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    Alka Kanaya, MD

    SchoolUCSF School of Medicine
    Address1545 Divisadero Street
    San Francisco CA 94143

       Education and Training
      University of California, San Francisco Residency School of Medicine
      University of California, San FranciscoM.D. School of Medicine1995

      I have focused my clinical research in the field of type 2 diabetes and obesity and have developed a three-pronged research program that is unified under this theme. The first arm consists of using existing cohort studies to test novel biomarkers that predict diabetes and cardiovascular disease. The second arm is to create a South Asian cohort to study these risk factors in a very high risk group. The final arm is to test behavioral interventions to prevent the onset of diabetes.

      The first arm of my research program focuses on understanding novel biomarkers secreted from adipose tissue that may be responsible for the metabolic sequelae associated with obesity. I assayed adiponectin from over 3,000 frozen serum specimens from a longitudinal cohort and have performed a series of analyses finding that abdominal visceral adiposity when directly measured by CT scan is significantly associated with type 2 diabetes and adipocytokines, proteins produced by adipose tissue, explain this association. We have found strong links between visceral adiposity and adipocytokines predicting risk of diabetes, cardiovascular disease, and mortality.

      The second arm of my research program has been to establish a population-based cohort of South Asian adults. South Asians have very high prevalence of diabetes and cardiovascular disease and have been poorly studied. With a K23 grant from the NHLBI, I recruited 150 South Asians in a pilot cohort study which was modelled on the existing Multi-Ethnic Study of Atherosclerosis (MESA). In this project, called the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA study), we have examined the relationship between metabolic factors and atherosclerosis measured by carotid ultrasound and coronary artery calcium. We found that compared to the four ethnic groups in MESA (Whites, African Americans, Latinos, and Chinese Americans), South Asians had higher diabetes prevalence[58] despite having favorable lifestyle risk factors. I received additional funding to study endothelial function in this cohort through the American Heart Association and we finished our second clinical examination visits in January 2010. I have been awarded a new R01 grant to expand and prospectively follow this South Asian cohort at two clinical sites to chart the natural history of diabetes and atherosclerosis and test novel risk factors. I have submitted another R01 grant to create a new multi-dimensional tool to measure cultural beliefs and adaptations among South Asian Americans. This project will involve both qualitative and quantitative methods and will help us understand cultural risk factors for cardiovascular disease in this high risk ethnic group.

      The third arm includes testing behavioral interventions to prevent diabetes in high risk individuals. We have conducted a translational randomized controlled trial testing the effectiveness of a lifestyle intervention provided by the Berkeley Public Health Department to decrease diabetes risk factors in low-income ethnic minority groups. I have also completed a pilot randomized controlled trial to test the feasibility of Restorative yoga in overweight adults with the metabolic syndrome. We found that Restorative yoga was feasible with trends toward improvements in waist circumference and blood pressure in the yoga group compared to the control group. I have been awarded an R01 grant to test this intervention vs. a stretching control group in a multicenter randomized controlled trial called PRYSMS which is currently underway.

      The three arms of my research agenda complement each other and provide fertile ground to develop and test new hypotheses with the ultimate goal of better caring for patients at high risk of diabetes and cardiovascular disease.

       ORNG Applications 
       In The News
       NIH Awarded Grants
       Global Health

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hsu WC, Araneta MR, Kanaya AM, Chiang JL, Fujimoto W. BMI cut points to identify at-risk Asian Americans for type 2 diabetes screening. Diabetes Care. 2015 Jan; 38(1):150-8.
        View in: PubMed
      2. Kanaya AM. Review: Diet and exercise counseling improve intermediate health outcomes in persons with CV risk factors. Ann Intern Med. 2014 Dec 16; 161(12):JC7.
        View in: PubMed
      3. Phelan S, Kanaya AM, Ma Y, Vittinghoff E, Barrett-Connor E, Wing R, Kusek JW, Orchard TJ, Crandall JP, Montez MG, Brown JS. Long-term prevalence and predictors of urinary incontinence among women in the Diabetes Prevention Program Outcomes Study. Int J Urol. 2014 Oct 28.
        View in: PubMed
      4. Shah AD, Vittinghoff E, Kandula NR, Srivastava S, Kanaya AM. Correlates of prediabetes and type II diabetes in US South Asians: findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Ann Epidemiol. 2014 Oct 22.
        View in: PubMed
      5. Kandula NR, Kanaya AM, Liu K, Lee JY, Herrington D, Hulley SB, Persell SD, Lloyd-Jones DM, Huffman MD. Association of 10-Year and Lifetime Predicted Cardiovascular Disease Risk With Subclinical Atherosclerosis in South Asians: Findings From the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. J Am Heart Assoc. 2014; 3(5).
        View in: PubMed
      6. Corey SM, Epel E, Schembri M, Pawlowsky SB, Cole RJ, Araneta MR, Barrett-Connor E, Kanaya AM. Effect of restorative yoga vs. stretching on diurnal cortisol dynamics and psychosocial outcomes in individuals with the metabolic syndrome: The PRYSMS randomized controlled trial. Psychoneuroendocrinology. 2014 Nov; 49:260-71.
        View in: PubMed
      7. Shah A, Kanaya AM. Diabetes and associated complications in the South asian population. Curr Cardiol Rep. 2014 May; 16(5):476.
        View in: PubMed
      8. Jih J, Mukherjea A, Vittinghoff E, Nguyen TT, Tsoh JY, Fukuoka Y, Bender MS, Tseng W, Kanaya AM. Using appropriate body mass index cut points for overweight and obesity among Asian Americans. Prev Med. 2014 Aug; 65:1-6.
        View in: PubMed
      9. Kanaya AM, Herrington D, Vittinghoff E, Ewing SK, Liu K, Blaha MJ, Dave SS, Qureshi F, Kandula NR. Understanding the High Prevalence of Diabetes in U.S. South Asians Compared With Four Racial/Ethnic Groups: The MASALA and MESA Studies. Diabetes Care. 2014 Jun; 37(6):1621-8.
        View in: PubMed
      10. Kanaya AM, Kandula NR, Ewing SK, Herrington D, Liu K, Blaha MJ, Srivastava S, Dave SS, Budoff MJ. Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: The MASALA and MESA studies. Atherosclerosis. 2014 May; 234(1):102-7.
        View in: PubMed
      11. Khan H, Kalogeropoulos AP, Zannad F, Marti CN, Wilson PW, Georgiopoulou VV, Kanaya AM, Newman AB, Schelbert E, Harris TB, Kritchevsky S, Yancy C, Gheorghiade M, Fonarow GC, Butler J. Incident heart failure in relation to vascular disease: Insights from the Health, Aging, and Body Composition Study. Eur J Heart Fail. 2014 May; 16(5):526-34.
        View in: PubMed
      12. Klein OL, Okwuosa T, Chan C, Schreiner P, Kanaya AM, Liu K, Green D. Changes in procoagulants track longitudinally with insulin resistance: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Diabet Med. 2014 Apr; 31(4):462-5.
        View in: PubMed
      13. Kanaya AM, Araneta MR, Pawlowsky SB, Barrett-Connor E, Grady D, Vittinghoff E, Schembri M, Chang A, Carrion-Petersen ML, Coggins T, Tanori D, Armas JM, Cole RJ. Restorative yoga and metabolic risk factors: The Practicing Restorative Yoga vs. Stretching for the Metabolic Syndrome (PRYSMS) randomized trial. J Diabetes Complications. 2014 May-Jun; 28(3):406-12.
        View in: PubMed
      14. Gadgil MD, Anderson CA, Kandula NR, Kanaya AM. Dietary patterns in asian indians in the United States: an analysis of the metabolic syndrome and atherosclerosis in South asians living in america study. J Acad Nutr Diet. 2014 Feb; 114(2):238-43.
        View in: PubMed
      15. Kanaya AM, Kandula N, Herrington D, Budoff MJ, Hulley S, Vittinghoff E, Liu K. Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Objectives, Methods, and Cohort Description. Clin Cardiol. 2013 Dec; 36(12):713-20.
        View in: PubMed
      16. Lipska KJ, Inzucchi SE, Van Ness PH, Gill TM, Kanaya A, Strotmeyer ES, Koster A, Johnson KC, Goodpaster BH, Harris T, De Rekeneire N. Elevated HbA1c and Fasting Plasma Glucose in Predicting Diabetes Incidence Among Older Adults: Are two better than one? Diabetes Care. 2013 Dec; 36(12):3923-9.
        View in: PubMed PMC3836095
      17. Gujral UP, Narayan KM, Kahn SE, Kanaya AM. The relative associations of ß-cell function and insulin sensitivity with glycemic status and incident glycemic progression in migrant Asian Indians in the United States: The MASALA study. J Diabetes Complications. 2014 Jan-Feb; 28(1):45-50.
        View in: PubMed
      18. Mukherjea A, Underwood KC, Stewart AL, Ivey SL, Kanaya AM. Asian Indian views on diet and health in the United States: importance of understanding cultural and social factors to address disparities. Fam Community Health. 2013 Oct-Dec; 36(4):311-23.
        View in: PubMed
      19. Oza-Frank R, Chan C, Liu K, Burke G, Kanaya AM. Incidence of type 2 diabetes by place of birth in the Multi-Ethnic Study of Atherosclerosis (MESA). J Immigr Minor Health. 2013 Oct; 15(5):918-24.
        View in: PubMed
      20. Doyle TA, de Groot M, Harris T, Schwartz F, Strotmeyer ES, Johnson KC, Kanaya A. Diabetes, depressive symptoms, and inflammation in older adults: Results from the Health, Aging, and Body Composition Study. J Psychosom Res. 2013 Nov; 75(5):419-24.
        View in: PubMed PMC3817497
      21. Wilson JP, Kanaya AM, Fan B, Shepherd JA. Ratio of trunk to leg volume as a new body shape metric for diabetes and mortality. PLoS One. 2013; 8(7):e68716.
        View in: PubMed PMC3707853
      22. Milaneschi Y, Cesari M, Simonsick EM, Vogelzangs N, Kanaya AM, Yaffe K, Patrignani P, Metti A, Kritchevsky SB, Pahor M, Ferrucci L, Penninx BW. Lipid peroxidation and depressed mood in community-dwelling older men and women. PLoS One. 2013; 8(6):e65406.
        View in: PubMed PMC3679197
      23. Mayeda ER, Haan MN, Kanaya AM, Yaffe K, Neuhaus J. Type 2 diabetes and 10-year risk of dementia and cognitive impairment among older Mexican Americans. Diabetes Care. 2013 Sep; 36(9):2600-6.
        View in: PubMed PMC3747945
      24. Kanaya AM, Dobrosielski DA, Ganz P, Creasman J, Gupta R, Nelacanti V, Vogel-Claussen J, Herrington D. Glycemic associations with endothelial function and biomarkers among 5 ethnic groups: the Multi-Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis in South Asians Living in America studies. J Am Heart Assoc. 2013 Feb; 2(1):e004283.
        View in: PubMed PMC3603246
      25. Coutinho T, Goel K, Corrêa de Sá D, Carter RE, Hodge DO, Kragelund C, Kanaya AM, Zeller M, Park JS, Kober L, Torp-Pedersen C, Cottin Y, Lorgis L, Lee SH, Kim YJ, Thomas R, Roger VL, Somers VK, Lopez-Jimenez F. Combining body mass index with measures of central obesity in the assessment of mortality in subjects with coronary disease: role of "normal weight central obesity". J Am Coll Cardiol. 2013 Feb 5; 61(5):553-60.
        View in: PubMed
      26. Casillas A, Leng M, Liu K, Hernandez A, Shrager S, Kanaya A. A long way from home: comparing mental health measures between foreign and U.S.-born Latinos in the Multi-Ethnic Study of Atherosclerosis (MESA). J Health Care Poor Underserved. 2012 Nov; 23(4):1719-32.
        View in: PubMed
      27. Karter AJ, Schillinger D, Adams AS, Moffet HH, Liu J, Adler NE, Kanaya AM. Elevated rates of diabetes in Pacific Islanders and Asian subgroups: The Diabetes Study of Northern California (DISTANCE). Diabetes Care. 2013 Mar; 36(3):574-9.
        View in: PubMed PMC3579366
      28. Qi Q, Menzaghi C, Smith S, Liang L, de Rekeneire N, Garcia ME, Lohman KK, Miljkovic I, Strotmeyer ES, Cummings SR, Kanaya AM, Tylavsky FA, Satterfield S, Ding J, Rimm EB, Trischitta V, Hu FB, Liu Y, Qi L. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. Hum Mol Genet. 2012 Nov 1; 21(21):4774-80.
        View in: PubMed PMC3471394
      29. Kanaya AM, Santoyo-Olsson J, Gregorich S, Grossman M, Moore T, Stewart AL. The Live Well, Be Well study: a community-based, translational lifestyle program to lower diabetes risk factors in ethnic minority and lower-socioeconomic status adults. Am J Public Health. 2012 Aug; 102(8):1551-8.
        View in: PubMed PMC3395772
      30. Waring AC, Rodondi N, Harrison S, Kanaya AM, Simonsick EM, Miljkovic I, Satterfield S, Newman AB, Bauer DC. Thyroid function and prevalent and incident metabolic syndrome in older adults: the Health, Ageing and Body Composition Study. Clin Endocrinol (Oxf). 2012 Jun; 76(6):911-8.
        View in: PubMed PMC3334430
      31. Hsu WC, Boyko EJ, Fujimoto WY, Kanaya A, Karmally W, Karter A, King GL, Look M, Maskarinec G, Misra R, Tavake-Pasi F, Arakaki R. Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications. Diabetes Care. 2012 May; 35(5):1189-98.
        View in: PubMed PMC3329855
      32. Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, Greenwood CM, Ladouceur M, Grimsby J, Manning AK, Liu CT, Kooner J, Mooser VE, Vollenweider P, Kapur KA, Chambers J, Wareham NJ, Langenberg C, Frants R, Willems-Vandijk K, Oostra BA, Willems SM, Lamina C, Winkler TW, Psaty BM, Tracy RP, Brody J, Chen I, Viikari J, Kähönen M, Pramstaller PP, Evans DM, St Pourcain B, Sattar N, Wood AR, Bandinelli S, Carlson OD, Egan JM, Böhringer S, van Heemst D, Kedenko L, Kristiansson K, Nuotio ML, Loo BM, Harris T, Garcia M, Kanaya A, Haun M, Klopp N, Wichmann HE, Deloukas P, Katsareli E, Couper DJ, Duncan BB, Kloppenburg M, Adair LS, Borja JB. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012; 8(3):e1002607.
        View in: PubMed PMC3315470
      33. Agarwal S, Jacobs DR, Vaidya D, Sibley CT, Jorgensen NW, Rotter JI, Chen YD, Liu Y, Andrews JS, Kritchevsky S, Goodpaster B, Kanaya A, Newman AB, Simonsick EM, Herrington DM. Metabolic Syndrome Derived from Principal Component Analysis and Incident Cardiovascular Events: The Multi Ethnic Study of Atherosclerosis (MESA) and Health, Aging, and Body Composition (Health ABC). Cardiol Res Pract. 2012; 2012:919425.
        View in: PubMed PMC3318892
      34. Kanaya AM. ACP Journal Club. In-person or remote behavioral interventions for obesity were better than a self-directed approach. Ann Intern Med. 2012 Mar 20; 156(6):JC3-10, JC3-11.
        View in: PubMed
      35. Kanaya AM. ACP Journal Club. Enhanced brief lifestyle counseling for obesity was better than usual care for weight loss at 2 years. Ann Intern Med. 2012 Mar 20; 156(6):JC3-11, JC3-10.
        View in: PubMed
      36. Cesari M, Kritchevsky SB, Nicklas B, Kanaya AM, Patrignani P, Tacconelli S, Tranah GJ, Tognoni G, Harris TB, Incalzi RA, Newman AB, Pahor M. Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):671-6.
        View in: PubMed PMC3348494
      37. Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS. Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. J Urol. 2012 Mar; 187(3):939-44.
        View in: PubMed PMC3646565
      38. Anderson AL, Harris TB, Tylavsky FA, Perry SE, Houston DK, Lee JS, Kanaya AM, Sahyoun NR. Dietary patterns, insulin sensitivity and inflammation in older adults. Eur J Clin Nutr. 2012 Jan; 66(1):18-24.
        View in: PubMed PMC3251708
      39. Barbour KE, Zmuda JM, Boudreau R, Strotmeyer ES, Horwitz MJ, Evans RW, Kanaya AM, Harris TB, Cauley JA. The effects of adiponectin and leptin on changes in bone mineral density. Osteoporos Int. 2012 Jun; 23(6):1699-710.
        View in: PubMed PMC3536828
      40. Shah A, Hernandez A, Mathur D, Budoff MJ, Kanaya AM. Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. Int J Obes (Lond). 2012 Jun; 36(6):810-6.
        View in: PubMed PMC3224670
      41. Barbour KE, Zmuda JM, Boudreau R, Strotmeyer ES, Horwitz MJ, Evans RW, Kanaya AM, Harris TB, Bauer DC, Cauley JA. Adipokines and the risk of fracture in older adults. J Bone Miner Res. 2011 Jul; 26(7):1568-76.
        View in: PubMed PMC3733555
      42. Santoyo-Olsson J, Cabrera J, Freyre R, Grossman M, Alvarez N, Mathur D, Guerrero M, Delgadillo AT, Kanaya AM, Stewart AL. An innovative multiphased strategy to recruit underserved adults into a randomized trial of a community-based diabetes risk reduction program. Gerontologist. 2011 Jun; 51 Suppl 1:S82-93.
        View in: PubMed PMC3092977
      43. Coutinho T, Goel K, Corrêa de Sá D, Kragelund C, Kanaya AM, Zeller M, Park JS, Kober L, Torp-Pedersen C, Cottin Y, Lorgis L, Lee SH, Kim YJ, Thomas R, Roger VL, Somers VK, Lopez-Jimenez F. Central obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data. J Am Coll Cardiol. 2011 May 10; 57(19):1877-86.
        View in: PubMed
      44. Wang S, Quan J, Kanaya AM, Fernandez A. Asian Americans and obesity in California: a protective effect of biculturalism. J Immigr Minor Health. 2011 Apr; 13(2):276-83.
        View in: PubMed PMC3056137
      45. Kanaya AM, Adler N, Moffet HH, Liu J, Schillinger D, Adams A, Ahmed AT, Karter AJ. Heterogeneity of diabetes outcomes among asians and pacific islanders in the US: the diabetes study of northern california (DISTANCE). Diabetes Care. 2011 Apr; 34(4):930-7.
        View in: PubMed PMC3064053
      46. Landau M, Kurella-Tamura M, Shlipak MG, Kanaya A, Strotmeyer E, Koster A, Satterfield S, Simsonick EM, Goodpaster B, Newman AB, Fried LF. Correlates of insulin resistance in older individuals with and without kidney disease. Nephrol Dial Transplant. 2011 Sep; 26(9):2814-9.
        View in: PubMed PMC3203409
      47. Kanaya AM, Wassel CL, Stoddard PJ, Harris TB, Cummings SR, Kritchevsky SB, Goodpaster BH, Green C, Satterfield S, Gross MD. F2-isoprostanes and adiposity in older adults. Obesity (Silver Spring). 2011 Apr; 19(4):861-7.
        View in: PubMed PMC3196361
      48. Fiocco AJ, Kanaya AM, Lindquist KM, Harris TB, Satterfield S, Simonsick EM, Kuller L, Rosano C, Yaffe K. Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study. Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb; 84(1-2):57-61.
        View in: PubMed PMC3015004
      49. Lipska KJ, De Rekeneire N, Van Ness PH, Johnson KC, Kanaya A, Koster A, Strotmeyer ES, Goodpaster BH, Harris T, Gill TM, Inzucchi SE. Identifying dysglycemic states in older adults: implications of the emerging use of hemoglobin A1c. J Clin Endocrinol Metab. 2010 Dec; 95(12):5289-95.
        View in: PubMed PMC2999974
      50. Schafer AL, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010 Nov; 95(11):E368-72.
        View in: PubMed PMC2968723
      51. Melamed A, Vittinghoff E, Sriram U, Schwartz AV, Kanaya AM. BMD reference standards among South Asians in the United States. J Clin Densitom. 2010 Oct-Dec; 13(4):379-84.
        View in: PubMed PMC2966549
      52. Delgadillo AT, Grossman M, Santoyo-Olsson J, Gallegos-Jackson E, Kanaya AM, Stewart AL. Description of an academic community partnership lifestyle program for lower income minority adults at risk for diabetes. Diabetes Educ. 2010 Jul-Aug; 36(4):640-50.
        View in: PubMed PMC3771540
      53. Kostek MC, Devaney JM, Gordish-Dressman H, Harris TB, Thompson PD, Clarkson PM, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Garcia M, Li R, Zmuda JM, Delmonico MJ, Kanaya A, Hoffman EP. A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study. Eur J Appl Physiol. 2010 Sep; 110(2):315-24.
        View in: PubMed PMC2928925
      54. Koster A, Stenholm S, Alley DE, Kim LJ, Simonsick EM, Kanaya AM, Visser M, Houston DK, Nicklas BJ, Tylavsky FA, Satterfield S, Goodpaster BH, Ferrucci L, Harris TB. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring). 2010 Dec; 18(12):2354-61.
        View in: PubMed PMC3095947
      55. Wang ET, de Koning L, Kanaya AM. Higher protein intake is associated with diabetes risk in South Asian Indians: the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. J Am Coll Nutr. 2010 Apr; 29(2):130-5.
        View in: PubMed
      56. Kanaya AM, Wassel CL, Mathur D, Stewart A, Herrington D, Budoff MJ, Ranpura V, Liu K. Prevalence and correlates of diabetes in South asian indians in the United States: findings from the metabolic syndrome and atherosclerosis in South asians living in america study and the multi-ethnic study of atherosclerosis. Metab Syndr Relat Disord. 2010 Apr; 8(2):157-64.
        View in: PubMed PMC3139526
      57. Houston DK, Ding J, Lee JS, Garcia M, Kanaya AM, Tylavsky FA, Newman AB, Visser M, Kritchevsky SB. Dietary fat and cholesterol and risk of cardiovascular disease in older adults: the Health ABC Study. Nutr Metab Cardiovasc Dis. 2011 Jun; 21(6):430-7.
        View in: PubMed PMC2911502
      58. Njajou OT, Kanaya AM, Holvoet P, Connelly S, Strotmeyer ES, Harris TB, Cummings SR, Hsueh WC. Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study. Diabetes Metab Res Rev. 2009 Nov; 25(8):733-9.
        View in: PubMed PMC3269343
      59. Stenholm S, Koster A, Alley DE, Houston DK, Kanaya A, Lee JS, Newman AB, Satterfield S, Simonsick EM, Visser M, Harris TB, Ferrucci L. Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2010 Jan; 65(1):84-92.
        View in: PubMed PMC2796880
      60. Spies C, Farzaneh-Far R, Na B, Kanaya A, Schiller NB, Whooley MA. Relation of obesity to heart failure hospitalization and cardiovascular events in persons with stable coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2009 Oct 1; 104(7):883-9.
        View in: PubMed
      61. Cohen BE, Barrett-Connor E, Wassel CL, Kanaya AM. Association of glucose measures with total and coronary heart disease mortality: does the effect change with time? The Rancho Bernardo Study. Diabetes Res Clin Pract. 2009 Oct; 86(1):67-73.
        View in: PubMed PMC2767115
      62. Hu D, Pawlikowska L, Kanaya A, Hsueh WC, Colbert L, Newman AB, Satterfield S, Rosen C, Cummings SR, Harris TB, Ziv E. Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study. J Am Geriatr Soc. 2009 Jul; 57(7):1213-8.
        View in: PubMed PMC2771612
      63. Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, Dilillo V, Gorin AA, West DS, Brown JS. Prevalence and risk factors for urinary incontinence in overweight and obese diabetic women: action for health in diabetes (look ahead) study. Diabetes Care. 2009 Aug; 32(8):1391-7.
        View in: PubMed PMC2713631
      64. Butler J, Kalogeropoulos A, Georgiopoulou V, de Rekeneire N, Rodondi N, Smith AL, Hoffmann U, Kanaya A, Newman AB, Kritchevsky SB, Vasan RS, Wilson PW, Harris TB. Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1144-9.
        View in: PubMed PMC2757290
      65. Sarma AV, Kanaya A, Nyberg LM, Kusek JW, Vittinghoff E, Rutledge B, Cleary PA, Gatcomb P, Brown JS. Risk factors for urinary incontinence among women with type 1 diabetes: findings from the epidemiology of diabetes interventions and complications study. Urology. 2009 Jun; 73(6):1203-9.
        View in: PubMed PMC2748226
      66. Brinkley TE, Nicklas BJ, Kanaya AM, Satterfield S, Lakatta EG, Simonsick EM, Sutton-Tyrrell K, Kritchevsky SB. Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study. Hypertension. 2009 May; 53(5):846-52.
        View in: PubMed PMC2692957
      67. Kanaya AM, Lindquist K, Harris TB, Launer L, Rosano C, Satterfield S, Yaffe K. Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) study. Arch Neurol. 2009 Mar; 66(3):329-35.
        View in: PubMed PMC2739693
      68. Hsu FC, Kritchevsky SB, Liu Y, Kanaya A, Newman AB, Perry SE, Visser M, Pahor M, Harris TB, Nicklas BJ. Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci. 2009 May; 64(5):581-9.
        View in: PubMed PMC2800809
      69. Poehls J, Wassel CL, Harris TB, Havel PJ, Swarbrick MM, Cummings SR, Newman AB, Satterfield S, Kanaya AM. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia. 2009 Apr; 52(4):591-5.
        View in: PubMed PMC2756826
      70. Sarma AV, Kanaya AM, Nyberg LM, Kusek JW, Vittinghoff E, Rutledge B, Cleary PA, Gatcomb P, Brown JS. Urinary incontinence among women with type 1 diabetes--how common is it? J Urol. 2009 Mar; 181(3):1224-30; discussion 1230.
        View in: PubMed PMC2696131
      71. Zhang MH, Spies C, Ali S, Kanaya AM, Schiller NB, Whooley MA. Adiponectin and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study. Atherosclerosis. 2009 Jul; 205(1):233-8.
        View in: PubMed PMC2779844
      72. Cohen BE, Chang AA, Grady D, Kanaya AM. Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial. Metab Syndr Relat Disord. 2008 Sep; 6(3):223-9.
        View in: PubMed
      73. Ix JH, Wassel CL, Kanaya AM, Vittinghoff E, Johnson KC, Koster A, Cauley JA, Harris TB, Cummings SR, Shlipak MG. Fetuin-A and incident diabetes mellitus in older persons. JAMA. 2008 Jul 9; 300(2):182-8.
        View in: PubMed PMC2779582
      74. Kanaya AM. Review: orlistat, sibutramine, and rimonabant reduce weight in overweight and obese persons. ACP J Club. 2008 Mar-Apr; 148(2):50.
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      75. Koster A, Patel KV, Visser M, van Eijk JT, Kanaya AM, de Rekeneire N, Newman AB, Tylavsky FA, Kritchevsky SB, Harris TB. Joint effects of adiposity and physical activity on incident mobility limitation in older adults. J Am Geriatr Soc. 2008 Apr; 56(4):636-43.
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      76. Sutton-Tyrrell K, Venkitachalam L, Kanaya AM, Boudreau R, Harris T, Thompson T, Mackey RH, Visser M, Vaidean GD, Newman AB. Relationship of ankle blood pressures to cardiovascular events in older adults. Stroke. 2008 Mar; 39(3):863-9.
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      77. Shin MJ, Kanaya AM, Krauss RM. Polymorphisms in the peroxisome proliferator activated receptor alpha gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians. Atherosclerosis. 2008 Jun; 198(2):313-9.
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      78. Seligman HK, Bindman AB, Vittinghoff E, Kanaya AM, Kushel MB. Food insecurity is associated with diabetes mellitus: results from the National Health Examination and Nutrition Examination Survey (NHANES) 1999-2002. J Gen Intern Med. 2007 Jul; 22(7):1018-23.
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      79. Ruhl CE, Harris TB, Ding J, Goodpaster BH, Kanaya AM, Kritchevsky SB, Simonsick EM, Tylavsky FA, Everhart JE. Body mass index and serum leptin concentration independently estimate percentage body fat in older adults. Am J Clin Nutr. 2007 Apr; 85(4):1121-6.
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      80. Wassel Fyr CL, Kanaya AM, Cummings SR, Reich D, Hsueh WC, Reiner AP, Harris TB, Moffett S, Li R, Ding J, Miljkovic-Gacic I, Ziv E. Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study. Hum Genet. 2007 Jun; 121(5):615-24.
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      81. Kanaya AM, Barrett-Connor E, Wassel Fyr CL. Endothelin-1 and prevalent coronary heart disease in older men and women (the Rancho Bernardo Study). Am J Cardiol. 2007 Feb 15; 99(4):486-90.
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      82. Tice JA, Kanaya A, Hue T, Rubin S, Buist DS, Lacroix A, Lacey JV, Cauley JA, Litwack S, Brinton LA, Bauer DC. Risk factors for mortality in middle-aged women. Arch Intern Med. 2006 Dec 11-25; 166(22):2469-77.
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      83. Yaffe K, Kanaya AM, Lindquist K, Hsueh WC, Cummings SR, Beamer B, Newman A, Rosano C, Li R, Harris T. PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders. Neurobiol Aging. 2008 Jan; 29(1):78-83.
        View in: PubMed PMC2233891
      84. Huang AJ, Brown JS, Kanaya AM, Creasman JM, Ragins AI, Van Den Eeden SK, Thom DH. Quality-of-life impact and treatment of urinary incontinence in ethnically diverse older women. Arch Intern Med. 2006 Oct 9; 166(18):2000-6.
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      85. Narayan KM, Zhang P, Williams D, Engelgau M, Imperatore G, Kanaya A, Ramachandran A. How should developing countries manage diabetes? CMAJ. 2006 Sep 26; 175(7):733.
        View in: PubMed PMC1569922
      86. Kanaya AM, Wassel Fyr C, Vittinghoff E, Havel PJ, Cesari M, Nicklas B, Harris T, Newman AB, Satterfield S, Cummings SR. Serum adiponectin and coronary heart disease risk in older Black and White Americans. J Clin Endocrinol Metab. 2006 Dec; 91(12):5044-50.
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      87. Cohen BE, Kanaya AM, Macer JL, Shen H, Chang AA, Grady D. Feasibility and acceptability of restorative yoga for treatment of hot flushes: a pilot trial. Maturitas. 2007 Feb 20; 56(2):198-204.
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      88. Maraldi C, Volpato S, Kritchevsky SB, Cesari M, Andresen E, Leeuwenburgh C, Harris TB, Newman AB, Kanaya A, Johnson KC, Rodondi N, Pahor M. Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study. Arch Intern Med. 2006 Jul 24; 166(14):1490-7.
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      89. Shorr RI, de Rekeneire N, Resnick HE, Yaffe K, Somes GW, Kanaya AM, Simonsick EM, Newman AB, Harris TB. Glycemia and cognitive function in older adults using glucose-lowering drugs. J Nutr Health Aging. 2006 Jul-Aug; 10(4):297-301.
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      90. Brown JS, Vittinghoff E, Lin F, Nyberg LM, Kusek JW, Kanaya AM. Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey (NHANES) 2001-2002. Diabetes Care. 2006 Jun; 29(6):1307-12.
        View in: PubMed PMC1557358
      91. Huang AJ, Thom DH, Kanaya AM, Wassel-Fyr CL, Van den Eeden SK, Ragins AI, Subak LL, Brown JS. Urinary incontinence and pelvic floor dysfunction in Asian-American women. Am J Obstet Gynecol. 2006 Nov; 195(5):1331-7.
        View in: PubMed PMC1630451
      92. Nicklas BJ, Cesari M, Penninx BW, Kritchevsky SB, Ding J, Newman A, Kitzman DW, Kanaya AM, Pahor M, Harris TB. Abdominal obesity is an independent risk factor for chronic heart failure in older people. J Am Geriatr Soc. 2006 Mar; 54(3):413-20.
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      93. Kanaya AM, Wassel Fyr C, Vittinghoff E, Harris TB, Park SW, Goodpaster BH, Tylavsky F, Cummings SR. Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med. 2006 Feb 13; 166(3):350-6.
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      94. Brown JS, Wing R, Barrett-Connor E, Nyberg LM, Kusek JW, Orchard TJ, Ma Y, Vittinghoff E, Kanaya AM. Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program. Diabetes Care. 2006 Feb; 29(2):385-90.
        View in: PubMed PMC1557353
      95. Ivey SL, Mehta KM, Fyr CL, Kanaya AM. Prevalence and correlates of cardiovascular risk factors in South Asians: population-based data from two California surveys. Ethn Dis. 2006; 16(4):886-93.
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      96. Yende S, Tuomanen EI, Wunderink R, Kanaya A, Newman AB, Harris T, de Rekeneire N, Kritchevsky SB. Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. Am J Respir Crit Care Med. 2005 Dec 1; 172(11):1440-6.
        View in: PubMed PMC2718438
      97. Sahyoun NR, Anderson AL, Kanaya AM, Koh-Banerjee P, Kritchevsky SB, de Rekeneire N, Tylavsky FA, Schwartz AV, Lee JS, Harris TB. Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults. Am J Clin Nutr. 2005 Sep; 82(3):547-52.
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      98. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Bittner V, Cauley JA, Hulley S, Barrett-Connor E. Impaired fasting glucose and cardiovascular outcomes in postmenopausal women with coronary artery disease. Ann Intern Med. 2005 May 17; 142(10):813-20.
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      99. Spies C, Otte C, Kanaya A, Pipkin SS, Schiller NB, Whooley MA. Association of metabolic syndrome with exercise capacity and heart rate recovery in patients with coronary heart disease in the heart and soul study. Am J Cardiol. 2005 May 15; 95(10):1175-9.
        View in: PubMed PMC2776681
      100. Kanaya AM, Wassel Fyr CL, de Rekeneire N, Shorr RI, Schwartz AV, Goodpaster BH, Newman AB, Harris T, Barrett-Connor E. Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule. Diabetes Care. 2005 Feb; 28(2):404-8.
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      101. Snijder MB, Visser M, Dekker JM, Goodpaster BH, Harris TB, Kritchevsky SB, De Rekeneire N, Kanaya AM, Newman AB, Tylavsky FA, Seidell JC. Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. Diabetologia. 2005 Feb; 48(2):301-8.
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      102. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004 Nov 10; 292(18):2237-42.
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      103. Colbert LH, Rosen CJ, Goodpaster BH, Newman AB, Kritchevsky SB, Satterfield S, Kanaya AM, Taaffe DR, Harris TB. Insulin-like growth factor-1. J Am Geriatr Soc. 2004 Nov; 52(11):1962-3.
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      104. Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB. Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. Am J Epidemiol. 2004 Oct 15; 160(8):741-9.
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      105. Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, Simonsick EM, Tylavsky FA, Harris TB. Serum leptin concentrations and body adipose measures in older black and white adults. Am J Clin Nutr. 2004 Sep; 80(3):576-83.
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      106. Yaffe K, Blackwell T, Kanaya AM, Davidowitz N, Barrett-Connor E, Krueger K. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology. 2004 Aug 24; 63(4):658-63.
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      107. Jackson RA, Vittinghoff E, Kanaya AM, Miles TP, Resnick HE, Kritchevsky SB, Simonsick EM, Brown JS. Urinary incontinence in elderly women: findings from the Health, Aging, and Body Composition Study. Obstet Gynecol. 2004 Aug; 104(2):301-7.
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      108. Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med. 2004 Jun 28; 164(12):1327-33.
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      109. Kanaya AM, Harris T, Goodpaster BH, Tylavsky F, Cummings SR. Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. Diabetes Care. 2004 Jun; 27(6):1375-80.
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      110. Kanaya AM, Vittinghoff E, Shlipak MG, Resnick HE, Visser M, Grady D, Barrett-Connor E. Association of total and central obesity with mortality in postmenopausal women with coronary heart disease. Am J Epidemiol. 2003 Dec 15; 158(12):1161-70.
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      111. Kanaya AM, Narayan KM. Prevention of type 2 diabetes: data from recent trials. Prim Care. 2003 Sep; 30(3):511-26.
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      112. Jha AK, Varosy PD, Kanaya AM, Hunninghake DB, Hlatky MA, Waters DD, Furberg CD, Shlipak MG. Differences in medical care and disease outcomes among black and white women with heart disease. Circulation. 2003 Sep 2; 108(9):1089-94.
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      113. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, Cauley JA, Barrett-Connor E. Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003 Jan 7; 138(1):1-9.
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      114. Narayan KM, Kanaya AM, Gregg EW. Lifestyle intervention for the prevention of type 2 diabetes mellitus: putting theory to practice. Treat Endocrinol. 2003; 2(5):315-20.
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      115. Kanaya AM, Grady D, Barrett-Connor E. Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysis. Arch Intern Med. 2002 Aug 12-26; 162(15):1737-45.
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      116. Kanaya AM, Harris F, Volpato S, Pérez-Stable EJ, Harris T, Bauer DC. Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study. Arch Intern Med. 2002 Apr 8; 162(7):773-9.
        View in: PubMed
      117. Brown JS, Vittinghoff E, Kanaya AM, Agarwal SK, Hulley S, Foxman B. Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factors. Obstet Gynecol. 2001 Dec; 98(6):1045-52.
        View in: PubMed
      118. Kanaya AM, Glidden DV, Chambers HF. Identifying pulmonary tuberculosis in patients with negative sputum smear results. Chest. 2001 Aug; 120(2):349-55.
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