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    Anthony Portale, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address550 16th. Street
    San Francisco CA 94158
    Phone415-476-1065
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      University of California, San FranciscoResidency School of Medicine

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Portale AA, Wolf MS, Messinger S, Perwad F, Jüppner H, Warady BA, Furth SL, Salusky IB. Fibroblast Growth Factor 23 and Risk of CKD Progression in Children. Clin J Am Soc Nephrol. 2016 Nov 7; 11(11):1989-1998. PMID: 27561289.
        View in: PubMed
      2. McEnhill ME, Brennan JL, Winnicki E, Lee MM, Tavakol M, Posselt AM, Stock PG, Portale AA. Effect of Immigration Status on Outcomes in Pediatric Kidney Transplant Recipients. Am J Transplant. 2016 Jun; 16(6):1827-33. PMID: 26699829.
        View in: PubMed
      3. Portale AA, Zhang MY, David V, Martin A, Jiao Y, Gu W, Perwad F. Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule. PLoS One. 2015; 10(11):e0142924. PMID: 26588476; PMCID: PMC4654537.
      4. Kumar J, McDermott K, Abraham AG, Friedman LA, Johnson VL, Kaskel FJ, Furth SL, Warady BA, Portale AA, Melamed ML. Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. Pediatr Nephrol. 2016 Jan; 31(1):121-9. PMID: 26307635.
        View in: PubMed
      5. Zhang X, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey J, Glorieux FH, Portale AA, Insogna K, Carpenter TO, Peacock M. Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia. J Clin Pharmacol. 2016 Feb; 56(2):176-85. PMID: 26073451.
        View in: PubMed
      6. Denburg MR, Kumar J, Jemielita T, Brooks ER, Skversky A, Portale AA, Salusky IB, Warady BA, Furth SL, Leonard MB. Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study. J Am Soc Nephrol. 2016 Feb; 27(2):543-50. PMID: 26139439.
        View in: PubMed
      7. Ku E, Glidden DV, Hsu CY, Portale AA, Grimes B, Johansen KL. Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD. J Am Soc Nephrol. 2016 Feb; 27(2):551-8. PMID: 26054540.
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      8. Ku E, Johansen KL, Portale AA, Grimes B, Hsu CY. State level variations in nephrology workforce and timing and incidence of dialysis in the United States among children and adults: a retrospective cohort study. BMC Nephrol. 2015; 16:2. PMID: 25589150; PMCID: PMC4361136.
      9. Wassner SJ, Chesney RW, Friedman A, Chantler C, Portale AA. Malcolm A. Holliday, M.D, January 12, 1924 - March 26, 2014. Pediatr Nephrol. 2014 Aug; 29(8):1473-4. PMID: 24817341.
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      10. Akber A, Portale AA, Johansen KL. Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease. Pediatr Nephrol. 2014 Aug; 29(8):1395-402. PMID: 24648129; PMCID: PMC4074553.
      11. Portale AA, Wolf M, Jüppner H, Messinger S, Kumar J, Wesseling-Perry K, Schwartz GJ, Furth SL, Warady BA, Salusky IB. Disordered FGF23 and mineral metabolism in children with CKD. Clin J Am Soc Nephrol. 2014 Feb; 9(2):344-53. PMID: 24311704; PMCID: PMC3913243.
      12. Chanakul A, Zhang MY, Louw A, Armbrecht HJ, Miller WL, Portale AA, Perwad F. FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. PLoS One. 2013; 8(9):e72816. PMID: 24019880; PMCID: PMC3760837.
      13. Benedict KA, Moassesfar S, Adi S, Gitelman SE, Brennan JL, McEnhill M, Stock PG, Portale AA, Posselt AM. Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease. Am J Transplant. 2013 Aug; 13(8):2207-10. PMID: 23763601; PMCID: PMC4063279.
      14. Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale AA, Shoback D, Schambelan M. Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone. J Bone Miner Res. 2013 Mar; 28(3):700-8. PMID: 23074096.
        View in: PubMed
      15. Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel TK, Hsieh SC, Dai H, Naesens M, Waskerwitz J, Salvatierra O, Terasaki PI, Sarwal MM. The clinical impact of humoral immunity in pediatric renal transplantation. J Am Soc Nephrol. 2013 Mar; 24(4):655-64. PMID: 23449533; PMCID: PMC3609135.
      16. Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Davis R, Butte AJ, Salvatierra O, Sarwal MM. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant. 2012 Oct; 12(10):2710-8. PMID: 23009139; PMCID: PMC4148014.
      17. Sarwal MM, Ettenger RB, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Tang L, Liu J, Li L, Naesens M, Sigdel T, Waskerwitz J, Salvatierra O. Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up. Am J Transplant. 2012 Oct; 12(10):2719-29. PMID: 22694755; PMCID: PMC3681527.
      18. Akber A, Portale AA, Johansen KL. Pedometer-assessed physical activity in children and young adults with CKD. Clin J Am Soc Nephrol. 2012 May; 7(5):720-6. PMID: 22422539; PMCID: PMC3338276.
      19. Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale AA, Perwad F. Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology. 2012 Apr; 153(4):1806-16. PMID: 22334725; PMCID: PMC3320256.
      20. Perwad F, Portale AA. Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23. Mol Cell Endocrinol. 2011 Dec 5; 347(1-2):17-24. PMID: 21914460.
        View in: PubMed
      21. Ranch D, Zhang MY, Portale AA, Perwad F. Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice. J Bone Miner Res. 2011 Aug; 26(8):1883-90. PMID: 21472778; PMCID: PMC4409871.
      22. McKay CP, Portale A. Emerging topics in pediatric bone and mineral disorders 2008. Semin Nephrol. 2009 Jul; 29(4):370-8. PMID: 19615558.
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      23. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008 Jan; 121(1):37-45. PMID: 18166555; PMCID: PMC3722048.
      24. Perwad F, Zhang MY, Tenenhouse HS, Portale AA. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1577-83. PMID: 17699549.
        View in: PubMed
      25. Kim CJ, Kaplan LE, Perwad F, Huang N, Sharma A, Choi Y, Miller WL, Portale AA. Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency. J Clin Endocrinol Metab. 2007 Aug; 92(8):3177-82. PMID: 17488797.
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      26. Antoniucci DM, Yamashita T, Portale AA. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab. 2006 Aug; 91(8):3144-9. PMID: 16735491.
        View in: PubMed
      27. Matsuda-Abedini M, Portale AA, Shah A, Neuhaus J, McEnhill M, Mathias RS. Persistent secondary hyperparathyroidism after renal transplantation in children. Pediatr Nephrol. 2006 Mar; 21(3):413-8. PMID: 16385389.
        View in: PubMed
      28. Perwad F, Azam N, Zhang MY, Yamashita T, Tenenhouse HS, Portale AA. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology. 2005 Dec; 146(12):5358-64. PMID: 16123154.
        View in: PubMed
      29. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 5; 352(18):1884-90. PMID: 15872203.
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      30. Azam N, Zhang MY, Wang X, Tenenhouse HS, Portale AA. Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice. Endocrinology. 2003 Aug; 144(8):3463-8. PMID: 12865326.
        View in: PubMed
      31. Miller WL, Portale AA. Vitamin D biosynthesis and vitamin D 1 alpha-hydroxylase deficiency. Endocr Dev. 2003; 6:156-74. PMID: 12964431.
        View in: PubMed
      32. Wang X, Zhang MY, Miller WL, Portale AA. Novel gene mutations in patients with 1alpha-hydroxylase deficiency that confer partial enzyme activity in vitro. J Clin Endocrinol Metab. 2002 Jun; 87(6):2424-30. PMID: 12050193.
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      33. Xie Z, Munson SJ, Huang N, Portale AA, Miller WL, Bikle DD. The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem. 2002 Oct 4; 277(40):36987-90. PMID: 11956203.
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      34. Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA. Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule. Endocrinology. 2002 Feb; 143(2):587-95. PMID: 11796514.
        View in: PubMed
      35. Miller WL, Portale AA. Genetics of vitamin D biosynthesis and its disorders. Best Pract Res Clin Endocrinol Metab. 2001 Mar; 15(1):95-109. PMID: 11469813.
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      36. Tenenhouse HS, Martel J, Gauthier C, Zhang MY, Portale AA. Renal expression of the sodium/phosphate cotransporter gene, Npt2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. Endocrinology. 2001 Mar; 142(3):1124-9. PMID: 11181527.
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      37. Miller WL, Portale AA. Vitamin D 1 alpha-hydroxylase. Trends Endocrinol Metab. 2000 Oct; 11(8):315-9. PMID: 10996526.
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      38. Portale AA, Miller WL. Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression. Pediatr Nephrol. 2000 Jul; 14(7):620-5. PMID: 10912530.
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      39. Goodman WG, Misra S, Veldhuis JD, Portale AA, Wang HJ, Ament ME, Salusky IB. Altered diurnal regulation of blood ionized calcium and serum parathyroid hormone concentrations during parenteral nutrition. Am J Clin Nutr. 2000 Feb; 71(2):560-8. PMID: 10648272.
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      40. Miller WL, Portale AA. Genetic disorders of vitamin D biosynthesis. Endocrinol Metab Clin North Am. 1999 Dec; 28(4):825-40, x. PMID: 10609122.
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      41. Miller WL, Portale AA. Genetic causes of rickets. Curr Opin Pediatr. 1999 Aug; 11(4):333-9. PMID: 10439207.
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      42. Hoppe B, Kemper MJ, Bökenkamp A, Portale AA, Cohn RA, Langman CB. Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure. Kidney Int. 1999 Jul; 56(1):268-74. PMID: 10411702.
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      43. Wang JT, Lin CJ, Burridge SM, Fu GK, Labuda M, Portale AA, Miller WL. Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families. Am J Hum Genet. 1998 Dec; 63(6):1694-702. PMID: 9837822; PMCID: PMC1377641.
      44. Portale AA, Miller WL. Hereditary rickets revealed. Kidney Int. 1998 Nov; 54(5):1762-4. PMID: 9844157.
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      45. Mathias RS, Nguyen HT, Zhang MY, Portale AA. Reduced expression of the renal calcium-sensing receptor in rats with experimental chronic renal insufficiency. J Am Soc Nephrol. 1998 Nov; 9(11):2067-74. PMID: 9808092.
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      46. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec; 11(13):1961-70. PMID: 9415400.
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      47. Fu GK, Portale AA, Miller WL. Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha. DNA Cell Biol. 1997 Dec; 16(12):1499-507. PMID: 9428799.
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      48. Portale AA, Lonergan ET, Tanney DM, Halloran BP. Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men. Am J Physiol. 1997 Jan; 272(1 Pt 1):E139-46. PMID: 9038863.
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      49. Halloran BP, Lonergan ET, Portale AA. Aging and renal responsiveness to parathyroid hormone in healthy men. J Clin Endocrinol Metab. 1996 Jun; 81(6):2192-7. PMID: 8964850.
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      50. Portale AA, Halloran BP, Morris RC, Lonergan ET. Effect of aging on the metabolism of phosphorus and 1,25-dihydroxyvitamin D in healthy men. Am J Physiol. 1996 Mar; 270(3 Pt 1):E483-90. PMID: 8638697.
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      51. Quan A, Portale A, Foster S, Lavine J. Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation. Pediatr Nephrol. 1995 Oct; 9(5):599-602. PMID: 8580018.
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      52. Sorof JM, Koerper MA, Portale AA, Potter D, DeSantes K, Cowan M. Renal transplantation without chronic immunosuppression after T cell-depleted, HLA-mismatched bone marrow transplantation. Transplantation. 1995 Jun 15; 59(11):1633-5. PMID: 7778182.
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      53. Sorof JM, Weidner N, Potter D, Portale AA. Acute post-streptococcal glomerulonephritis in a renal allograft. Pediatr Nephrol. 1995 Jun; 9(3):317-9. PMID: 7632522.
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      54. Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. Am J Physiol. 1992 Dec; 263(6 Pt 1):E1164-70. PMID: 1476189.
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      55. Bikle DD, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992 Aug; 75(2):519-23. PMID: 1639954.
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      56. Jacobson MA, Gambertoglio JG, Aweeka FT, Causey DM, Portale AA. Foscarnet-induced hypocalcemia and effects of foscarnet on calcium metabolism. J Clin Endocrinol Metab. 1991 May; 72(5):1130-5. PMID: 1827127.
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      57. Potter DE, Portale AA, Melzer JS, Feduska NJ, Garovoy MR, Husing RM, Salvatierra O. Are blood transfusions beneficial in the cyclosporine era? Pediatr Nephrol. 1991 Jan; 5(1):168-72. PMID: 2025530.
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      58. Portale AA, Morris RC. Pathogenesis of secondary hyperparathyroidism in chronic renal insufficiency. Miner Electrolyte Metab. 1991; 17(4):211-20. PMID: 1813783.
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      59. Sebastian A, Hernandez RE, Portale AA, Colman J, Tatsuno J, Morris RC. Dietary potassium influences kidney maintenance of serum phosphorus concentration. Kidney Int. 1990 May; 37(5):1341-9. PMID: 2345430.
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      60. Halloran BP, Portale AA, Lonergan ET, Morris RC. Production and metabolic clearance of 1,25-dihydroxyvitamin D in men: effect of advancing age. J Clin Endocrinol Metab. 1990 Feb; 70(2):318-23. PMID: 2298850.
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      61. Portale AA, Halloran BP, Morris RC. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest. 1989 May; 83(5):1494-9. PMID: 2708521; PMCID: PMC303852.
      62. Farine D, Jackson U, Portale A, Baxi L, Fox HE. Pregnancy complicated by maternal spina bifida. A report of two cases. J Reprod Med. 1988 Mar; 33(3):323-6. PMID: 3283355.
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      63. Portale AA, Halloran BP, Morris RC. Dietary intake of phosphorus modulates the circadian rhythm in serum concentration of phosphorus. Implications for the renal production of 1,25-dihydroxyvitamin D. J Clin Invest. 1987 Oct; 80(4):1147-54. PMID: 3654974; PMCID: PMC442358.
      64. Kurtz TW, Portale AA, Morris RC. Evidence for a difference in vitamin D metabolism between spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 1986 Nov; 8(11):1015-20. PMID: 3770864.
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      65. Potter DE, San Luis E, Wipfler JE, Portale AA. Comparison of continuous ambulatory peritoneal dialysis and hemodialysis in children. Kidney Int Suppl. 1986 Jul; 19:S11-4. PMID: 3462423.
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      66. Kurtz TW, Kabra PM, Booth BE, Al-Bander HA, Portale AA, Serena BG, Tsai HC, Morris RC. Liquid-chromatographic measurements of inosine, hypoxanthine, and xanthine in studies of fructose-induced degradation of adenine nucleotides in humans and rats. Clin Chem. 1986 May; 32(5):782-6. PMID: 3698269.
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      67. Chesney RW, Mehls O, Anast CS, Brown E, Hammerman MR, Portale A, Fallon MD, Mahan J, Alfrey AC. Renal osteodystrophy in children: the role of vitamin D, phosphorus, and parathyroid hormone. Am J Kidney Dis. 1986 Apr; 7(4):275-84. PMID: 3515907.
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      68. Portale AA, Halloran BP, Murphy MM, Morris RC. Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans. J Clin Invest. 1986 Jan; 77(1):7-12. PMID: 3753709; PMCID: PMC423300.
      69. Halloran BP, Portale AA, Castro M, Morris RC, Goldsmith RS. Serum concentration of 1,25-dihydroxyvitamin D in the human: diurnal variation. J Clin Endocrinol Metab. 1985 Jun; 60(6):1104-10. PMID: 3998063.
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      70. Portale AA, Booth BE, Halloran BP, Morris RC. Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest. 1984 Jun; 73(6):1580-9. PMID: 6547151; PMCID: PMC437069.
      71. Powell D, Pond SM, Allen TB, Portale AA. Hemoperfusion in a child who ingested diquat and died from pontine infarction and hemorrhage. J Toxicol Clin Toxicol. 1983 Jul; 20(5):405-20. PMID: 6668627.
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      72. Portale AA, Booth BE, Tsai HC, Morris RC. Reduced plasma concentration of 1,25-dihydroxyvitamin D in children with moderate renal insufficiency. Kidney Int. 1982 Apr; 21(4):627-32. PMID: 6896541.
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      73. Galvagna S, Rosella PP, Portale A. [Clinical study of the effects of metisoprinol in the treatment of mumps in adults]. Clin Ter. 1980 Dec 31; 95(6):681-5. PMID: 6163586.
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      74. Holliday MA, McHenry-Richardson K, Portale A. Nutritional management of chronic renal disease. Med Clin North Am. 1979 Sep; 63(5):945-62. PMID: 388114.
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