Vasanth Vedantham

TitleAssociate Professor
InstitutionUniversity of California San Francisco
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    University of California, San FranciscoClinical Fellowship School of Medicine - Cardiology
    Harvard UniversityM.D.2002School of Medicine

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    Collapse Overview
    CLINICAL INTERESTS: Dr. Vedantham is cardiologist and clinical cardiac electrophysiologist, specializing in treatment of heart rhythm disorders using catheter ablation, pacemaker and defibrillator implantation, and antiarrhythmic medications. Specific conditions include supraventricular tachycardia, atrial fibrillation, atrial flutter, ventricular tachycardia, bradycardia, syncope, and sudden cardiac death. He also implants biventricular devices for cardiac resynchronization therapy in patients with heart failure.

    RESEARCH INTERESTS: Dr. Vedantham’s research focuses on the molecular biology of the electrical system of the heart. His specific area of interest is understanding how transcription factors, microRNAs, and other regulatory molecules cooperatively determine the electrical properties of different types of heart cell by controlling the differential expression of ion channels in normal development and in heart disease. To address this problem, Dr. Vedantham combines molecular biology techniques with electrophysiological studies in genetically engineered mouse models. His goal is to make advances in basic cardiovascular science that will lead to improvements in the treatment and prevention of arrhythmias.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of MicroRNA-1 in the Cardiac Ventricular Conduction System
    NIH/NHLBI K08HL101989Aug 6, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Identification of MicroRNAs in the Mammalian Cardiac Conduction System
    NIH/NHLBI F32HL087628Aug 1, 2007 - Jul 31, 2010
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Guo X, Vittinghoff E, Vedantham V, Pletcher MJ, Lee BK. Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011. Circ J. 2017 Oct 25; 81(11):1739-1741. PMID: 28904267.
      View in: PubMed
    2. Szilágyi J, Marcus GM, Badhwar N, Lee BK, Lee RJ, Vedantham V, Tseng ZH, Walters T, Scheinman M, Olgin J, Gerstenfeld EP. Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable? J Cardiovasc Electrophysiol. 2017 Jul; 28(7):754-761. PMID: 28429499.
      View in: PubMed
    3. Vedantham V, Scheinman MM. Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies. Eur Heart J. 2017 Jan 21; 38(4):289-291. PMID: 28182236.
      View in: PubMed
    4. Roberts JD, Gollob MH, Young C, Connors SP, Gray C, Wilton SB, Green MS, Zhu DW, Hodgkinson KA, Poon A, Li Q, Orr N, Tang AS, Klein GJ, Wojciak J, Campagna J, Olgin JE, Badhwar N, Vedantham V, Marcus GM, Kwok PY, Deo RC, Scheinman MM. Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia. JACC Clin Electrophysiol. 2017 Mar; 3(3):276-288. PMID: 29759522.
      View in: PubMed
    5. Nguyen KT, Gladstone RA, Dukes JW, Nazer B, Vittinghoff E, Badhwar N, Vedantham V, Gerstenfeld EP, Lee BK, Lee RJ, Tseng ZH, Olgin JE, Scheinman MM, Marcus GM. The QT Interval as a Noninvasive Marker of Atrial Refractoriness. Pacing Clin Electrophysiol. 2016 Dec; 39(12):1366-1372. PMID: 27753113.
      View in: PubMed
    6. Kawamura M, Scheinman MM, Vedantham V, Marcus GM, Tseng ZH, Badhwar N. Clinical and Electrophysiological Characteristics of Incessant Atrioventricular Nodal Re-Entrant Tachycardia. JACC Clin Electrophysiol. 2016 Oct; 2(5):596-602. PMID: 29759579.
      View in: PubMed
    7. Vedantham V. New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development. Trends Mol Med. 2015 Dec; 21(12):749-761. PMID: 26611337.
      View in: PubMed
    8. Hoffmayer KS, Lee BK, Vedantham V, Bhimani AA, Cakulev IT, Mackall JA, Sahadevan J, Rho RW, Scheinman MM. Response to letter regarding article, "variable clinical features and ablation of manifest nodofascicular/ventricular pathways". Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):995. PMID: 26286312.
      View in: PubMed
    9. Ito H, Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Gerstenfeld EP, Scheinman MM. The Effect of Direct Current Stimulation versus T-Wave Shock on Defibrillation Threshold Testing. Pacing Clin Electrophysiol. 2015 Oct; 38(10):1173-80. PMID: 26137999.
      View in: PubMed
    10. Kawamura M, Hsu JC, Vedantham V, Marcus GM, Hsia HH, Gerstenfeld EP, Scheinman MM, Badhwar N. Clinical and electrocardiographic characteristics of idiopathic ventricular arrhythmias with right bundle branch block and superior axis: Comparison of apical crux area and posterior septal left ventricle. Heart Rhythm. 2015 Jun; 12(6):1137-44. PMID: 25728755.
      View in: PubMed
    11. Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Circ Res. 2015 Feb 27; 116(5):797-803. PMID: 25623957; PMCID: PMC4344860.
    12. Hoffmayer KS, Lee BK, Vedantham V, Bhimani AA, Cakulev IT, Mackall JA, Sahadevan J, Rho RW, Scheinman MM. Variable clinical features and ablation of manifest nodofascicular/ventricular pathways. Circ Arrhythm Electrophysiol. 2015 Feb; 8(1):117-27. PMID: 25472957.
      View in: PubMed
    13. Kawamura M, Gerstenfeld EP, Vedantham V, Rodrigues DM, Burkhardt JD, Kobayashi Y, Hsia HH, Marcus GM, Marchlinski FE, Scheinman MM, Badhwar N. Idiopathic ventricular arrhythmia originating from the cardiac crux or inferior septum: epicardial idiopathic ventricular arrhythmia. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1152-8. PMID: 25225238.
      View in: PubMed
    14. Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL. Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Dev Biol. 2014 Sep 15; 393(2):245-254. PMID: 25050930; PMCID: PMC4143461.
    15. Singh DK, Viswanathan MN, Tanel RE, Lee RJ, Lee BK, Marcus GM, Olgin JE, Han F, Vedantham V, Tseng ZH, Pellegrini C, Kawamura M, Gerstenfeld EP, Badhwar N, Scheinman M. His overdrive pacing during supraventricular tachycardia: a novel maneuver for distinguishing atrioventricular nodal reentrant tachycardia from atrioventricular reciprocating tachycardia. Heart Rhythm. 2014 Aug; 11(8):1327-35. PMID: 24793458.
      View in: PubMed
    16. Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Olgin JE, Gerstenfeld EP, Scheinman MM. Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy. J Cardiovasc Electrophysiol. 2014 Jul; 25(7):756-62. PMID: 24612052.
      View in: PubMed
    17. Stepanyan G, Badhwar N, Lee RJ, Marcus GM, Lee BK, Tseng ZH, Vedantham V, Olgin J, Scheinman M, Gerstenfeld EP. Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation. J Interv Card Electrophysiol. 2014 Jun; 40(1):33-8. PMID: 24643666.
      View in: PubMed
    18. Kawamura M, Vedantham V, Dewland TA, Scheinman MM. Incessant long RP tachycardia: what is the mechanism? Heart Rhythm. 2014 May; 11(5):904-6. PMID: 24561158.
      View in: PubMed
    19. Hsu JC, Badhwar N, Gerstenfeld EP, Lee RJ, Mandyam MC, Dewland TA, Imburgia KE, Hoffmayer KS, Vedantham V, Lee BK, Tseng ZH, Scheinman MM, Olgin JE, Marcus GM. Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study). J Am Heart Assoc. 2013 Sep 17; 2(5):e000428. PMID: 24045120; PMCID: PMC3835257.
    20. Vedantham V, Jackman WM, Scheinman MM. Unexpected potential following ablation of a right atriofascicular accessory pathway. J Cardiovasc Electrophysiol. 2013 Aug; 24(8):939-41. PMID: 23601047.
      View in: PubMed
    21. Vedantham V, Evangelista M, Huang Y, Srivastava D. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Dev Biol. 2013 Jan 01; 373(1):149-62. PMID: 23085412; PMCID: PMC3510001.
    22. Scheinman MM, Vedantham V. Ivabradine: a ray of hope for inappropriate sinus tachycardia. J Am Coll Cardiol. 2012 Oct 09; 60(15):1330-2. PMID: 22981552.
      View in: PubMed
    23. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31; 485(7400):593-8. PMID: 22522929; PMCID: PMC3369107.
    24. Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Gerstenfeld EP, Olgin JE, Marcus GM. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. Am J Cardiol. 2012 Aug 01; 110(3):364-8. PMID: 22521307; PMCID: PMC3398200.
    25. Hsu JC, Badhwar N, Lee BK, Vedantham V, Tseng ZH, Marcus GM. Predictors of fluoroscopy time and procedural failure during biventricular device implantation. Am J Cardiol. 2012 Jul 15; 110(2):240-5. PMID: 22483384; PMCID: PMC3383869.
    26. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 06; 142(3):375-86. PMID: 20691899; PMCID: PMC2919844.
    27. Vedantham V, Tseng ZH. Changing QRS Morphology in a Patient with Wolff-Parkinson-White Syndrome. Card Electrophysiol Clin. 2010 Jun; 2(2):239-243. PMID: 28770758.
      View in: PubMed
    28. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20; 129(2):303-17. PMID: 17397913.
      View in: PubMed
    29. Vedantham V, Cannon SC. Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels. Biophys J. 2000 Jun; 78(6):2943-58. PMID: 10827974; PMCID: PMC1300879.
    30. Vedantham V, Cannon SC. The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels. J Gen Physiol. 1999 Jan; 113(1):7-16. PMID: 9874684; PMCID: PMC2222985.
    31. Vedantham V, Cannon SC. Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels. J Gen Physiol. 1998 Jan; 111(1):83-93. PMID: 9417137; PMCID: PMC1887763.