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Kole Roybal, PhD

Title(s)Assistant Professor, Microbiology and Immunology
SchoolSchool of Medicine
Phone415-476-8289
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical Center Ph.D.2013Immunology
    Austin CollegeB.A.2005Biology
    Collapse Awards and Honors
    NIH - National Cancer Institute2018  - 2023NIH New Innovator Award
    Science Magazine & Sartorius2018Award for Regenerative Medicine and Cell Therapy
    Parker Institute for Cancer Immunotherapy2017Member Researcher
    Chan Zuckerberg Biohub2017Chan Zuckerberg Biohub Investigator
    Jane Coffin Childs Memorial Fund2014  - 2017Postdoctoral Fellowship
    National Institutes of Health2007  - 2010Ruth L. Kirschstein National Research Service Award

    Collapse Overview 
    Collapse Overview
    In the Roybal Lab we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response.

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering the Next-generation of Custom Immune Cell Therapies
    NIH/NCI DP2CA239143Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Axel Hyrenius-Wittsten, Kole T. Roybal. Paving New Roads for CARs. 2019 Oct 1.
      View in: Publisher Site
    2. Kyle Landgraf, Steven R. Williams, Daniel Steiger, Dana Gebhart, Stephen Lok, David W. Martin, Kole T. Roybal, Kaman Chan Kim. convertibleCAR-T cells provide a modular universal system for dose control of activity, flexible targeting, and versatile maintenance of CAR-cells. 2019 Jul 9; 696401.
      View in: Publisher Site
    3. Azimi CS, Tang Q, Roybal KT, Bluestone JA. NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 Aug; 59:79-87. PMID: 31071513.
      View in: PubMed
    4. Theodore L Roth, P. Jonathan Li, Jasper Nies, Ruby Yu, Michelle L.T. Nguyen, Youjin Lee, Ryan Apathy, Anna Truong, Joseph Hiatt, David Wu, David N. Nguyen, Daniel Goodman, Jeffrey A. Bluestone, Kole Roybal, Eric Shifrut, Alexander Marson. Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. 2019 Apr 12; 604561.
      View in: Publisher Site
    5. Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L. Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. 2019 02 19; 50(2):477-492.e8. PMID: 30737146.
      View in: PubMed
    6. Avishai Shemesh, Kole T. Roybal, Lewis L. Lanier. Abstract B044: Engineering CAR NK cells for antigen-dependent autocrine expansion. 2019 Feb 1; b044-b044.
      View in: Publisher Site
    7. Shalini T. Low-Nam, Jenny JY Lin, Darren B. McAffee, Steven A. Alvarez, Scott D. Hansen, Kole T. Roybal, Jay T. Groves. Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate. 2019 Feb 1; 116(3):530a.
      View in: Publisher Site
    8. Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. 2018 Nov 29; 132(Supplement 1):1926-1926.
      View in: Publisher Site
    9. Chien-Chun Steven Pai, Xiaoqing Lu, Donald Simons, Michel DuPage, Kole T. Roybal, Mingyi Chen, Serena Kwek, Amy-Jo Casbon, Gillian A. Kinsbury, Lawrence Fong. Abstract 2981: Clonal deletion of tumor-specific T cells by combination checkpoint blockade compromises antitumor efficacy in low tumor burden states. 2018 Jul 1; 2981-2981.
      View in: Publisher Site
    10. Roybal KT. Refining cell therapy. Science. 2018 Mar 09; 359(6380):1112-1113. PMID: 29590036.
      View in: PubMed
    11. Roybal KT, Lim WA. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 04 26; 35:229-253. PMID: 28446063.
      View in: PubMed
    12. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737. PMID: 28389661.
      View in: PubMed
    13. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. PMID: 27693353.
      View in: PubMed
    14. Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19; 9(424):rs3. PMID: 27095595.
      View in: PubMed
    15. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. PMID: 26830878.
      View in: PubMed
    16. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. PMID: 26830879.
      View in: PubMed
    17. C. Wülfing, K.T. Roybal. Cellular Structures Controlling T Cell Signaling in Time and Space. 2016 Jan 1; 677-686.
      View in: Publisher Site
    18. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. PMID: 26405231.
      View in: PubMed
    19. Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. PMID: 26237588.
      View in: PubMed
    20. Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. PMID: 26237050.
      View in: PubMed
    21. Wu CY, Rupp LJ, Roybal KT, Lim WA. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. PMID: 26218616.
      View in: PubMed
    22. Wülfing C, Roybal KT.. Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686.
      View Publication
    23. Huber JP, Gonzales-van Horn SR, Roybal KT, Gill MA, Farrar JD. IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. PMID: 24813204.
      View in: PubMed
    24. Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. PMID: 24284965.
      View in: PubMed
    25. Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. PMID: 24117818.
      View in: PubMed
    26. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA. Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. PMID: 23776671.
      View in: PubMed
    27. Roybal KT, Wülfing C. New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. PMID: 23183270.
      View in: PubMed
    28. Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS. Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. PMID: 22820329.
      View in: PubMed
    29. DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS. The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. PMID: 21543646.
      View in: PubMed
    30. Sinai P, Roybal KT, Wülfing C. Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. PMID: 21331235.
      View in: PubMed
    31. Roybal KT, Wülfing C. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010 Jul 27; 3(132):pe24. PMID: 20664063.
      View in: PubMed
    32. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009 Apr 07; 2(65):ra15. PMID: 19351954.
      View in: PubMed
    33. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11. PMID: 17379666.
      View in: PubMed
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