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Su Guo, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-502-4949
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    Collapse Biography 
    Collapse Awards and Honors
    Fudan University1991  - 1991Outstanding Student Award
    Cornell Graduate School1994  - 1994Liu Memorial Award
    Pharmacia Biotech and Science 1998  - 1998Finalist, Amersham Pharmacia Biotech and Science Prize for Young Scientist
    2001  - 2001Searle Scholar
    2001  - 2001Burroughs Wellcome Fund New Investigator
    UCSF2002  - 2002Sandler Award
    David and Lucile Packard Foundation2002  - 2002Science and Engineering Fellow of the David and Lucile Packard Foundation
    UCSF2005  - 2005Sandler Award
    UCSF2006  - 2006Byers Award

    Collapse Overview 
    Collapse Overview
    Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. After graduation, she became fascinated with how the brain works. As a research and postdoctoral fellow at Harvard Medical School and Genentech Inc. respectively, she carried out neurobiological studies of the development of brain neurotransmitter systems, using the vertebrate genetic model organism zebrafish. After establishing her independent research lab at the University of California, San Francisco, Dr. Guo has continued to study the molecular genetics of neural development and has expanded her research into the understanding of behavior. With her research, Dr. Guo strives to make significant contributions to our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.


    Collapse Research 
    Collapse Research Activities and Funding
    Explore in vivo functional connectivity at cellular resolution in drugged brains
    NIH/NIDA R21DA044007Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Functional connectivity at cellular resolution in brains with mutations in ASD genes
    NIH/NIMH R21MH113961Jun 16, 2017 - May 31, 2019
    Role: Principal Investigator
    Asymmetric Cell Division in Vertebrate Brain Development
    NIH/NINDS R01NS095734Sep 30, 2015 - Jun 30, 2020
    Role: Principal Investigator
    A novel RNA-guided platform for dissecting cannabinoid signaling in reward circuit development
    NIH/NIDA R21DA038447Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Developing tools for understanding neuromodulation of hypothalamic func
    NIH/NIDA R01DA035680Sep 15, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Mapping neuronal circuitry for aversion in the developing vertebrate brain
    NIH/NIDA R21DA034983May 1, 2013 - Apr 30, 2015
    Role: Principal Investigator
    Advancing Whole-Organism Screening for Chemical Modifiers of the Brain
    NIH/NINDS R21NS082938Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Chemical Genetics to Elucidate the Development of Dopaminergic Neurons
    NIH/NIDA R01DA023904Jul 1, 2008 - Jul 31, 2013
    Role: Principal Investigator
    An in vivo cellular model to study the biological effects of alcohol
    NIH/NIAAA R01AA016021Sep 30, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Role of conserved non-coding elements in vertebrate brain development
    NIH/NICHD R21HD051835Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    Using zebrafish to study Parkinson's disease
    NIH/NINDS R21NS043590Feb 1, 2002 - Jan 31, 2005
    Role: Principal Investigator
    Development of Dopaminergic Neurons in Zebrafish
    NIH/NINDS R01NS042626Dec 1, 2001 - Jul 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lu JG, Bishop J, Cheyette S, Zhulin IB, Guo S, Sobreira N, Brenner SE. A novel PRRT2 pathogenic variant in a family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures. Cold Spring Harb Mol Case Stud. 2018 Feb; 4(1). PMID: 29167286.
      View in: PubMed
    2. Wagle M, Nguyen J, Lee S, Zaitlen N, Guo S. Heritable natural variation of an anxiety-like behavior in larval zebrafish. J Neurogenet. 2017 Sep; 31(3):138-148. PMID: 28678579.
      View in: PubMed
    3. Oltrabella F, Melgoza A, Nguyen B, Guo S. Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model. Dev Growth Differ. 2017 May; 59(4):194-210. PMID: 28516445.
      View in: PubMed
    4. Liu H, Chen S, Huang K, Kim J, Mo H, Iovine R, Gendre J, Pascal P, Li Q, Sun Y, Dong Z, Arkin M, Guo S, Huang B. A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery. PLoS One. 2016; 11(10):e0164645. PMID: 27732643.
      View in: PubMed
    5. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016; 25(2):308-15.
    6. McGorty R, Liu H, Kamiyama D, Dong Z, Guo S, Huang B. Open-top selective plane illumination microscope for conventionally mounted specimens. Opt Express. 2015 Jun 15; 23(12):16142-53. PMID: 26193587; PMCID: PMC4523553.
      View in: PubMed, PubMed Central
    7. Gehrke S, Wu Z, Klinkenberg M, Sun Y, Auburger G, Guo S, Lu B. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Cell Metab. 2015 Jan 06; 21(1):95-108. PMID: 25565208; PMCID: PMC4455944.
      View in: PubMed, PubMed Central
    8. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. PMID: 25319688; PMCID: PMC4198537.
      View in: PubMed, PubMed Central
    9. Liu C, Sun Y, Arnold J, Lu B, Guo S. Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells. Biochem Biophys Res Commun. 2014 Oct 03; 452(4):895-900. PMID: 25218470; PMCID: PMC4193974.
      View in: PubMed, PubMed Central
    10. Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508. PMID: 24040509; PMCID: PMC3771564.
      View in: PubMed, PubMed Central
    11. Dong Z, Peng J, Guo S. Stable gene silencing in zebrafish with spatiotemporally targetable RNA interference. Genetics. 2013 Apr; 193(4):1065-71. PMID: 23378068; PMCID: PMC3606086.
      View in: PubMed, PubMed Central
    12. Yang N, Dong Z, Guo S. Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain. J Neurosci. 2012 Aug 08; 32(32):10940-8. PMID: 22875928; PMCID: PMC3478895.
      View in: PubMed, PubMed Central
    13. Ritter DI, Dong Z, Guo S, Chuang JH. Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 2012; 7(5):e35202. PMID: 22567096; PMCID: PMC3342275.
      View in: PubMed, PubMed Central
    14. Sun Y, Dong Z, Khodabakhsh H, Chatterjee S, Guo S. Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides. PLoS One. 2012; 7(4):e35645. PMID: 22563390.
      View in: PubMed
    15. Dong Z, Yang N, Yeo SY, Chitnis A, Guo S. Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron. 2012 Apr 12; 74(1):65-78. PMID: 22500631; PMCID: PMC3466114.
      View in: PubMed, PubMed Central
    16. Guo S, Wagle M, Mathur P. Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors. Dev Neurobiol. 2012 Mar; 72(3):358-65. PMID: 21634015.
      View in: PubMed
    17. Yu W, Sun Y, Guo S, Lu B. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet. 2011 Aug 15; 20(16):3227-40. PMID: 21613270; PMCID: PMC3140825.
      View in: PubMed, PubMed Central
    18. Dong Z, Wagle M, Guo S. Time-lapse live imaging of clonally related neural progenitor cells in the developing zebrafish forebrain. J Vis Exp. 2011 Apr 06; (50). PMID: 21505407; PMCID: PMC3169268.
      View in: PubMed, PubMed Central
    19. Chen L, Zheng J, Yang N, Li H, Guo S. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J Biol Chem. 2011 May 27; 286(21):18641-9. PMID: 21471212; PMCID: PMC3099680.
      View in: PubMed, PubMed Central
    20. Mathur P, Lau B, Guo S. Conditioned place preference behavior in zebrafish. Nat Protoc. 2011 Mar; 6(3):338-45. PMID: 21372814.
      View in: PubMed
    21. Lau BY, Mathur P, Gould GG, Guo S. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2581-6. PMID: 21262817; PMCID: PMC3038752.
      View in: PubMed, PubMed Central
    22. Mathur P, Guo S. Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behav Brain Res. 2011 Jun 01; 219(2):234-9. PMID: 21255611; PMCID: PMC3062742.
      View in: PubMed, PubMed Central
    23. Mueller T, Dong Z, Berberoglu MA, Guo S. The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain Res. 2011 Mar 24; 1381:95-105. PMID: 21219890; PMCID: PMC3052766.
      View in: PubMed, PubMed Central
    24. Wagle M, Mathur P, Guo S. Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. J Neurosci. 2011 Jan 05; 31(1):214-24. PMID: 21209207; PMCID: PMC3030280.
      View in: PubMed, PubMed Central
    25. Mathur P, Berberoglu MA, Guo S. Preference for ethanol in zebrafish following a single exposure. Behav Brain Res. 2011 Feb 02; 217(1):128-33. PMID: 20974186; PMCID: PMC3466104.
      View in: PubMed, PubMed Central
    26. Ritter DI, Li Q, Kostka D, Pollard KS, Guo S, Chuang JH. The importance of being cis: evolution of orthologous fish and mammalian enhancer activity. Mol Biol Evol. 2010 Oct; 27(10):2322-32. PMID: 20494938; PMCID: PMC3107594.
      View in: PubMed, PubMed Central
    27. Mathur P, Guo S. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis. 2010 Oct; 40(1):66-72. PMID: 20493262; PMCID: PMC3021971.
      View in: PubMed, PubMed Central
    28. Li Q, Ritter D, Yang N, Dong Z, Li H, Chuang JH, Guo S. A systematic approach to identify functional motifs within vertebrate developmental enhancers. Dev Biol. 2010 Jan 15; 337(2):484-95. PMID: 19850031; PMCID: PMC3330829.
      View in: PubMed, PubMed Central
    29. Mueller T, Guo S. The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. J Comp Neurol. 2009 Oct 20; 516(6):553-68. PMID: 19673006; PMCID: PMC2828780.
      View in: PubMed, PubMed Central
    30. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. PMID: 19842929; PMCID: PMC2923222.
      View in: PubMed, PubMed Central
    31. Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 2009 Sep 09; 4(9):e6918. PMID: 19742326; PMCID: PMC2735033.
      View in: PubMed, PubMed Central
    32. Peng J, Wagle M, Mueller T, Mathur P, Lockwood BL, Bretaud S, Guo S. Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. J Neurosci. 2009 Jul 01; 29(26):8408-18. PMID: 19571131; PMCID: PMC2722107.
      View in: PubMed, PubMed Central
    33. Guo S. Using zebrafish to assess the impact of drugs on neural development and function. Expert Opin Drug Discov. 2009 Jul 01; 4(7):715-726. PMID: 19774094.
      View in: PubMed
    34. Berberoglu MA, Dong Z, Mueller T, Guo S. fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr Patterns. 2009 Sep; 9(6):411-22. PMID: 19524703; PMCID: PMC2746713.
      View in: PubMed, PubMed Central
    35. Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7798-803. PMID: 19416841; PMCID: PMC2683122.
      View in: PubMed, PubMed Central
    36. Guo, S., Peng, J., Wagle, M., Mueller, T. and Mathur, P. Communicative & Integrative Biology . Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying Alcoholism . 2009; 2(6):512-514.
    37. Krishnan K, Salomonis N, Guo S. Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 2008; 3(11):e3621. PMID: 18978947; PMCID: PMC2575381.
      View in: PubMed, PubMed Central
    38. Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH. cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation. Bioinformatics. 2008 Oct 15; 24(20):2418-9. PMID: 18718943; PMCID: PMC2562007.
      View in: PubMed, PubMed Central
    39. Mueller T, Wullimann MF, Guo S. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol. 2008 Mar 10; 507(2):1245-57. PMID: 18181142.
      View in: PubMed
    40. Guo, S. Biomarkers for Psychiatric Disorders. Animal models for anxiety disorders. 2008; New York, NY.
    41. Guo, S. Parkinson’s Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models. Insights from zebrafish PD models, and their potential for identifying novel drug targets and therapeutic compounds. 2008.
    42. Bretaud S, Li Q, Lockwood BL, Kobayashi K, Lin E, Guo S. A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish. Neuroscience. 2007 May 25; 146(3):1109-16. PMID: 17428610.
      View in: PubMed
    43. Jeong JY, Einhorn Z, Mathur P, Chen L, Lee S, Kawakami K, Guo S. Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development. 2007 Jan; 134(1):127-36. PMID: 17164418.
      View in: PubMed
    44. Wang X, Yang N, Uno E, Roeder RG, Guo S. A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17284-9. PMID: 17088561; PMCID: PMC1859923.
      View in: PubMed, PubMed Central
    45. Lau B, Bretaud S, Huang Y, Lin E, Guo S. Dissociation of food and opiate preference by a genetic mutation in zebrafish. Genes Brain Behav. 2006 Oct; 5(7):497-505. PMID: 17010096.
      View in: PubMed
    46. Jeong JY, Einhorn Z, Mercurio S, Lee S, Lau B, Mione M, Wilson SW, Guo S. Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5143-8. PMID: 16549779; PMCID: PMC1458808.
      View in: PubMed, PubMed Central
    47. Giacomini NJ, Rose B, Kobayashi K, Guo S. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol. 2006 Mar-Apr; 28(2):245-50. PMID: 16527449.
      View in: PubMed
    48. Bretaud S, Lee S, Guo S. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol. 2004 Nov-Dec; 26(6):857-64. PMID: 15451049.
      View in: PubMed
    49. Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol. 2004 Sep; 53(6):1677-93. PMID: 15341647.
      View in: PubMed
    50. Guo S. Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? Genes Brain Behav. 2004 Apr; 3(2):63-74. PMID: 15005714.
      View in: PubMed
    51. Lockwood B, Bjerke S, Kobayashi K, Guo S. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol Biochem Behav. 2004 Mar; 77(3):647-54. PMID: 15006478.
      View in: PubMed
    52. Rink E, Guo S. The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. 2004; 127(1):147-54. PMID: 15219677.
      View in: PubMed
    53. Lee SA, Shen EL, Fiser A, Sali A, Guo S. The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development. 2003 Jun; 130(12):2669-79. PMID: 12736211.
      View in: PubMed
    54. Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J Neurochem. 2002 Mar; 80(5):905-16. PMID: 11948255.
      View in: PubMed
    55. Gerlai R, Lahav M, Guo S, Rosenthal A. Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav. 2000 Dec; 67(4):773-82. PMID: 11166068.
      View in: PubMed
    56. Guo S, Yamaguchi Y, Schilbach S, Wada T, Lee J, Goddard A, French D, Handa H, Rosenthal A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 2000 Nov 16; 408(6810):366-9. PMID: 11099044.
      View in: PubMed
    57. Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, Mullins MC, Rosenthal A. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron. 1999 Nov; 24(3):555-66. PMID: 10595509.
      View in: PubMed
    58. Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol. 1999 Apr 15; 208(2):473-87. PMID: 10191060.
      View in: PubMed
    59. Guo, S., W. Driever, and A. Rosenthal . Handbook of Molecular Genetic Techniques for Brain and Behavior Research. Mutagenesis in zebrafish: studying the brain dopamine systems. 1999.
    60. Boyd L, Guo S, Levitan D, Stinchcomb DT, Kemphues KJ. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development. 1996 Oct; 122(10):3075-84. PMID: 8898221.
      View in: PubMed
    61. Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development. 1996 Oct; 122(10):3133-40. PMID: 8898226.
      View in: PubMed
    62. Guo S, Kemphues KJ. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature. 1996 Aug 01; 382(6590):455-8. PMID: 8684486.
      View in: PubMed
    63. Guo S, Kemphues KJ. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo. Curr Opin Genet Dev. 1996 Aug; 6(4):408-15. PMID: 8791533.
      View in: PubMed
    64. Etemad-Moghadam B, Guo S, Kemphues KJ. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell. 1995 Dec 01; 83(5):743-52. PMID: 8521491.
      View in: PubMed
    65. Guo S, Kemphues KJ. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 1995 May 19; 81(4):611-20. PMID: 7758115.
      View in: PubMed
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