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Abul Abbas

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPathology
Address513 Parnassus Ave
San Francisco CA 94143
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    Other Positions
    TitleChair, Pathology


    Collapse Biography 
    Collapse Awards and Honors
    American Academy of Arts and Sciences2009Fellow
    UCSF2008Outstanding Lecture Series
    American Society of Investigative Pathology2008Rous-Whipple Award
    UCSF2002Outstanding Lecture Series
    National Academy of Sciences2002Member, Institute of Medicine
    Harvard Medical School1994Faculty Prize for Excellence in Teaching
    American Society of Investigative Pathology1987Warner-Lambert/Parke-Davis Award

    Collapse Research 
    Collapse Research Activities and Funding
    FOCIS 2014 - 2018: The 14th through 18th Annual Meetings of the Federation of Cli
    NIH/NIAID R13AI084162Jun 9, 2009 - May 31, 2019
    Role: Co-Principal Investigator
    Interleukin-2 and autoimmune disease
    NIH/NIAID R01AI073656Dec 1, 2007 - Nov 30, 2013
    Role: Principal Investigator
    13th International Congress of Immunology
    NIH/NIAID R13AI075941Jul 1, 2007 - Jun 30, 2008
    Role: Principal Investigator
    Immunodeficiency and Autoimmunity
    NIH/NIAID R01AI064677Feb 1, 2005 - Jan 31, 2011
    Role: Principal Investigator
    Autoimmunity Center of Excellence
    NIH/NIAID U19AI056388Sep 30, 2003 - Apr 30, 2014
    Role: Co-Investigator
    MEMORY T CELL DEVELOPMENT
    NIH/NIAID R01AI045845Aug 1, 2000 - Jul 31, 2005
    Role: Principal Investigator
    REGULATION OF LYMPHOCYTE APOPTOSIS
    NIH/NIAID R01AI042100Jun 1, 1998 - Apr 30, 2006
    Role: Principal Investigator
    MECHANISMS IN THE GENRATION OF PROTECTIVE IMMUNITY
    NIH P01AI037963Jun 1, 1995 - May 31, 2000
    Role: Co-Investigator
    Immune Tolerance and Autoimmunity
    NIH/NIAID P01AI035297Sep 30, 1993 - Jul 31, 2012
    Role: Principal Investigator
    CELLULAR AND MOLECULAR MECHANISMS OF AUTOIMMUNITY
    NIH/NIAID R01AI032531Jan 1, 1993 - Jun 30, 2002
    Role: Principal Investigator
    FUNCTION AND ACTIVATION OF HELPER T LYMPHOCYTES
    NIH/NIAID R37AI025022Jul 1, 1987 - Mar 31, 2004
    Role: Principal Investigator
    FUNCTION AND ACTIVATION OF HELPER T LYMPHOCYTES
    NIH/NIAID R01AI025022Jul 1, 1987 - Jun 30, 1993
    Role: Principal Investigator
    VIRUS TRANSFORMED HAPTEN-SPECIFIC B LYMPHOCYTE LINES
    NIH/NCI R01CA045497Jan 1, 1987 - Dec 31, 1988
    Role: Principal Investigator
    PATHOLOGY B STUDY SECTION
    NIH/CSR U09RG011662Jul 1, 1986 - Jun 30, 1991
    Role: Co-Principal Investigator
    REGULATORY MECHANISMS IN ANTIBODY PRODUCTION
    NIH/NIAID R01AI022802Jun 1, 1986 - May 31, 1996
    Role: Principal Investigator
    REGULATORY MECHANISMS IN ANTIBODY PRODUCTION
    NIH/NIAID R01AI022827Mar 1, 1985 - Feb 28, 1986
    Role: Principal Investigator
    VIRUS TRANSFORMED HAPTEN-SPECIFIC B LYMPHOCYTE LINES
    NIH/NIAID R01AI022560Jan 1, 1985 - Dec 31, 1986
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Abbas A, Trotta E, R Simeonov D, Marson A, Bluestone JA. Revisiting IL-2: Biology and therapeutic prospects. Sci Immunol. 2018 Jul 06; 3(25). PMID: 29980618.
      View in: PubMed
    2. Ali N, Zirak B, Truong HA, Maurano MM, Gratz IK, Abbas A, Rosenblum MD. Skin-Resident T Cells Drive Dermal Dendritic Cell Migration in Response to Tissue Self-Antigen. J Immunol. 2018 Mar 21. PMID: 29563179.
      View in: PubMed
    3. Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas A, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Golab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grzes D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2017; 8:1844. PMID: 29379498.
      View in: PubMed
    4. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas A, Rosenblum MD. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 01; 169(6):1119-1129.e11. PMID: 28552347.
      View in: PubMed
    5. Colmone AC, Sallusto F, Abbas A. Promoting immunology: The future is here. Sci Immunol. 2016 Jul 14; 1(1):aag2713. PMID: 28783678.
      View in: PubMed
    6. Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas A, Rosenblum MD. Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing. J Immunol. 2016 Mar 01; 196(5):2010-4. PMID: 26826250; PMCID: PMC4761457 [Available on 03/01/17].
    7. Rosenblum MD, Way SS, Abbas A. Regulatory T cell memory. Nat Rev Immunol. 2016 Feb; 16(2):90-101. PMID: 26688349.
      View in: PubMed
    8. Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas A, Fischbach MA, Rosenblum MD. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17; 43(5):1011-21. PMID: 26588783; PMCID: PMC4654993 [Available on 11/17/16].
    9. Rosenblum MD, Remedios KA, Abbas A. Mechanisms of human autoimmunity. J Clin Invest. 2015 Jun; 125(6):2228-33. PMID: 25893595; PMCID: PMC4518692.
    10. Klatzmann D, Abbas A. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol. 2015 May; 15(5):283-94. PMID: 25882245.
      View in: PubMed
    11. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas A, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar; 124(3):1027-36. PMID: 24509084; PMCID: PMC3934172.
    12. Gratz IK, Rosenblum MD, Maurano MM, Paw JS, Truong HA, Marshak-Rothstein A, Abbas A. Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. J Immunol. 2014 Feb 15; 192(4):1351-5. PMID: 24442443; PMCID: PMC3925257.
    13. Abbas A, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr; 14(4):307-8. PMID: 23507634.
      View in: PubMed
    14. Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas A, Rosenblum MD. Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol. 2013 May 01; 190(9):4483-7. PMID: 23543753; PMCID: PMC3660612.
    15. Gratz IK, Rosenblum MD, Abbas A. The life of regulatory T cells. Ann N Y Acad Sci. 2013 Apr; 1283:8-12. PMID: 23402657.
      View in: PubMed
    16. Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas A, Dooms H. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12668-73. PMID: 22733744; PMCID: PMC3411948.
    17. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas A, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91. PMID: 22570807.
      View in: PubMed
    18. Rosenblum MD, Gratz IK, Paw JS, Abbas A. Treating human autoimmunity: current practice and future prospects. Sci Transl Med. 2012 Mar 14; 4(125):125sr1. PMID: 22422994; PMCID: PMC4061980.
    19. Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas A. Response to self antigen imprints regulatory memory in tissues. Nature. 2011 Nov 27; 480(7378):538-42. PMID: 22121024; PMCID: PMC3263357.
    20. Abbas A. A network of regulatory pathways in lepromatous leprosy. Clin Immunol. 2011 Nov; 141(2):127. PMID: 21903479.
      View in: PubMed
    21. Katzman SD, Hoyer KK, Dooms H, Gratz IK, Rosenblum MD, Paw JS, Isakson SH, Abbas A. Opposing functions of IL-2 and IL-7 in the regulation of immune responses. Cytokine. 2011 Oct; 56(1):116-21. PMID: 21807532; PMCID: PMC3171642.
    22. Katzman SD, Gallo E, Hoyer KK, Abbas A. Differential requirements for Th1 and Th17 responses to a systemic self-antigen. J Immunol. 2011 Apr 15; 186(8):4668-73. PMID: 21402892.
      View in: PubMed
    23. Villarino AV, Katzman SD, Gallo E, Miller O, Jiang S, McManus MT, Abbas A. Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells. Immunity. 2011 Jan 28; 34(1):50-60. PMID: 21236706; PMCID: PMC3955755.
    24. Barron L, Dooms H, Hoyer KK, Kuswanto W, Hofmann J, O'Gorman WE, Abbas A. Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J Immunol. 2010 Dec 01; 185(11):6426-30. PMID: 21037099; PMCID: PMC3059533.
    25. Villarino AV, Gallo E, Abbas A. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol. 2010 Dec 01; 185(11):6461-71. PMID: 20974984; PMCID: PMC2988093.
    26. Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas A. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18085-90. PMID: 20921406; PMCID: PMC2964228.
    27. Dooms H, Abbas A. Revisiting the role of IL-2 in autoimmunity. Eur J Immunol. 2010 Jun; 40(6):1538-40. PMID: 20458706.
      View in: PubMed
    28. Caretto D, Katzman SD, Villarino AV, Gallo E, Abbas A. Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol. 2010 Jan 01; 184(1):30-4. PMID: 19949064; PMCID: PMC2908389.
    29. O'Gorman WE, Dooms H, Thorne SH, Kuswanto WF, Simonds EF, Krutzik PO, Nolan GP, Abbas A. The initial phase of an immune response functions to activate regulatory T cells. J Immunol. 2009 Jul 01; 183(1):332-9. PMID: 19542444; PMCID: PMC2753472.
    30. Lohr J, Knoechel B, Caretto D, Abbas A. Balance of Th1 and Th17 effector and peripheral regulatory T cells. Microbes Infect. 2009 Apr; 11(5):589-93. PMID: 19376259; PMCID: PMC2720614.
    31. Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas A, Sharpe AH, Sansom DM, Walker LS. Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J Immunol. 2009 Jan 01; 182(1):274-82. PMID: 19109158.
      View in: PubMed
    32. Hoyer KK, Dooms H, Barron L, Abbas A. Interleukin-2 in the development and control of inflammatory disease. Immunol Rev. 2008 Dec; 226:19-28. PMID: 19161413.
      View in: PubMed
    33. Hoyer KK, Kuswanto WF, Gallo E, Abbas A. Distinct roles of helper T-cell subsets in a systemic autoimmune disease. Blood. 2009 Jan 08; 113(2):389-95. PMID: 18815283; PMCID: PMC2615653.
    34. Barron L, Knoechel B, Lohr J, Abbas A. Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance. J Immunol. 2008 Mar 01; 180(5):2762-6. PMID: 18292495.
      View in: PubMed
    35. Rock KL, Benacerraf B, Abbas A. Pillars article: antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. 1984. J Immunol. 2007 Dec 01; 179(11):7194-205. PMID: 18025159.
      View in: PubMed
    36. van Schaik SM, Abbas A. Role of T cells in a murine model of Escherichia coli sepsis. Eur J Immunol. 2007 Nov; 37(11):3101-10. PMID: 17948264.
      View in: PubMed
    37. Hoyer KK, Wolslegel K, Dooms H, Abbas A. Targeting T cell-specific costimulators and growth factors in a model of autoimmune hemolytic anemia. J Immunol. 2007 Sep 01; 179(5):2844-50. PMID: 17709498.
      View in: PubMed
    38. Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas A, Bluestone JA. Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J Immunol. 2007 Jul 15; 179(2):1004-12. PMID: 17617592.
      View in: PubMed
    39. Abbas A, Lohr J, Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun. 2007 Mar-May; 28(2-3):59-61. PMID: 17363216; PMCID: PMC2700848.
    40. Dooms H, Wolslegel K, Lin P, Abbas A. Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med. 2007 Mar 19; 204(3):547-57. PMID: 17312008; PMCID: PMC2137906.
    41. Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas A. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med. 2006 Dec 25; 203(13):2785-91. PMID: 17130300; PMCID: PMC2118184.
    42. Sharpe AH, Abbas A. T-cell costimulation--biology, therapeutic potential, and challenges. N Engl J Med. 2006 Sep 07; 355(10):973-5. PMID: 16908487.
      View in: PubMed
    43. Fife BT, Griffin MD, Abbas A, Locksley RM, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006 Aug; 116(8):2252-61. PMID: 16886063; PMCID: PMC1523399.
    44. Lohr J, Knoechel B, Abbas A. Regulatory T cells in the periphery. Immunol Rev. 2006 Aug; 212:149-62. PMID: 16903912.
      View in: PubMed
    45. Dooms H, Abbas A. Control of CD4+ T-cell memory by cytokines and costimulators. Immunol Rev. 2006 Jun; 211:23-38. PMID: 16824114.
      View in: PubMed
    46. Knoechel B, Lohr J, Zhu S, Wong L, Hu D, Ausubel L, Abbas A. Functional and molecular comparison of anergic and regulatory T lymphocytes. J Immunol. 2006 Jun 01; 176(11):6473-83. PMID: 16709804.
      View in: PubMed
    47. Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas A. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med. 2005 Nov 21; 202(10):1375-86. PMID: 16287710; PMCID: PMC2212975.
    48. Knoechel B, Lohr J, Kahn E, Abbas A. The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance. J Immunol. 2005 Jul 01; 175(1):21-6. PMID: 15972626.
      View in: PubMed
    49. Chikuma S, Abbas A, Bluestone JA. B7-independent inhibition of T cells by CTLA-4. J Immunol. 2005 Jul 01; 175(1):177-81. PMID: 15972645.
      View in: PubMed
    50. Rioux JD, Abbas A. Paths to understanding the genetic basis of autoimmune disease. Nature. 2005 Jun 02; 435(7042):584-9. PMID: 15931210.
      View in: PubMed
    51. Lohr J, Knoechel B, Nagabhushanam V, Abbas A. T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens. Immunol Rev. 2005 Apr; 204:116-27. PMID: 15790354.
      View in: PubMed
    52. Abbas A, Sharpe AH. Dendritic cells giveth and taketh away. Nat Immunol. 2005 Mar; 6(3):227-8. PMID: 15716967.
      View in: PubMed
    53. Abbas A, Lohr J, Knoechel B, Nagabhushanam V. T cell tolerance and autoimmunity. Autoimmun Rev. 2004 Nov; 3(7-8):471-5. PMID: 15546793.
      View in: PubMed
    54. Lohr J, Knoechel B, Kahn EC, Abbas A. Role of B7 in T cell tolerance. J Immunol. 2004 Oct 15; 173(8):5028-35. PMID: 15470046.
      View in: PubMed
    55. Sarween N, Chodos A, Raykundalia C, Khan M, Abbas A, Walker LS. CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol. 2004 Sep 01; 173(5):2942-51. PMID: 15322152.
      View in: PubMed
    56. Eggena MP, Walker LS, Nagabhushanam V, Barron L, Chodos A, Abbas A. Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J Exp Med. 2004 Jun 21; 199(12):1725-30. PMID: 15210748.
      View in: PubMed
    57. Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas A, Krummel MF. CD28 signals in the immature immunological synapse. J Immunol. 2004 May 15; 172(10):5880-6. PMID: 15128767.
      View in: PubMed
    58. Dooms H, Kahn E, Knoechel B, Abbas A. IL-2 induces a competitive survival advantage in T lymphocytes. J Immunol. 2004 May 15; 172(10):5973-9. PMID: 15128779.
      View in: PubMed
    59. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas A. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr; 5(4):435-42. PMID: 15004555.
      View in: PubMed
    60. Walker LS, Chodos A, Eggena M, Dooms H, Abbas A. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med. 2003 Jul 21; 198(2):249-58. PMID: 12874258.
      View in: PubMed
    61. Abbas A, Sen R. The activation of lymphocytes is in their CARMA. Immunity. 2003 Jun; 18(6):721-2. PMID: 12818152.
      View in: PubMed
    62. Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas A. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol. 2003 Jul; 4(7):664-9. PMID: 12766766.
      View in: PubMed
    63. Abbas A. The control of T cell activation vs. tolerance. Autoimmun Rev. 2003 May; 2(3):115-8. PMID: 12848951.
      View in: PubMed
    64. Bluestone JA, Abbas A. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003 Mar; 3(3):253-7. PMID: 12658273.
      View in: PubMed
    65. Walker LS, Ausubel LJ, Chodos A, Bekarian N, Abbas A. CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen. J Immunol. 2002 Dec 01; 169(11):6202-9. PMID: 12444125.
      View in: PubMed
    66. Refaeli Y, Van Parijs L, Alexander SI, Abbas A. Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med. 2002 Oct 07; 196(7):999-1005. PMID: 12370261; PMCID: PMC2194022.
    67. Ausubel LJ, Chodos A, Bekarian N, Abbas A, Walker LS. Functional tolerance is maintained despite proliferation of CD4 T cells after encounter with tissue-derived antigen. Dev Immunol. 2002 Sep; 9(3):173-6. PMID: 12885158; PMCID: PMC2276103.
    68. Dooms H, Abbas A. Life and death in effector T cells. Nat Immunol. 2002 Sep; 3(9):797-8. PMID: 12205464.
      View in: PubMed
    69. Walker LS, Abbas A. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol. 2002 Jan; 2(1):11-9. PMID: 11908514.
      View in: PubMed