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    Clay Gustafson, MD, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address1450 3rd Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Rice University, Houston, TexasBABiochemistry/English Literature1996
      University of Texas Medical BranchMD, PhDMedicine/Biochemistry and Genetics2005
      University of Texas SouthwesternPediatrics ResidencyPediatrics2008
      University of California San FranciscoHematology/Oncology FellowshipPediatric Hematology/Oncology2012
      Collapse Awards and Honors
      Alex's Lemonade Stand2012 - 2014ALSF "A" Award

      Collapse Overview 
      Collapse Interests
      Novel Therapeutics for Childhood Cancer, Neuroblastoma, I131-MIBG, Pediatric Solid Tumors, MYC and MYCN signaling in cancer

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Clinical Trials
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016 Feb; 25(2):308-15. PMID: 26549191.
        View in: PubMed
      2. Lee JS, Wu R, Wong T, DuBois SG, Matthay K, Gustafson C, Hawkins R, Roy-Burman A. Extended Sedation With Continuous Midazolam or Dexmedetomidine Infusion for Young Children Receiving (131) I-MIBG Radiopharmaceutical Therapy for Advanced Neuroblastoma. Pediatr Blood Cancer. 2016 Mar; 63(3):471-8. PMID: 26585842.
        View in: PubMed
      3. Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Front Oncol. 2015; 5:111. PMID: 26029667; PMCID: PMC4429235.
      4. Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA. The genetics of splicing in neuroblastoma. Cancer Discov. 2015 Apr; 5(4):380-95. PMID: 25637275; PMCID: PMC4390477.
      5. Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 2014 Nov 6; 9(3):1034-46. PMID: 25437558; PMCID: PMC4251494.
      6. Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 8; 26(3):414-27. PMID: 25175806; PMCID: PMC4160413.
      7. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014; 5:3626. PMID: 24832154; PMCID: PMC4077998.
      8. Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS, Olshen AB, Cha S, Zhao Y, Moore RA, Mungall AJ, Jones SJ, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger MS, Chang SM, Taylor BS, Costello JF. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014 Jan 10; 343(6167):189-93. PMID: 24336570; PMCID: PMC3998672.
      9. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14; 24(4):438-49. PMID: 24135280; PMCID: PMC3819146.
      10. Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar; 3(3):308-23. PMID: 23430699; PMCID: PMC3672953.
      11. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42. PMID: 22382618; PMCID: PMC3369020.
      12. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7. PMID: 22802621; PMCID: PMC3411950.
      13. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 4; 4(115):115ra3. PMID: 22218692; PMCID: PMC3402217.
      14. Gustafson WC, Matthay KK. Progress towards personalized therapeutics: biologic- and risk-directed therapy for neuroblastoma. Expert Rev Neurother. 2011 Oct; 11(10):1411-23. PMID: 21955198.
        View in: PubMed
      15. Gustafson WC, Weiss WA. Addiction to B-MYB. Oncotarget. 2010 Aug; 1(4):235-6. PMID: 21304174; PMCID: PMC3248101.
      16. Gustafson WC, Weiss WA. Myc proteins as therapeutic targets. Oncogene. 2010 Mar 4; 29(9):1249-59. PMID: 20101214; PMCID: PMC2904682.
      17. Gustafson WC, De Berry BB, Evers BM, Chung DH. Role of gastrointestinal hormones in neuroblastoma. World J Surg. 2005 Mar; 29(3):281-6. PMID: 15706438.
        View in: PubMed
      18. Ray S, Lu Y, Kaufmann SH, Gustafson WC, Karp JE, Boldogh I, Fields AP, Brasier AR. Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J Biol Chem. 2004 Aug 20; 279(34):35604-15. PMID: 15155749.
        View in: PubMed
      19. Gustafson WC, Ray S, Jamieson L, Thompson EA, Brasier AR, Fields AP. Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. J Biol Chem. 2004 Mar 5; 279(10):9400-8. PMID: 14670960.
        View in: PubMed
      20. Chen L, Finnerty C, Gustafson WC, Bush CR, Chi P, Guo H, Luxon B, Fields AP, Thompson EA. Genomic analysis of glucocorticoid-regulated promoters in murine T-lymphoma cells. Recent Prog Horm Res. 2003; 58:155-74. PMID: 12795418.
        View in: PubMed
      21. Fields AP, Gustafson WC. Protein kinase C in disease: cancer. Methods Mol Biol. 2003; 233:519-37. PMID: 12840532.
        View in: PubMed
      22. Fields AP, Murray NR, Gustafson WC. Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models. Methods Mol Biol. 2003; 233:539-53. PMID: 12840533.
        View in: PubMed
      23. Stuart CA, Wen G, Gustafson WC, Thompson EA. Comparison of GLUT1, GLUT3, and GLUT4 mRNA and the subcellular distribution of their proteins in normal human muscle. Metabolism. 2000 Dec; 49(12):1604-9. PMID: 11145124.
        View in: PubMed
      24. Gustafson WC, Taylor CW, Valdez BC, Henning D, Phippard A, Ren Y, Busch H, Durban E. Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA. Biochem J. 1998 Apr 15; 331 ( Pt 2):387-93. PMID: 9531475; PMCID: PMC1219366.
      25. Ren Y, Busch R, Durban E, Taylor C, Gustafson WC, Valdez B, Li YP, Smetana K, Busch H. Overexpression of human nucleolar proteins in insect cells: characterization of nucleolar protein p120. Protein Expr Purif. 1996 Mar; 7(2):212-9. PMID: 8812864.
        View in: PubMed
      26. Durban E, Valdez BC, Gustafson WC, Taylor CW, Cardellini E, Busch H. Functional domains of nucleolar phosphoprotein p120. Physiol Chem Phys Med NMR. 1995; 27(4):303-11. PMID: 8768786.
        View in: PubMed
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