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    Ralph Marcucio, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentOrthopaedic Surgery
    Address1001 Potrero Ave, SFGH 9
    San Francisco CA 94143
    Phone415-206-5366

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       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Li X, Young NM, Tropp S, Hu D, Xu Y, Hallgrímsson B, Marcucio RS. Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis. Hum Mol Genet. 2013 Dec 20; 22(25):5160-72.
        View in: PubMed
      2. Marcucio R, Hunt TK, Miclau T. Beneficial effects of oxygen- and lactate-production in scaffold designs. Bone. 2013 Nov; 57(1):324.
        View in: PubMed
      3. Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS. The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos. Dis Model Mech. 2013 Jul; 6(4):915-24.
        View in: PubMed
      4. Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD. Disruption of thrombospondin-2 accelerates ischemic fracture healing. J Orthop Res. 2013 Jun; 31(6):935-43.
        View in: PubMed
      5. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1; 374(1):185-97.
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      6. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS. The role of oxygen during fracture healing. Bone. 2013 Jan; 52(1):220-9.
        View in: PubMed
      7. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 2013 Jan; 52(1):111-9.
        View in: PubMed
      8. Hallgrímsson B, Jamniczky HA, Young NM, Rolian C, Schmidt-Ott U, Marcucio RS. The generation of variation and the developmental basis for evolutionary novelty. J Exp Zool B Mol Dev Evol. 2012 Sep; 318(6):501-17.
        View in: PubMed
      9. Lu C, Xing Z, Wang X, Mao J, Marcucio RS, Miclau T. Anti-inflammatory treatment increases angiogenesis during early fracture healing. Arch Orthop Trauma Surg. 2012 Aug; 132(8):1205-13.
        View in: PubMed
      10. Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012; (62).
        View in: PubMed
      11. Hu D, Marcucio RS. Neural crest cells pattern the surface cephalic ectoderm during FEZ formation. Dev Dyn. 2012 Apr; 241(4):732-40.
        View in: PubMed
      12. Acaroglu E, Bobe R, Enouf J, Marcucio R, Moldovan F, Moreau A. The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel. Eur Spine J. 2012 Jun; 21(6):1033-42.
        View in: PubMed
      13. Chong HJ, Young NM, Hu D, Jeong J, McMahon AP, Hallgrimsson B, Marcucio RS. Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn. 2012 Feb; 241(2):247-56.
        View in: PubMed
      14. Ogilvie CM, Lu C, Marcucio R, Lee M, Thompson Z, Hu D, Helms JA, Miclau T. Vascular endothelial growth factor improves bone repair in a murine nonunion model. Iowa Orthop J. 2012; 32:90-4.
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      15. Dede O, Akel I, Demirkiran G, Yalcin N, Marcucio R, Acaroglu E. Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model. Scoliosis. 2011; 6(1):24.
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      16. Parsons TE, Schmidt EJ, Boughner JC, Jamniczky HA, Marcucio RS, Hallgrímsson B. Epigenetic integration of the developing brain and face. Dev Dyn. 2011 Oct; 240(10):2233-44.
        View in: PubMed
      17. Lu C, Saless N, Hu D, Wang X, Xing Z, Hou H, Williams B, Swartz HM, Colnot C, Miclau T, Marcucio RS. Mechanical stability affects angiogenesis during early fracture healing. J Orthop Trauma. 2011 Aug; 25(8):494-9.
        View in: PubMed
      18. Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8.
        View in: PubMed
      19. Hu D, Marcucio RS. Assessing signaling properties of ectodermal epithelia during craniofacial development. J Vis Exp. 2011; (49).
        View in: PubMed
      20. Marcucio RS, Young NM, Hu D, Hallgrimsson B. Mechanisms that underlie co-variation of the brain and face. Genesis. 2011 Apr; 49(4):177-89.
        View in: PubMed
      21. Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Dis Model Mech. 2011 Mar; 4(2):203-11.
        View in: PubMed
      22. Young NM, Chong HJ, Hu D, Hallgrímsson B, Marcucio RS. Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape. Development. 2010 Oct; 137(20):3405-9.
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      23. Pape HC, Marcucio R, Humphrey C, Colnot C, Knobe M, Harvey EJ. Trauma-induced inflammation and fracture healing. J Orthop Trauma. 2010 Sep; 24(9):522-5.
        View in: PubMed
      24. Xing Z, Lu C, Hu D, Miclau T, Marcucio RS. Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. J Orthop Res. 2010 Aug; 28(8):1000-6.
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      25. Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T, Marcucio RS. Action of IL-1beta during fracture healing. J Orthop Res. 2010 Jun; 28(6):778-84.
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      26. Lu C, Xing Z, Yu YY, Colnot C, Miclau T, Marcucio RS. Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environment. J Orthop Res. 2010 May; 28(5):687-96.
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      27. Xing Z, Lu C, Hu D, Yu YY, Wang X, Colnot C, Nakamura M, Wu Y, Miclau T, Marcucio RS. Multiple roles for CCR2 during fracture healing. Dis Model Mech. 2010 Jul-Aug; 3(7-8):451-8.
        View in: PubMed
      28. Hu D, Lu C, Sapozhnikova A, Barnett M, Sparrey C, Miclau T, Marcucio RS. Absence of beta3 integrin accelerates early skeletal repair. J Orthop Res. 2010 Jan; 28(1):32-7.
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      29. Yu YY, Lieu S, Lu C, Miclau T, Marcucio RS, Colnot C. Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair. Bone. 2010 Mar; 46(3):841-51.
        View in: PubMed
      30. Lu C, Buckley JM, Colnot C, Marcucio R, Miclau T. Basic research in orthopedic surgery: Current trends and future directions. Indian J Orthop. 2009 Oct; 43(4):318-23.
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      31. Acaroglu E, Akel I, Alanay A, Yazici M, Marcucio R. Comparison of the melatonin and calmodulin in paravertebral muscle and platelets of patients with or without adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2009 Aug 15; 34(18):E659-63.
        View in: PubMed
      32. Akel I, Kocak O, Bozkurt G, Alanay A, Marcucio R, Acaroglu E. The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model. Spine (Phila Pa 1976). 2009 Mar 15; 34(6):533-8.
        View in: PubMed
      33. Akel I, Demirkiran G, Alanay A, Karahan S, Marcucio R, Acaroglu E. The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model. Eur Spine J. 2009 Apr; 18(4):499-505.
        View in: PubMed
      34. Hu D, Colnot C, Marcucio RS. Effect of bone morphogenetic protein signaling on development of the jaw skeleton. Dev Dyn. 2008 Dec; 237(12):3727-37.
        View in: PubMed
      35. Hu D, Marcucio RS. A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm. Development. 2009 Jan; 136(1):107-16.
        View in: PubMed
      36. Hu D, Marcucio RS. Unique organization of the frontonasal ectodermal zone in birds and mammals. Dev Biol. 2009 Jan 1; 325(1):200-10.
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      37. Lu C, Hansen E, Sapozhnikova A, Hu D, Miclau T, Marcucio RS. Effect of age on vascularization during fracture repair. J Orthop Res. 2008 Oct; 26(10):1384-9.
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      38. Lu C, Rollins M, Hou H, Swartz HM, Hopf H, Miclau T, Marcucio RS. Tibial fracture decreases oxygen levels at the site of injury. Iowa Orthop J. 2008; 28:14-21.
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      39. Miclau T, Lu C, Thompson Z, Choi P, Puttlitz C, Marcucio R, Helms JA. Effects of delayed stabilization on fracture healing. J Orthop Res. 2007 Dec; 25(12):1552-8.
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      40. Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One. 2007; 2(11):e1150.
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      41. Foppiano S, Hu D, Marcucio RS. Signaling by bone morphogenetic proteins directs formation of an ectodermal signaling center that regulates craniofacial development. Dev Biol. 2007 Dec 1; 312(1):103-14.
        View in: PubMed
      42. Lu C, Miclau T, Hu D, Marcucio RS. Ischemia leads to delayed union during fracture healing: a mouse model. J Orthop Res. 2007 Jan; 25(1):51-61.
        View in: PubMed
      43. Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006 Mar; 117(3):698-703.
        View in: PubMed
      44. Lu C, Marcucio R, Miclau T. Assessing angiogenesis during fracture healing. Iowa Orthop J. 2006; 26:17-26.
        View in: PubMed
      45. Marcucio RS, Cordero DR, Hu D, Helms JA. Molecular interactions coordinating the development of the forebrain and face. Dev Biol. 2005 Aug 1; 284(1):48-61.
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      46. Lu C, Miclau T, Hu D, Hansen E, Tsui K, Puttlitz C, Marcucio RS. Cellular basis for age-related changes in fracture repair. J Orthop Res. 2005 Nov; 23(6):1300-7.
        View in: PubMed
      47. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7.
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      48. Cordero D, Marcucio R, Hu D, Gaffield W, Tapadia M, Helms JA. Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest. 2004 Aug; 114(4):485-94.
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      49. Ruberte J, Carretero A, Navarro M, Marcucio RS, Noden D. Morphogenesis of blood vessels in the head muscles of avian embryo: spatial, temporal, and VEGF expression analyses. Dev Dyn. 2003 Aug; 227(4):470-83.
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      50. Hu D, Marcucio RS, Helms JA. A zone of frontonasal ectoderm regulates patterning and growth in the face. Development. 2003 May; 130(9):1749-58.
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      51. Radlanski RJ, Renz H, Müller U, Schneider RS, Marcucio RS, Helms JA. Prenatal morphogenesis of the human mental foramen. Eur J Oral Sci. 2002 Dec; 110(6):452-9.
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      52. Noden DM, Marcucio R, Borycki AG, Emerson CP. Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis. Dev Dyn. 1999 Oct; 216(2):96-112.
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      53. Marcucio RS, Noden DM. Myotube heterogeneity in developing chick craniofacial skeletal muscles. Dev Dyn. 1999 Mar; 214(3):178-94.
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      54. Ellington JE, Ignotz GG, Varner DD, Marcucio RS, Mathison P, Ball BA. In vitro interaction between oviduct epithelial and equine sperm. Arch Androl. 1993 Sep-Oct; 31(2):79-86.
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