Paul Simpson, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
AddressLocation Required, #Suite 40
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    Collapse Biography 
    Collapse Education and Training
    Mass General Hospital, Boston Clinical Fellow1977Cardiology
    University of California, San FranciscoResident1975Medicine
    NIH, NHLBI, BethesdaResearch Fellow1974Neurobiology
    Mass General Hospital, BostonResident1972Medicine
    Washington Univ School of Medicine, St. LouisMD1970Medicine
    Davidson College, North CarolinaBS1966Biology & Psychology

    Collapse Overview 
    Collapse Overview
    I am a clinical cardiologist at the San Francisco VA Medical Center treating inpatients and outpatients with heart disease since 1978. I also direct a lab at the VA, with a main goal to discover new drugs to treat heart failure, a major problem in cardiology. The lab has pursued initial findings from the early 1980s to the present, identifying a subclass of receptors for adrenaline as potential targets for a heart failure drug. Efforts in the lab are directed to this new drug, as well as discovering novel aspects of the class of adrenaline receptors. The lab has been funded continuously by the NIH and the VA, with additional important contribution from the AHA.

    Collapse Research 
    Collapse Research Activities and Funding
    ShEEP Request for Ultrasound Imaging System
    NIH IS1BX005021Sep 1, 2019 - Sep 30, 2020
    Role: Principal Investigator
    Novel adrenergic mechanisms in heart failure therapy
    VA BX004314Oct 1, 2018 - Sep 30, 2022
    Role: PI
    Novel adrenergic mechanisms in heart failure therapy
    NIH I01BX004314Oct 1, 2018 - Sep 30, 2022
    Role: Principal Investigator
    An alpha-1A-adrenergic drug for heart failure
    NIH/NHLBI RO1 HL31113-27Jan 1, 2018 - Nov 30, 2021
    Role: PI
    A mutant alpha-1A adrenergic receptor with impaired Gq coupling to identify a novel treatment in heart and brain disease
    Johnson & Johnson NAMay 1, 2016 - Dec 31, 2018
    Role: PI
    Novel therapy for cardiotoxicity of cancer drugs
    NIH I01BX001970Oct 1, 2012 - Sep 30, 2016
    Role: Principal Investigator
    UCSF Living Heart Resource
    NIH RC1HL099789Sep 30, 2009 - Aug 31, 2011
    Role: Co-Principal Investigator
    NIH R01HL054890Feb 1, 1997 - Jan 31, 2004
    Role: Principal Investigator
    NIH R01HL042150Jul 1, 1989 - Dec 31, 2001
    Role: Principal Investigator
    NIH R01HL033651Sep 30, 1984 - May 1, 1988
    Role: Principal Investigator
    An alpha-1A-adrenergic agonist drug for heart failure
    NIH R01HL031113Jul 1, 1983 - Nov 30, 2021
    Role: PI

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Norepinephrine links astrocytic activity to regulation of cortical state. Nat Neurosci. 2023 04; 26(4):579-593. Reitman ME, Tse V, Mi X, Willoughby DD, Peinado A, Aivazidis A, Myagmar BE, Simpson PC, Bayraktar OA, Yu G, Poskanzer KE. PMID: 36997759; PMCID: PMC10089924.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    2. Cardiac α1A-adrenergic receptors: emerging protective roles in cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2021 02 01; 320(2):H725-H733. Zhang J, Simpson PC, Jensen BC. PMID: 33275531; PMCID: PMC8082792.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    3. Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Circ Res. 2019 09 13; 125(7):699-706. Myagmar BE, Ismaili T, Swigart PM, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC. PMID: 31426700; PMCID: PMC6742539.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy. Am J Physiol Heart Circ Physiol. 2019 01 01; 316(1):H224-H232. Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ. PMID: 30412439; PMCID: PMC6859419.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice. PLoS One. 2017; 12(12):e0188471. Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ. PMID: 29216197; PMCID: PMC5720786.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations. PLoS One. 2017; 12(10):e0186792. López JE, Jaradeh K, Silva E, Aminololama-Shakeri S, Simpson PC. PMID: 29084228; PMCID: PMC5662089.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. α1A-Subtype adrenergic agonist therapy for the failing right ventricle. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1109-H1118. Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. PMID: 28822963; PMCID: PMC5814653.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    8. Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development. J Mol Cell Cardiol. 2017 10; 111:114-122. López JE, Sharma J, Avila J, Wood TS, VanDyke JE, McLaughlin B, Abbey CK, Wong A, Myagmar BE, Swigart PM, Simpson PC, Chiamvimonvat N. PMID: 28780067; PMCID: PMC5791888.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent". Circ Res. 2017 06 09; 120(12):e56-e57. Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ. PMID: 28596177; PMCID: PMC5501172.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31; 120(7):1103-1115. Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. PMID: 28219977; PMCID: PMC5376223.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    11. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017 Feb; 2(1):39-53. Beak J, Huang W, Parker JS, Hicks ST, Patterson C, Simpson PC, Ma A, Jin J, Jensen BC. PMID: 28286875; PMCID: PMC5343290.
      View in: PubMed   Mentions: 23  
    12. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. PLoS One. 2017; 12(1):e0168409. Montgomery MD, Chan T, Swigart PM, Myagmar BE, Dash R, Simpson PC. PMID: 28081170; PMCID: PMC5231318.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    13. The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo. Metabolomics. 2016 Oct; 12(10). Willis MS, Ilaiwy A, Montgomery MD, Simpson PC, Jensen BC. PMID: 28533737; PMCID: PMC5437747.
      View in: PubMed   Mentions: 4     Fields:    
    14. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS One. 2016; 11(6):e0155238. Thomas RC, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. PMID: 27258143; PMCID: PMC4892533.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016 04; 1(3):155-167. Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC. PMID: 27453955; PMCID: PMC4955869.
      View in: PubMed   Mentions: 21  
    16. A New Pathway for Sympathetic Cardioprotection in Heart Failure. Circ Res. 2015 Sep 11; 117(7):592-5. Simpson PC. PMID: 26358108; PMCID: PMC4692358.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    17. The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2015 Sep; 309(5):H888-96. Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. PMID: 26116709; PMCID: PMC4591405.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    18. Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1150-8. Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. PMID: 25128171; PMCID: PMC4200338.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation. J Cardiovasc Pharmacol. 2014 Apr; 63(4):291-301. Jensen BC, O'Connell TD, Simpson PC. PMID: 24145181; PMCID: PMC3980029.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    20. Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev. 2014; 66(1):308-33. O'Connell TD, Jensen BC, Baker AJ, Simpson PC. PMID: 24368739; PMCID: PMC3880467.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    21. Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H946-53. Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. PMID: 23355341; PMCID: PMC3625891.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. Synthesis of an in vivo MRI-detectable apoptosis probe. J Vis Exp. 2012 Jul 31; (65). Lam J, Simpson PC, Yang PC, Dash R. PMID: 22871963; PMCID: PMC3476424.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    23. Large-scale discovery of enhancers from human heart tissue. Nat Genet. 2011 Dec 04; 44(1):89-93. May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A. PMID: 22138689; PMCID: PMC3246570.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    24. Where are the new drugs to treat heart failure? Introduction to the special issue on "key signaling molecules in hypertrophy and heart failure". J Mol Cell Cardiol. 2011 Oct; 51(4):435-7. Simpson PC. PMID: 21851824.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity. Mol Pharmacol. 2011 Oct; 80(4):747-58. Doze VA, Papay RS, Goldenstein BL, Gupta MK, Collette KM, Nelson BW, Lyons MJ, Davis BA, Luger EJ, Wood SG, Haselton JR, Simpson PC, Perez DM. PMID: 21791575; PMCID: PMC3187532.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    26. β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. Circ Res. 2011 Sep 02; 109(6):629-38. López JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC. PMID: 21778428; PMCID: PMC3166391.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    27. A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med. 2011 Oct; 66(4):1152-62. Dash R, Chung J, Chan T, Yamada M, Barral J, Nishimura D, Yang PC, Simpson PC. PMID: 21360750; PMCID: PMC3138815.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):518-28. Jensen BC, O'Connell TD, Simpson PC. PMID: 21118696; PMCID: PMC3085055.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    29. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec; 382(5-6):475-82. Jensen BC, Swigart PM, Montgomery MD, Simpson PC. PMID: 20857090; PMCID: PMC2991196.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    30. Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis. 2010 Jul; 19(4):459-65. Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA. PMID: 20845893; PMCID: PMC4242684.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    31. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J Cell Biochem. 2010 Apr 15; 109(6):1185-91. Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ. PMID: 20186881; PMCID: PMC3397305.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    32. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest. 2010 Jan; 120(1):266-79. Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM. PMID: 20038810; PMCID: PMC2798685.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    33. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H913-20. Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. PMID: 20035030; PMCID: PMC2838546.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. Alpha1A/B-knockout mice explain the native alpha1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other alpha1-subtypes. Br J Pharmacol. 2009 Dec; 158(7):1663-75. Methven L, Simpson PC, McGrath JC. PMID: 19888965; PMCID: PMC2801207.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    35. The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries. J Am Coll Cardiol. 2009 Sep 22; 54(13):1137-45. Jensen BC, Swigart PM, Laden ME, DeMarco T, Hoopes C, Simpson PC. PMID: 19761933; PMCID: PMC2812029.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    36. {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium. Circ Heart Fail. 2009 Nov; 2(6):654-63. Jensen BC, Swigart PM, De Marco T, Hoopes C, Simpson PC. PMID: 19919991; PMCID: PMC2780440.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    37. Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific. Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr; 379(4):409-12. Jensen BC, Swigart PM, Simpson PC. PMID: 18989658; PMCID: PMC2653258.
      View in: PubMed   Mentions: 96     Fields:    Translation:Animals
    38. Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout. Br J Pharmacol. 2008 Dec; 155(8):1224-34. Muramatsu I, Morishima S, Suzuki F, Yoshiki H, Anisuzzaman AS, Tanaka T, Rodrigo MC, Myagmar BE, Simpson PC. PMID: 18806813; PMCID: PMC2607200.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    39. Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Circulation. 2007 Aug 28; 116(9):1024-31. Bao X, Lu CM, Liu F, Gu Y, Dalton ND, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J, Simpson PC, Ziegler MG. PMID: 17698731.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    40. Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H514-9. Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, Simpson PC, Tsujimoto G, Tanoue A. PMID: 17384126.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007 Feb 13; 115(6):763-72. Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, O'Connell TD. PMID: 17283256.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    42. Isolation and culture of adult mouse cardiac myocytes. Methods Mol Biol. 2007; 357:271-96. O'Connell TD, Rodrigo MC, Simpson PC. PMID: 17172694.
      View in: PubMed   Mentions: 193     Fields:    Translation:AnimalsCells
    43. Left ventricular pressure-volume relationship in conscious mice. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H369-77. Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. PMID: 16905597.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    44. Localization of the mouse alpha1A-adrenergic receptor (AR) in the brain: alpha1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors. J Comp Neurol. 2006 Jul 10; 497(2):209-22. Papay R, Gaivin R, Jha A, McCune DF, McGrath JC, Rodrigo MC, Simpson PC, Doze VA, Perez DM. PMID: 16705673.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    45. Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H2013-7. Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ. PMID: 16731650.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    46. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest. 2006 Apr; 116(4):1005-15. O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. PMID: 16585965; PMCID: PMC1421341.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    47. Ischemic preconditioning depends on age and gender. Basic Res Cardiol. 2006 May; 101(3):235-43. Turcato S, Turnbull L, Wang GY, Honbo N, Simpson PC, Karliner JS, Baker AJ. PMID: 16450074.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    48. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1103-9. Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. PMID: 16243914.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    49. Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Cardiovasc Res. 2006 Feb 15; 69(3):688-96. Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. PMID: 16183043.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    50. Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways. J Mol Cell Cardiol. 2005 Nov; 39(5):777-84. Rorabaugh BR, Gaivin RJ, Papay RS, Shi T, Simpson PC, Perez DM. PMID: 16171811.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics. 2005 Jun 16; 22(1):118-26. McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. PMID: 15797971.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    52. alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism. Cardiovasc Res. 2005 Feb 01; 65(2):436-45. Rorabaugh BR, Ross SA, Gaivin RJ, Papay RS, McCune DF, Simpson PC, Perez DM. PMID: 15639483.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    53. Aldosterone directly stimulates cardiac myocyte hypertrophy. J Card Fail. 2004 Dec; 10(6):511-8. Okoshi MP, Yan X, Okoshi K, Nakayama M, Schuldt AJ, O'Connell TD, Simpson PC, Lorell BH. PMID: 15599842.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    54. New technique for measurement of left ventricular pressure in conscious mice. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1208-15. Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. PMID: 14563661.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    55. Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice. J Mol Cell Cardiol. 2003 Oct; 35(10):1207-16. McCloskey DT, Turnbull L, Swigart P, O'Connell TD, Simpson PC, Baker AJ. PMID: 14519431.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. Cerebral ischemia and infarction from atheroemboli <100 microm in Size. Stroke. 2003 Aug; 34(8):1976-80. Rapp JH, Pan XM, Yu B, Swanson RA, Higashida RT, Simpson P, Saloner D. PMID: 12855822.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    57. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest. 2003 Jun; 111(11):1783-91. O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC. PMID: 12782680; PMCID: PMC156101.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    58. Basal and alpha1-adrenergic-induced activity of minimal rat betaMHC promoters in cardiac myocytes requires multiple TEF-1 but not NFAT binding sites. J Mol Cell Cardiol. 2003 May; 35(5):461-71. McLean BG, Lee KS, Simpson PC, Farrance IK. PMID: 12738228.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    59. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR, Participating investigators and scientists of the Alliance for Cellular Signaling. PMID: 12478301.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    60. Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1104-9. Turnbull L, McCloskey DT, O'Connell TD, Simpson PC, Baker AJ. PMID: 12595294.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    61. Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice. J Mol Cell Cardiol. 2002 Aug; 34(8):1007-17. McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC, Baker AJ. PMID: 12234770.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    62. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9474-9. Rokosh DG, Simpson PC. PMID: 12093905; PMCID: PMC123165.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    63. Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res. 2001 Sep 28; 89(7):591-8. Kinugawa K, Yonekura K, Ribeiro RC, Eto Y, Aoyagi T, Baxter JD, Camacho SA, Bristow MR, Long CS, Simpson PC. PMID: 11577024.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    64. LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1104-12. Nakamura A, Rokosh DG, Paccanaro M, Yee RR, Simpson PC, Grossman W, Foster E. PMID: 11514276.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    65. Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1). Mol Pharmacol. 2001 May; 59(5):1225-34. O'Connell TD, Rokosh DG, Simpson PC. PMID: 11306707.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    66. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2001 Apr; 280(4):H1653-9. Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. PMID: 11247776.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    67. Tumor cell splice variants of the transcription factor TEF-1 induced by SV40 T-antigen transformation. Biochim Biophys Acta. 2000 Dec 15; 1517(1):82-90. Zuzarte PC, Farrance IK, Simpson PC, Wildeman AG. PMID: 11118619.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    68. Autonomous and growth factor-induced hypertrophy in cultured neonatal mouse cardiac myocytes. Comparison with rat. Circ Res. 2000 Oct 27; 87(9):781-8. Deng XF, Rokosh DG, Simpson PC. PMID: 11055982.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    69. Beta-protein kinase C and hypertrophic signaling in human heart failure. Circulation. 1999 Jan 26; 99(3):334-7. Simpson PC. PMID: 9918516.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    70. Post-infarction heart failure in the rat is associated with distinct alterations in cardiac myocyte molecular phenotype. J Mol Cell Cardiol. 1998 Aug; 30(8):1615-30. Yue P, Long CS, Austin R, Chang KC, Simpson PC, Massie BM. PMID: 9737947.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    71. Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure. Am J Physiol. 1998 07; 275(1):H250-8. Yue P, Massie BM, Simpson PC, Long CS. PMID: 9688921.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    72. Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy. Association with increased sarcoplasmic reticulum Ca2+-ATPase and alpha-myosin heavy chain in rat hearts. J Clin Invest. 1997 Oct 01; 100(7):1742-9. Chang KC, Figueredo VM, Schreur JH, Kariya K, Weiner MW, Simpson PC, Camacho SA. PMID: 9312172; PMCID: PMC508357.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    73. Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C. J Biol Chem. 1996 Mar 08; 271(10):5839-43. Rokosh DG, Stewart AF, Chang KC, Bailey BA, Karliner JS, Camacho SA, Long CS, Simpson PC. PMID: 8621454.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    74. M-CAT, CArG, and Sp1 elements are required for alpha 1-adrenergic induction of the skeletal alpha-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth. J Biol Chem. 1995 Jan 06; 270(1):410-7. Karns LR, Kariya K, Simpson PC. PMID: 7814403.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    75. Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Circ Res. 1994 Oct; 75(4):796-802. Stewart AF, Rokosh DG, Bailey BA, Karns LR, Chang KC, Long CS, Kariya K, Simpson PC. PMID: 7923624.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    76. Distribution of alpha 1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with alpha 1B and alpha 1D. Biochem Biophys Res Commun. 1994 May 16; 200(3):1177-84. Rokosh DG, Bailey BA, Stewart AF, Karns LR, Long CS, Simpson PC. PMID: 8185565.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    77. An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes. J Biol Chem. 1994 Feb 04; 269(5):3775-82. Kariya K, Karns LR, Simpson PC. PMID: 8106422.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    78. Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter. J Biol Chem. 1993 Dec 15; 268(35):26658-62. Kariya K, Farrance IK, Simpson PC. PMID: 8253797.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    79. Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium. J Mol Cell Cardiol. 1993 Aug; 25(8):915-25. Long CS, Hartogensis WE, Simpson PC. PMID: 7505339.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    80. Sympathetic modulation of the cardiac myocyte phenotype: studies with a cell-culture model of myocardial hypertrophy. Basic Res Cardiol. 1992; 87 Suppl 2:19-31. Long CS, Kariya K, Karns L, Simpson PC. PMID: 1338564.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    81. A growth factor for cardiac myocytes is produced by cardiac nonmyocytes. Cell Regul. 1991 Dec; 2(12):1081-95. Long CS, Henrich CJ, Simpson PC. PMID: 1801925; PMCID: PMC361907.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    82. Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene. J Biol Chem. 1991 Jun 05; 266(16):10023-6. Kariya K, Karns LR, Simpson PC. PMID: 2037558.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    83. Adrenergic hormones and control of cardiac myocyte growth. Mol Cell Biochem. 1991 May 29-Jun 12; 104(1-2):35-43. Simpson PC, Kariya K, Karns LR, Long CS, Karliner JS. PMID: 1656195.
      View in: PubMed   Mentions: 23     Fields:    
    84. Sympathetic activity: modulator of myocardial hypertrophy. J Cardiovasc Pharmacol. 1991; 17 Suppl 2:S20-4. Long CS, Kariya K, Karns L, Simpson PC. PMID: 1715479.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    85. Trophic factors for cardiac myocytes. J Hypertens Suppl. 1990 Dec; 8(7):S219-24. Long CS, Kariya K, Karns L, Simpson PC. PMID: 1965655.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    86. A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul. 1990 Aug; 1(9):693-706. Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. PMID: 2078573; PMCID: PMC361636.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    87. The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes. J Clin Invest. 1990 Apr; 85(4):1206-14. Waspe LE, Ordahl CP, Simpson PC. PMID: 2156896; PMCID: PMC296553.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    88. Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes. Experientia. 1990 Jan 15; 46(1):81-4. Karliner JS, Kagiya T, Simpson PC. PMID: 2153573.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    89. Transcription of early developmental isogenes in cardiac myocyte hypertrophy. J Mol Cell Cardiol. 1989 Dec; 21 Suppl 5:79-89. Simpson PC, Long CS, Waspe LE, Henrich CJ, Ordahl CP. PMID: 2560798.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    90. Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. J Clin Invest. 1989 Mar; 83(3):1078-82. Long CS, Ordahl CP, Simpson PC. PMID: 2537847; PMCID: PMC303787.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    91. Proto-oncogenes and cardiac hypertrophy. Annu Rev Physiol. 1989; 51:189-202. Simpson PC. PMID: 2469381.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    92. Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to alpha 1-adrenergic and phorbol ester stimulation. J Mol Cell Cardiol. 1988 Dec; 20(12):1081-5. Henrich CJ, Simpson PC. PMID: 2907916.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    93. Beta-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth. Basic Res Cardiol. 1988 Nov-Dec; 83(6):655-63. Karliner JS, Simpson PC. PMID: 2851972.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    94. Role of proto-oncogenes in myocardial hypertrophy. Am J Cardiol. 1988 Oct 05; 62(11):13G-19G. Simpson PC. PMID: 2972186.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    95. Comments on "Load regulation of the properties of adult feline cardiocytes: the role of substrate adhesion."Circ Res 1986;58:692-705. Circ Res. 1988 Apr; 62(4):864-9. Simpson PC. PMID: 3349579.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    96. Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes. J Clin Invest. 1987 Oct; 80(4):1194-9. Bishopric NH, Simpson PC, Ordahl CP. PMID: 2821075; PMCID: PMC442365.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    97. Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8348-50. Starksen NF, Simpson PC, Bishopric N, Coughlin SR, Lee WM, Escobedo JA, Williams LT. PMID: 3022291; PMCID: PMC386925.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    98. Mechanisms and time course of beta 1 adrenoceptor desensitisation in mammalian cardiac myocytes. Cardiovasc Res. 1986 Mar; 20(3):221-8. Karliner JS, Simpson PC, Honbo N, Woloszyn W. PMID: 3011269.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    99. Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating. Circ Res. 1985 Jun; 56(6):884-94. Simpson P. PMID: 2988814.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    100. Adrenergic receptor characteristics of cardiac myocytes cultured in serum-free medium: comparison with serum-supplemented medium. Biochem Biophys Res Commun. 1985 Apr 16; 128(1):376-82. Karliner JS, Simpson PC, Taylor JE, Honbo N, Woloszyn W. PMID: 3985976.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    101. Antihypertensive therapy with diltiazem and comparison with hydrochlorothiazide. Am J Cardiol. 1984 Jun 01; 53(11):1588-92. Inouye IK, Massie BM, Benowitz N, Simpson P, Loge D. PMID: 6375339.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    102. Failure of antihypertensive therapy with diuretic, beta-blocking and calcium channel-blocking drugs to consistently reverse left ventricular diastolic filling abnormalities. Am J Cardiol. 1984 Jun 01; 53(11):1583-7. Inouye IK, Massie BM, Loge D, Simpson P, Tubau JF. PMID: 6731303.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    103. Monotherapy in mild to moderate hypertension: comparison of hydrochlorothiazide, propranolol and prazosin. Am J Cardiol. 1984 Jan 27; 53(3):24A-28A. Inouye I, Massie B, Benowitz N, Simpson P, Loge D, Topic N. PMID: 6320622.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    104. Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension. Am J Cardiol. 1984 Jan 01; 53(1):120-6. Inouye I, Massie B, Loge D, Topic N, Silverstein D, Simpson P, Tubau J. PMID: 6691248.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    105. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. J Clin Invest. 1983 Aug; 72(2):732-8. Simpson P. PMID: 6135712; PMCID: PMC1129233.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    106. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res. 1982 Dec; 51(6):787-801. Simpson P, McGrath A, Savion S. PMID: 6216022.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    107. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res. 1982 Jan; 50(1):101-16. Simpson P, Savion S. PMID: 7053872.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    108. Computed tomography: a new method for diagnosing tumor of the heart. Circulation. 1981 Feb; 63(2):448-51. Godwin JD, Axel L, Adams JR, Schiller NB, Simpson PC, Gertz EW. PMID: 7449067.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    109. Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1314-8. McGee R, Simpson P, Christian C, Mata M, Nelson P, Nirenberg M. PMID: 206894; PMCID: PMC411461.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    110. scyllo-inositol and myo-inositol levels in tissues of the skate Raja erinacea. Comp Biochem Physiol B. 1978; 59(3):201-2. Sherman WR, Simpson PC, Goodwin SL. PMID: 318234.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    111. Effect of cyanide and electrical stimulation on phosphoinositide metabolism in lobster nerves. J Neurochem. 1971 Jul; 18(7):1291-8. Birnberger AC, Birnberger KL, Eliasson SG, Simpson PC. PMID: 4330289.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    112. The identification of myo-inosose-2 and scyllo-inositol in mammalian tissues. Biochemistry. 1968 Feb; 7(2):819-24. Sherman WR, Stewart MA, Simpson PC, Goodwin SL. PMID: 5644141.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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