):352ec130-352ec130. Bhattacharya BM. .
      View in: Publisher Site   Mentions:
    18. The gut takes a “Toll” on the lung. Science Translational Medicine. 2016 Jul 6; 8(346):346ec106-346ec106. Bhattacharya BM. .
      View in: Publisher Site   Mentions:
    19. Unwanted guests: Bacterial microbiome in COPD. Science Translational Medicine. 2016 May 25; 8(340):340ec82-340ec82. Bhattacharya BM. .
      View in: Publisher Site   Mentions:
    20. H5N1 stems the alveolar tide: MSCs to the rescue!. Science Translational Medicine. 2016 Apr 13; 8(334):334ec59-334ec59. Bhattacharya BM. .
      View in: Publisher Site   Mentions:
    21. Negative-Pressure Pulmonary Edema. Chest. 2016 Oct; 150(4):927-933. Bhattacharya M, Kallet RH, Ware LB, Matthay MA. PMID: 27063348.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    22. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. PMID: 25271629; PMCID: PMC4347230.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5. Crit Care Med. 2013 Feb; 41(2):546-53. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. PMID: 23263571.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    24. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. PMID: 22561460; PMCID: PMC3426434.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    25. Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):58-66. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. PMID: 21980034; PMCID: PMC3262039.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    26. CHAPTER 188 Acute Respiratory Distress Syndrome and the Kidney: Lung and Kidney Crosstalk. . 2009 Jan 1; 1019-1023. Bhattacharya BM, Matthay MM, Rabb RH. .
      View in: Publisher Site   Mentions:
    27. Case 81. Radiology. 2004 Dec 1; 233(3):695-696. Bhattacharya BM, Yeh YB, Qayyum QA, Coakley CF. .
      View in: Publisher Site   Mentions:
    28. Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. J Cell Sci. 2004 Sep 01; 117(Pt 19):4481-94. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG. PMID: 15316072.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
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