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    Kurt Giles, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentInstitute for Neurodegenerative Diseases
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    Phone415-502-7090
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB, et al. Optimization of aryl amides that extend survival in prion-infected mice. J Pharmacol Exp Ther. 2016 Jun 17. PMID: 27317802.
        View in: PubMed
      2. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. PMID: 26324905; PMCID: PMC4586853 [Available on 03/22/16].
      3. Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB. Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation. Ann Neurol. 2015 Oct; 78(4):540-53. PMID: 26094969.
        View in: PubMed
      4. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A. 2015 Sep 1; 112(35):E4949-58. PMID: 26286986; PMCID: PMC4568231 [Available on 03/01/16].
      5. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. PMID: 26224882; PMCID: PMC4576665 [Available on 10/01/16].
      6. Berry D, Giles K, Oehler A, Bhardwaj S, DeArmond SJ, Prusiner SB. Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. J Infect Dis. 2015 Jul 15; 212 Suppl 1:S17-25. PMID: 26116725; PMCID: PMC4551108 [Available on 07/15/16].
      7. Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aß prions from Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10323-8. PMID: 24982139; PMCID: PMC4104857.
      8. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aß prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. PMID: 24982137; PMCID: PMC4104853.
      9. Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB. Evidence that bank vole PrP is a universal acceptor for prions. PLoS Pathog. 2014 Apr; 10(4):e1003990. PMID: 24699458; PMCID: PMC3974871.
      10. Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorg Med Chem. 2014 Mar 15; 22(6):1960-72. PMID: 24530226; PMCID: PMC3984052.
      11. Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Transmission of multiple system atrophy prions to transgenic mice. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19555-60. PMID: 24218576; PMCID: PMC3845125.
      12. Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Drug resistance confounding prion therapeutics. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):E4160-9. PMID: 24128760; PMCID: PMC3816483.
      13. Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB. Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice. J Pharmacol Exp Ther. 2013 Nov; 347(2):325-38. PMID: 23965382; PMCID: PMC3807058.
      14. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. PMID: 23417511; PMCID: PMC3640342.
      15. Tamgüney G, Giles K, Oehler A, Johnson NL, DeArmond SJ, Prusiner SB. Chimeric elk/mouse prion proteins in transgenic mice. J Gen Virol. 2013 Feb; 94(Pt 2):443-52. PMID: 23100369; PMCID: PMC3709613.
      16. Ahn M, Ghaemmaghami S, Huang Y, Phuan PW, May BC, Giles K, DeArmond SJ, Prusiner SB. Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter. PLoS One. 2012; 7(7):e39112. PMID: 22768295; PMCID: PMC3388068.
      17. Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K. Purified and synthetic Alzheimer's amyloid beta (Aß) prions. Proc Natl Acad Sci U S A. 2012 Jul 3; 109(27):11025-30. PMID: 22711819; PMCID: PMC3390876.
      18. Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB. Identification of I137M and other mutations that modulate incubation periods for two human prion strains. J Virol. 2012 Jun; 86(11):6033-41. PMID: 22438549; PMCID: PMC3372217.
      19. Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB. Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3498-503. PMID: 22331873; PMCID: PMC3295307.
      20. Nazor Friberg K, Hung G, Wancewicz E, Giles K, Black C, Freier S, Bennett F, Dearmond SJ, Freyman Y, Lessard P, Ghaemmaghami S, Prusiner SB. Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice. Mol Ther Nucleic Acids. 2012; 1:e9. PMID: 23344724; PMCID: PMC3381600.
      21. Tamgüney G, Richt JA, Hamir AN, Greenlee JJ, Miller MW, Wolfe LL, Sirochman TM, Young AJ, Glidden DV, Johnson NL, Giles K, DeArmond SJ, Prusiner SB. Salivary prions in sheep and deer. Prion. 2012 Jan-Mar; 6(1):52-61. PMID: 22453179; PMCID: PMC3338966.
      22. Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K. Spontaneous generation of anchorless prions in transgenic mice. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21223-8. PMID: 22160704; PMCID: PMC3248514.
      23. Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB. Protease-resistant prions selectively decrease Shadoo protein. PLoS Pathog. 2011 Nov; 7(11):e1002382. PMID: 22163178; PMCID: PMC3219722.
      24. Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB. Conserved properties of human and bovine prion strains on transmission to guinea pigs. Lab Invest. 2011 Sep; 91(9):1326-36. PMID: 21727894; PMCID: PMC3164925.
      25. Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2528-33. PMID: 21262831; PMCID: PMC3038719.
      26. Zhang Y, Kim SO, Opsahl-Vital S, Ho SP, Souron JB, Kim C, Giles K, Den Besten PK. Multiple effects of the cellular prion protein on tooth development. Int J Dev Biol. 2011; 55(10-12):953-60. PMID: 22252492.
        View in: PubMed
      27. Giles K, Glidden DV, Patel S, Korth C, Groth D, Lemus A, DeArmond SJ, Prusiner SB. Human prion strain selection in transgenic mice. Ann Neurol. 2010 Aug; 68(2):151-61. PMID: 20695008; PMCID: PMC2935907.
      28. Ghaemmaghami S, Ahn M, Lessard P, Giles K, Legname G, DeArmond SJ, Prusiner SB. Continuous quinacrine treatment results in the formation of drug-resistant prions. PLoS Pathog. 2009 Nov; 5(11):e1000673. PMID: 19956709; PMCID: PMC2777304.
      29. Colby DW, Giles K, Legname G, Wille H, Baskakov IV, DeArmond SJ, Prusiner SB. Design and construction of diverse mammalian prion strains. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20417-22. PMID: 19915150; PMCID: PMC2787151.
      30. Tamgüney G, Francis KP, Giles K, Lemus A, DeArmond SJ, Prusiner SB. Measuring prions by bioluminescence imaging. Proc Natl Acad Sci U S A. 2009 Sep 1; 106(35):15002-6. PMID: 19706444; PMCID: PMC2736416.
      31. Tamgüney G, Miller MW, Giles K, Lemus A, Glidden DV, DeArmond SJ, Prusiner SB. Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein. J Gen Virol. 2009 Apr; 90(Pt 4):1035-47. PMID: 19264659; PMCID: PMC2804060.
      32. Giles K, Glidden DV, Beckwith R, Seoanes R, Peretz D, DeArmond SJ, Prusiner SB. Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation. PLoS Pathog. 2008 Nov; 4(11):e1000206. PMID: 19008948; PMCID: PMC2576443.
      33. Spilman P, Lessard P, Sattavat M, Bush C, Tousseyn T, Huang EJ, Giles K, Golde T, Das P, Fauq A, Prusiner SB, Dearmond SJ. A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10595-600. PMID: 18647832; PMCID: PMC2492499.
      34. Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-88. PMID: 18559949; PMCID: PMC2828448.
      35. Phuan PW, Zorn JA, Safar J, Giles K, Prusiner SB, Cohen FE, May BC. Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds. J Gen Virol. 2007 Apr; 88(Pt 4):1392-401. PMID: 17374787.
        View in: PubMed
      36. Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB. Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells. Mol Med. 2007 Mar-Apr; 13(3-4):190-8. PMID: 17592554; PMCID: PMC1892763.
      37. Philipp WJ, Groth D, Giles K, Vodrazka P, Schimmel H, Feyssaguet M, Toomik R, Schacher P, Osman AA, Lachmann I, Wear A, Arsac JN, Prusiner SB. Transgenic mouse brains for the evaluation and quality control of BSE tests. Biol Chem. 2007 Mar; 388(3):349-54. PMID: 17338644.
        View in: PubMed
      38. Tamgüney G, Giles K, Bouzamondo-Bernstein E, Bosque PJ, Miller MW, Safar J, DeArmond SJ, Prusiner SB. Transmission of elk and deer prions to transgenic mice. J Virol. 2006 Sep; 80(18):9104-14. PMID: 16940522; PMCID: PMC1563923.
      39. Peretz D, Supattapone S, Giles K, Vergara J, Freyman Y, Lessard P, Safar JG, Glidden DV, McCulloch C, Nguyen HO, Scott M, Dearmond SJ, Prusiner SB. Inactivation of prions by acidic sodium dodecyl sulfate. J Virol. 2006 Jan; 80(1):322-31. PMID: 16352557; PMCID: PMC1317507.
      40. Safar JG, Geschwind MD, Deering C, Didorenko S, Sattavat M, Sanchez H, Serban A, Vey M, Baron H, Giles K, Miller BL, Dearmond SJ, Prusiner SB. Diagnosis of human prion disease. Proc Natl Acad Sci U S A. 2005 Mar 1; 102(9):3501-6. PMID: 15741275; PMCID: PMC552933.
      41. Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL. Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr D Biol Crystallogr. 2000 Nov; 56(Pt 11):1385-94. PMID: 11053835.
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      42. Navaratnam DS, Fernando FS, Priddle JD, Giles K, Clegg SM, Pappin DJ, Craig I, Smith AD. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. J Neurochem. 2000 May; 74(5):2146-53. PMID: 10800960.
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      43. Cousin X, Hotelier T, Giles K, Toutant JP, Chatonnet A. aCHEdb: the database system for ESTHER, the alpha/beta fold family of proteins and the Cholinesterase gene server. Nucleic Acids Res. 1998 Jan 1; 26(1):226-8. PMID: 9399841; PMCID: PMC147245.
      44. Giles K. Interactions underlying subunit association in cholinesterases. Protein Eng. 1997 Jun; 10(6):677-85. PMID: 9278281.
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      45. Cousin X, Hotelier T, Giles K, Lievin P, Toutant JP, Chatonnet A. The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER. Nucleic Acids Res. 1997 Jan 1; 25(1):143-6. PMID: 9016525; PMCID: PMC146416.
      46. Webb CP, Nedergaard S, Giles K, Greenfield SA. Involvement of the NMDA receptor in a non-cholinergic action of acetylcholinesterase in guinea-pig substantia nigra pars compacta neurons. Eur J Neurosci. 1996 Apr; 8(4):837-41. PMID: 9081636.
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