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Shinya Yamanaka, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnatomy
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2547
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    Collapse Awards and Honors
    2013Breakthrough Prize in Life Sciences
    2012Nobel Prize in Physiology or Medicine
    2012Millennium Technology Award
    2011Wolf Prize in Medicine
    2010March of Dimes Prize in Developmental Biology
    2010Kyoto Prize for Advanced Technology
    2009Lasker Basic Medical Research Award
    2008Shaw Prize in Life Science and Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Shinya Yamanaka is a Senior Investigator and the L.K. Whittier Foundation Investigator in Stem Cell Biology at the Gladstone Institute for Cardiovascular Disease (GICD). Dr. Yamanaka is also a Professor of Anatomy at the University of California, San Francisco, as well as the Director of the Center for iPS Cell Research and Application (CiRA) and a Principal Investigator at the Institute for Integrated Cell-Material Sciences, both at Kyoto University.

    Dr. Yamanaka’s research focuses on ways to generate cells resembling embryonic stem cells by reprogramming somatic, or skin, cells. He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells—they can become any type of cell in the body—and to identify the factors that induce reprogramming.

    Dr. Yamanaka’s discovery that adult somatic cells can be reprogrammed into pluripotent cells has had a profound effect on developmental and stem cell biology. By introducing the genes for four factors that turn genes on and off, he induced the skin cells of adult mice to become like embryonic stem cells, which he called induced pluripotent stem (iPS) cells. This iPS cell technology represents an entirely new platform for fundamental studies of developmental biology. Rather than using disease models made in yeast, flies, mice or other animals, iPS cells can be taken from patients with a specific disease. As a result, they contain a complete set of the genes that resulted in that disease—representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.

    In 1996, Dr. Yamanaka became an Assistant Professor at Osaka City University Medical School. In 1999, he was appointed Associate Professor at Nara Institute of Science and Technology, where he became a full professor in 2003. He took his current position as a professor at Kyoto University in 2004 and was appointed as a Senior Investigator at the Gladstone Institutes in 2007. Since 2008, he has directed CiRA.

    Dr. Yamanaka has received many awards and honors, including the Albert Lasker Basic Medical Research Award, the Wolf Prize in Medicine, the Millennium Technology Award, the Shaw Prize, the Kyoto Prize for Advanced Technology, the Gairdner International Award, the Robert Koch Award and the March of Dimes Prize.

    Dr. Yamanaka earned an MD from Kobe University in 1987 and a PhD from Osaka City University in 1993. From 1987 to 1989, he was a resident at the National Osaka Hospital. From 1993 to 1996, he was a postdoctoral fellow at GICD.


    Collapse Research 
    Collapse Research Activities and Funding
    Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas
    NIH/NHLBI U01HL100406Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI U01HL098179Sep 30, 2009 - Aug 31, 2015
    Role: Co-Principal Investigator
    Induced pluripotent stem cells in the understanding and treatment of heart diseas
    NIH/NHLBI R03HL096254Dec 1, 2008 - May 31, 2009
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yagi M, Yamanaka S, Yamada Y. Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency. Lab Invest. 2017 Sep 04. PMID: 28869587.
      View in: PubMed
    2. Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat Commun. 2017 Aug 30; 8(1):385. PMID: 28855509.
      View in: PubMed
    3. Kawamura M, Miyagawa S, Fukushima S, Saito A, Miki K, Funakoshi S, Yoshida Y, Yamanaka S, Shimizu T, Okano T, Daimon T, Toda K, Sawa Y. Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model. Sci Rep. 2017 Aug 18; 7(1):8824. PMID: 28821761.
      View in: PubMed
    4. Yoshida Y, Yamanaka S. Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications. Circ Res. 2017 Jun 09; 120(12):1958-1968. PMID: 28596174.
      View in: PubMed
    5. Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y, Terada M, Nomiya Y, Tanishima S, Nakamura M, Kamao H, Sugita S, Onishi A, Ito T, Fujita K, Kawamata S, Go MJ, Shinohara C, Hata KI, Sawada M, Yamamoto M, Ohta S, Ohara Y, Yoshida K, Kuwahara J, Kitano Y, Amano N, Umekage M, Kitaoka F, Tanaka A, Okada C, Takasu N, Ogawa S, Yamanaka S, Takahashi M. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017 03 16; 376(11):1038-1046. PMID: 28296613.
      View in: PubMed
    6. Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, Rand TA, Nakagawa M, Watanabe A, Yamanaka S. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2017 Jan 10; 114(2):340-345. PMID: 28003464.
      View in: PubMed
    7. Shi Y, Inoue H, Wu JC, Yamanaka S. Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov. 2017 02; 16(2):115-130. PMID: 27980341.
      View in: PubMed
    8. Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):13057-13062. PMID: 27794120.
      View in: PubMed
    9. Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Kawamura M, Ohno S, Itoh H, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T. Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. PLoS One. 2016; 11(10):e0164795. PMID: 27764147.
      View in: PubMed
    10. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 Nov 01; 113(44):12478-12483. PMID: 27738243.
      View in: PubMed
    11. Parr CJ, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, Takahashi J, Yamanaka S, Saito H. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells. Sci Rep. 2016 Sep 09; 6:32532. PMID: 27608814; PMCID: PMC5016789.
    12. Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, Yoshida Y. Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. Cell Stem Cell. 2016 Sep 01; 19(3):341-54. PMID: 27476965.
      View in: PubMed
    13. Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae S, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori Y, Koizumi A, Nakao K, Yamanaka S, Osafune K. Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models. Sci Rep. 2016 Jul 15; 6:30013. PMID: 27418197; PMCID: PMC4945931.
    14. Yamakawa T, Sato Y, Matsumura Y, Kobayashi Y, Kawamura Y, Goshima N, Yamanaka S, Okita K. Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency. Stem Cells. 2016 Nov; 34(11):2661-2669. PMID: 27335261.
      View in: PubMed
    15. Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y. Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins. Stem Cells Int. 2016; 2016:7235757. PMID: 27212953; PMCID: PMC4861799.
    16. Nakagawa M, Karagiannis P, Yamanaka S. When Myc's asleep, embryonic stem cells are dormant. EMBO J. 2016 Apr 15; 35(8):801-2. PMID: 26968984; PMCID: PMC4972139 [Available on 04/15/17].
    17. Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B. SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells. Elife. 2016 Mar 07; 5:e10647. PMID: 26949256; PMCID: PMC4841768.
    18. Takahashi K, Yamanaka S. A decade of transcription factor-mediated reprogramming to pluripotency. Nat Rev Mol Cell Biol. 2016 Mar; 17(3):183-93. PMID: 26883003.
      View in: PubMed
    19. Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y. Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes. Sci Rep. 2016 Jan 08; 6:19111. PMID: 26743035; PMCID: PMC4705488.
    20. Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA. Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells. Curr Protoc Hum Genet. 2016 Jan 01; 88:Unit 21.4. PMID: 26724721; PMCID: PMC4726454 [Available on 01/01/17].
    21. Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K. Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016; 1357:111-31. PMID: 26025620.
      View in: PubMed
    22. Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K. Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells. Curr Protoc Hum Genet. 2015 Oct 06; 87:21.2.1-21. PMID: 26439714.
      View in: PubMed
    23. Takahashi K, Yamanaka S. A developmental framework for induced pluripotency. Development. 2015 Oct 01; 142(19):3274-85. PMID: 26443632.
      View in: PubMed
    24. Hotta A, Yamanaka S. From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing. Annu Rev Genet. 2015; 49:47-70. PMID: 26407033.
      View in: PubMed
    25. Toyohara T, Mae S, Sueta S, Inoue T, Yamagishi Y, Kawamoto T, Kasahara T, Hoshina A, Toyoda T, Tanaka H, Araoka T, Sato-Otsubo A, Takahashi K, Sato Y, Yamaji N, Ogawa S, Yamanaka S, Osafune K. Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice. Stem Cells Transl Med. 2015 Sep; 4(9):980-92. PMID: 26198166; PMCID: PMC4542865.
    26. Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. 2015 Aug 06; 17(2):178-94. PMID: 26189426.
      View in: PubMed
    27. Miki K, Endo K, Takahashi S, Funakoshi S, Takei I, Katayama S, Toyoda T, Kotaka M, Takaki T, Umeda M, Okubo C, Nishikawa M, Oishi A, Narita M, Miyashita I, Asano K, Hayashi K, Osafune K, Yamanaka S, Saito H, Yoshida Y. Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches. Cell Stem Cell. 2015 Jun 04; 16(6):699-711. PMID: 26004781.
      View in: PubMed
    28. Sadahiro T, Yamanaka S, Ieda M. Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. Circ Res. 2015 Apr 10; 116(8):1378-91. PMID: 25858064.
      View in: PubMed
    29. Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4666-71. PMID: 25825768; PMCID: PMC4403148.
    30. Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K. KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14; 4(4):727-43. PMID: 25772473; PMCID: PMC4400650.
    31. Wilmut I, Leslie S, Martin NG, Peschanski M, Rao M, Trounson A, Turner D, Turner ML, Yamanaka S, Taylor CJ. Development of a global network of induced pluripotent stem cell haplobanks. Regen Med. 2015; 10(3):235-8. PMID: 25933231.
      View in: PubMed
    32. Tamaoki N, Takahashi K, Aoki H, Iida K, Kawaguchi T, Hatakeyama D, Inden M, Chosa N, Ishisaki A, Kunisada T, Shibata T, Goshima N, Yamanaka S, Tezuka K. The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells. Sci Rep. 2014 Dec 04; 4:7283. PMID: 25471527; PMCID: PMC4255186.
    33. Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A. Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Stem Cell Reports. 2015 Jan 13; 4(1):143-54. PMID: 25434822; PMCID: PMC4297888.
    34. Tokunaga K, Saitoh N, Goldberg IG, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M. Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci Rep. 2014 Nov 11; 4:6996. PMID: 25385348; PMCID: PMC4227026.
    35. Karagiannis P, Yamanaka S. The fate of cell reprogramming. Nat Methods. 2014 Oct; 11(10):1006-8. PMID: 25264776.
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    36. Ohnuki M, Tanabe K, Sutou K, Teramoto I, Sawamura Y, Narita M, Nakamura M, Tokunaga Y, Nakamura M, Watanabe A, Yamanaka S, Takahashi K. Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12426-31. PMID: 25097266; PMCID: PMC4151758.
    37. Andrews PW, Cavanagro J, Deans R, Feigel E, Horowitz E, Keating A, Rao M, Turner M, Wilmut I, Yamanaka S. Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells. Nat Biotechnol. 2014 Aug; 32(8):724-6. PMID: 25093882.
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    38. Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR. Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports. 2014 Aug 12; 3(2):269-81. PMID: 25254341; PMCID: PMC4175159.
    39. Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H. Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Reports. 2014 Aug 12; 3(2):242-9. PMID: 25254338; PMCID: PMC4175543.
    40. Takahashi K, Tanabe K, Ohnuki M, Narita M, Sasaki A, Yamamoto M, Nakamura M, Sutou K, Osafune K, Yamanaka S. Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm. Nat Commun. 2014 Apr 24; 5:3678. PMID: 24759836.
      View in: PubMed
    41. Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes. Stem Cell Reports. 2014 May 06; 2(5):648-61. PMID: 24936452; PMCID: PMC4050482.
    42. Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS One. 2014; 9(4):e94735. PMID: 24718089; PMCID: PMC3981863.
    43. Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M. A chemical probe that labels human pluripotent stem cells. Cell Rep. 2014 Mar 27; 6(6):1165-1174. PMID: 24613351.
      View in: PubMed
    44. Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells. Cell Stem Cell. 2014 Apr 03; 14(4):535-48. PMID: 24529595.
      View in: PubMed
    45. Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 2014 Feb 13; 156(4):663-77. PMID: 24529372.
      View in: PubMed
    46. Inoue H, Nagata N, Kurokawa H, Yamanaka S. iPS cells: a game changer for future medicine. EMBO J. 2014 Mar 03; 33(5):409-17. PMID: 24500035; PMCID: PMC3989624.
    47. Nagata N, Yamanaka S. Perspectives for induced pluripotent stem cell technology: new insights into human physiology involved in somatic mosaicism. Circ Res. 2014 Jan 31; 114(3):505-10. PMID: 24481841.
      View in: PubMed
    48. Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One. 2014; 9(1):e84881. PMID: 24454758; PMCID: PMC3893162.
    49. Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A. Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature. 2014 Mar 06; 507(7490):99-103. PMID: 24413397; PMCID: PMC4030630.
    50. Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, Yamanaka S. A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells. Sci Rep. 2014 Jan 08; 4:3594. PMID: 24399248; PMCID: PMC3884228.
    51. Tanabe K, Takahashi K, Yamanaka S. Induction of pluripotency by defined factors. Proc Jpn Acad Ser B Phys Biol Sci. 2014; 90(3):83-96. PMID: 24621955; PMCID: PMC3997808.
    52. Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet J Rare Dis. 2013 Dec 09; 8:190. PMID: 24321451; PMCID: PMC3892046.
    53. Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT. Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell. 2013 Dec 26; 52(6):805-18. PMID: 24268575; PMCID: PMC3950835.
    54. Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S. Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20569-74. PMID: 24259714; PMCID: PMC3870695.
    55. Yamanaka S. The winding road to pluripotency (Nobel Lecture). Angew Chem Int Ed Engl. 2013 Dec 23; 52(52):13900-9. PMID: 24255017.
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    56. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S. The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. Cell Stem Cell. 2014 Jan 02; 14(1):40-52. PMID: 24239284; PMCID: PMC3982312.
    57. Ohta S, Nishida E, Yamanaka S, Yamamoto T. Global splicing pattern reversion during somatic cell reprogramming. Cell Rep. 2013 Oct 31; 5(2):357-66. PMID: 24139801.
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    58. Turner M, Leslie S, Martin NG, Peschanski M, Rao M, Taylor CJ, Trounson A, Turner D, Yamanaka S, Wilmut I. Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell. 2013 Oct 03; 13(4):382-4. PMID: 24094319.
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    59. Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J. Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate. Stem Cell Reports. 2013; 1(4):283-92. PMID: 24319664; PMCID: PMC3849265.
    60. Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16492-7. PMID: 24067652; PMCID: PMC3799322.
    61. Tanabe K, Nakamura M, Narita M, Takahashi K, Yamanaka S. Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12172-9. PMID: 23812749; PMCID: PMC3725041.
    62. Miki K, Yoshida Y, Yamanaka S. Making steady progress on direct cardiac reprogramming toward clinical application. Circ Res. 2013 Jun 21; 113(1):13-5. PMID: 23788502.
      View in: PubMed
    63. Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H. Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med. 2013 Jun 05; 5(188):188lr2. PMID: 23740898.
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    64. Takahashi K, Yamanaka S. Induced pluripotent stem cells in medicine and biology. Development. 2013 Jun; 140(12):2457-61. PMID: 23715538.
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    65. Kaneko S, Yamanaka S. To be immunogenic, or not to be: that's the iPSC question. Cell Stem Cell. 2013 Apr 04; 12(4):385-6. PMID: 23561437.
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    145. Daley GQ, Lensch MW, Jaenisch R, Meissner A, Plath K, Yamanaka S. Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell. 2009 Mar 06; 4(3):200-1; author reply 202. PMID: 19265657.
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    146. Taura D, Noguchi M, Sone M, Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, Nakatsuji N, Okano H, Yamanaka S, Nakao K. Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS Lett. 2009 Mar 18; 583(6):1029-33. PMID: 19250937.
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    147. Tanaka Y, Ikeda T, Kishi Y, Masuda S, Shibata H, Takeuchi K, Komura M, Iwanaka T, Muramatsu S, Kondo Y, Takahashi K, Yamanaka S, Hanazono Y. ERas is expressed in primate embryonic stem cells but not related to tumorigenesis. Cell Transplant. 2009; 18(4):381-9. PMID: 19622226.
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    148. Aiba K, Nedorezov T, Piao Y, Nishiyama A, Matoba R, Sharova LV, Sharov AA, Yamanaka S, Niwa H, Ko MS. Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells. DNA Res. 2009 Feb; 16(1):73-80. PMID: 19112179; PMCID: PMC2644347.
    149. Aoyama Y, Nomura M, Yamanaka S, Ogawa Y, Kitajima Y. Subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica in a non-Hodgkin lymphoma patient. Med Mycol. 2009 Feb; 47(1):95-9. PMID: 19107636.
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    150. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science. 2008 Nov 07; 322(5903):949-53. PMID: 18845712.
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    151. Narazaki G, Uosaki H, Teranishi M, Okita K, Kim B, Matsuoka S, Yamanaka S, Yamashita JK. Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation. 2008 Jul 29; 118(5):498-506. PMID: 18625891.
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    152. Yamanaka S. Pluripotency and nuclear reprogramming. Philos Trans R Soc Lond B Biol Sci. 2008 Jun 27; 363(1500):2079-87. PMID: 18375377; PMCID: PMC2610180.
    153. Aoi T, Yae K, Nakagawa M, Ichisaka T, Okita K, Takahashi K, Chiba T, Yamanaka S. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science. 2008 Aug 01; 321(5889):699-702. PMID: 18276851.
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    154. Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2008 Jan; 26(1):101-6. PMID: 18059259.
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    155. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30; 131(5):861-72. PMID: 18035408.
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    156. Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S. New advances in iPS cell research do not obviate the need for human embryonic stem cells. Cell Stem Cell. 2007 Oct 11; 1(4):367-8. PMID: 18371375.
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    157. Lewitzky M, Yamanaka S. Reprogramming somatic cells towards pluripotency by defined factors. Curr Opin Biotechnol. 2007 Oct; 18(5):467-73. PMID: 18024106.
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    158. Yoshikane N, Nakamura N, Ueda R, Ueno N, Yamanaka S, Nakamura M. Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis. Dev Growth Differ. 2007 Sep; 49(7):623-34. PMID: 17716306.
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    159. Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell. 2007 Jun 07; 1(1):39-49. PMID: 18371333.
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    160. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature. 2007 Jul 19; 448(7151):313-7. PMID: 17554338.
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    161. Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc. 2007; 2(12):3081-9. PMID: 18079707.
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    162. Yamanaka S, Takahashi K. [Induction of pluripotent stem cells from mouse fibroblast cultures]. Tanpakushitsu Kakusan Koso. 2006 Dec; 51(15):2346-51. PMID: 17154061.
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    163. Nimura K, Ishida C, Koriyama H, Hata K, Yamanaka S, Li E, Ura K, Kaneda Y. Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Genes Cells. 2006 Oct; 11(10):1225-37. PMID: 16999741.
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    164. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25; 126(4):663-76. PMID: 16904174.
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    165. Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS. Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets. Dev Growth Differ. 2006 Aug; 48(6):381-90. PMID: 16872451.
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    166. Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S. Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC Dev Biol. 2006 Jul 21; 6:34. PMID: 16859545; PMCID: PMC1564388.
    167. Amano H, Itakura K, Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S. Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Dev Biol. 2006 Feb 28; 6:11. PMID: 16504174; PMCID: PMC1420271.
    168. Okita K, Yamanaka S. Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther. 2006 Jan; 1(1):103-11. PMID: 18220859.
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    169. Takahashi K, Ichisaka T, Yamanaka S. Identification of genes involved in tumor-like properties of embryonic stem cells. Methods Mol Biol. 2006; 329:449-58. PMID: 16846009.
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    170. Tokuzawa Y, Maruyama M, Yamanaka S. Utilization of digital differential display to identify novel targets of Oct3/4. Methods Mol Biol. 2006; 329:223-31. PMID: 16845994.
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    171. Yamanaka S. [Molecular mechanisms underlying pluripotency of embryonic stem cells]. Seikagaku. 2006 Jan; 78(1):27-33. PMID: 16491909.
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    172. Takahashi K, Nakagawa M, Young SG, Yamanaka S. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. J Biol Chem. 2005 Sep 23; 280(38):32768-74. PMID: 16046393.
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    173. Nakagawa M, Yamanaka S. [Mechanism for maintaining pluripotency in embryonic stem cells and inner cell mass]. Tanpakushitsu Kakusan Koso. 2005 May; 50(6 Suppl):546-50. PMID: 15926478.
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    174. Ishiyama K, Takami A, Okumura H, Ozaki J, Shimadoi S, Yamanaka S, Nakao S. Complete and durable remission of refractory mantle cell lymphoma with repeated rituximab monotherapy. Int J Hematol. 2005 May; 81(4):319-22. PMID: 15914363.
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    175. Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S. Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005 Jul 01; 280(26):24371-9. PMID: 15863505.
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    176. Takahashi K, Maruyama M, Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Genomics. 2005 Mar; 85(3):360-71. PMID: 15718103.
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    177. Tomoda K, Yoneda-Kato N, Fukumoto A, Yamanaka S, Kato JY. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004 Oct 08; 279(41):43013-8. PMID: 15299027.
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    178. Matsuda E, Shigeoka T, Iida R, Yamanaka S, Kawaichi M, Ishida Y. Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4170-4. PMID: 15010531; PMCID: PMC384713.
    179. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30; 113(5):631-42. PMID: 12787504.
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    180. Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature. 2003 May 29; 423(6939):541-5. PMID: 12774123.
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    181. Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, Niwa H, Yamanaka S. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003 Apr; 23(8):2699-708. PMID: 12665572; PMCID: PMC152544.
    182. Qian X, Balestra ME, Yamanaka S, Borén J, Lee I, Innerarity TL. Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. Arterioscler Thromb Vasc Biol. 1998 Jun; 18(6):1013-20. PMID: 9633945.
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    183. Yamanaka S, Poksay KS, Arnold KS, Innerarity TL. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 1997 Feb 01; 11(3):321-33. PMID: 9030685.
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    184. Yamanaka S, Poksay KS, Driscoll DM, Innerarity TL. Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif. J Biol Chem. 1996 May 10; 271(19):11506-10. PMID: 8626710.
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    185. Yamanaka S, Poksay KS, Balestra ME, Zeng GQ, Innerarity TL. Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed. J Biol Chem. 1994 Aug 26; 269(34):21725-34. PMID: 8063816.
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