Kimberly Kirkwood, MD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-353-9846
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    Collapse Biography 
    Collapse Education and Training
    Reed CollegeB.A.1981
    University of PennsylvaniaM.D.1985School of Medicine
    Massachusetts General HospitalResidency in General Surgery1993Department of Surgery
    UCLAPancreas/GI Research Fellowship1991Department of Surgery
    Massachusetts General HospitalClinical Instructor/Pancreas Fellow1994Department of Surgery
    Massachusetts General HospitalPancreas/Advanced General Surgery Fellowship1994Department of Surgery
    UCSFGeneral Surgery Board Certification2004Department of Surgery
    UCSFGeneral Surgery Board Certification2014Department of Surgery
    Collapse Awards and Honors
    Phi Beta Kappa National Honor Society1981Phi Beta Kappa National Honor Society
    University of Pennsylvania Chapter1983President, Alpha Omega Alpha National Medical Honor Society
    UCSF School of Medicine1997Kaiser Award for Excellence in Teaching Nomination
    UCSF Department of Surgery Residents2001Excellence in Teaching Award
    UCSF Department of Surgery Chief Residents2008  - 2009Excellence in Teaching Award
    Pancreas Club2010Pancreas Club Warren Award (Victoria Lyo),
    Inaugural, UCSF Department of Surgery Junior Residents2015Excellence in Teaching Award
    University of Pennsylvania School of Medicine1981Walter Croll Scholarship
    Department of Surgery, Massachusetts General Hospita1989  - 1990Claude E. Welch Research Fellowship Award
    UCSF School of Medicine1999 Kaiser Award for Excellence in Teaching Nomination
    UCSF Department of Surgery Chief Residents2004Excellence in Teaching Award
    UCSF School of Medicine2004Kaiser Award for Excellence in Teaching Nomination
    UCSF Department of Surgery Chief Residents2008  - 2009Excellence in Teaching Award
    American Gastroenterological Association (AGA) Foundation2010AGA Student Abstract Prize (Victoria Lyo),
    UCSF School of Medicine2010Kaiser Award for Excellence in Teaching Nomination
    Howard Hughes Medical Institute2010Howard Hughes Research Fellowship (Victoria Lyo),
    Howard Hughes Medical Institute2010Howard Hughes Research Fellowship (Victoria Lyo),
    UCSF Department of Surgery Chief Residents2012Excellence in Teaching Award
    UCSF School of Medicine, Surgical Clerkship2013Excellence in Teaching Award
    UCSF Department of Surgery Chief Residents2014Excellence in Teaching Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Minimally Invasive Classification of Pancreatic Cystic Neoplasms
    V Foundation T2017-013Nov 1, 2017 - Nov 1, 2020
    Role: Principal Investigator
    Role Description: Our goal is to develop new tools to differentiate low risk from high risk lesions among patients with pancreatic cysts
    Development of fluorogenic substrates for the diagnosis of pancreatic cysts
    UCSF Clinical and Translational Sciences Institute Catalyst Awards ProgramFeb 1, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Molecular Correlates of progression in pancreatic cystic neoplasms
    NCI/NIH U01Jul 1, 2015 - Jun 30, 2021
    Role: Site Principal Investigator, UCSF
    Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer
    NIH R21CA185689Jan 1, 2015 - Dec 31, 2017
    Role: Co-Principal Investigator
    Neural Regulation of Pancreatic Function
    NIH R01DK046285Oct 1, 1995 - Mar 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis. Clin Transl Gastroenterol. 2021 04 27; 12(5):e00347. Thiruvengadam NR, Miranda J, Kim C, Behr S, Corvera C, Dai SC, Kirkwood K, Harris HW, Hirose K, Nakakura E, Ostroff JW, Kochman ML, Arain MA. PMID: 33904509.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer. Cancer Prev Res (Phila). 2021 Jul; 14(7):729-740. Dittmar RL, Liu S, Tai MC, Rajapakshe K, Huang Y, Longton G, DeCapite C, Hurd MW, Paris PL, Kirkwood KS, Coarfa C, Maitra A, Brand RE, Killary AM, Sen S. PMID: 33893071.
      View in: PubMed   Mentions:    Fields:    
    3. Cost-effectiveness of consensus guideline based management of pancreatic cysts: The sensitivity and specificity required for guidelines to be cost-effective. Surgery. 2020 10; 168(4):601-609. Sharib J, Esserman L, Koay EJ, Maitra A, Shen Y, Kirkwood KS, Ozanne EM. PMID: 32739138.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer. Clin Cancer Res. 2020 07 15; 26(14):3608-3615. Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. PMID: 32341034.
      View in: PubMed   Mentions: 3     Fields:    
    5. Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention. HPB (Oxford). 2020 10; 22(10):1496-1503. Wisneski AD, Carter J, Nakakura EK, Posselt A, Rogers SJ, Cello JP, Arain M, Kirkwood KS, Hirose K, Stewart L, Corvera CU. PMID: 32340857.
      View in: PubMed   Mentions:    Fields:    
    6. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biol Chem. 2019 11 26; 400(12):1629-1638. Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 31256057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study. J Am Coll Surg. 2020 01; 230(1):53-63.e1. Cao CX, Sharib JM, Blanco AM, Goldberg D, Bracci P, Mukhtar RA, Esserman LJ, Kirkwood KS. PMID: 31672679.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization? Am J Surg Pathol. 2019 03; 43(3):334-340. Kim SS, Ko AH, Nakakura EK, Wang ZJ, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Kim GE. PMID: 30211728.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Managing Refractory Postoperative Fistulas as Chronic Wounds Using Video-Assisted Hydrodebridement (VAHD). J Gastrointest Surg. 2019 03; 23(3):608-612. Changala M, Laberge J, Kerlan R, Taylor A, Arain M, Kirkwood K. PMID: 30465188.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Surgical overtreatment of pancreatic intraductal papillary mucinous neoplasms: Do the 2017 International Consensus Guidelines improve clinical decision making? Surgery. 2018 12; 164(6):1178-1184. Sharib JM, Fonseca AL, Swords DS, Jaradeh K, Bracci PM, Firpo MA, Hatcher S, Scaife CL, Wang H, Kim GE, Mulvihill SJ, Maitra A, Koay EJ, Kirkwood KS. PMID: 30170819.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk. Pancreas. 2018 03; 47(3):272-279. Fonseca AL, Kirkwood K, Kim MP, Maitra A, Koay EJ. PMID: 29424809.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Gangrenous cholecystitis: innovative laparoscopic techniques to facilitate subtotal fenestrating cholecystectomy when a critical view of safety cannot be achieved. Surg Endosc. 2017 12; 31(12):5258-5266. Kirkwood R, Damon L, Wang J, Hong E, Kirkwood K. PMID: 28597281.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 28424202.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    14. Early and accurate diagnosis of pancreatic cancer? Oncotarget. 2016 12 27; 7(52):85676-85677. Sharib J, Kirkwood K. PMID: 27829239.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. PMID: 27444658.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    16. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett. 2015 Jan 28; 356(2 Pt B):404-9. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. PMID: 25304377.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    17. Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants. Br J Pharmacol. 2014 Aug; 171(16):3814-26. Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW. PMID: 24749982.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 01; 304(11):G1002-12. Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS. PMID: 23558009.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    19. Informed consent for innovative surgery: a survey of patients and surgeons. Surgery. 2013 Apr; 153(4):473-80. Lee Char SJ, Hills NK, Lo B, Kirkwood KS. PMID: 23218878.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Active cathepsins B, L, and S in murine and human pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15; 303(8):G894-903. Lyo V, Cattaruzza F, Kim TN, Walker AW, Paulick M, Cox D, Cloyd J, Buxbaum J, Ostroff J, Bogyo M, Grady EF, Bunnett NW, Kirkwood KS. PMID: 22899821.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Ethical management of conflict of interest: proposed standards for academic surgical societies. J Am Coll Surg. 2011 Nov; 213(5):677-82. Minter RM, Angelos P, Coimbra R, Dale P, de Vera ME, Hardacre J, Hawkins W, Kirkwood K, Matthews JB, McLoughlin J, Peralta E, Schmidt M, Zhou W, Schwarze ML. PMID: 21880513.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Serine proteases mediate inflammatory pain in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G1033-42. Ceppa EP, Lyo V, Grady EF, Knecht W, Grahn S, Peterson A, Bunnett NW, Kirkwood KS, Cattaruzza F. PMID: 21436316.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G556-71. Ceppa E, Cattaruzza F, Lyo V, Amadesi S, Pelayo JC, Poole DP, Vaksman N, Liedtke W, Cohen DM, Grady EF, Bunnett NW, Kirkwood KS. PMID: 20539005.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    24. Technique for placement of lumboperitoneal catheters using a combined laparoscopic procedure with the Seldinger micropuncture technique. J Am Coll Surg. 2008 Jul; 207(1):e5-7. Maa J, Carter JT, Kirkwood KS, Gosnell JE, Wang V, McDermott MW. PMID: 18589351.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder. Am J Pathol. 2006 Dec; 169(6):2031-41. Finzi L, Barbu V, Burgel PR, Mergey M, Kirkwood KS, Wick EC, Scoazec JY, Peschaud F, Paye F, Nadel JA, Housset C. PMID: 17148666.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Trends in laparoscopic splenectomy for massive splenomegaly. Arch Surg. 2006 Aug; 141(8):755-61; discussion 761-2. Grahn SW, Alvarez J, Kirkwood K. PMID: 16924082.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    27. Calcitonin gene-related peptide partially mediates nociception in acute experimental pancreatitis. Surgery. 2006 Feb; 139(2):197-201. Wick EC, Pikios S, Grady EF, Kirkwood KS. PMID: 16455328.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G959-69. Wick EC, Hoge SG, Grahn SW, Kim E, Divino LA, Grady EF, Bunnett NW, Kirkwood KS. PMID: 16399878.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    29. Neutral endopeptidase determines the severity of pancreatitis-associated lung injury. J Surg Res. 2005 Sep; 128(1):21-7. Day AL, Wick E, Jordan TH, Jaffray CE, Bunnett NW, Grady EF, Kirkwood KS. PMID: 15993898.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    30. Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R). Pancreas. 2005 Apr; 30(3):260-5. Hutter MM, Wick EC, Day AL, Maa J, Zerega EC, Richmond AC, Jordan TH, Grady EF, Mulvihill SJ, Bunnett NW, Kirkwood KS. PMID: 15782105.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    31. Medical versus surgical management of biliary tract disease in pregnancy. Am J Surg. 2004 Dec; 188(6):755-9. Lu EJ, Curet MJ, El-Sayed YY, Kirkwood KS. PMID: 15619495.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    32. Pancreatic resection in the elderly. J Am Coll Surg. 2004 May; 198(5):697-706. Lightner AM, Glasgow RE, Jordan TH, Krassner AD, Way LW, Mulvihill SJ, Kirkwood KS. PMID: 15110802.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    33. Activation of nociceptive neurons in T9 and T10 in cerulein pancreatitis. J Surg Res. 2004 Apr; 117(2):195-201. Kim EH, Hoge SG, Lightner AM, Grady EF, Coelho AM, Kirkwood KS. PMID: 15047123.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. SIR 2003 film panel case 5: massive hemorrhage from portal vein disruption. J Vasc Interv Radiol. 2003 Jun; 14(6):797-802. Kerlan RK, LaBerge JM, Wilson MW, Gordon RL, Kirkwood K, Sawhney R. PMID: 12817050.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogs. Dig Dis Sci. 2002 Oct; 47(10):2192-210. Abedin MZ, Narins SC, Park EH, Smith PR, Kirkwood KS. PMID: 12395892.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    36. Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury. Surgery. 2002 Aug; 132(2):193-9. Lightner AM, Jordan TH, Bunnett NW, Grady EF, Kirkwood KS. PMID: 12219011.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    37. Pathophysiology of gallstone pancreatitis. Front Biosci. 2001 Oct 01; 6:E66-76. Lightner AM, Kirkwood KS. PMID: 11578966.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2):G544-51. Kirkwood KS, Bunnett NW, Maa J, Castagliolo I, Liu B, Gerard N, Zacks J, Pothoulakis C, Grady EF. PMID: 11447035.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation. Am J Physiol Gastrointest Liver Physiol. 2000 Oct; 279(4):G726-32. Maa J, Grady EF, Kim EH, Yoshimi SK, Hutter MM, Bunnett NW, Kirkwood KS. PMID: 11005759.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    40. Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice. Surgery. 2000 Aug; 128(2):232-9. Maa J, Grady EF, Yoshimi SK, Drasin TE, Kim EH, Hutter MM, Bunnett NW, Kirkwood KS. PMID: 10922997.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice. Br J Pharmacol. 2000 Jun; 130(3):505-12. Grady EF, Yoshimi SK, Maa J, Valeroso D, Vartanian RK, Rahim S, Kim EH, Gerard C, Gerard N, Bunnett NW, Kirkwood KS. PMID: 10821777.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    42. Substance P inhibits pancreatic exocrine secretion via a neural mechanism. Am J Physiol. 1999 08; 277(2):G314-20. Kirkwood KS, Kim EH, He XD, Calaustro EQ, Domush C, Yoshimi SK, Grady EF, Maa J, Bunnett NW, Debas HT. PMID: 10444445.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. Recent advances. General surgery. BMJ. 1997 Sep 06; 315(7108):586-9. Corvera CU, Kirkwood KS. PMID: 9302958.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Prognostic indicators for cancer. Gastric cancer. Surg Oncol Clin N Am. 1997 Jul; 6(3):495-514. Kirkwood KS, Khitin LM, Barwick KW. PMID: 9210353.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. Am J Physiol. 1997 Apr; 272(4 Pt 1):G785-93. Figini M, Emanueli C, Grady EF, Kirkwood K, Payan DG, Ansel J, Gerard C, Geppetti P, Bunnett N. PMID: 9142909.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    46. Neuroendocrine tumors: common presentations of uncommon diseases. Compr Ther. 1995 Dec; 21(12):719-25. Kirkwood KS, Debas HT. PMID: 8789136.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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