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    Ron Vale, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentCMP (Cellular Molecular Pha)
    Address600 16th Street
    San Francisco CA 94158
    Phone415-476-6380
      Other Positions
      TitleHoward Hughes Investigator


       Biography 
       Awards and Honors
      2012Albert Lasker Basic Medical Research Award

       ORNG Applications 
       Websites
       In The News
       Awarded Grants
       Global Health

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hendershott MC, Vale RD. Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5860-5.
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      2. Sirajuddin M, Rice LM, Vale RD. Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat Cell Biol. 2014 Apr; 16(4):335-44.
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      3. Hui E, Vale RD. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42.
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      4. Toret CP, D'Ambrosio MV, Vale RD, Simon MA, Nelson WJ. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014 Jan 20; 204(2):265-79.
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      5. Vale RD. Preface: the role of reconstitution in cytoskeleton research. Methods Enzymol. 2014; 540:xix-xxiii.
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      6. Moutinho-Pereira S, Stuurman N, Afonso O, Hornsveld M, Aguiar P, Goshima G, Vale RD, Maiato H. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49):19808-13.
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      7. Doyle KM, Vale RD. Creating opportunities for science PhDs to pursue careers in high school education. Mol Biol Cell. 2013 Nov; 24(21):3292-6.
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      8. Tanenbaum ME, Vale RD, McKenney RJ. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013; 2:e00943.
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      9. Vale RD. The value of asking questions. Mol Biol Cell. 2013 Mar; 24(6):680-2.
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      10. Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD. Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 2013 Feb 14; 152(4):768-77.
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      11. Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3.
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      12. Vale RD. How lucky can one be? A perspective from a young scientist at the right place at the right time. Nat Med. 2012 Oct; 18(10):1486-8.
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      13. Vale RD. Evaluating how we evaluate. Mol Biol Cell. 2012 Sep; 23(17):3285-9.
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      14. James JR, Vale RD. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature. 2012 Jul 5; 487(7405):64-9.
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      15. Zou W, Wang X, Vale RD, Ou G. Autophagy genes promote apoptotic cell corpse clearance. Autophagy. 2012 Aug; 8(8):1267-8.
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      16. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X, Vale RD, Ou G. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 2012 Apr 2; 197(1):27-35.
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      17. Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, López MP, Vale RD, Jülicher F, Reck-Peterson SL, Dogterom M. Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012 Feb 3; 148(3):502-14.
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      18. Petry S, Vale RD. A new cap for kinetochore fibre minus ends. Nat Cell Biol. 2011 Dec; 13(12):1389-91.
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      19. Cho C, Vale RD. The mechanism of dynein motility: insight from crystal structures of the motor domain. Biochim Biophys Acta. 2012 Jan; 1823(1):182-91.
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      20. Petry S, Pugieux C, Nédélec FJ, Vale RD. Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14473-8.
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      21. Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G. The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions. Curr Biol. 2011 Jun 7; 21(11):948-54.
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      22. Carter AP, Cho C, Jin L, Vale RD. Crystal structure of the dynein motor domain. Science. 2011 Mar 4; 331(6021):1159-65.
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      23. Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale RD. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem. 2011 Mar 4; 286(9):7457-67.
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      24. Yudushkin IA, Vale RD. Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3? in the endosomal compartment. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22128-33.
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      25. D'Ambrosio MV, Vale RD. A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J Cell Biol. 2010 Nov 1; 191(3):471-8.
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      26. Goodwin SS, Vale RD. Patronin regulates the microtubule network by protecting microtubule minus ends. Cell. 2010 Oct 15; 143(2):263-74.
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      27. Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N. Computer control of microscopes using µManager. Curr Protoc Mol Biol. 2010 Oct; Chapter 14:Unit14.20.
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      28. Ou G, Stuurman N, D'Ambrosio M, Vale RD. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science. 2010 Oct 29; 330(6004):677-80.
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      29. Tole S, Vale RD. Young leaders for biology in India. Science. 2010 Sep 17; 329(5998):1441.
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      30. Yu CH, Wu HJ, Kaizuka Y, Vale RD, Groves JT. Altered actin centripetal retrograde flow in physically restricted immunological synapses. PLoS One. 2010; 5(7):e11878.
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      31. Uehara R, Goshima G, Mabuchi I, Vale RD, Spudich JA, Griffis ER. Determinants of myosin II cortical localization during cytokinesis. Curr Biol. 2010 Jun 22; 20(12):1080-5.
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      32. Carter AP, Vale RD. Communication between the AAA+ ring and microtubule-binding domain of dynein. Biochem Cell Biol. 2010 Feb; 88(1):15-21.
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      33. Vale RD. It's a wonderful life: a career as an academic scientist. Mol Biol Cell. 2010 Jan 1; 21(1):11-4.
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      34. Kardon JR, Vale RD. Regulators of the cytoplasmic dynein motor. Nat Rev Mol Cell Biol. 2009 Dec; 10(12):854-65.
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      35. Vale RD, Spudich JA, Griffis ER. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol. 2009 Sep 7; 186(5):727-38.
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      36. DePristo MA, Chang L, Vale RD, Khan SM, Lipkow K. Introducing simulated cellular architecture to the quantitative analysis of fluorescent microscopy. Prog Biophys Mol Biol. 2009 Sep-Oct; 100(1-3):25-32.
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      37. Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, Vale RD. The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol. 2009 May 4; 185(3):521-34.
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      38. Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6998-7003.
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      39. Ou G, Vale RD. Molecular signatures of cell migration in C. elegans Q neuroblasts. J Cell Biol. 2009 Apr 6; 185(1):77-85.
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      40. Kardon JR, Reck-Peterson SL, Vale RD. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5669-74.
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      41. Vale RD, Dell K. The biological sciences in India: aiming high for the future. J Cell Biol. 2009 Feb 9; 184(3):342-53.
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      42. Gennerich A, Vale RD. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb; 21(1):59-67.
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      43. Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale RD, Gibbons IR. Structure and functional role of dynein's microtubule-binding domain. Science. 2008 Dec 12; 322(5908):1691-5.
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      44. Vale RD. Microscopes for fluorimeters: the era of single molecule measurements. Cell. 2008 Nov 28; 135(5):779-85.
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      45. Yildiz A, Tomishige M, Gennerich A, Vale RD. Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell. 2008 Sep 19; 134(6):1030-41.
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      46. Cho C, Reck-Peterson SL, Vale RD. Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem. 2008 Sep 19; 283(38):25839-45.
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      47. Goshima G, Mayer M, Zhang N, Stuurman N, Vale RD. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol. 2008 May 5; 181(3):421-9.
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      48. Trammell MA, Mahoney NM, Agard DA, Vale RD. Mob4 plays a role in spindle focusing in Drosophila S2 cells. J Cell Sci. 2008 Apr 15; 121(Pt 8):1284-92.
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      49. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61.
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      50. Roll-Mecak A, Vale RD. Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature. 2008 Jan 17; 451(7176):363-7.
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      51. Douglass AD, Vale RD. Single-molecule imaging of fluorescent proteins. Methods Cell Biol. 2008; 85:113-25.
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      52. Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale RD. Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20296-301.
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      53. Gennerich A, Carter AP, Reck-Peterson SL, Vale RD. Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007 Nov 30; 131(5):952-65.
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      54. Mori T, Vale RD, Tomishige M. How kinesin waits between steps. Nature. 2007 Nov 29; 450(7170):750-4.
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      55. Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. J Biol Chem. 2007 Nov 30; 282(48):34748-57.
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      56. Slep KC, Vale RD. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. Mol Cell. 2007 Sep 21; 27(6):976-91.
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      57. Griffis ER, Stuurman N, Vale RD. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007 Jun 18; 177(6):1005-15.
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      58. Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale RD, Stuurman N. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science. 2007 Apr 20; 316(5823):417-21.
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      59. Roll-Mecak A, Vale RD. Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? J Cell Biol. 2006 Dec 18; 175(6):849-51.
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      60. Tomishige M, Stuurman N, Vale RD. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol. 2006 Oct; 13(10):887-94.
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      61. Imanishi M, Endres NF, Gennerich A, Vale RD. Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3. J Cell Biol. 2006 Sep 25; 174(7):931-7.
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      62. Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale RD, Scholey JM. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol. 2006 Sep 25; 174(7):1035-45.
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      63. Reck-Peterson SL, Yildiz A, Carter AP, Gennerich A, Zhang N, Vale RD. Single-molecule analysis of dynein processivity and stepping behavior. Cell. 2006 Jul 28; 126(2):335-48.
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      64. Mahoney NM, Goshima G, Douglass AD, Vale RD. Making microtubules and mitotic spindles in cells without functional centrosomes. Curr Biol. 2006 Mar 21; 16(6):564-9.
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      65. Endres NF, Yoshioka C, Milligan RA, Vale RD. A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature. 2006 Feb 16; 439(7078):875-8.
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      66. Jambhekar A, McDermott K, Sorber K, Shepard KA, Vale RD, Takizawa PA, DeRisi JL. Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18005-10.
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      67. Goshima G, Wollman R, Stuurman N, Scholey JM, Vale RD. Length control of the metaphase spindle. Curr Biol. 2005 Nov 22; 15(22):1979-88.
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      68. Goshima G, Nédélec F, Vale RD. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J Cell Biol. 2005 Oct 24; 171(2):229-40.
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      69. Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale RD, Portnoy DA. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13646-51.
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      70. Dean SO, Rogers SL, Stuurman N, Vale RD, Spudich JA. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13473-8.
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      71. Dzhindzhev NS, Rogers SL, Vale RD, Ohkura H. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J Cell Sci. 2005 Aug 15; 118(Pt 16):3781-90.
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      72. Douglass AD, Vale RD. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell. 2005 Jun 17; 121(6):937-50.
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      73. Goshima G, Vale RD. Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell. 2005 Aug; 16(8):3896-907.
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      74. Roll-Mecak A, Vale RD. The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Curr Biol. 2005 Apr 12; 15(7):650-5.
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      75. Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale RD, Carter AP. The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem. 2005 Jun 24; 280(25):23960-5.
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      76. Mennella V, Rogers GC, Rogers SL, Buster DW, Vale RD, Sharp DJ. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Nat Cell Biol. 2005 Mar; 7(3):235-45.
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      77. Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale RD. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J Cell Biol. 2005 Feb 14; 168(4):587-98.
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      78. Rogers SL, Wiedemann U, Häcker U, Turck C, Vale RD. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr Biol. 2004 Oct 26; 14(20):1827-33.
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      79. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22.
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      80. Reck-Peterson SL, Vale RD. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14305.
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      81. Collins SR, Douglass A, Vale RD, Weissman JS. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2004 Oct; 2(10):e321.
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      82. Klopfenstein DR, Vale RD. The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell. 2004 Aug; 15(8):3729-39.
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      83. Dell KR, Vale RD. A tribute to Shinya Inoue and innovation in light microscopy. J Cell Biol. 2004 Apr; 165(1):21-5.
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      84. Reck-Peterson SL, Vale RD. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1491-5.
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      85. Yildiz A, Tomishige M, Vale RD, Selvin PR. Kinesin walks hand-over-hand. Science. 2004 Jan 30; 303(5658):676-8.
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      86. Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22; 427(6972):364-70.
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      87. Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale RD, Milligan RA. Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J Cell Biol. 2003 Nov 24; 163(4):743-53.
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      88. Vale RD. Myosin V motor proteins: marching stepwise towards a mechanism. J Cell Biol. 2003 Nov 10; 163(3):445-50.
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      89. Shepard KA, Gerber AP, Jambhekar A, Takizawa PA, Brown PO, Herschlag D, DeRisi JL, Vale RD. Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11429-34.
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      90. Rogers SL, Wiedemann U, Stuurman N, Vale RD. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol. 2003 Sep 15; 162(6):1079-88.
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      91. Goshima G, Vale RD. The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J Cell Biol. 2003 Sep 15; 162(6):1003-16.
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      92. Yaffe MP, Stuurman N, Vale RD. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8.
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      93. Rothenberg ME, Rogers SL, Vale RD, Jan LY, Jan YN. Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron. 2003 Aug 28; 39(5):779-91.
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      94. Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale RD, Kollman PA, Car R, Yount RG, Cooke R, Pate E. Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules. Science. 2003 May 2; 300(5620):798-801.
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      95. Naber N, Rice S, Matuska M, Vale RD, Cooke R, Pate E. EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain. Biophys J. 2003 May; 84(5):3190-6.
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      96. Rice S, Cui Y, Sindelar C, Naber N, Matuska M, Vale R, Cooke R. Thermodynamic properties of the kinesin neck-region docking to the catalytic core. Biophys J. 2003 Mar; 84(3):1844-54.
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      97. Vale RD. The molecular motor toolbox for intracellular transport. Cell. 2003 Feb 21; 112(4):467-80.
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      98. Tomishige M, Klopfenstein DR, Vale RD. Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization. Science. 2002 Sep 27; 297(5590):2263-7.
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      99. Rogers SL, Rogers GC, Sharp DJ, Vale RD. Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J Cell Biol. 2002 Sep 2; 158(5):873-84.
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      100. Klopfenstein DR, Tomishige M, Stuurman N, Vale RD. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell. 2002 May 3; 109(3):347-58.
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      101. Irie K, Tadauchi T, Takizawa PA, Vale RD, Matsumoto K, Herskowitz I. The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J. 2002 Mar 1; 21(5):1158-67.
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      102. Klopfenstein DR, Holleran EA, Vale RD. Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum. J Muscle Res Cell Motil. 2002; 23(7-8):631-8.
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      103. Tomishige M, Vale RD. Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change. J Cell Biol. 2000 Nov 27; 151(5):1081-92.
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      104. Thorn KS, Ubersax JA, Vale RD. Engineering the processive run length of the kinesin motor. J Cell Biol. 2000 Nov 27; 151(5):1093-100.
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      105. Wilhelm JE, Vale RD, Hegde RS. Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13132-7.
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      106. Klopfenstein DR, Vale RD, Rogers SL. Motor protein receptors: moonlighting on other jobs. Cell. 2000 Nov 10; 103(4):537-40.
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      107. Prahlad V, Helfand BT, Langford GM, Vale RD, Goldman RD. Fast transport of neurofilament protein along microtubules in squid axoplasm. J Cell Sci. 2000 Nov; 113 ( Pt 22):3939-46.
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      108. Takizawa PA, DeRisi JL, Wilhelm JE, Vale RD. Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science. 2000 Oct 13; 290(5490):341-4.
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      109. Vale RD. AAA proteins. Lords of the ring. J Cell Biol. 2000 Jul 10; 150(1):F13-9.
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      110. Khan S, Pierce D, Vale RD. Interactions of the chemotaxis signal protein CheY with bacterial flagellar motors visualized by evanescent wave microscopy. Curr Biol. 2000 Jul 27-Aug 10; 10(15):927-30.
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      111. Shimizu T, Thorn KS, Ruby A, Vale RD. ATPase kinetic characterization and single molecule behavior of mutant human kinesin motors defective in microtubule-based motility. Biochemistry. 2000 May 9; 39(18):5265-73.
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      112. Takizawa PA, Vale RD. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Proc Natl Acad Sci U S A. 2000 May 9; 97(10):5273-8.
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      113. Vale RD, Case R, Sablin E, Hart C, Fletterick R. Searching for kinesin's mechanical amplifier. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):449-57.
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      114. Vale RD, Milligan RA. The way things move: looking under the hood of molecular motor proteins. Science. 2000 Apr 7; 288(5463):88-95.
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      115. Hopkins SC, Vale RD, Kuntz ID. Inhibitors of kinesin activity from structure-based computer screening. Biochemistry. 2000 Mar 14; 39(10):2805-14.
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      116. Case RB, Rice S, Hart CL, Ly B, Vale RD. Role of the kinesin neck linker and catalytic core in microtubule-based motility. Curr Biol. 2000 Feb 10; 10(3):157-60.
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      117. Wilhelm JE, Mansfield J, Hom-Booher N, Wang S, Turck CW, Hazelrigg T, Vale RD. Isolation of a ribonucleoprotein complex involved in mRNA localization in Drosophila oocytes. J Cell Biol. 2000 Feb 7; 148(3):427-40.
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      118. Thorn KS, Naber N, Matuska M, Vale RD, Cooke R. A novel method of affinity-purifying proteins using a bis-arsenical fluorescein. Protein Sci. 2000 Feb; 9(2):213-7.
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      119. Govindan B, Vale RD. Characterization of a microtubule assembly inhibitor from Xenopus oocytes. Cell Motil Cytoskeleton. 2000 Jan; 45(1):51-7.
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      120. Dell KR, Turck CW, Vale RD. Mitotic phosphorylation of the dynein light intermediate chain is mediated by cdc2 kinase. Traffic. 2000 Jan; 1(1):38-44.
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      121. Rice S, Lin AW, Safer D, Hart CL, Naber N, Carragher BO, Cain SM, Pechatnikova E, Wilson-Kubalek EM, Whittaker M, Pate E, Cooke R, Taylor EW, Milligan RA, Vale RD. A structural change in the kinesin motor protein that drives motility. Nature. 1999 Dec 16; 402(6763):778-84.
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      122. Silva MM, Goreti M, Vale R, Caramão EB. Slurry sampling graphite furnace atomic absorption spectrometry: determination of trace metals in mineral coal. Talanta. 1999 Dec 6; 50(5):1035-43.
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      123. Vale RD. Millennial musings on molecular motors. Trends Cell Biol. 1999 Dec; 9(12):M38-42.
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      124. Pollock N, de Hostos EL, Turck CW, Vale RD. Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium. J Cell Biol. 1999 Nov 1; 147(3):493-506.
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      125. Hartman JJ, Vale RD. Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin. Science. 1999 Oct 22; 286(5440):782-5.
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      126. Friedman DS, Vale RD. Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain. Nat Cell Biol. 1999 Sep; 1(5):293-7.
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      127. Pierce DW, Hom-Booher N, Otsuka AJ, Vale RD. Single-molecule behavior of monomeric and heteromeric kinesins. Biochemistry. 1999 Apr 27; 38(17):5412-21.
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      128. Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999 Jan 11; 144(1):125-38.
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      129. Pierce DW, Vale RD. Single-molecule fluorescence detection of green fluorescence protein and application to single-protein dynamics. Methods Cell Biol. 1999; 58:49-73.
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      130. Kull FJ, Vale RD, Fletterick RJ. The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J Muscle Res Cell Motil. 1998 Nov; 19(8):877-86.
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      131. Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 1998 Oct 22; 395(6704):813-6.
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      132. Prahlad V, Yoon M, Moir RD, Vale RD, Goldman RD. Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks. J Cell Biol. 1998 Oct 5; 143(1):159-70.
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      133. de Hostos EL, McCaffrey G, Sucgang R, Pierce DW, Vale RD. A developmentally regulated kinesin-related motor protein from Dictyostelium discoideum. Mol Biol Cell. 1998 Aug; 9(8):2093-106.
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      134. Wells SE, Hillner PE, Vale RD, Sachs AB. Circularization of mRNA by eukaryotic translation initiation factors. Mol Cell. 1998 Jul; 2(1):135-40.
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      135. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell. 1998 Apr 17; 93(2):277-87.
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      136. Lohman TM, Thorn K, Vale RD. Staying on track: common features of DNA helicases and microtubule motors. Cell. 1998 Apr 3; 93(1):9-12.
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      137. Romberg L, Pierce DW, Vale RD. Role of the kinesin neck region in processive microtubule-based motility. J Cell Biol. 1998 Mar 23; 140(6):1407-16.
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      138. Pollock N, Koonce MP, de Hostos EL, Vale RD. In vitro microtubule-based organelle transport in wild-type Dictyostelium and cells overexpressing a truncated dynein heavy chain. Cell Motil Cytoskeleton. 1998; 40(3):304-14.
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      139. Pierce DW, Vale RD. Assaying processive movement of kinesin by fluorescence microscopy. Methods Enzymol. 1998; 298:154-71.
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      140. Funatsu T, Harada Y, Higuchi H, Tokunaga M, Saito K, Ishii Y, Vale RD, Yanagida T. Imaging and nano-manipulation of single biomolecules. Biophys Chem. 1997 Oct; 68(1-3):63-72.
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      141. Case RB, Pierce DW, Hom-Booher N, Hart CL, Vale RD. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell. 1997 Sep 5; 90(5):959-66.
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      142. Takizawa PA, Sil A, Swedlow JR, Herskowitz I, Vale RD. Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature. 1997 Sep 4; 389(6646):90-3.
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      143. Coppin CM, Pierce DW, Hsu L, Vale RD. The load dependence of kinesin's mechanical cycle. Proc Natl Acad Sci U S A. 1997 Aug 5; 94(16):8539-44.
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      144. Woehlke G, Ruby AK, Hart CL, Ly B, Hom-Booher N, Vale RD. Microtubule interaction site of the kinesin motor. Cell. 1997 Jul 25; 90(2):207-16.
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      145. Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale RD, Milligan RA. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 1997 Jul 25; 90(2):217-24.
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      146. Pierce DW, Hom-Booher N, Vale RD. Imaging individual green fluorescent proteins. Nature. 1997 Jul 24; 388(6640):338.
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      147. Tripet B, Vale RD, Hodges RS. Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides. Implications for motor activity. J Biol Chem. 1997 Apr 4; 272(14):8946-56.
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      148. Vale RD, Fletterick RJ. The design plan of kinesin motors. Annu Rev Cell Dev Biol. 1997; 13:745-77.
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      149. Vale RD. Switches, latches, and amplifiers: common themes of G proteins and molecular motors. J Cell Biol. 1996 Oct; 135(2):291-302.
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      150. Niclas J, Allan VJ, Vale RD. Cell cycle regulation of dynein association with membranes modulates microtubule-based organelle transport. J Cell Biol. 1996 May; 133(3):585-93.
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      151. Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 1996 Apr 11; 380(6574):555-9.
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      152. Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996 Apr 11; 380(6574):550-5.
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      153. Vale RD, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T. Direct observation of single kinesin molecules moving along microtubules. Nature. 1996 Apr 4; 380(6573):451-3.
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      154. Coppin CM, Finer JT, Spudich JA, Vale RD. Detection of sub-8-nm movements of kinesin by high-resolution optical-trap microscopy. Proc Natl Acad Sci U S A. 1996 Mar 5; 93(5):1913-7.
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      155. McNally FJ, Okawa K, Iwamatsu A, Vale RD. Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. J Cell Sci. 1996 Mar; 109 ( Pt 3):561-7.
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      156. Vignali G, Niclas J, Sprocati MT, Vale RD, Sirtori C, Navone F. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Eur J Neurosci. 1996 Mar; 8(3):536-44.
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      157. Wilhelm JE, Vale RD. A one-hybrid system for detecting RNA-protein interactions. Genes Cells. 1996 Mar; 1(3):317-23.
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      158. Fowler VM, Vale R. Cytoskeleton. Curr Opin Cell Biol. 1996 Feb; 8(1):1-3.
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      159. Shimizu T, Sablin E, Vale RD, Fletterick R, Pechatnikova E, Taylor EW. Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain. Biochemistry. 1995 Oct 10; 34(40):13259-66.
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      160. Hoenger A, Sablin EP, Vale RD, Fletterick RJ, Milligan RA. Three-dimensional structure of a tubulin-motor-protein complex. Nature. 1995 Jul 20; 376(6537):271-4.
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      161. Coppin CM, Finer JT, Spudich JA, Vale RD. Measurement of the isometric force exerted by a single kinesin molecule. Biophys J. 1995 Apr; 68(4 Suppl):242S-244S.
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      162. Shimizu T, Toyoshima YY, Edamatsu M, Vale RD. Comparison of the motile and enzymatic properties of two microtubule minus-end-directed motors, ncd and cytoplasmic dynein. Biochemistry. 1995 Feb 7; 34(5):1575-82.
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      163. Vale RD, Coppin CM, Malik F, Kull FJ, Milligan RA. Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules. J Biol Chem. 1994 Sep 23; 269(38):23769-75.
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      164. Vale RD. Getting a grip on myosin. Cell. 1994 Sep 9; 78(5):733-7.
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      165. Allan V, Vale R. Movement of membrane tubules along microtubules in vitro: evidence for specialised sites of motor attachment. J Cell Sci. 1994 Jul; 107 ( Pt 7):1885-97.
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      166. Malik F, Brillinger D, Vale RD. High-resolution tracking of microtubule motility driven by a single kinesin motor. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4584-8.
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      167. Niclas J, Navone F, Hom-Booher N, Vale RD. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron. 1994 May; 12(5):1059-72.
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      168. McNally FJ, Vale RD. Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell. 1993 Nov 5; 75(3):419-29.
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      169. Wilhelm JE, Vale RD. RNA on the move: the mRNA localization pathway. J Cell Biol. 1993 Oct; 123(2):269-74.
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      170. Vale RD. Measuring single protein motors at work. Science. 1993 Apr 9; 260(5105):169-70.
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      171. Romberg L, Vale RD. Chemomechanical cycle of kinesin differs from that of myosin. Nature. 1993 Jan 14; 361(6408):168-70.
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      172. Shimizu T, Toyoshima YY, Vale RD. Use of ATP analogs in motor assays. Methods Cell Biol. 1993; 39:167-77.
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      173. Vale RD, Malik F, Brown D. Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity motor proteins. J Cell Biol. 1992 Dec; 119(6):1589-96.
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      174. Goldstein LS, Vale RD. Cell biology. New cytoskeletal liaisons. Nature. 1992 Sep 17; 359(6392):193-4.
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      175. Vale RD. Microtubule motors: many new models off the assembly line. Trends Biochem Sci. 1992 Aug; 17(8):300-4.
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      176. Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. J Cell Biol. 1992 Jun; 117(6):1263-75.
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      177. Ferreira A, Niclas J, Vale RD, Banker G, Kosik KS. Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J Cell Biol. 1992 May; 117(3):595-606.
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      178. Goldstein LS, Vale RD. Motor proteins. A brave new world for dynein. Nature. 1991 Aug 15; 352(6336):569-70.
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      179. Allan VJ, Vale RD. Cell cycle control of microtubule-based membrane transport and tubule formation in vitro. J Cell Biol. 1991 Apr; 113(2):347-59.
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      180. Schliwa M, Shimizu T, Vale RD, Euteneuer U. Nucleotide specificities of anterograde and retrograde organelle transport in Reticulomyxa are indistinguishable. J Cell Biol. 1991 Mar; 112(6):1199-203.
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      181. Shimizu T, Furusawa K, Ohashi S, Toyoshima YY, Okuno M, Malik F, Vale RD. Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. J Cell Biol. 1991 Mar; 112(6):1189-97.
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      182. Vale RD. Severing of stable microtubules by a mitotically activated protein in Xenopus egg extracts. Cell. 1991 Feb 22; 64(4):827-39.
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      183. Malik F, Vale R. Cell biology. A new direction for kinesin. Nature. 1990 Oct 25; 347(6295):713-4.
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      184. Vale RD, Goldstein LS. One motor, many tails: an expanding repertoire of force-generating enzymes. Cell. 1990 Mar 23; 60(6):883-5.
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      185. Vale RD. Microtubule-based motor proteins. Curr Opin Cell Biol. 1990 Feb; 2(1):15-22.
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      186. Vale RD, Oosawa F. Protein motors and Maxwell's demons: does mechanochemical transduction involve a thermal ratchet? Adv Biophys. 1990; 26:97-134.
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      187. Vale RD, Soll DR, Gibbons IR. One-dimensional diffusion of microtubules bound to flagellar dynein. Cell. 1989 Dec 1; 59(5):915-25.
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      188. Howard J, Hudspeth AJ, Vale RD. Movement of microtubules by single kinesin molecules. Nature. 1989 Nov 9; 342(6246):154-8.
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      189. McCaffrey G, Vale RD. Identification of a kinesin-like microtubule-based motor protein in Dictyostelium discoideum. EMBO J. 1989 Nov; 8(11):3229-34.
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      190. Vale RD, Toyoshima YY. Microtubule translocation properties of intact and proteolytically digested dyneins from Tetrahymena cilia. J Cell Biol. 1989 Jun; 108(6):2327-34.
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      191. Vale RD, Hotani H. Formation of membrane networks in vitro by kinesin-driven microtubule movement. J Cell Biol. 1988 Dec; 107(6 Pt 1):2233-41.
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      192. Vale RD, Toyoshima YY. Rotation and translocation of microtubules in vitro induced by dyneins from Tetrahymena cilia. Cell. 1988 Feb 12; 52(3):459-69.
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      193. Porter ME, Scholey JM, Stemple DL, Vigers GP, Vale RD, Sheetz MP, McIntosh JR. Characterization of the microtubule movement produced by sea urchin egg kinesin. J Biol Chem. 1987 Feb 25; 262(6):2794-802.
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      194. Sheetz MP, Vale R, Schnapp B, Schroer T, Reese T. Movements of vesicles on microtubules. Ann N Y Acad Sci. 1987; 493:409-16.
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      195. Vale RD. Intracellular transport using microtubule-based motors. Annu Rev Cell Biol. 1987; 3:347-78.
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      196. Sheetz MP, Vale R, Schnapp B, Schroer T, Reese T. Vesicle movements and microtubule-based motors. J Cell Sci Suppl. 1986; 5:181-8.
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      197. Vale RD, Schnapp BJ, Mitchison T, Steuer E, Reese TS, Sheetz MP. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 1985 Dec; 43(3 Pt 2):623-32.
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      198. Vale RD, Reese TS, Sheetz MP. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 1985 Aug; 42(1):39-50.
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      199. Vale RD, Schnapp BJ, Reese TS, Sheetz MP. Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon. Cell. 1985 Mar; 40(3):559-69.
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      200. Schnapp BJ, Vale RD, Sheetz MP, Reese TS. Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell. 1985 Feb; 40(2):455-62.
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      201. Vale RD, Schnapp BJ, Reese TS, Sheetz MP. Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon. Cell. 1985 Feb; 40(2):449-54.
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      202. Vale RD, Shooter EM. Assaying binding of nerve growth factor to cell surface receptors. Methods Enzymol. 1985; 109:21-39.
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      203. Vale RD, Szent-Gyorgyi AG, Sheetz MP. Movement of scallop myosin on Nitella actin filaments: regulation by calcium. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6775-8.
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      204. Vale RD, Peterson SW, Matiuck NV, Fox CF. Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. J Cell Biol. 1984 Mar; 98(3):1129-32.
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      205. Vale RD, Shooter EM. Alteration of binding properties and cytoskeletal attachment of nerve growth factor receptors in PC12 cells by wheat germ agglutinin. J Cell Biol. 1982 Sep; 94(3):710-7.
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