Kole Roybal, PhD
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Title(s) | Assistant Professor, Microbiology and Immunology |
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School | School of Medicine |
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Address | 513 Parnassus Ave, HSE San Francisco CA 94143
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Phone | 415-476-8289 |
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vCard | Download vCard |
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Biography UT Southwestern Medical Center | Ph.D. | 2013 | Immunology | Austin College | B.A. | 2005 | Biology |
NIH - National Cancer Institute | 2018
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| 2023 | NIH New Innovator Award | Science Magazine & Sartorius | 2018 | | Award for Regenerative Medicine and Cell Therapy | Parker Institute for Cancer Immunotherapy | 2017 | | Member Researcher | Chan Zuckerberg Biohub | 2017 | | Chan Zuckerberg Biohub Investigator | Jane Coffin Childs Memorial Fund | 2014
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| 2017 | Postdoctoral Fellowship | National Institutes of Health | 2007
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| 2010 | Ruth L. Kirschstein National Research Service Award |
Overview In the Roybal Lab we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response.
Research ORNG Applications Bibliographic
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DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat Nanotechnol. 2020 Dec 14.
Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. PMID: 33318641.
View in: PubMed Mentions: Fields:
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Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science. 2020 Nov 27; 370(6520):1099-1104.
Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. PMID: 33243890.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii111-ii112.
Payal Watchmaker, Joseph Choe, Milos Simic, Ryan Gilbert, Aileen li, Nira Krasnow, Diego Carrera, Wei Yu, Kira Downey, Anna Celli, Juhyun Cho, Jessica Briones, Ruth Dannenfelser, Lia Cardarelli, Sachdev Sidhu, Kole Roybal, Wendell Lim, Hideho Okada. .
View in: Publisher Site Mentions:
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MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309.
August Dietrich, Cassandra Burnett, Thomas Martin, Arun Wiita, Kole Roybal, Justin Eyquem. .
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CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 Jul 14; 4(13):2899-2911.
Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729.
View in: PubMed Mentions: 1 Fields:
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convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting. Commun Biol. 2020 Jun 09; 3(1):296.
Landgraf KE, Williams SR, Steiger D, Gebhart D, Lok S, Martin DW, Roybal KT, Kim KC. PMID: 32518350.
View in: PubMed Mentions:
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Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21.
Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591.
View in: PubMed Mentions: 5 Fields:
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IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi123-vi123.
Payal Watchmaker, Joseph Choe, Diego Carrera, Ryan Gilbert, Wei Yu, Kira Downey, Kole Roybal, Wendell Lim, Hideho Okada. .
View in: Publisher Site Mentions:
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Paving New Roads for CARs. Trends Cancer. 2019 10; 5(10):583-592.
Hyrenius-Wittsten A, Roybal KT. PMID: 31706506.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87.
Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. 2019 02 19; 50(2):477-492.e8.
Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L. PMID: 30737146.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate. Biophysical Journal. 2019 Feb 1; 116(3):530a.
Shalini T. Low-Nam, Jenny JY Lin, Darren B. McAffee, Steven A. Alvarez, Scott D. Hansen, Kole T. Roybal, Jay T. Groves. .
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Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926.
Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann. .
View in: Publisher Site Mentions:
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IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi134-vi134.
Payal Watchmaker, Joseph Choe, Diego Carrera, Kira Downey, Maryam Shahin, Kole Roybal, Wendell Lim, Hideho Okada. .
View in: Publisher Site Mentions:
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Refining cell therapy. Science. 2018 Mar 09; 359(6380):1112-1113.
Roybal KT. PMID: 29590036.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 04 26; 35:229-253.
Roybal KT, Lim WA. PMID: 28446063.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737.
Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. PMID: 28389661.
View in: PubMed Mentions: 108 Fields: Translation: HumansAnimalsCells
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Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16.
Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. PMID: 27693353.
View in: PubMed Mentions: 103 Fields: Translation: HumansCells
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Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19; 9(424):rs3.
Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. PMID: 27095595.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91.
Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. PMID: 26830878.
View in: PubMed Mentions: 129 Fields: Translation: HumansAnimalsCells
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Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9.
Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. PMID: 26830879.
View in: PubMed Mentions: 174 Fields: Translation: HumansAnimalsCells
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Cellular Structures Controlling T Cell Signaling in Time and Space. Encyclopedia of Cell Biology. 2016 Jan 1; 677-686.
C. Wülfing, K.T. Roybal. .
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Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077.
Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. PMID: 26405231.
View in: PubMed Mentions: 156 Fields: Translation: HumansAnimalsCells
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Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231.
Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. PMID: 26237588.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299.
Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. PMID: 26237050.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30.
Wu CY, Rupp LJ, Roybal KT, Lim WA. PMID: 26218616.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686.
Wülfing C, Roybal KT. . View Publication.
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IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94.
PMID: 24813204.
View in: PubMed Mentions: 13 Fields: Translation: HumansCellsCTClinical Trials
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Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18.
PMID: 24284965.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47.
PMID: 24117818.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438.
PMID: 23776671.
View in: PubMed Mentions: 17 Fields: Translation: Animals
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New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2.
PMID: 23183270.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37.
PMID: 22820329.
View in: PubMed Mentions: 2 Fields: Translation: Cells
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The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47.
PMID: 21543646.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8.
Sinai P, Roybal KT, Wülfing C. PMID: 21331235.
View in: PubMed Mentions:
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Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010 Jul 27; 3(132):pe24.
Roybal KT, Wülfing C. PMID: 20664063.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009 Apr 07; 2(65):ra15.
Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. PMID: 19351954.
View in: PubMed Mentions: 43 Fields: Translation: AnimalsCells
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Spatiotemporal patterning of T cell signaling as an important regulator of T cell activation at the systems level. The FASEB Journal. 2008 Mar 1; 22:1064.16-1064.16.
Christoph Wuelfing, Kentner L. Singleton, Kole T. Roybal, Yi Sun. .
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Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11.
Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. PMID: 17379666.
View in: PubMed Mentions: 272 Fields: Translation: Animals
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Year | Publications |
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2007 | 1 | 2008 | 1 | 2009 | 1 | 2010 | 2 | 2011 | 1 | 2012 | 2 | 2013 | 2 | 2014 | 2 | 2015 | 5 | 2016 | 5 | 2017 | 2 | 2018 | 3 | 2019 | 5 | 2020 | 7 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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