Kole Roybal, PhD

Title(s)Associate Professor, Microbiology and Immunology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-8289
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical Center Ph.D.2013Immunology
    Austin CollegeB.A.2005Biology
    Collapse Awards and Honors
    NIH - National Cancer Institute2018  - 2023NIH New Innovator Award
    Science Magazine & Sartorius2018Award for Regenerative Medicine and Cell Therapy
    Parker Institute for Cancer Immunotherapy2017Member Researcher
    Chan Zuckerberg Biohub2017Chan Zuckerberg Biohub Investigator
    Jane Coffin Childs Memorial Fund2014  - 2017Postdoctoral Fellowship
    National Institutes of Health2007  - 2010Ruth L. Kirschstein National Research Service Award

    Collapse Overview 
    Collapse Overview
    In the Roybal Lab we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science. 2022 Dec 16; 378(6625):eaba1624. Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. PMID: 36520915.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Multidimensional control of therapeutic human cell function with synthetic gene circuits. Science. 2022 Dec 16; 378(6625):1227-1234. Li HS, Israni DV, Gagnon KA, Gan KA, Raymond MH, Sander JD, Roybal KT, Joung JK, Wong WW, Khalil AS. PMID: 36520914.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors. J Cell Biol. 2023 Feb 06; 222(3). Beppler C, Eichorst J, Marchuk K, Cai E, Castellanos CA, Sriram V, Roybal KT, Krummel MF. PMID: 36520493; PMCID: PMC9757849.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Sci Transl Med. 2022 11 09; 14(670):eabm1463. Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT. PMID: 36350984.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. J Exp Med. 2022 11 07; 219(11). Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL. PMID: 36066491; PMCID: PMC9448639.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma. J Nucl Med. 2023 Jan; 64(1):137-144. Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, Roybal KT, Wilson DM. PMID: 35981900.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion. J Exp Med. 2022 08 01; 219(8). Shemesh A, Pickering H, Roybal KT, Lanier LL. PMID: 35758909; PMCID: PMC9240274.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Modular design of synthetic receptors for programmed gene regulation in cell therapies. Cell. 2022 04 14; 185(8):1431-1443.e16. Zhu I, Liu R, Garcia JM, Hyrenius-Wittsten A, Piraner DI, Alavi J, Israni DV, Liu B, Khalil AS, Roybal KT. PMID: 35427499; PMCID: PMC9108009.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Cellular Structures Controlling T Cell Signaling in Time and Space. . 2022 Jan 1; (Annu Rev Immunol 36 2018). Roybal RK, Alamir AH, Lu LJ, Wülfing WC. .
      View in: Publisher Site   Mentions:
    10. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):98-117. Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, De Coster T, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, Chen WCW. PMID: 34786712.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Sci Transl Med. 2021 04 28; 13(591). Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. PMID: 33910979; PMCID: PMC8362330.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    12. SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Sci Transl Med. 2021 04 28; 13(591). Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT. PMID: 33910981; PMCID: PMC8594452.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    13. DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat Nanotechnol. 2021 02; 16(2):214-223. Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. PMID: 33318641; PMCID: PMC7878327.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science. 2020 11 27; 370(6520):1099-1104. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. PMID: 33243890; PMCID: PMC8054651.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    15. IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii111-ii112. Watchmaker WP, Choe CJ, Simic SM, Gilbert GR, li lA, Krasnow KN, Carrera CD, Yu YW, Downey DK, Celli CA, Cho CJ, Briones BJ, Dannenfelser DR, Cardarelli CL, Sidhu SS, Roybal RK, Lim LW, Okada OH. .
      View in: Publisher Site   Mentions:
    16. MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309. Dietrich DA, Burnett BC, Martin MT, Wiita WA, Roybal RK, Eyquem EJ. .
      View in: Publisher Site   Mentions:
    17. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729; PMCID: PMC7362346.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    18. convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting. Commun Biol. 2020 06 09; 3(1):296. Landgraf KE, Williams SR, Steiger D, Gebhart D, Lok S, Martin DW, Roybal KT, Kim KC. PMID: 32518350; PMCID: PMC7283332.
      View in: PubMed   Mentions: 13  Translation:HumansAnimalsCells
    19. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591; PMCID: PMC7219528.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    20. IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi123-vi123. Watchmaker WP, Choe CJ, Carrera CD, Gilbert GR, Yu YW, Downey DK, Roybal RK, Lim LW, Okada OH. .
      View in: Publisher Site   Mentions:
    21. Paving New Roads for CARs. Trends Cancer. 2019 10; 5(10):583-592. Hyrenius-Wittsten A, Roybal KT. PMID: 31706506.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87. Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    23. Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. 2019 02 19; 50(2):477-492.e8. Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L. PMID: 30737146; PMCID: PMC6886475.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    24. Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate. Biophysical Journal. 2019 Feb 1; 116(3):530a. Low-Nam LS, Lin LJ, McAffee MD, Alvarez AS, Hansen HS, Roybal RK, Groves GJ. .
      View in: Publisher Site   Mentions:
    25. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Ramkumar RP, Leong LJ, Seyler SM, Georgoulis GS, Hyrenius Wittsten HA, Choudhry CP, Roybal RK, Wiita WA, Kampmann KM. .
      View in: Publisher Site   Mentions:
    26. IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi134-vi134. Watchmaker WP, Choe CJ, Carrera CD, Downey DK, Shahin SM, Roybal RK, Lim LW, Okada OH. .
      View in: Publisher Site   Mentions:
    27. Refining cell therapy. Science. 2018 Mar 09; 359(6380):1112-1113. Roybal KT. PMID: 29590036.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 04 26; 35:229-253. Roybal KT, Lim WA. PMID: 28446063; PMCID: PMC5555230.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    29. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. PMID: 28389661; PMCID: PMC5428439.
      View in: PubMed   Mentions: 272     Fields:    Translation:HumansAnimalsCells
    30. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. PMID: 27693353; PMCID: PMC5072533.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansCells
    31. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19; 9(424):rs3. Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. PMID: 27095595; PMCID: PMC4871116.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. PMID: 26830878; PMCID: PMC4752866.
      View in: PubMed   Mentions: 274     Fields:    Translation:HumansAnimalsCells
    33. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. PMID: 26830879; PMCID: PMC4752902.
      View in: PubMed   Mentions: 359     Fields:    Translation:HumansAnimalsCells
    34. Cellular Structures Controlling T Cell Signaling in Time and Space. Encyclopedia of Cell Biology. 2016 Jan 1; 677-686. Wülfing WC, Roybal RK. .
      View in: Publisher Site   Mentions:
    35. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. PMID: 26405231; PMCID: PMC4721629.
      View in: PubMed   Mentions: 275     Fields:    Translation:HumansAnimalsCells
    36. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. PMID: 26237588; PMCID: PMC4523178.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. PMID: 26237050; PMCID: PMC4523204.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. Wu CY, Rupp LJ, Roybal KT, Lim WA. PMID: 26218616; PMCID: PMC4553068.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686. Wülfing C, Roybal KT. View Publication.
    40. IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. Huber JP, Gonzales-van Horn SR, Roybal KT, Gill MA, Farrar JD. PMID: 24813204; PMCID: PMC4104489.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCellsCTClinical Trials
    41. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. PMID: 24284965; PMCID: PMC3929435.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    42. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C. PMID: 24117818.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    43. Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA. PMID: 23776671; PMCID: PMC3679086.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    44. New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. Roybal KT, Wülfing C. PMID: 23183270.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    45. Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS. PMID: 22820329; PMCID: PMC3457510.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    46. The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS. PMID: 21543646; PMCID: PMC3110614.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    47. Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. Sinai P, Roybal KT, Wülfing C. PMID: 21331235; PMCID: PMC3038059.
      View in: PubMed   Mentions: 1  
    48. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010 Jul 27; 3(132):pe24. Roybal KT, Wülfing C. PMID: 20664063.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    49. Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009 Apr 07; 2(65):ra15. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. PMID: 19351954; PMCID: PMC2694444.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    50. Spatiotemporal patterning of T cell signaling as an important regulator of T cell activation at the systems level. The FASEB Journal. 2008 Mar 1; 22:1064.16-1064.16. Wuelfing WC, Singleton SK, Roybal RK, Sun SY. .
      View in: Publisher Site   Mentions:
    51. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. PMID: 17379666; PMCID: PMC1851061.
      View in: PubMed   Mentions: 327     Fields:    Translation:Animals
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