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Saul Villeda, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentAnatomy
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-502-1929
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityPh.D.2011Neuroscience
    University of California, Los AngelesB.S.2004Physiological Science
    Collapse Awards and Honors
    2015Glenn Award for Research on the Biological Mechanisms of Aging
    2012NIH Director's Early Independence Award (DP5)

    Collapse Overview 
    Collapse Overview
    The ability to reverse aging in the brain may enable us to sidestep the effects of aging that promote vulnerability to neurodegenerative diseases, providing a unique and unexplored therapeutic approach. We have recently shown that systemic manipulations such as heterochronic parabiosis or young blood administration can partially reverse age-related impairments in regenerative, synaptic and cognitive functions in the aged brain. Interestingly, heterochronic parabiosis studies revealed an age-dependent bi-directionality in the influence of the systemic environment indicating pro-youthful factors in young blood elicit rejuvenation while pro-aging factors in old blood drive pre-mature aging. Therefore, targeting pro-aging factors in old blood may provide an alternative approach to rejuvenate aging phenotypes. Our lab is interested in understanding what drives regenerative and cognitive impairments in the aging brain, and how the effects of aging can be reversed in the old brain. Ultimately, our goal is to elucidate cellular and molecular mechanisms that promote brain rejuvenation as a means by which to combat age-related neurodegeneration and cognitive dysfunction.


    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of brain rejuvenation
    NIH/NIA R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Mechanisms of brain rejuvenation
    NIH/NIA R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Mechanisms of brain rejuvenation
    NIH/NIA R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Mechanisms of brain rejuvenation
    NIH/NIA R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Mechanisms of brain rejuvenation
    NIH/NIA R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Mechanisms of brain rejuvenation
    NIH/NIA R01AG053382Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
    NIH DP5OD012178Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH/NIA F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH/NIA F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH/NIA F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH/NIA F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH/NIA F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator
    Regulation of Neural Stem Cells by Changes in the Aging Systemic Environment
    NIH/NIA F31AG034045Mar 13, 2009 - Mar 12, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T. Preclinical Assessment of Young Blood Plasma for Alzheimer Disease. JAMA Neurol. 2016 Nov 1; 73(11):1325-1333. PMID: 27598869.
      View in: PubMed
    2. Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 2016; 5. PMID: 27487469.
      View in: PubMed
    3. Udeochu JC, Shea JM, Villeda SA. Microglia communication: Parallels between aging and Alzheimer's disease. Clin Exp Neuroimmunol. 2016 May; 7(2):114-125. PMID: 27840659.
      View in: PubMed
    4. Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S. Translational strategies in aging and age-related disease. Nat Med. 2015 Dec 8; 21(12):1395-9. PMID: 26646495.
      View in: PubMed
    5. Gontier G, Lin K, Villeda S. Fat Chance for Neural Stem Cells in Alzheimer's Disease. Cell Stem Cell. 2015 Oct 1; 17(4):373-4. PMID: 26431177.
      View in: PubMed
    6. Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda S. ß2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med. 2015 Aug; 21(8):932-7. PMID: 26147761; PMCID: PMC4529371 [Available on 02/01/16].
    7. Bouchard J, Villeda S. Aging and brain rejuvenation as systemic events. J Neurochem. 2015 Jan; 132(1):5-19. PMID: 25327899; PMCID: PMC4301186.
    8. He Y, Zhang H, Yung A, Villeda S, Jaeger PA, Olayiwola O, Fainberg N, Wyss-Coray T. ALK5-dependent TGF-ß signaling is a major determinant of late-stage adult neurogenesis. Nat Neurosci. 2014 Jul; 17(7):943-52. PMID: 24859199; PMCID: PMC4096284.
    9. Villeda S, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. 2014 Jun; 20(6):659-63. PMID: 24793238; PMCID: PMC4224436.
    10. Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T. Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury. Front Neurol. 2014; 5:12. PMID: 24550885; PMCID: PMC3912443.
    11. Luo J, Elwood F, Britschgi M, Villeda S, Zhang H, Ding Z, Zhu L, Alabsi H, Getachew R, Narasimhan R, Wabl R, Fainberg N, James ML, Wong G, Relton J, Gambhir SS, Pollard JW, Wyss-Coray T. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013 Jan 14; 210(1):157-72. PMID: 23296467; PMCID: PMC3549715.
    12. Villeda S, Wyss-Coray T. The circulatory systemic environment as a modulator of neurogenesis and brain aging. Autoimmun Rev. 2013 Apr; 12(6):674-7. PMID: 23201925.
      View in: PubMed
    13. Villeda S, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011 Sep 1; 477(7362):90-4. PMID: 21886162; PMCID: PMC3170097.
    14. Moriyama M, Fukuhara T, Britschgi M, He Y, Narasimhan R, Villeda S, Molina H, Huber BT, Holers M, Wyss-Coray T. Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. J Neurosci. 2011 Mar 16; 31(11):3981-9. PMID: 21411641; PMCID: PMC3071463.
    15. Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda S, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 6; 5(5):527-39. PMID: 19896443; PMCID: PMC2775802.
    16. Villeda S, Wyss-Coray T. Microglia--a wrench in the running wheel? Neuron. 2008 Aug 28; 59(4):527-9. PMID: 18760689.
      View in: PubMed
    17. Villeda S, Akopians AL, Babayan AH, Basbaum AI, Phelps PE. Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience. 2006; 139(4):1385-96. PMID: 16580148.
      View in: PubMed
    18. Kubasak MD, Brooks R, Chen S, Villeda S, Phelps PE. Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord. J Comp Neurol. 2004 Jan 6; 468(2):165-78. PMID: 14648677.
      View in: PubMed
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