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Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 2023 09 14; 186(19):4216-4234.e33.
Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. PMID: 37714135; PMCID: PMC10508323.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails. Nat Biotechnol. 2023 04; 41(4):521-531.
Shy BR, Vykunta VS, Ha A, Talbot A, Roth TL, Nguyen DN, Pfeifer WG, Chen YY, Blaeschke F, Shifrut E, Vedova S, Mamedov MR, Chung JJ, Li H, Yu R, Wu D, Wolf J, Martin TG, Castro CE, Ye L, Esensten JH, Eyquem J, Marson A. PMID: 36008610; PMCID: PMC10065198.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182.
Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function. Front Immunol. 2022; 13:845499.
Blaeschke F, Ortner E, Stenger D, Mahdawi J, Apfelbeck A, Habjan N, Weißer T, Kaeuferle T, Willier S, Kobold S, Feuchtinger T. PMID: 35464394; PMCID: PMC9018974.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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CRISPR activation and interference screens decode stimulation responses in primary human T cells. Science. 2022 02 04; 375(6580):eabj4008.
Schmidt R, Steinhart Z, Layeghi M, Freimer JW, Bueno R, Nguyen VQ, Blaeschke F, Ye CJ, Marson A. PMID: 35113687; PMCID: PMC9307090.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Robust T cell activation requires an eIF3-driven burst in T cell receptor translation. Elife. 2021 12 31; 10.
De Silva D, Ferguson L, Chin GH, Smith BE, Apathy RA, Roth TL, Blaeschke F, Kudla M, Marson A, Ingolia NT, Cate JH. PMID: 34970966; PMCID: PMC8758144.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins. Blood Cancer J. 2021 06 04; 11(6):108.
Blaeschke F, Stenger D, Apfelbeck A, Cadilha BL, Benmebarek MR, Mahdawi J, Ortner E, Lepenies M, Habjan N, Rataj F, Willier S, Kaeuferle T, Majzner RG, Busch DH, Kobold S, Feuchtinger T. PMID: 34088894; PMCID: PMC8178409.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering. Cell Rep. 2021 06 01; 35(9):109207.
Hamilton JR, Tsuchida CA, Nguyen DN, Shy BR, McGarrigle ER, Sandoval Espinoza CR, Carr D, Blaeschke F, Marson A, Doudna JA. PMID: 34077734; PMCID: PMC8236216.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Protective T cell receptor identification for orthotopic reprogramming of immunity in refractory virus infections. Mol Ther. 2022 01 05; 30(1):198-208.
Stief TA, Kaeuferle T, Müller TR, Döring M, Jablonowski LM, Schober K, Feucht J, Dennehy KM, Willier S, Blaeschke F, Handgretinger R, Lang P, Busch DH, Feuchtinger T. PMID: 34058386; PMCID: PMC8753271.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy. Blood. 2021 02 25; 137(8):1037-1049.
Willier S, Rothämel P, Hastreiter M, Wilhelm J, Stenger D, Blaeschke F, Rohlfs M, Kaeuferle T, Schmid I, Albert MH, Binder V, Subklewe M, Klein C, Feuchtinger T. PMID: 33094319.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:42-53.
Cordes N, Kolbe C, Lock D, Holzer T, Althoff D, Schäfer D, Blaeschke F, Kotter B, Karitzky S, Rossig C, Cathomen T, Feuchtinger T, Bürger I, Assenmacher M, Schaser T, Kaiser AD. PMID: 33768128; PMCID: PMC7966970.
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PubMed Mentions:
1
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TCF-1 regulates HIV-specific CD8+ T cell expansion capacity. JCI Insight. 2021 02 08; 6(3).
Rutishauser RL, Deguit CDT, Hiatt J, Blaeschke F, Roth TL, Wang L, Raymond KA, Starke CE, Mudd JC, Chen W, Smullin C, Matus-Nicodemos R, Hoh R, Krone M, Hecht FM, Pilcher CD, Martin JN, Koup RA, Douek DC, Brenchley JM, Sékaly RP, Pillai SK, Marson A, Deeks SG, McCune JM, Hunt PW. PMID: 33351785; PMCID: PMC7934879.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR. Blood. 2020 09 17; 136(12):1407-1418.
Stenger D, Stief TA, Kaeuferle T, Willier S, Rataj F, Schober K, Vick B, Lotfi R, Wagner B, Grünewald TGP, Kobold S, Busch DH, Jeremias I, Blaeschke F, Feuchtinger T. PMID: 32483603; PMCID: PMC7612202.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells. J Immunother Cancer. 2020 09; 8(2).
Willier S, Raedler J, Blaeschke F, Stenger D, Pazos Escudero M, Jurgeleit F, Grünewald TGP, Binder V, Schmid I, Albert MH, Wolf A, Feuchtinger T. PMID: 32938628; PMCID: PMC7497522.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR). EMBO J. 2020 08 17; 39(16):e104730.
Dong R, Libby KA, Blaeschke F, Fuchs W, Marson A, Vale RD, Su X. PMID: 32643825; PMCID: PMC7429742.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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CRISPR-Cas9-Mediated Glucocorticoid Resistance in Virus-Specific T Cells for Adoptive T Cell Therapy Posttransplantation. Mol Ther. 2020 09 02; 28(9):1965-1973.
Kaeuferle T, Deisenberger L, Jablonowski L, Stief TA, Blaeschke F, Willier S, Feuchtinger T. PMID: 32559432; PMCID: PMC7474265.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21.
Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591; PMCID: PMC7219528.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Leukemia-induced dysfunctional TIM-3+CD4+ bone marrow T cells increase risk of relapse in pediatric B-precursor ALL patients. Leukemia. 2020 10; 34(10):2607-2620.
Blaeschke F, Willier S, Stenger D, Lepenies M, Horstmann MA, Escherich G, Zimmermann M, Rojas Ringeling F, Canzar S, Kaeuferle T, Rohlfs M, Binder V, Klein C, Feuchtinger T. PMID: 32203137.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Efficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic chemotherapy - results of a non-interventional observation study. BMC Cancer. 2019 Nov 15; 19(1):1118.
Willier S, Cabanillas Stanchi KM, von Have M, Binder V, Blaeschke F, Feucht J, Feuchtinger T, Döring M. PMID: 31730451; PMCID: PMC6858739.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Landscape of stimulation-responsive chromatin across diverse human immune cells. Nat Genet. 2019 10; 51(10):1494-1505.
Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. PMID: 31570894; PMCID: PMC6858557.
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PubMed Mentions:
96 Fields:
Translation:
HumansCells
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Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy. Cytotherapy. 2019 09; 21(9):973-986.
Blaeschke F, Paul MC, Schuhmann MU, Rabsteyn A, Schroeder C, Casadei N, Matthes J, Mohr C, Lotfi R, Wagner B, Kaeuferle T, Feucht J, Willier S, Handgretinger R, StevanoviC S, Lang P, Feuchtinger T. PMID: 31351799.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation. J Hematol Oncol. 2019 02 06; 12(1):13.
Kaeuferle T, Krauss R, Blaeschke F, Willier S, Feuchtinger T. PMID: 30728058; PMCID: PMC6364410.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Systematic identification of cancer-specific MHC-binding peptides with RAVEN. Oncoimmunology. 2018; 7(9):e1481558.
Baldauf MC, Gerke JS, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio RA, Kanaseki T, Kiran MM, Dallmayer M, Musa J, Akpolat N, Akatli AN, Rosman FC, Özen Ö, Sugita S, Hasegawa T, Sugimura H, Baumhoer D, Knott MML, Sannino G, Marchetto A, Li J, Busch DH, Feuchtinger T, Ohmura S, Orth MF, Thiel U, Kirchner T, Grünewald TGP. PMID: 30228952; PMCID: PMC6140548.
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PubMed Mentions:
10 Fields:
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Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia. Cancer Immunol Immunother. 2018 07; 67(7):1053-1066.
Blaeschke F, Stenger D, Kaeuferle T, Willier S, Lotfi R, Kaiser AD, Assenmacher M, Döring M, Feucht J, Feuchtinger T. PMID: 29605883.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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MRD response in a refractory paediatric T-ALL patient through anti-programmed cell death 1 (PD-1) Ab treatment associated with induction of fatal GvHD. Bone Marrow Transplant. 2017 08; 52(8):1221-1224.
Boekstegers AM, Blaeschke F, Schmid I, Wiebking V, Immler S, Hoffmann F, Bochmann K, Müller S, Grünewald TGP, Feucht J, Feuchtinger T. PMID: 28581460.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Posaconazole plasma concentrations in pediatric patients receiving antifungal prophylaxis during neutropenia. Med Mycol. 2017 Jun 01; 55(4):375-384.
Döring M, Cabanillas Stanchi KM, Klinker H, Eikemeier M, Feucht J, Blaeschke F, Schwarze CP, Ebinger M, Feuchtinger T, Handgretinger R, Heinz WJ. PMID: 27703016.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells. Oncoimmunology. 2017; 6(5):e1312239.
Thiel U, Schober SJ, Einspieler I, Kirschner A, Thiede M, Schirmer D, Gall K, Blaeschke F, Schmidt O, Jabar S, Ranft A, Alba Rubío R, Dirksen U, Grunewald TGP, Sorensen PH, Richter GHS, von Lüttichau IT, Busch DH, Burdach SEG. PMID: 28638739; PMCID: PMC5467994.
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PubMed Mentions:
15 Fields:
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Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation. J Cancer Res Clin Oncol. 2017 Jul; 143(7):1281-1292.
Döring M, Cabanillas Stanchi KM, Queudeville M, Feucht J, Blaeschke F, Schlegel P, Feuchtinger T, Lang P, Müller I, Handgretinger R, Heinz WJ. PMID: 28258343.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCTClinical Trials
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T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts. Oncotarget. 2016 Nov 22; 7(47):76902-76919.
Feucht J, Kayser S, Gorodezki D, Hamieh M, Döring M, Blaeschke F, Schlegel P, Bösmüller H, Quintanilla-Fend L, Ebinger M, Lang P, Handgretinger R, Feuchtinger T. PMID: 27708227; PMCID: PMC5363558.
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PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow. Oncotarget. 2016 Oct 25; 7(43):70959-70968.
Thiel U, Wawer A, von Luettichau I, Bender HU, Blaeschke F, Grunewald TG, Steinborn M, Röper B, Bonig H, Klingebiel T, Bader P, Koscielniak E, Paulussen M, Dirksen U, Juergens H, Kolb HJ, Burdach SE. PMID: 27486822; PMCID: PMC5342601.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens. Oncotarget. 2016 Aug 30; 7(35):56584-56597.
Kirschner A, Thiede M, Blaeschke F, Richter GH, Gerke JS, Baldauf MC, Grünewald TG, Busch DH, Burdach S, Thiel U. PMID: 27447745; PMCID: PMC5302936.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo. Oncotarget. 2016 Jul 12; 7(28):43267-43280.
Blaeschke F, Thiel U, Kirschner A, Thiede M, Rubio RA, Schirmer D, Kirchner T, Mall S, Klar R, Riddell S, Busch DH, Krackhardt A, Grunewald TG, Burdach S. PMID: 27281613; PMCID: PMC5190022.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment. Br J Cancer. 2013 Nov 12; 109(10):2523-32.
Thiel U, Koscielniak E, Blaeschke F, Grunewald TG, Badoglio M, Diaz MA, Paillard C, Prete A, Ussowicz M, Lang P, Fagioli F, Lutz P, Ehninger G, Schneider P, Santucci A, Bader P, Gruhn B, Faraci M, Antunovic P, Styczynski J, Krüger WH, Castagna L, Rohrlich P, Ouachée-Chardin M, Salmon A, Peters C, Bregni M, Burdach S, Solid Tumour Working Party and the Paediatric Disease Working Party of the European Group for Blood . PMID: 24149176; PMCID: PMC3833217.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Human leukocyte antigen distribution in German Caucasians with advanced Ewing's sarcoma. Klin Padiatr. 2012 Oct; 224(6):353-8.
Thiel U, Wolf P, Wawer A, Blaeschke F, Grunewald TG, von Lüttichau IT, Klingebiel T, Bader P, Borkhardt A, Laws HJ, Handgretinger R, Lang P, Schlegel PG, Eyrich M, Gruhn B, Ehninger G, Koscielniak E, Klein C, Sykora KW, Holler E, Mauz-Körholz C, Woessmann W, Richter GH, Schmidt AH, Peters C, Dirksen U, Jürgens H, Bregni M, Burdach S. PMID: 22821288.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans