Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Su Guo, PhD

    SchoolUCSF School of Pharmacy
    Address1550 4th Street, Bldg 19B
    San Francisco CA 94158
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      Fudan University1991 - 1991Outstanding Student Award
      Cornell Graduate School1994 - 1994Liu Memorial Award
      Pharmacia Biotech and Science 1998 - 1998Finalist, Amersham Pharmacia Biotech and Science Prize for Young Scientist
      2001 - 2001Searle Scholar
      2001 - 2001Burroughs Wellcome Fund New Investigator
      UCSF2002 - 2002Sandler Award
      David and Lucile Packard Foundation2002 - 2002Science and Engineering Fellow of the David and Lucile Packard Foundation
      UCSF2005 - 2005Sandler Award
      UCSF2006 - 2006Byers Award

      Collapse Overview 
      Collapse Overview
      Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. After graduation, she became fascinated with how the brain works. As a research and postdoctoral fellow at Harvard Medical School and Genentech Inc. respectively, she carried out neurobiological studies of the development of brain neurotransmitter systems, using the vertebrate genetic model organism zebrafish. After establishing her independent research lab at the University of California, San Francisco, Dr. Guo has continued to study the molecular genetics of neural development and has expanded her research into the understanding of behavior. With her research, Dr. Guo strives to make significant contributions to our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.

      Collapse Interests
      Stem Cells, dopamine, noradrenaline, serotonin, reward/emotion-related neural circuits and behavior, drug and alcohol addiction, regulation of camouflage, parkinson's disease, neurodegeneration, zebrafish

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Benagiano G, Guo SW, Bianchi P, Puttemans P, Gordts S, Petraglia F, Brosens I. Pharmacologic treatment of the ovarian endometrioma. Expert Opin Pharmacother. 2016 Oct; 17(15):2019-31. PMID: 27615386.
        View in: PubMed
      2. Hu X, Li J, Zhang Q, Zheng L, Wang G, Zhang X, Zhang J, Gu Q, Ye Y, Guo SW, Yang X, Wang L. Phosphoinositide 3-Kinase (PI3K) Subunit p110d Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse. Sci Rep. 2016; 6:28201. PMID: 27306493.
        View in: PubMed
      3. Guo SW, Du Y, Liu X. Platelet-derived TGF-ß1 mediates the down-modulation of NKG2D expression and may be responsible for impaired natural killer (NK) cytotoxicity in women with endometriosis. Hum Reprod. 2016 Jul; 31(7):1462-74. PMID: 27130956.
        View in: PubMed
      4. Jiang H, Zhu J, Guo SW, Liu X. Vaginal extension improves sexual function in patients receiving laparoscopic radical hysterectomy. Gynecol Oncol. 2016 Jun; 141(3):550-8. PMID: 27085713.
        View in: PubMed
      5. Zhang Q, Duan J, Olson M, Fazleabas A, Guo SW. Cellular Changes Consistent With Epithelial-Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons. Reprod Sci. 2016 Oct; 23(10):1409-21. PMID: 27076446.
        View in: PubMed
      6. Sun Q, Ding D, Liu X, Guo SW. Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Reprod Biol Endocrinol. 2016; 14(1):17. PMID: 27062244.
        View in: PubMed
      7. Brosens I, Gargett CE, Guo SW, Puttemans P, Gordts S, Brosens JJ, Benagiano G. Origins and Progression of Adolescent Endometriosis. Reprod Sci. 2016 Oct; 23(10):1282-8. PMID: 27036950.
        View in: PubMed
      8. Zhang Q, Duan J, Liu X, Guo SW. Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation. Mol Cell Endocrinol. 2016 Jun 15; 428:1-16. PMID: 26992563.
        View in: PubMed
      9. Long Q, Liu X, Guo SW. Surgery accelerates the development of endometriosis in mice. Am J Obstet Gynecol. 2016 Sep; 215(3):320.e1-320.e15. PMID: 26945602.
        View in: PubMed
      10. Liu X, Long Q, Guo SW. Surgical History and the Risk of Endometriosis: A Hospital-Based Case-Control Study. Reprod Sci. 2016 Sep; 23(9):1217-24. PMID: 26919976.
        View in: PubMed
      11. Guo SW, Du Y, Liu X. Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation. Reprod Sci. 2016 Aug; 23(8):1044-52. PMID: 26902428.
        View in: PubMed
      12. Liu X, Shen M, Qi Q, Zhang H, Guo SW. Corroborating evidence for platelet-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis†. Hum Reprod. 2016 Apr; 31(4):734-49. PMID: 26908845.
        View in: PubMed
      13. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. . Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016; 25(2):308-15.
      14. McGorty R, Liu H, Kamiyama D, Dong Z, Guo S, Huang B. Open-top selective plane illumination microscope for conventionally mounted specimens. Opt Express. 2015 Jun 15; 23(12):16142-53. PMID: 26193587; PMCID: PMC4523553 [Available on 06/09/16].
      15. Gehrke S, Wu Z, Klinkenberg M, Sun Y, Auburger G, Guo S, Lu B. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Cell Metab. 2015 Jan 6; 21(1):95-108. PMID: 25565208; PMCID: PMC4455944 [Available on 01/06/16].
      16. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. PMID: 25319688; PMCID: PMC4198537.
      17. Liu C, Sun Y, Arnold J, Lu B, Guo S. Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells. Biochem Biophys Res Commun. 2014 Oct 3; 452(4):895-900. PMID: 25218470; PMCID: PMC4193974.
      18. Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013; 2:e00508. PMID: 24040509; PMCID: PMC3771564.
      19. Dong Z, Peng J, Guo S. Stable gene silencing in zebrafish with spatiotemporally targetable RNA interference. Genetics. 2013 Apr; 193(4):1065-71. PMID: 23378068; PMCID: PMC3606086.
      20. Yang N, Dong Z, Guo S. Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain. J Neurosci. 2012 Aug 8; 32(32):10940-8. PMID: 22875928; PMCID: PMC3478895.
      21. Ritter DI, Dong Z, Guo S, Chuang JH. Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 2012; 7(5):e35202. PMID: 22567096; PMCID: PMC3342275.
      22. Sun Y, Dong Z, Khodabakhsh H, Chatterjee S, Guo S. Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides. PLoS One. 2012; 7(4):e35645. PMID: 22563390; PMCID: PMC3338518.
      23. Dong Z, Yang N, Yeo SY, Chitnis A, Guo S. Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron. 2012 Apr 12; 74(1):65-78. PMID: 22500631; PMCID: PMC3466114.
      24. Guo S, Wagle M, Mathur P. Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors. Dev Neurobiol. 2012 Mar; 72(3):358-65. PMID: 21634015.
        View in: PubMed
      25. Yu W, Sun Y, Guo S, Lu B. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet. 2011 Aug 15; 20(16):3227-40. PMID: 21613270; PMCID: PMC3140825.
      26. Dong Z, Wagle M, Guo S. Time-lapse live imaging of clonally related neural progenitor cells in the developing zebrafish forebrain. J Vis Exp. 2011; (50). PMID: 21505407; PMCID: PMC3169268.
      27. Chen L, Zheng J, Yang N, Li H, Guo S. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J Biol Chem. 2011 May 27; 286(21):18641-9. PMID: 21471212; PMCID: PMC3099680.
      28. Mathur P, Lau B, Guo S. Conditioned place preference behavior in zebrafish. Nat Protoc. 2011 Mar; 6(3):338-45. PMID: 21372814.
        View in: PubMed
      29. Lau BY, Mathur P, Gould GG, Guo S. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2581-6. PMID: 21262817; PMCID: PMC3038752.
      30. Mathur P, Guo S. Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behav Brain Res. 2011 Jun 1; 219(2):234-9. PMID: 21255611; PMCID: PMC3062742.
      31. Mueller T, Dong Z, Berberoglu MA, Guo S. The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain Res. 2011 Mar 24; 1381:95-105. PMID: 21219890; PMCID: PMC3052766.
      32. Wagle M, Mathur P, Guo S. Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. J Neurosci. 2011 Jan 5; 31(1):214-24. PMID: 21209207; PMCID: PMC3030280.
      33. Mathur P, Berberoglu MA, Guo S. Preference for ethanol in zebrafish following a single exposure. Behav Brain Res. 2011 Feb 2; 217(1):128-33. PMID: 20974186; PMCID: PMC3466104.
      34. Ritter DI, Li Q, Kostka D, Pollard KS, Guo S, Chuang JH. The importance of being cis: evolution of orthologous fish and mammalian enhancer activity. Mol Biol Evol. 2010 Oct; 27(10):2322-32. PMID: 20494938; PMCID: PMC3107594.
      35. Mathur P, Guo S. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis. 2010 Oct; 40(1):66-72. PMID: 20493262; PMCID: PMC3021971.
      36. Li Q, Ritter D, Yang N, Dong Z, Li H, Chuang JH, Guo S. A systematic approach to identify functional motifs within vertebrate developmental enhancers. Dev Biol. 2010 Jan 15; 337(2):484-95. PMID: 19850031; PMCID: PMC3330829.
      37. Mueller T, Guo S. The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. J Comp Neurol. 2009 Oct 20; 516(6):553-68. PMID: 19673006; PMCID: PMC2828780.
      38. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. PMID: 19842929; PMCID: PMC2923222.
      39. Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 2009; 4(9):e6918. PMID: 19742326; PMCID: PMC2735033.
      40. Peng J, Wagle M, Mueller T, Mathur P, Lockwood BL, Bretaud S, Guo S. Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. J Neurosci. 2009 Jul 1; 29(26):8408-18. PMID: 19571131; PMCID: PMC2722107.
      41. Guo S. Using zebrafish to assess the impact of drugs on neural development and function. Expert Opin Drug Discov. 2009 Jul 1; 4(7):715-726. PMID: 19774094.
        View in: PubMed
      42. Berberoglu MA, Dong Z, Mueller T, Guo S. fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr Patterns. 2009 Sep; 9(6):411-22. PMID: 19524703; PMCID: PMC2746713.
      43. Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7798-803. PMID: 19416841; PMCID: PMC2683122.
      44. Guo, S., Peng, J., Wagle, M., Mueller, T. and Mathur, P. . Communicative & Integrative Biology . Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying Alcoholism . 2009; 2(6):512-514.
      45. Krishnan K, Salomonis N, Guo S. Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 2008; 3(11):e3621. PMID: 18978947; PMCID: PMC2575381.
      46. Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH. cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation. Bioinformatics. 2008 Oct 15; 24(20):2418-9. PMID: 18718943; PMCID: PMC2562007.
      47. Mueller T, Wullimann MF, Guo S. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol. 2008 Mar 10; 507(2):1245-57. PMID: 18181142.
        View in: PubMed
      48. Guo, S. . Biomarkers for Psychiatric Disorders. Animal models for anxiety disorders. 2008; New York, NY.
      49. Guo, S. . Parkinson’s Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models. Insights from zebrafish PD models, and their potential for identifying novel drug targets and therapeutic compounds. 2008.
      50. Bretaud S, Li Q, Lockwood BL, Kobayashi K, Lin E, Guo S. A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish. Neuroscience. 2007 May 25; 146(3):1109-16. PMID: 17428610.
        View in: PubMed
      51. Jeong JY, Einhorn Z, Mathur P, Chen L, Lee S, Kawakami K, Guo S. Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development. 2007 Jan; 134(1):127-36. PMID: 17164418.
        View in: PubMed
      52. Wang X, Yang N, Uno E, Roeder RG, Guo S. A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17284-9. PMID: 17088561; PMCID: PMC1859923.
      53. Lau B, Bretaud S, Huang Y, Lin E, Guo S. Dissociation of food and opiate preference by a genetic mutation in zebrafish. Genes Brain Behav. 2006 Oct; 5(7):497-505. PMID: 17010096.
        View in: PubMed
      54. Jeong JY, Einhorn Z, Mercurio S, Lee S, Lau B, Mione M, Wilson SW, Guo S. Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5143-8. PMID: 16549779; PMCID: PMC1458808.
      55. Giacomini NJ, Rose B, Kobayashi K, Guo S. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol. 2006 Mar-Apr; 28(2):245-50. PMID: 16527449.
        View in: PubMed
      56. Bretaud S, Lee S, Guo S. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol. 2004 Nov-Dec; 26(6):857-64. PMID: 15451049.
        View in: PubMed
      57. Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol. 2004 Sep; 53(6):1677-93. PMID: 15341647.
        View in: PubMed
      58. Guo S. Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? Genes Brain Behav. 2004 Apr; 3(2):63-74. PMID: 15005714.
        View in: PubMed
      59. Lockwood B, Bjerke S, Kobayashi K, Guo S. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol Biochem Behav. 2004 Mar; 77(3):647-54. PMID: 15006478.
        View in: PubMed
      60. Rink E, Guo S. The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. 2004; 127(1):147-54. PMID: 15219677.
        View in: PubMed
      61. Lee SA, Shen EL, Fiser A, Sali A, Guo S. The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development. 2003 Jun; 130(12):2669-79. PMID: 12736211.
        View in: PubMed
      62. Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J Neurochem. 2002 Mar; 80(5):905-16. PMID: 11948255.
        View in: PubMed
      63. Gerlai R, Lahav M, Guo S, Rosenthal A. Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav. 2000 Dec; 67(4):773-82. PMID: 11166068.
        View in: PubMed
      64. Guo S, Yamaguchi Y, Schilbach S, Wada T, Lee J, Goddard A, French D, Handa H, Rosenthal A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 2000 Nov 16; 408(6810):366-9. PMID: 11099044.
        View in: PubMed
      65. Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, Mullins MC, Rosenthal A. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron. 1999 Nov; 24(3):555-66. PMID: 10595509.
        View in: PubMed
      66. Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol. 1999 Apr 15; 208(2):473-87. PMID: 10191060.
        View in: PubMed
      67. Guo, S., W. Driever, and A. Rosenthal . . Handbook of Molecular Genetic Techniques for Brain and Behavior Research. Mutagenesis in zebrafish: studying the brain dopamine systems. 1999.
      68. Boyd L, Guo S, Levitan D, Stinchcomb DT, Kemphues KJ. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development. 1996 Oct; 122(10):3075-84. PMID: 8898221.
        View in: PubMed
      69. Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development. 1996 Oct; 122(10):3133-40. PMID: 8898226.
        View in: PubMed
      70. Guo S, Kemphues KJ. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature. 1996 Aug 1; 382(6590):455-8. PMID: 8684486.
        View in: PubMed
      71. Guo S, Kemphues KJ. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo. Curr Opin Genet Dev. 1996 Aug; 6(4):408-15. PMID: 8791533.
        View in: PubMed
      72. Etemad-Moghadam B, Guo S, Kemphues KJ. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell. 1995 Dec 1; 83(5):743-52. PMID: 8521491.
        View in: PubMed
      73. Guo S, Kemphues KJ. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 1995 May 19; 81(4):611-20. PMID: 7758115.
        View in: PubMed
      Su's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP