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John Imboden, JR, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Research 
    Collapse Research Activities and Funding
    Immunodominant Epitopes in Kawasaki Disease
    NIH/NHLBI R21HL087905Sep 30, 2007 - Jun 30, 2010
    Role: Principal Investigator
    MUTATIONAL ANALYSIS OF CTLA-4 FUNCTION IN VIVO
    NIH/NIAID R03AI043962Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    MYCOBACTERIUM TUBERCULOSIS;INDUCED MACROPHAGE SIGNALLING
    NIH/NHLBI R01HL051992Sep 30, 1993 - Aug 31, 2003
    Role: Principal Investigator
    GP35--A SIGNAL TRANSDUCER ON NK CELL
    NIH/NCI R01CA052669Aug 6, 1990 - May 31, 1995
    Role: Principal Investigator
    COSTIMULATION OF T LYMPHOCYTES OF CD28
    NIH/NIAID R01AI026644Aug 1, 1988 - Jun 30, 2005
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017 May 11. PMID: 28492133.
      View in: PubMed
    2. Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X, et al. Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1? imaging. J Magn Reson Imaging. 2016 Sep 23. PMID: 27661002.
      View in: PubMed
    3. Barton JL, Trupin L, Schillinger D, Evans-Young G, Imboden J, Montori VM, Yelin E. Use of Low-Literacy Decision Aid to Enhance Knowledge and Reduce Decisional Conflict Among a Diverse Population of Adults With Rheumatoid Arthritis: Results of a Pilot Study. Arthritis Care Res (Hoboken). 2016 Jul; 68(7):889-98. PMID: 26605752.
      View in: PubMed
    4. Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X. High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients. NMR Biomed. 2016 Jan; 29(1):15-23. PMID: 26608949.
      View in: PubMed
    5. Scheibe MM, Imboden JB, Schmajuk G, Margaretten M, Graf JD, Chen AH, Yelin EH, Yazdany J. Efficiency Gains for Rheumatology Consultation Using a Novel Electronic Referral System in a Safety-Net Health Setting. Arthritis Care Res (Hoboken). 2015 Aug; 67(8):1158-63. PMID: 25623810; PMCID: PMC4515392 [Available on 08/01/16].
    6. Hellmann DB, Imboden JB. Update in rheumatology: evidence published in 2014. Ann Intern Med. 2015 May 5; 162(9):W122-6. PMID: 25927977.
      View in: PubMed
    7. Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden J, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. Int J Rheum Dis. 2015 Apr 10. PMID: 25865349.
      View in: PubMed
    8. Yang H, Rivoire J, Hoppe M, Srikhum W, Imboden J, Link TM, Li X. Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist. Skeletal Radiol. 2015 Apr; 44(4):539-47. PMID: 25488101.
      View in: PubMed
    9. Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J. Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. J Am Heart Assoc. 2014 Oct; 3(5):e001267. PMID: 25336464; PMCID: PMC4323827.
    10. Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X. Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis. 2015 Jul; 18(6):628-39. PMID: 25293500.
      View in: PubMed
    11. Carlson AQ, Tuot DS, Jen KY, Butcher B, Graf J, Sam R, Imboden JB. Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. Medicine (Baltimore). 2014 Oct; 93(17):290-7. PMID: 25398064; PMCID: PMC4602417.
    12. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73. PMID: 25086074.
      View in: PubMed
    13. Barton JL, Trupin L, Tonner C, Imboden J, Katz P, Schillinger D, Yelin E. English language proficiency, health literacy, and trust in physician are associated with shared decision making in rheumatoid arthritis. J Rheumatol. 2014 Jul; 41(7):1290-7. PMID: 24931952; PMCID: PMC4286372.
    14. Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U. Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis. Pharmacol Res Perspect. 2013 Dec; 1(2):e00016. PMID: 25505569; PMCID: PMC4186432.
    15. Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013 Dec; 41(12):2553-64. PMID: 23887879; PMCID: PMC3823828.
    16. Richman NC, Yazdany J, Graf J, Chernitskiy V, Imboden JB. Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients. Medicine (Baltimore). 2013 Mar; 92(2):92-7. PMID: 23429352; PMCID: PMC4028062.
    17. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. J Rheumatol. 2013 Apr; 40(4):408-16. PMID: 23418386.
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    18. Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D. Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort. Arthritis Res Ther. 2013; 15(5):R157. PMID: 24432366; PMCID: PMC3978686.
    19. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Arthritis Rheum. 2012 Aug; 64(8):2451-9. PMID: 22392608; PMCID: PMC3374037.
    20. Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Arthritis Rheum. 2011 Dec; 63(12):3998-4001. PMID: 22127712.
      View in: PubMed
    21. Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J. Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):211-7. PMID: 21987483.
      View in: PubMed
    22. Barton JL, Trupin L, Schillinger D, Gansky SA, Tonner C, Margaretten M, Chernitskiy V, Graf J, Imboden J, Yelin E. Racial and ethnic disparities in disease activity and function among persons with rheumatoid arthritis from university-affiliated clinics. Arthritis Care Res (Hoboken). 2011 Sep; 63(9):1238-46. PMID: 21671414; PMCID: PMC3169768.
    23. Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden JB, Grunfeld C. Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis. Rheumatology (Oxford). 2011 Aug; 50(8):1458-65. PMID: 21441551.
      View in: PubMed
    24. Margaretten M, Barton J, Julian L, Katz P, Trupin L, Tonner C, Graf J, Imboden J, Yelin E. Socioeconomic determinants of disability and depression in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011 Feb; 63(2):240-6. PMID: 20824800; PMCID: PMC3716282.
    25. Gratton SB, Imboden JB. A 23-year-old woman with fever, rash, and arthritis. Arthritis Care Res (Hoboken). 2010 Oct; 62(10):1507-12. PMID: 20506489.
      View in: PubMed
    26. Barton JL, Imboden J, Graf J, Glidden D, Yelin EH, Schillinger D. Patient-physician discordance in assessments of global disease severity in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Jun; 62(6):857-64. PMID: 20535797; PMCID: PMC2885009.
    27. Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, Julian L. Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. Arthritis Rheum. 2009 Nov 15; 61(11):1586-91. PMID: 19877099; PMCID: PMC2835470.
    28. Graf J, Scherzer R, Grunfeld C, Imboden J. Levels of C-reactive protein associated with high and very high cardiovascular risk are prevalent in patients with rheumatoid arthritis. PLoS One. 2009; 4(7):e6242. PMID: 19606218; PMCID: PMC2707000.
    29. Ku IA, Imboden JB, Hsue PY, Ganz P. Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ J. 2009 Jun; 73(6):977-85. PMID: 19430165.
      View in: PubMed
    30. Imboden JB. The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol. 2009; 4:417-34. PMID: 18954286.
      View in: PubMed
    31. Hellmann DB, Imboden JB. Update in rheumatology. Ann Intern Med. 2006 Dec 5; 145(11):834-8. PMID: 17146068.
      View in: PubMed
    32. Sadra A, Cinek T, Imboden JB. Translocation of CD28 to lipid rafts and costimulation of IL-2. Proc Natl Acad Sci U S A. 2004 Aug 3; 101(31):11422-7. PMID: 15280538; PMCID: PMC509216.
    33. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr; 5(4):435-42. PMID: 15004555.
      View in: PubMed
    34. Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003 Jan 6; 197(1):129-35. PMID: 12515820; PMCID: PMC2193802.
    35. Imboden JB, Shoback DM, Inokuchi S. Analysis of inositol phospholipid turnover during lymphocyte activation. Curr Protoc Immunol. 2001 May; Chapter 11:Unit 11.1. PMID: 18432702.
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    36. Sadra A, Cinek T, Imboden JB. Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity. Anal Biochem. 2000 Feb 15; 278(2):235-7. PMID: 10660470.
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    37. Cinek T, Sadra A, Imboden JB. Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol. 2000 Jan 1; 164(1):5-8. PMID: 10604984.
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    38. Sadra A, Cinek T, Arellano JL, Shi J, Truitt KE, Imboden JB. Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells. J Immunol. 1999 Feb 15; 162(4):1966-73. PMID: 9973466.
      View in: PubMed
    39. Barz C, Nagel T, Truitt KE, Imboden JB. Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production. J Immunol. 1998 Nov 15; 161(10):5366-72. PMID: 9820510.
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    40. Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med. 1998 Apr 6; 187(7):1157-61. PMID: 9529333; PMCID: PMC2212210.
    41. Daikh D, Wofsy D, Imboden JB. The CD28-B7 costimulatory pathway and its role in autoimmune disease. J Leukoc Biol. 1997 Aug; 62(2):156-62. PMID: 9261329.
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    42. Shapiro VS, Truitt KE, Imboden JB, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol. 1997 Jul; 17(7):4051-8. PMID: 9199340; PMCID: PMC232258.
    43. Shi J, Cinek T, Truitt KE, Imboden JB. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells. J Immunol. 1997 May 15; 158(10):4688-95. PMID: 9144481.
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    44. Imboden J. Turning off natural killers. Innate immunity. Curr Biol. 1996 Sep 1; 6(9):1070-2. PMID: 8805356.
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    45. Truitt KE, Nagel T, Suen LF, Imboden JB. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J Immunol. 1996 Jun 15; 156(12):4539-41. PMID: 8648094.
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    46. Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB. The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2. J Exp Med. 1996 Jan 1; 183(1):169-78. PMID: 8551220; PMCID: PMC2192399.
    47. Truitt KE, Shi J, Gibson S, Segal LG, Mills GB, Imboden JB. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J Immunol. 1995 Nov 15; 155(10):4702-10. PMID: 7594470.
      View in: PubMed
    48. Bell GM, Imboden JB. CD2 and the regulation of T cell anergy. J Immunol. 1995 Sep 15; 155(6):2805-7. PMID: 7673695.
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    49. Imboden JB, Koretsky GA. Intracellular signalling. Switching off signals. Curr Biol. 1995 Jul 1; 5(7):727-9. PMID: 7583115.
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    50. Sánchez-Margalet V, Goldfine ID, Truitt K, Imboden J, Sung CK. Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1. Mol Endocrinol. 1995 Apr; 9(4):435-42. PMID: 7659087.
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    51. Truitt KE, Hicks CM, Imboden JB. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med. 1994 Mar 1; 179(3):1071-6. PMID: 7509360; PMCID: PMC2191424.
    52. Truitt KE, Mills GB, Turck CW, Imboden JB. SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain. J Biol Chem. 1994 Feb 25; 269(8):5937-43. PMID: 7509794.
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    53. Bell GM, Dethloff GM, Imboden JB. CD45-negative mutants of a rat natural killer cell line fail to lyse tumor target cells. J Immunol. 1993 Oct 1; 151(7):3646-53. PMID: 8104222.
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    54. Bell GM, Bolen JB, Imboden J. Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Mol Cell Biol. 1992 Dec; 12(12):5548-54. PMID: 1280324; PMCID: PMC360493.
    55. Weber JR, Bell GM, Han MY, Pawson T, Imboden J. Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor. J Exp Med. 1992 Aug 1; 176(2):373-9. PMID: 1500851; PMCID: PMC2119313.
    56. Bell GM, Seaman WE, Niemi EC, Imboden J. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med. 1992 Feb 1; 175(2):527-36. PMID: 1346273; PMCID: PMC2119111.
    57. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. J Immunol. 1991 Jun 1; 146(11):3703-8. PMID: 2033247.
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    58. Imboden J, Bell G, Seaman WE. Characterization of signal-transducing molecules on natural killer cells. Biochem Soc Trans. 1991 Apr; 19(2):265-8. PMID: 1679728.
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    59. Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden J. Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling. J Exp Med. 1991 Jan 1; 173(1):251-60. PMID: 1845873; PMCID: PMC2118766.
    60. Inokuchi S, Imboden J. Antigen receptor-mediated regulation of sustained polyphosphoinositide turnover in a human T cell line. Evidence for a receptor-regulated pathway for production of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 1990 Apr 15; 265(11):5983-9. PMID: 2156835.
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    61. Imboden J, June CH, McCutcheon MA, Ledbetter JA. Stimulation of CD5 enhances signal transduction by the T cell antigen receptor. J Clin Invest. 1990 Jan; 85(1):130-4. PMID: 1688565; PMCID: PMC296396.
    62. Imboden J, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE. Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. J Immunol. 1989 Nov 1; 143(9):3100-3. PMID: 2809220.
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    63. Imboden JB, Weiss A. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. Biochem J. 1987 Nov 1; 247(3):695-700. PMID: 3426556; PMCID: PMC1148468.
    64. Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol. 1987 Oct 15; 139(8):2755-60. PMID: 3116093.
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    65. Weiss A, Imboden JB. Cell surface molecules and early events involved in human T lymphocyte activation. Adv Immunol. 1987; 41:1-38. PMID: 2961214.
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    66. Imboden JB, Weiss A, Stobo JD. Transmembrane signalling by the T3-antigen receptor complex. Immunol Today. 1985 Nov; 6(11):328-31. PMID: 25291003.
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    67. Kramer PH, Imboden JB, Waldman FM, Turley K, Ports TA. Severe aortic insufficiency in juvenile chronic arthritis. Am J Med. 1983 Jun; 74(6):1088-91. PMID: 6859059.
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