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    Christopher Allen, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentCardiovascular Research Inst
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
    Phone415-476-5178
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPh.D. Graduate Division (Biomedical Sciences)2007
      University of California, San Francisco Postdoctoral StudiesGraduate Division
      Collapse Awards and Honors
      2012 - 2017NIH Director's New Innovator Award
      2016Pew Scholar in the Biomedical Sciences

      Collapse Overview 
      Collapse Overview
      My laboratory is interested in the cellular communication and differentiation programs in allergic immune responses, particularly in asthma. My laboratory is applying sophisticated imaging, flow cytometry, mouse genetics, and other techniques to uncover novel paradigms underlying allergic inflammation. As a major area of emphasis, we are studying the generation and function of IgE antibodies that initiate allergic inflammation. We recently generated fluorescent IgE reporter mice allowing us to identify and track rare IgE-producing B cells in vivo. We are imaging the lungs and associated lymphoid tissues by two-photon laser scanning microscopy to directly visualize cellular interactions in situ. Using this approach, we achieved the first in vivo analysis of the interactions of CD4 T cells with basophils, which are rare IgE effector cells. We are now analyzing the interactions of basophils with other cell types during secondary immune responses to further elucidate the functions of these cells. More broadly, we are considering the combined cellular interactions among various types of inflammatory cells in the lungs in mouse models of asthma.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Allen CD. Germinal center quality control: death by Fas. Immunity. 2015 May 19; 42(5):783-5. PMID: 25992852.
        View in: PubMed
      2. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6; 212(4):513-24. PMID: 25779634; PMCID: PMC4387286.
      3. Yang Z, Robinson MJ, Allen CD. Regulatory constraints in the generation and differentiation of IgE-expressing B cells. Curr Opin Immunol. 2014 Jun; 28:64-70. PMID: 24632082; PMCID: PMC4069329.
      4. Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 2013 Nov 14; 39(5):912-24. PMID: 24184055; PMCID: PMC3828484.
      5. Yang Z, Sullivan BM, Allen CD. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity. 2012 May 25; 36(5):857-72. PMID: 22406270.
        View in: PubMed
      6. Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81. PMID: 21820330; PMCID: PMC3361370.
      7. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jul; 12(7):672-80. PMID: 21642988; PMCID: PMC3158008.
      8. Beltman JB, Allen CD, Cyster JG, de Boer RJ. B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8755-60. PMID: 21555569; PMCID: PMC3102384.
      9. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. PMID: 21552267; PMCID: PMC3271435.
      10. Allen CD, Cyster JG. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol. 2008 Feb; 20(1):14-25. PMID: 18261920; PMCID: PMC2366796.
      11. Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007 Oct 15; 179(8):5099-108. PMID: 17911595.
        View in: PubMed
      12. Allen CD, Okada T, Cyster JG. Germinal-center organization and cellular dynamics. Immunity. 2007 Aug; 27(2):190-202. PMID: 17723214; PMCID: PMC2242846.
      13. Allen CD, Okada T, Tang HL, Cyster JG. Imaging of germinal center selection events during affinity maturation. Science. 2007 Jan 26; 315(5811):528-31. PMID: 17185562.
        View in: PubMed
      14. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65. PMID: 16203866; PMCID: PMC2213179.
      15. Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004 Sep; 5(9):943-52. PMID: 15300245.
        View in: PubMed
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