Marta Margeta, MD, PhD
|School||UCSF School of Medicine|
|Address||513 Parnassus Ave|
San Francisco CA 94143
|University of Zagreb||M.D.||1991||School of Medicine|
|University of Illinois at Chicago||Ph.D.||1996||Graduate College (Pharmacology)|
Biological stress response pathways (such as wound healing and tissue repair, ischemic preconditioning, and heat shock response) play a critical role in the prevention and/or repair of cell and tissue injury; however, unchecked activation of these pathways over long periods of time can be harmful, resulting in disease and even premature death. The long term goal of our lab is to elucidate how activation of stress response signaling in the brain and skeletal muscle contributes to neurologic health and disease. Specifically, we use a combination of different experimental approaches (molecular and cell biology, immunohistochemistry, biochemistry, and electrophysiology) in human tissue and animal / cellular models of disease to investigate three distinct but related stress response pathways: (1) the Keap1/Nrf2 antioxidant pathway; (2) autophagy; and (3) astrocyte activation in response to injury.
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