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Kole Roybal, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentMicrobiology and Immunology
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-8289
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical Center Ph.D.2013Immunology
    Austin CollegeB.A.2005Biology
    Collapse Awards and Honors
    Parker Institute for Cancer Immunotherapy2017Member Researcher
    Chan Zuckerberg Biohub2017Chan Zuckerberg Biohub Investigator
    Jane Coffin Childs Memorial Fund2014  - 2017Postdoctoral Fellowship
    National Institutes of Health2007  - 2010Ruth L. Kirschstein National Research Service Award

    Collapse Overview 
    Collapse Overview
    In the Roybal Lab we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response.


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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Roybal K, Lim WA. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 Apr 26; 35:229-253. PMID: 28446063.
      View in: PubMed
    2. Rupp LJ, Schumann K, Roybal K, Gate RE, Ye CJ, Lim WA, Marson A. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 Apr 07; 7(1):737. PMID: 28389661.
      View in: PubMed
    3. Roybal K, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 6; 167(2):419-432.e16. PMID: 27693353.
      View in: PubMed
    4. Roybal K, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016; 9(424):rs3. PMID: 27095595.
      View in: PubMed
    5. Roybal K, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. PMID: 26830879.
      View in: PubMed
    6. Morsut L, Roybal K, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. PMID: 26830878.
      View in: PubMed
    7. Wu CY, Roybal K, Puchner EM, Onuffer J, Lim WA. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. PMID: 26405231.
      View in: PubMed
    8. Roybal K, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. PMID: 26237050; PMCID: PMC4523204.
      View in: PubMed, PubMed Central
    9. Roybal K, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. PMID: 26237588; PMCID: PMC4523178.
      View in: PubMed, PubMed Central
    10. Wu CY, Rupp LJ, Roybal K, Lim WA. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. PMID: 26218616; PMCID: PMC4553068 [Available on 08/01/16].
      View in: PubMed, PubMed Central
    11. Wülfing C, Roybal K . Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686.
      View Publication
    12. Huber JP, Gonzales-van Horn SR, Roybal K, Gill MA, Farrar JD. IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. PMID: 24813204; PMCID: PMC4104489.
      View in: PubMed, PubMed Central
    13. Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. PMID: 24284965; PMCID: PMC3929435.
      View in: PubMed, PubMed Central
    14. Roybal K, Sinai P, Verkade P, Murphy RF, Wülfing C. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. PMID: 24117818.
      View in: PubMed
    15. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA. Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. PMID: 23776671; PMCID: PMC3679086.
      View in: PubMed, PubMed Central
    16. Roybal K, Wülfing C. New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. PMID: 23183270.
      View in: PubMed
    17. Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal K, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS. Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. PMID: 22820329; PMCID: PMC3457510.
      View in: PubMed, PubMed Central
    18. DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal K, Barylko B, Albanesi JP, Wülfing C, van Oers NS. The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. PMID: 21543646; PMCID: PMC3110614.
      View in: PubMed, PubMed Central
    19. Sinai P, Roybal K, Wülfing C. Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. PMID: 21331235; PMCID: PMC3038059.
      View in: PubMed, PubMed Central
    20. Roybal K, Wülfing C. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010; 3(132):pe24. PMID: 20664063.
      View in: PubMed
    21. Singleton KL, Roybal K, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009; 2(65):ra15. PMID: 19351954; PMCID: PMC2694444.
      View in: PubMed, PubMed Central
    22. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11. PMID: 17379666; PMCID: PMC1851061.
      View in: PubMed, PubMed Central
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