Kole Roybal, PhD

Title(s)Associate Professor, Microbiology and Immunology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-8289
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical Center Ph.D.2013Immunology
    Austin CollegeB.A.2005Biology
    Collapse Awards and Honors
    NIH - National Cancer Institute2018  - 2023NIH New Innovator Award
    Science Magazine & Sartorius2018Award for Regenerative Medicine and Cell Therapy
    Parker Institute for Cancer Immunotherapy2017Member Researcher
    Chan Zuckerberg Biohub2017Chan Zuckerberg Biohub Investigator
    Jane Coffin Childs Memorial Fund2014  - 2017Postdoctoral Fellowship
    National Institutes of Health2007  - 2010Ruth L. Kirschstein National Research Service Award

    Collapse Overview 
    Collapse Overview
    In the Roybal Lab we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response.

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering the Next-generation of Custom Immune Cell Therapies
    NIH DP2CA239143Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Sci Transl Med. 2021 Apr 28; 13(591). Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. PMID: 33910979.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Sci Transl Med. 2021 Apr 28; 13(591). Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT. PMID: 33910981.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat Nanotechnol. 2021 02; 16(2):214-223. Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. PMID: 33318641.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science. 2020 11 27; 370(6520):1099-1104. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. PMID: 33243890.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii111-ii112. Payal Watchmaker, Joseph Choe, Milos Simic, Ryan Gilbert, Aileen li, Nira Krasnow, Diego Carrera, Wei Yu, Kira Downey, Anna Celli, Juhyun Cho, Jessica Briones, Ruth Dannenfelser, Lia Cardarelli, Sachdev Sidhu, Kole Roybal, Wendell Lim, Hideho Okada. .
      View in: Publisher Site   Mentions:
    6. MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309. August Dietrich, Cassandra Burnett, Thomas Martin, Arun Wiita, Kole Roybal, Justin Eyquem. .
      View in: Publisher Site   Mentions:
    7. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting. Commun Biol. 2020 06 09; 3(1):296. Landgraf KE, Williams SR, Steiger D, Gebhart D, Lok S, Martin DW, Roybal KT, Kim KC. PMID: 32518350.
      View in: PubMed   Mentions:
    9. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    10. IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi123-vi123. Payal Watchmaker, Joseph Choe, Diego Carrera, Ryan Gilbert, Wei Yu, Kira Downey, Kole Roybal, Wendell Lim, Hideho Okada. .
      View in: Publisher Site   Mentions:
    11. Paving New Roads for CARs. Trends Cancer. 2019 10; 5(10):583-592. Hyrenius-Wittsten A, Roybal KT. PMID: 31706506.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87. Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. 2019 02 19; 50(2):477-492.e8. Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L. PMID: 30737146.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    14. Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate. Biophysical Journal. 2019 Feb 1; 116(3):530a. Shalini T. Low-Nam, Jenny JY Lin, Darren B. McAffee, Steven A. Alvarez, Scott D. Hansen, Kole T. Roybal, Jay T. Groves. .
      View in: Publisher Site   Mentions:
    15. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann. .
      View in: Publisher Site   Mentions:
    16. IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi134-vi134. Payal Watchmaker, Joseph Choe, Diego Carrera, Kira Downey, Maryam Shahin, Kole Roybal, Wendell Lim, Hideho Okada. .
      View in: Publisher Site   Mentions:
    17. Refining cell therapy. Science. 2018 Mar 09; 359(6380):1112-1113. Roybal KT. PMID: 29590036.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 04 26; 35:229-253. Roybal KT, Lim WA. PMID: 28446063.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    19. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. PMID: 28389661.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    20. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. PMID: 27693353.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    21. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19; 9(424):rs3. Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. PMID: 27095595.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. PMID: 26830878.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    23. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. PMID: 26830879.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    24. Cellular Structures Controlling T Cell Signaling in Time and Space. Encyclopedia of Cell Biology. 2016 Jan 1; 677-686. C. Wülfing, K.T. Roybal. .
      View in: Publisher Site   Mentions:
    25. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. PMID: 26405231.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimalsCells
    26. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. PMID: 26237588.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. PMID: 26237050.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. Wu CY, Rupp LJ, Roybal KT, Lim WA. PMID: 26218616.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686. Wülfing C, Roybal KT. . View Publication.
    30. IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. Huber JP, Gonzales-van Horn SR, Roybal KT, Gill MA, Farrar JD. PMID: 24813204.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    31. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. PMID: 24284965.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C. PMID: 24117818.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    33. Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA. PMID: 23776671.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    34. New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. Roybal KT, Wülfing C. PMID: 23183270.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS. PMID: 22820329.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    36. The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS. PMID: 21543646.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    37. Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. Sinai P, Roybal KT, Wülfing C. PMID: 21331235.
      View in: PubMed   Mentions:
    38. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010 Jul 27; 3(132):pe24. Roybal KT, Wülfing C. PMID: 20664063.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009 Apr 07; 2(65):ra15. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. PMID: 19351954.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    40. Spatiotemporal patterning of T cell signaling as an important regulator of T cell activation at the systems level. The FASEB Journal. 2008 Mar 1; 22:1064.16-1064.16. Christoph Wuelfing, Kentner L. Singleton, Kole T. Roybal, Yi Sun. .
      View in: Publisher Site   Mentions:
    41. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. PMID: 17379666.
      View in: PubMed   Mentions: 294     Fields:    Translation:Animals
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