Su Guo, PhD
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Title | Professor |
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School | UCSF School of Pharmacy |
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Department | Bioengineering |
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Address | 1550 4th Street, Bldg 19B San Francisco CA 94158
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Phone | 415-502-4949 |
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vCard | Download vCard |
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Biography Fudan University | 1991
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| 1991 | Outstanding Student Award | Cornell Graduate School | 1994
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| 1994 | Liu Memorial Award | Pharmacia Biotech and Science | 1998
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| 1998 | Finalist, Amersham Pharmacia Biotech and Science Prize for Young Scientist | | 2001
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| 2001 | Searle Scholar | | 2001
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| 2001 | Burroughs Wellcome Fund New Investigator | UCSF | 2002
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| 2002 | Sandler Award | David and Lucile Packard Foundation | 2002
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| 2002 | Science and Engineering Fellow of the David and Lucile Packard Foundation | UCSF | 2005
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| 2005 | Sandler Award | UCSF | 2006
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| 2006 | Byers Award |
Overview Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. After graduation, she became fascinated with how the brain works. As a research and postdoctoral fellow at Harvard Medical School and Genentech Inc. respectively, she carried out neurobiological studies of the development of brain neurotransmitter systems, using the vertebrate genetic model organism zebrafish. After establishing her independent research lab at the University of California, San Francisco, Dr. Guo has continued to study the molecular genetics of neural development and has expanded her research into the understanding of behavior. With her research, Dr. Guo strives to make significant contributions to our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.
Research ORNG Applications Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Lu JG, Bishop J, Cheyette S, Zhulin IB, Guo S, Sobreira N, Brenner SE. A novel PRRT2 pathogenic variant in a family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures. Cold Spring Harb Mol Case Stud. 2018 Feb; 4(1). PMID: 29167286.
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Wagle M, Nguyen J, Lee S, Zaitlen N, Guo S. Heritable natural variation of an anxiety-like behavior in larval zebrafish. J Neurogenet. 2017 Sep; 31(3):138-148. PMID: 28678579.
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Oltrabella F, Melgoza A, Nguyen B, Guo S. Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model. Dev Growth Differ. 2017 May; 59(4):194-210. PMID: 28516445.
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Liu H, Chen S, Huang K, Kim J, Mo H, Iovine R, Gendre J, Pascal P, Li Q, Sun Y, Dong Z, Arkin M, Guo S, Huang B. A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery. PLoS One. 2016; 11(10):e0164645. PMID: 27732643.
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Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016; 25(2):308-15.
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McGorty R, Liu H, Kamiyama D, Dong Z, Guo S, Huang B. Open-top selective plane illumination microscope for conventionally mounted specimens. Opt Express. 2015 Jun 15; 23(12):16142-53. PMID: 26193587; PMCID: PMC4523553.
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Gehrke S, Wu Z, Klinkenberg M, Sun Y, Auburger G, Guo S, Lu B. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Cell Metab. 2015 Jan 06; 21(1):95-108. PMID: 25565208; PMCID: PMC4455944.
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Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. PMID: 25319688; PMCID: PMC4198537.
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Liu C, Sun Y, Arnold J, Lu B, Guo S. Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells. Biochem Biophys Res Commun. 2014 Oct 03; 452(4):895-900. PMID: 25218470; PMCID: PMC4193974.
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Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508. PMID: 24040509; PMCID: PMC3771564.
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Dong Z, Peng J, Guo S. Stable gene silencing in zebrafish with spatiotemporally targetable RNA interference. Genetics. 2013 Apr; 193(4):1065-71. PMID: 23378068; PMCID: PMC3606086.
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Yang N, Dong Z, Guo S. Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain. J Neurosci. 2012 Aug 08; 32(32):10940-8. PMID: 22875928; PMCID: PMC3478895.
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Ritter DI, Dong Z, Guo S, Chuang JH. Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 2012; 7(5):e35202. PMID: 22567096; PMCID: PMC3342275.
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Sun Y, Dong Z, Khodabakhsh H, Chatterjee S, Guo S. Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides. PLoS One. 2012; 7(4):e35645. PMID: 22563390.
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Dong Z, Yang N, Yeo SY, Chitnis A, Guo S. Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron. 2012 Apr 12; 74(1):65-78. PMID: 22500631; PMCID: PMC3466114.
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Guo S, Wagle M, Mathur P. Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors. Dev Neurobiol. 2012 Mar; 72(3):358-65. PMID: 21634015.
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Yu W, Sun Y, Guo S, Lu B. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet. 2011 Aug 15; 20(16):3227-40. PMID: 21613270; PMCID: PMC3140825.
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Dong Z, Wagle M, Guo S. Time-lapse live imaging of clonally related neural progenitor cells in the developing zebrafish forebrain. J Vis Exp. 2011 Apr 06; (50). PMID: 21505407; PMCID: PMC3169268.
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Chen L, Zheng J, Yang N, Li H, Guo S. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J Biol Chem. 2011 May 27; 286(21):18641-9. PMID: 21471212; PMCID: PMC3099680.
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Mathur P, Lau B, Guo S. Conditioned place preference behavior in zebrafish. Nat Protoc. 2011 Mar; 6(3):338-45. PMID: 21372814.
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Lau BY, Mathur P, Gould GG, Guo S. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2581-6. PMID: 21262817; PMCID: PMC3038752.
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Mathur P, Guo S. Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behav Brain Res. 2011 Jun 01; 219(2):234-9. PMID: 21255611; PMCID: PMC3062742.
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Mueller T, Dong Z, Berberoglu MA, Guo S. The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain Res. 2011 Mar 24; 1381:95-105. PMID: 21219890; PMCID: PMC3052766.
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Wagle M, Mathur P, Guo S. Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. J Neurosci. 2011 Jan 05; 31(1):214-24. PMID: 21209207; PMCID: PMC3030280.
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Mathur P, Berberoglu MA, Guo S. Preference for ethanol in zebrafish following a single exposure. Behav Brain Res. 2011 Feb 02; 217(1):128-33. PMID: 20974186; PMCID: PMC3466104.
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Ritter DI, Li Q, Kostka D, Pollard KS, Guo S, Chuang JH. The importance of being cis: evolution of orthologous fish and mammalian enhancer activity. Mol Biol Evol. 2010 Oct; 27(10):2322-32. PMID: 20494938; PMCID: PMC3107594.
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Mathur P, Guo S. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis. 2010 Oct; 40(1):66-72. PMID: 20493262; PMCID: PMC3021971.
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Li Q, Ritter D, Yang N, Dong Z, Li H, Chuang JH, Guo S. A systematic approach to identify functional motifs within vertebrate developmental enhancers. Dev Biol. 2010 Jan 15; 337(2):484-95. PMID: 19850031; PMCID: PMC3330829.
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Mueller T, Guo S. The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. J Comp Neurol. 2009 Oct 20; 516(6):553-68. PMID: 19673006; PMCID: PMC2828780.
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Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. PMID: 19842929; PMCID: PMC2923222.
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Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 2009 Sep 09; 4(9):e6918. PMID: 19742326; PMCID: PMC2735033.
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Peng J, Wagle M, Mueller T, Mathur P, Lockwood BL, Bretaud S, Guo S. Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. J Neurosci. 2009 Jul 01; 29(26):8408-18. PMID: 19571131; PMCID: PMC2722107.
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Guo S. Using zebrafish to assess the impact of drugs on neural development and function. Expert Opin Drug Discov. 2009 Jul 01; 4(7):715-726. PMID: 19774094.
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Berberoglu MA, Dong Z, Mueller T, Guo S. fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr Patterns. 2009 Sep; 9(6):411-22. PMID: 19524703; PMCID: PMC2746713.
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Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7798-803. PMID: 19416841; PMCID: PMC2683122.
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Guo, S., Peng, J., Wagle, M., Mueller, T. and Mathur, P. Communicative &
Integrative Biology
. Camouflage response in zebrafish: A
model for genetic dissection of molecular and cellular circuitries underlying Alcoholism
. 2009; 2(6):512-514.
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Krishnan K, Salomonis N, Guo S. Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 2008; 3(11):e3621. PMID: 18978947; PMCID: PMC2575381.
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Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH. cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation. Bioinformatics. 2008 Oct 15; 24(20):2418-9. PMID: 18718943; PMCID: PMC2562007.
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Mueller T, Wullimann MF, Guo S. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol. 2008 Mar 10; 507(2):1245-57. PMID: 18181142.
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Guo, S. Biomarkers for Psychiatric Disorders. Animal models for anxiety disorders. 2008; New York, NY.
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Guo, S. Parkinson’s Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models. Insights from zebrafish PD models, and their potential for identifying novel drug targets and therapeutic compounds. 2008.
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Bretaud S, Li Q, Lockwood BL, Kobayashi K, Lin E, Guo S. A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish. Neuroscience. 2007 May 25; 146(3):1109-16. PMID: 17428610.
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Jeong JY, Einhorn Z, Mathur P, Chen L, Lee S, Kawakami K, Guo S. Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development. 2007 Jan; 134(1):127-36. PMID: 17164418.
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Wang X, Yang N, Uno E, Roeder RG, Guo S. A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17284-9. PMID: 17088561; PMCID: PMC1859923.
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Lau B, Bretaud S, Huang Y, Lin E, Guo S. Dissociation of food and opiate preference by a genetic mutation in zebrafish. Genes Brain Behav. 2006 Oct; 5(7):497-505. PMID: 17010096.
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Jeong JY, Einhorn Z, Mercurio S, Lee S, Lau B, Mione M, Wilson SW, Guo S. Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5143-8. PMID: 16549779; PMCID: PMC1458808.
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Giacomini NJ, Rose B, Kobayashi K, Guo S. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol. 2006 Mar-Apr; 28(2):245-50. PMID: 16527449.
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Bretaud S, Lee S, Guo S. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol. 2004 Nov-Dec; 26(6):857-64. PMID: 15451049.
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Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol. 2004 Sep; 53(6):1677-93. PMID: 15341647.
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Guo S. Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? Genes Brain Behav. 2004 Apr; 3(2):63-74. PMID: 15005714.
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Lockwood B, Bjerke S, Kobayashi K, Guo S. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol Biochem Behav. 2004 Mar; 77(3):647-54. PMID: 15006478.
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Rink E, Guo S. The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. 2004; 127(1):147-54. PMID: 15219677.
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Lee SA, Shen EL, Fiser A, Sali A, Guo S. The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development. 2003 Jun; 130(12):2669-79. PMID: 12736211.
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Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J Neurochem. 2002 Mar; 80(5):905-16. PMID: 11948255.
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Gerlai R, Lahav M, Guo S, Rosenthal A. Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav. 2000 Dec; 67(4):773-82. PMID: 11166068.
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Guo S, Yamaguchi Y, Schilbach S, Wada T, Lee J, Goddard A, French D, Handa H, Rosenthal A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 2000 Nov 16; 408(6810):366-9. PMID: 11099044.
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Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, Mullins MC, Rosenthal A. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron. 1999 Nov; 24(3):555-66. PMID: 10595509.
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Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol. 1999 Apr 15; 208(2):473-87. PMID: 10191060.
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Guo, S., W. Driever, and A. Rosenthal . Handbook of Molecular Genetic Techniques for Brain and Behavior Research. Mutagenesis in zebrafish: studying the brain dopamine systems. 1999.
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Boyd L, Guo S, Levitan D, Stinchcomb DT, Kemphues KJ. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development. 1996 Oct; 122(10):3075-84. PMID: 8898221.
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Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development. 1996 Oct; 122(10):3133-40. PMID: 8898226.
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Guo S, Kemphues KJ. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature. 1996 Aug 01; 382(6590):455-8. PMID: 8684486.
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Guo S, Kemphues KJ. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo. Curr Opin Genet Dev. 1996 Aug; 6(4):408-15. PMID: 8791533.
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Etemad-Moghadam B, Guo S, Kemphues KJ. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell. 1995 Dec 01; 83(5):743-52. PMID: 8521491.
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Guo S, Kemphues KJ. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 1995 May 19; 81(4):611-20. PMID: 7758115.
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Year | Publications |
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1995 | 2 | 1996 | 4 | 1999 | 3 | 2000 | 2 | 2002 | 1 | 2003 | 1 | 2004 | 5 | 2006 | 4 | 2007 | 2 | 2008 | 5 | 2009 | 9 | 2010 | 3 | 2011 | 8 | 2012 | 5 | 2013 | 2 | 2014 | 2 | 2015 | 2 | 2016 | 2 | 2017 | 2 | 2018 | 1 |
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