Saul Villeda, PhD

Title(s)Associate Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #1349C
San Francisco CA 94117
Phone415-502-1929
ORCID ORCID Icon0000-0002-2726-9582 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityPh.D.2011Neuroscience
    University of California, Los AngelesB.S.2004Physiological Science
    Collapse Awards and Honors
    2023Byers Award in Basic Science
    2022McKnight Brain Research Foundation Innovator Award in Cognitive Aging and Memory Loss
    2019Endowed Chair in Biomedical Sciences
    2018W.M. Keck Foundation Medical Research Award (Co-PI)
    2015Glenn Award for Research on the Biological Mechanisms of Aging
    2012NIH Director's Early Independence Award (DP5)

    Collapse Overview 
    Collapse Overview
    My lab has previously shown that systemic manipulations such as heterochronic parabiosis (in which the circulatory system of an old and young animal are connected), administration of young blood plasma, or administration of exercise-induced blood factors can partially reverse age-related loss of plasticity in the aged brain. As a consequence, we can now consider reactivating latent plasticity dormant in the aged brain as a means to rejuvenate regenerative, synaptic and cognitive functions late in life. Interestingly, work from my lab has revealed bi-directionality in the influence of the systemic environment indicating pro-youthful factors in young blood or following exercise elicit rejuvenation while pro-aging factors in old blood drive pre-mature aging. Our work has further indicated that mitigating the effect of pro-aging factors in old blood may also provide an effective approach to rejuvenate aging phenotypes. The goal of my research program is to elucidate cellular and molecular mechanisms that can be targeted to halt the aging process or promote rejuvenation in the old brain, as a means to counteract dementia-related neurodegenerative disease in the elderly, providing a unique therapeutic approach.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Cellular and Tissue Rejuvenation through Transcriptional Reprogramming
    NIH R01AG083524Aug 1, 2023 - Apr 30, 2028
    Role: Co-Investigator
    Systemic Mechanisms of Brain Rejuvenation
    NIH R01AG077816Jun 15, 2022 - Feb 28, 2027
    Role: Principal Investigator
    Pro-youthful role of Gpld1 on regenerative and cognitive function in the aged brain
    NIH R01AG077770May 15, 2022 - Apr 30, 2027
    Role: Principal Investigator
    Role of exercise-induced blood factors in rejuvenating the aged brain
    NIH R01AG067740May 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Role of O-GlcNAcylation in Regulating Neurodegeneration in Aging and Alzheimer?s Disease
    NIH RF1AG062357Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Investigating the pro-aging role of B2M and MHC molecules on regenerative and cognitive function in the brain
    NIH R01AG055797Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Mechanisms of brain rejuvenation
    NIH R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice. Mol Ther. 2024 Apr 03; 32(4):935-951. Clarke MT, Remesal L, Lentz L, Tan DJ, Young D, Thapa S, Namuduri SR, Borges B, Kirn G, Valencia J, Lopez ME, Lui JH, Shiow LR, Dindot S, Villeda S, Sanders SJ, MacKenzie TC. PMID: 38327047.
      View in: PubMed   Mentions:    Fields:    
    2. Plasma rejuvenation factor GDF11 associates with amyloid-related cognitive decline in older adults across the Alzheimer’s Disease spectrum. Alzheimer's & Dementia. 2023 Dec 25; 19(S15). Lee LS, Paolillo PE, Saloner SR, VandeBunte VA, Rabinovici RG, La Joie LR, Kramer KJ, Villeda VS, Casaletto CK. .
      View in: Publisher Site   Mentions:
    3. Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females. bioRxiv. 2023 Nov 16. Babey ME, Krause WC, Herber CB, Chen K, Nikkanen J, Rodriquez R, Zhang X, Castro-Navarro F, Wang Y, Villeda S, Lane NE, Scheller EL, Chan CKF, Ambrosi TH, Ingraham HA. PMID: 37693376; PMCID: PMC10491109.
      View in: PubMed   Mentions:
    4. Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species. Cell Rep. 2023 09 26; 42(9):113151. Stevenson ME, Bieri G, Kaletsky R, St Ange J, Remesal L, Pratt KJB, Zhou S, Weng Y, Murphy CT, Villeda SA. PMID: 37713310; PMCID: PMC10627507.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. Nat Aging. 2023 09; 3(9):1067-1078. Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB. PMID: 37587231; PMCID: PMC10501899.
      View in: PubMed   Mentions: 8  Translation:Animals
    6. Platelet factors attenuate inflammation and rescue cognition in ageing. Nature. 2023 Aug; 620(7976):1071-1079. Schroer AB, Ventura PB, Sucharov J, Misra R, Chui MKK, Bieri G, Horowitz AM, Smith LK, Encabo K, Tenggara I, Couthouis J, Gross JD, Chan JM, Luke A, Villeda SA. PMID: 37587343; PMCID: PMC10468395.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nat Commun. 2023 08 16; 14(1):4375. Leiter O, Brici D, Fletcher SJ, Yong XLH, Widagdo J, Matigian N, Schroer AB, Bieri G, Blackmore DG, Bartlett PF, Anggono V, Villeda SA, Walker TL. PMID: 37587147; PMCID: PMC10432533.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Pain and Itch Processing in Aged Mice. J Pain. 2024 Jan; 25(1):53-63. Braz JM, Hamel K, Craik V, Rodriguez-Rosado S, Bhardwaj K, Jewell M, Bieri G, Villeda SA, Basbaum AI. PMID: 37482234.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study. Front Mol Biosci. 2023; 10:1196083. de Sousa DMB, Poupardin R, Villeda SA, Schroer AB, Fröhlich T, Frey V, Staffen W, Mrowetz H, Altendorfer B, Unger MS, Iglseder B, Paulweber B, Trinka E, Cadamuro J, Drerup M, Schallmoser K, Aigner L, Kniewallner KM. PMID: 37457829; PMCID: PMC10348715.
      View in: PubMed   Mentions:
    10. Neurobiology of Aging: New Insights From Across the Research Spectrum. J Gerontol A Biol Sci Med Sci. 2023 06 01; 78(6):869-871. Villeda S, Brown-Borg H, Anderson R. PMID: 37264524; PMCID: PMC10465077.
      View in: PubMed   Mentions:    Fields:    
    11. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function. Cell Rep. 2023 Feb 28; 42(2):111926. Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA. PMID: 36719799.
      View in: PubMed   Mentions:    Fields:    
    12. Blood-to-brain communication in aging and rejuvenation. Nat Neurosci. 2023 03; 26(3):379-393. Bieri G, Schroer AB, Villeda SA. PMID: 36646876.
      View in: PubMed   Mentions: 19     Fields:    
    13. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function. Cell Rep. 2022 11 08; 41(6):111612. Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA. PMID: 36351399; PMCID: PMC10032941.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Reply to 'Lactate as a major myokine and exerkine'. Nat Rev Endocrinol. 2022 11; 18(11):713. Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder M. PMID: 35915255.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Corrigendum: Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury. Front Neurol. 2022; 13:730576. Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T. PMID: 35847232; PMCID: PMC9277579.
      View in: PubMed   Mentions:
    16. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Sci Adv. 2022 05 06; 8(18):eabm2545. Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, Villeda SA, Piao X. PMID: 35544642; PMCID: PMC9075805.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Exerkines in health, resilience and disease. Nat Rev Endocrinol. 2022 05; 18(5):273-289. Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder MP. PMID: 35304603; PMCID: PMC9554896.
      View in: PubMed   Mentions: 128     Fields:    Translation:Humans
    18. SYSTEMIC MECHANISMS OF BRAIN REJUVENATION. Innovation in Aging. 2021 Dec 17; 5(Suppl 1):198-198. Villeda VS. .
      View in: Publisher Site   Mentions:
    19. MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling. PLoS Biol. 2021 06; 19(6):e3001311. Lin K, Bieri G, Gontier G, Müller S, Smith LK, Snethlage CE, White CW, Maybury-Lewis SY, Villeda SA. PMID: 34181639; PMCID: PMC8270425.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions. J Exp Med. 2021 07 05; 218(7). Ho TT, Dellorusso PV, Verovskaya EV, Bakker ST, Flach J, Smith LK, Ventura PB, Lansinger OM, Hérault A, Zhang SY, Kang YA, Mitchell CA, Villeda SA, Passegué E. PMID: 34032859; PMCID: PMC8155813.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    21. O27: MICROGLIAL CORRECTION AFTER FETAL THERAPY WITHOUT CONDITIONING IN MICE WITH MUCOPOLYSACCHARIDOSIS TYPE VII. British Journal of Surgery. 2021 Apr 27; 108(Supplement_1):znab117.027. Nguyen NQ, Witt WR, Bowen BW, Eikani EC, Shea SJ, Smith SL, Boyle BG, Cadaoas CJ, Sper SR, MacKenzie MJ, Villeda VS, MacKenzie MT. .
      View in: Publisher Site   Mentions:
    22. Regeneration and Cognition in Aging. Innovation in Aging. 2020 Dec 16; 4(Suppl 1):738-738. Villeda VS. .
      View in: Publisher Site   Mentions:
    23. Cognitive Aging: New Insights Into How Our Brains Age. Innovation in Aging. 2020 Dec 16; 4(Suppl 1):738-738. Murphy MC, Villeda VS. .
      View in: Publisher Site   Mentions:
    24. Dampening the Power of the Brain-When Aging Meets Cognition. J Gerontol A Biol Sci Med Sci. 2020 09 16; 75(9):1607-1608. Shea JM, Villeda SA. PMID: 32936914; PMCID: PMC7494031.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    25. Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22214-22224. White CW, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA. PMID: 32848054; PMCID: PMC7486730.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    26. The aged hematopoietic system promotes hippocampal-dependent cognitive decline. Aging Cell. 2020 08; 19(8):e13192. Smith LK, Verovskaya E, Bieri G, Horowitz AM, von Ungern-Sternberg SNI, Lin K, Seizer P, Passegué E, Villeda SA. PMID: 33073926; PMCID: PMC7431826.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Science. 2020 07 10; 369(6500):167-173. Horowitz AM, Fan X, Bieri G, Smith LK, Sanchez-Diaz CI, Schroer AB, Gontier G, Casaletto KB, Kramer JH, Williams KE, Villeda SA. PMID: 32646997; PMCID: PMC7879650.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    28. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nat Metab. 2020 08; 2(8):688-702. Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbären N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A. PMID: 32694825; PMCID: PMC7438316.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    29. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII. Sci Transl Med. 2020 02 26; 12(532). Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC. PMID: 32102934.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    30. OPCs on a Diet: A Youthful Serving of Remyelination. Cell Metab. 2019 12 03; 30(6):1004-1006. White CW, Pratt K, Villeda SA. PMID: 31801054.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    31. MECHANISMS OF BRAIN REJUVENATION. Innovation in Aging. 2019 Nov 8; 3(Supplement_1):s587-s587. Villeda VS. .
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    32. Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. Curr Biol. 2019 10 21; 29(20):3359-3369.e4. Wheatley EG, Albarran E, White CW, Bieri G, Sanchez-Diaz C, Pratt K, Snethlage CE, Ding JB, Villeda SA. PMID: 31588002; PMCID: PMC7199460.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    33. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity. 2019 06 18; 50(6):1425-1438.e5. Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. PMID: 31128962; PMCID: PMC6645687.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    34. Innovative approaches in cognitive aging. Neurobiol Aging. 2019 11; 83:150-154. Austad SN, Wood MA, Villeda SA, Voss JL, Sahay A, Albert M. PMID: 31277894; PMCID: PMC7039185.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    35. Platelets Give a Running Start to Adult Hippocampal Neurogenesis. Stem Cell Reports. 2019 04 09; 12(4):643-646. Schroer AB, Horowitz AM, Villeda SA. PMID: 30951653; PMCID: PMC6450820.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    36. Fetal enzyme replacement and stem cell transplantation in murine Sly syndrome targeting microglia. Molecular Genetics and Metabolism. 2019 Feb 1; 126(2):s107. Nguyen NQ, Witt WR, Smith SL, Shea SJ, Wang WB, Eikani EC, Villeda VS, MacKenzie MT. .
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    37. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nat Metab. 2019 02; 1(2):276-290. Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H. PMID: 31489403; PMCID: PMC6727652.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    38. Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Mol Neurodegener. 2018 12 29; 13(1):68. Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T. PMID: 30594228; PMCID: PMC6310967.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Hematopoietic Stem Cell Transplantation Using a Non-Toxic Regimen to Ablate the Fetal Bone Marrow Niche Enables Engraftment of Brain Microglial Cells. Journal of the American College of Surgeons. 2018 Oct 1; 227(4):s252-s253. Nguyen NQ, Witt WR, Wang WB, Shea SJ, Villeda VS, Mackenzie MT. .
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    40. 1021 Origin of type 2 innate lymphoid cells in the skin. Journal of Investigative Dermatology. 2018 May 1; 138(5):s173. Lee LJ, Schneider SC, Liang LH, Ricardo-Gonzalez RR, Nussbaum NJ, Smith SL, Villeda VS, Locksley LR. .
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    41. Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain. Cell Rep. 2018 02 20; 22(8):1974-1981. Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA. PMID: 29466726; PMCID: PMC5870899.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    42. The systemic environment: at the interface of aging and adult neurogenesis. Cell Tissue Res. 2018 01; 371(1):105-113. Smith LK, White CW, Villeda SA. PMID: 29124393; PMCID: PMC5748432.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    43. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun. 2017 09 28; 8(1):717. Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, Villeda S, Citri A, Amit I, Schwartz M. PMID: 28959042; PMCID: PMC5620041.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    44. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease. F1000Res. 2017; 6:1291. Horowitz AM, Villeda SA. PMID: 28815019; PMCID: PMC5539850.
      View in: PubMed   Mentions: 12     Fields:    
    45. Mechanisms of Hippocampal Aging and the Potential for Rejuvenation. Annu Rev Neurosci. 2017 07 25; 40:251-272. Fan X, Wheatley EG, Villeda SA. PMID: 28441118.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    46. Preclinical Assessment of Young Blood Plasma for Alzheimer Disease. JAMA Neurol. 2016 Nov 01; 73(11):1325-1333. Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T. PMID: 27598869; PMCID: PMC5172595.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals
    47. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 2016 08 03; 5. Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. PMID: 27487469; PMCID: PMC5017864.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    48. Microglia communication: Parallels between aging and Alzheimer's disease. Clin Exp Neuroimmunol. 2016 05; 7(2):114-125. Udeochu JC, Shea JM, Villeda SA. PMID: 27840659; PMCID: PMC5084774.
      View in: PubMed   Mentions: 33  
    49. Translational strategies in aging and age-related disease. Nat Med. 2015 Dec; 21(12):1395-9. Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S. PMID: 26646495; PMCID: PMC8785908.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    50. Fat Chance for Neural Stem Cells in Alzheimer's Disease. Cell Stem Cell. 2015 Oct 01; 17(4):373-4. Gontier G, Lin K, Villeda SA. PMID: 26431177.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    51. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med. 2015 Aug; 21(8):932-7. Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA. PMID: 26147761; PMCID: PMC4529371.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimals
    52. Aging and brain rejuvenation as systemic events. J Neurochem. 2015 Jan; 132(1):5-19. Bouchard J, Villeda SA. PMID: 25327899; PMCID: PMC4301186.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    53. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis. Nat Neurosci. 2014 Jul; 17(7):943-52. He Y, Zhang H, Yung A, Villeda SA, Jaeger PA, Olayiwola O, Fainberg N, Wyss-Coray T. PMID: 24859199; PMCID: PMC4096284.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    54. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. 2014 Jun; 20(6):659-63. Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T. PMID: 24793238; PMCID: PMC4224436.
      View in: PubMed   Mentions: 479     Fields:    Translation:AnimalsCells
    55. Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury. Front Neurol. 2014; 5:12. Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T. PMID: 24550885; PMCID: PMC3912443.
      View in: PubMed   Mentions: 68  
    56. Focused Plasma Proteomics for the Study of Brain Aging and Neurodegeneration. The OMICs. 2013 Dec 1; 183-192. Jaeger JP, Villeda VS, Berdnik BD, Britschgi BM, Wyss WT. .
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    57. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013 Jan 14; 210(1):157-72. Luo J, Elwood F, Britschgi M, Villeda S, Zhang H, Ding Z, Zhu L, Alabsi H, Getachew R, Narasimhan R, Wabl R, Fainberg N, James ML, Wong G, Relton J, Gambhir SS, Pollard JW, Wyss-Coray T. PMID: 23296467; PMCID: PMC3549715.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    58. The circulatory systemic environment as a modulator of neurogenesis and brain aging. Autoimmun Rev. 2013 Apr; 12(6):674-7. Villeda SA, Wyss-Coray T. PMID: 23201925.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    59. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011 Aug 31; 477(7362):90-4. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. PMID: 21886162; PMCID: PMC3170097.
      View in: PubMed   Mentions: 856     Fields:    Translation:Animals
    60. Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. J Neurosci. 2011 Mar 16; 31(11):3981-9. Moriyama M, Fukuhara T, Britschgi M, He Y, Narasimhan R, Villeda S, Molina H, Huber BT, Holers M, Wyss-Coray T. PMID: 21411641; PMCID: PMC3071463.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    61. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):527-39. Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. PMID: 19896443; PMCID: PMC2775802.
      View in: PubMed   Mentions: 307     Fields:    Translation:AnimalsCells
    62. Microglia--a wrench in the running wheel? Neuron. 2008 Aug 28; 59(4):527-9. Villeda S, Wyss-Coray T. PMID: 18760689.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    63. Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience. 2006; 139(4):1385-96. Villeda SA, Akopians AL, Babayan AH, Basbaum AI, Phelps PE. PMID: 16580148.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord. J Comp Neurol. 2004 Jan 06; 468(2):165-78. Kubasak MD, Brooks R, Chen S, Villeda SA, Phelps PE. PMID: 14648677.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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