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    Duygu Tosun-Turgut, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address4150 Clement St
    San Francisco CA 94121
    Phone415-221-4810x23650
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      American Federation for Aging Research and GE Healthcare, Santa Barbara, CA2011AFAR-GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research
      Alzheimer's Association, Paris, France2011de Leon Prize in Neuroimaging
      American Federation for Aging Research and GE Healthcare, Santa Barbara, CA2010AFAR-GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research
      Information Processing in Medical Imaging (IPMI) Conference, Glenwood Springs, CO2005Francois Erbsmann Prize

      Collapse Overview 
      Collapse Overview
      Duygu Tosun-Turgut, PhD, is an Assistant Professor and Co-Director of the Center for Imaging of Neurodegenerative Diseases (CIND) at the San Francisco Veterans Affairs Medical Center. Dr. Tosun obtained her BSc in Electrical and Electronic Engineering from Bilkent University, Turkey in 1999, and she received her MSE in Electrical and Computer Engineering from The Johns Hopkins University, Maryland in 2001. In 2003, she completed her MA in Mathematics from The Johns Hopkins University, and she earned her PhD in Electrical and Computer Engineering from The Johns Hopkins University in 2005, followed by a postdoctoral fellowship in Neurology from the University of California, Los Angeles in 2008.

      Dr. Tosun’s long-term research goal is to develop new algorithmic approaches for processing and analysis of multi-disciplinary/modality data including neuroimages, genetics, proteomics, as well as cognitive functioning measures in a unified framework by using recent advances in image processing, medical physics, and computation medicine. The primary aim is to identify multi-disciplinary/modality biomarkers for detecting the changes associated with disease specific neuropathology, improving understanding of pathophysiological progression and potentially providing a means of monitoring the efficacy and regional specificity of drug therapy for neurodegenerative diseases. This will have a broad use in early diagnosis, facilitating initiation of prevention strategies in those at risk, and boost the power of drug therapy trials by selecting those at greatest risk of neurodegenerative diseases.

      Dr. Tosun is a reviewer for 17 scientific journals. She has 29 published articles and she has written 30 peer-reviewed articles, 50 abstracts, and 5 significant publications.

      Expertise:
      Neurodegenerative

      Specialty:
      Neurodegenerative brain diseases; Neuroimaging; Alzheimer’s disease; Front temporal dementia; Late-life depression; Biomarkers; Imaging statistics

      Professional Interests:
      Medical image processing and analysis, computational medicine, magnetic resonance imaging (MRI), positron emission tomography (PET), multi-modality neuroimaging research, aging, Alzheimer's disease, neurodegenerative diseases, late-life depression, imaging biomarkers, biomarkers, prediction models, neuropathology

      Education and Training:
      • Bachelor of Science: Bilkent University, Turkey - Electrical and Electronic Engineering
      • Masters of Science: Johns Hopkins University, Maryland - Electrical and Computer Engineering
      • Masters in Art: Johns Hopkins University, Maryland - Mathematics
      • Doctor of Philosophy: Johns Hopkins University, Maryland - Electrical and Computer Engineering
      • Postdoctoral Fellowship: University of California, Los Angeles - Neurology

      Collapse Interests
      Medical image processing and analysis, computational medicine, magnetic resonance imaging (MRI), positron emission tomography (PET), multi-modality neuroimaging research, aging, Alzheimer's disease, neurodegenerative diseases, late-life depression, imaging biomarkers, biomarkers, prediction models, neuropathology

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tosun D, Chen YF, Yu P, Sundell KL, Suhy J, Siemers E, Schwarz AJ, Weiner MW. Amyloid status imputed from a multimodal classifier including structural MRI distinguishes progressors from nonprogressors in a mild Alzheimer's disease clinical trial cohort. Alzheimers Dement. 2016 Apr 21. PMID: 27109039.
        View in: PubMed
      2. Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW. Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology. Neurology. 2016 May 17; 86(20):1887-96. PMID: 27164667.
        View in: PubMed
      3. Chao LL, Tosun D, Woodward SH, Kaufer D, Neylan TC. Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. Front Behav Neurosci. 2015; 9:333. PMID: 26696852.
        View in: PubMed
      4. Scott JA, Braskie MN, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. Front Aging Neurosci. 2015; 7:221. PMID: 26648866.
        View in: PubMed
      5. Tosun D, Schuff N, Jagust W, Weiner MW. Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-ß-Positive Subjects in the Alzheimer's Disease Continuum. Neurodegener Dis. 2016; 16(1-2):87-94. PMID: 26560336.
        View in: PubMed
      6. Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS. Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia. Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35. PMID: 26238228.
        View in: PubMed
      7. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW. Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47. PMID: 26000325; PMCID: PMC4435707.
      8. Song Z, Insel PS, Buckley S, Yohannes S, Mezher A, Simonson A, Wilkins S, Tosun D, Mueller S, Kramer JH, Miller BL, Weiner MW. Brain amyloid-ß burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly. J Neurosci. 2015 Feb 18; 35(7):3240-7. PMID: 25698758; PMCID: PMC4331637.
      9. Raj A, LoCastro E, Kuceyeski A, Tosun D, Relkin N, Weiner M. Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer's Disease. Cell Rep. 2015 Jan 14. PMID: 25600871.
        View in: PubMed
      10. Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW. Emerging ß-amyloid pathology and accelerated cortical atrophy. JAMA Neurol. 2014 Jun; 71(6):725-34. PMID: 24781145; PMCID: PMC4410966.
      11. Laforce R, Tosun D, Ghosh P, Lehmann M, Madison CM, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD. Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology. Neuroimage Clin. 2014; 4:508-16. PMID: 24818077; PMCID: PMC3984448.
      12. Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW. Association of brain amyloid-ß with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain. 2014 May; 137(Pt 5):1550-61. PMID: 24625697; PMCID: PMC3999717.
      13. Tosun D, Joshi S, Weiner MW. Multimodal MRI-based Imputation of the Aß+ in Early Mild Cognitive Impairment. Ann Clin Transl Neurol. 2014 Mar; 1(3):160-170. PMID: 24729983.
        View in: PubMed
      14. Mattsson N, Insel P, Tosun D, Zhang J, Jack CR, Galasko D, Weiner M. Effects of baseline CSF a-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. PLoS One. 2013; 8(12):e85443. PMID: 24392009; PMCID: PMC3877372.
      15. Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M. Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiol Aging. 2014 Mar; 35(3):614-22. PMID: 24094581; PMCID: PMC3864623.
      16. Tosun D, Joshi S, Weiner MW. Neuroimaging predictors of brain amyloidosis in mild cognitive impairment. Ann Neurol. 2013 Aug; 74(2):188-98. PMID: 23686534; PMCID: PMC4603555.
      17. Liu X, Tosun D, Weiner MW, Schuff N. Locally linear embedding (LLE) for MRI based Alzheimer's disease classification. Neuroimage. 2013 Dec; 83:148-57. PMID: 23792982; PMCID: PMC3815961.
      18. Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43. PMID: 23421601; PMCID: PMC3951683.
      19. Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A. Voxelwise multivariate analysis of multimodality magnetic resonance imaging. Hum Brain Mapp. 2014 Mar; 35(3):831-46. PMID: 23408378; PMCID: PMC4324330.
      20. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802. PMID: 23567394; PMCID: PMC3732520.
      21. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14. PMID: 23567388.
        View in: PubMed
      22. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response. Am J Geriatr Psychiatry. 2012 Aug 17. PMID: 22902859.
        View in: PubMed
      23. Luders E, Sánchez FJ, Tosun D, Shattuck DW, Gaser C, Vilain E, Toga AW. Increased Cortical Thickness in Male-to-Female Transsexualism. J Behav Brain Sci. 2012 Aug; 2(3):357-362. PMID: 23724358.
        View in: PubMed
      24. Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N. MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia. Neuroimage. 2012 Feb 1; 59(3):2098-109. PMID: 22036676; PMCID: PMC3254855.
      25. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW. Impact of apolipoprotein E4-cerebrospinal fluid ß-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011 Sep; 7(5):514-20. PMID: 21889115; PMCID: PMC3177162.
      26. Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW. Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia. Int J Alzheimers Dis. 2011; 2011:546871. PMID: 21760989; PMCID: PMC3132541.
      27. Tosun D, Caplan R, Siddarth P, Seidenberg M, Gurbani S, Toga AW, Hermann B. Intelligence and cortical thickness in children with complex partial seizures. Neuroimage. 2011 Jul 15; 57(2):337-45. PMID: 21586333; PMCID: PMC3117889.
      28. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW. Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes. Radiology. 2011 Jun; 259(3):844-51. PMID: 21467255; PMCID: PMC3099048.
      29. Tosun D, Siddarth P, Toga AW, Hermann B, Caplan R. Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities. Hum Brain Mapp. 2011 Apr; 32(4):580-91. PMID: 21391248; PMCID: PMC3058615.
      30. Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW. Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Brain. 2011 Apr; 134(Pt 4):1077-88. PMID: 21429865; PMCID: PMC3069703.
      31. Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ. Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcohol Clin Exp Res. 2011 Jun; 35(6):1187-200. PMID: 21410483; PMCID: PMC3097308.
      32. Tosun D, Dabbs K, Caplan R, Siddarth P, Toga A, Seidenberg M, Hermann B. Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy. Brain. 2011 Apr; 134(Pt 4):1003-14. PMID: 21398377; PMCID: PMC3069702.
      33. Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW. Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data. J Alzheimers Dis. 2011; 26 Suppl 3:77-90. PMID: 21971452; PMCID: PMC4587763.
      34. Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW. Nonlinear time course of brain volume loss in cognitively normal and impaired elders. Neurobiol Aging. 2012 May; 33(5):845-55. PMID: 20855131; PMCID: PMC3032014.
      35. Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW. Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study. Neurobiol Aging. 2010 Aug; 31(8):1340-54. PMID: 20570401; PMCID: PMC2902689.
      36. Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW. Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative. Alzheimers Dement. 2010 May; 6(3):212-20. PMID: 20451869; PMCID: PMC2886577.
      37. Tosun D, Mojabi P, Weiner MW, Schuff N. Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging. Neuroimage. 2010 Aug 1; 52(1):186-97. PMID: 20406691.
        View in: PubMed
      38. Tosun D, Schuff N, Weiner M. An integrated multimodality MR brain imaging study: gray matter tissue loss mediates the association between cerebral hypoperfusion and Alzheimer's disease. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6981-4. PMID: 19964722; PMCID: PMC2804924.
      39. Tosun D, Prince JL. A geometry-driven optical flow warping for spatial normalization of cortical surfaces. IEEE Trans Med Imaging. 2008 Dec; 27(12):1739-53. PMID: 19033090; PMCID: PMC2597639.
      40. Tosun D, Duchesne S, Rolland Y, Toga AW, Vérin M, Barillot C. 3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients. Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):891-9. PMID: 18044653.
        View in: PubMed
      41. Tosun D, Rettmann ME, Naiman DQ, Resnick SM, Kraut MA, Prince JL. Cortical reconstruction using implicit surface evolution: accuracy and precision analysis. Neuroimage. 2006 Feb 1; 29(3):838-52. PMID: 16269250; PMCID: PMC4587757.
      42. Rettmann ME, Tosun D, Tao X, Resnick SM, Prince JL. Program for Assisted Labeling of Sulcal Regions (PALS): description and reliability. Neuroimage. 2005 Jan 15; 24(2):398-416. PMID: 15627582.
        View in: PubMed
      43. Tosun D, Prince JL. Cortical surface alignment using geometry driven multispectral optical flow. Inf Process Med Imaging. 2005; 19:480-92. PMID: 17354719.
        View in: PubMed
      44. Han X, Pham DL, Tosun D, Rettmann ME, Xu C, Prince JL. CRUISE: cortical reconstruction using implicit surface evolution. Neuroimage. 2004 Nov; 23(3):997-1012. PMID: 15528100.
        View in: PubMed
      45. Tosun D, Rettmann ME, Prince JL. Mapping techniques for aligning sulci across multiple brains. Med Image Anal. 2004 Sep; 8(3):295-309. PMID: 15450224; PMCID: PMC4587758.
      46. Tosun D, Rettmann ME, Han X, Tao X, Xu C, Resnick SM, Pham DL, Prince JL. Cortical surface segmentation and mapping. Neuroimage. 2004; 23 Suppl 1:S108-18. PMID: 15501080; PMCID: PMC4587756.
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