Stephen Gitelman, MD
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Title(s) | Professor, Pediatrics |
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School | School of Medicine |
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Address | 550 16th. Street San Francisco CA 94158
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Phone | 415-476-1016 |
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vCard | Download vCard |
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Biography University of California, San Francisco | Post-Doc Fellow/Scholar | 1990 | Medicine (Pediatrics) | University of California, San Francisco | Residency | | School of Medicine | University of North Carolina | M.D. | 1984 | School of Medicine |
Overview I am involved in a variety of different translational and clinical research projects, most related to diabetes. A number of the on-going studies are attempts to alter the course of autoimmune-mediated type 1 diabetes, often via immunomodulation, in order to preserve endogenous beta cell function. Some of the recent and on-going projects are described below.
Most of this work occurs in multi-center clinical trials. I am the Clinical Center director for the NIH sponsored program TrialNet, a multi-center research consortium that develops trials to delay or prevent the onset of type 1 diabetes in those at risk, or prolong endogenous insulin secretion (the honeymoon phase) in those with new onset disease. UCSF is one of 14 national centers for this 7-year study. Current studies include: -natural history study to screen and predict who might develop type 1 diabetes -a prevention trial with omega 3 fatty acids to determine if treatment during pregnancy or shortly after birth can serve as a primary means to prevent type 1 diabetes -a new onset diabetes trial with mycophenolate mofetil with our without IL-2 receptor monoclonal antibody to determine if this will preserve endogenous insulin secretion -a new onset study with anti-CD20 monoclonal antibody to determine if this will preserve endogenous insulin secretion The consortium is continuing to develop additional prevention and new onset studies over time.
In addition, I have served as the site director for a novel study evaluating the role of an anti-CD3 monoclonal antibody in prolonging the honeymoon phase in those with new onset type 1 diabetes. The initial phase 1 / 2 study results were published in the N Engl J Med 2002, and our 2 year follow-up data was just published (Diabetes 2005). These exciting results were confirmed in an independent study with a related drug in Europe, and have spawned a series of studies to build on these initial findings. We are now launching an NIH-sponsored phase 2 study for new onset diabetes, evaluating the efficacy of antibody treatment every 12 months for 2 courses. In addition to these efforts, we have several additional NIH-funded new onset type 1 diabetes studies that will soon begin. We are evaluating the window of opportunity for anti-CD3 therapy, with a trial planned for subjects from 4 to 12 months from diagnosis. We are developing clinical trials the assess the effect of anti-CD3 therapy coupled with antigen, and another study coupling with an incretin hormone analgoue, exenatide, which may help with beta cell regeneration. Finally, I am the study principal investigator for a multi-center new onset type 1 diabetes trial with anti-thymocyte globulin, sponsored by the Immune Tolerance Network.
I am partnering with other members of the UCSF Diabetes Center to pursue other clinical trials, and translational studies that may help us better understand the pathogenesis of type 1 diabetes. Such studies include development of T cell assays; characterization of patients with novel disorders in carbohydrate metabolism; possible use of T regulatory cells as an immunotherapy. As technology advances, we anticipate to one day be able to use beta cells developed from stem cells as a definitive treatment for type 1 diabetes.
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Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report. Diabetes. 2021 Feb 25.
Lin A, Mack JA, Bruggeman B, Jacobsen LM, Posgai AL, Wasserfall CH, Brusko TM, Atkinson MA, Gitelman SE, Gottlieb PA, Gurka MJ, Mathews CE, Schatz DA, Haller MJ. PMID: 33632742.
View in: PubMed Mentions:
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Continuous Glucose Monitoring to Diagnose Hypoglycemia Due to Late Dumping Syndrome in Children After Gastric Surgeries. J Endocr Soc. 2021 Mar 01; 5(3):bvaa197.
Chesser H, Abdulhussein F, Huang A, Lee JY, Gitelman SE. PMID: 33506160.
View in: PubMed Mentions:
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Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes. Diabetes Technol Ther. 2020 12; 22(12):948-953.
Jacobsen LM, Bundy BN, Greco MN, Schatz DA, Atkinson MA, Brusko TM, Mathews CE, Herold KC, Gitelman SE, Krischer JP, Haller MJ. PMID: 32833543.
View in: PubMed Mentions: Fields:
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Exenatide extended release in patients with type 1 diabetes with and without residual insulin production. Diabetes Obes Metab. 2020 Nov; 22(11):2045-2054.
Herold KC, Reynolds J, Dziura J, Baidal D, Gaglia J, Gitelman SE, Gottlieb PA, Marks J, Philipson LH, Pop-Busui R, Weinstock RS. PMID: 32573927.
View in: PubMed Mentions: Fields:
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Clinical trial data validate the C-peptide estimate model in type 1 diabetes. Diabetologia. 2020 04; 63(4):885-886.
Wentworth JM, Bediaga NG, Gitelman SE, Evans-Molina C, Gottlieb PA, Colman PG, Haller MJ, Harrison LC. PMID: 31982961.
View in: PubMed Mentions: Fields:
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Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents. Diabetes Care. 2020 03; 43(3):580-587.
Ferrara-Cook C, Geyer SM, Evans-Molina C, Libman IM, Becker DJ, Gitelman SE, Redondo MJ. PMID: 31937610.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes. JCI Insight. 2019 12 19; 4(24).
Herold KC, Bucktrout SL, Wang X, Bode BW, Gitelman SE, Gottlieb PA, Hughes J, Joh T, McGill JB, Pettus JH, Potluri S, Schatz D, Shannon M, Udata C, Wong G, Levisetti M, Ganguly BJ, Garzone PD. PMID: 31852846.
View in: PubMed Mentions: 1 Fields: Translation: HumansCellsCTClinical Trials
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Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care. 2020 01; 43(1):5-12.
Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. PMID: 31753960.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome. Xenotransplantation. 2019 11; 26(6):e12535.
Le Berre L, Danger R, Mai HL, Amon R, Leviatan Ben-Arye S, Bruneau S, Senage T, Perreault H, Teraiya M, Nguyen TVH, Le Tourneau T, Yu H, Chen X, Galli C, Roussel JC, Manez R, Costa C, Brouard S, Galinanes M, Harris KM, Gitelman S, Cozzi E, Charreau B, Padler-Karavani V, Soulillou JP. PMID: 31293002.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 08 15; 381(7):603-613.
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ. PMID: 31180194.
View in: PubMed Mentions: 55 Fields: Translation: HumansCellsCTClinical Trials
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Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data. Diabetes. 2019 06; 68(6):1267-1276.
Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ. PMID: 30967424.
View in: PubMed Mentions: 8 Fields: Translation: HumansCellsCTClinical Trials
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Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables. Diabetologia. 2019 01; 62(1):33-40.
Wentworth JM, Bediaga NG, Giles LC, Ehlers M, Gitelman SE, Geyer S, Evans-Molina C, Harrison LC. PMID: 30167735.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Low-Dose Anti-Thymocyte Globulin (ATG) Preserves ß-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes. Diabetes Care. 2018 Sep; 41(9):1917-1925.
Haller MJ, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Miller JL, Atkinson MA, Becker DJ, Baidal D, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell W, Wilson DM, Greenbaum CJ. PMID: 30012675.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
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Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy. Oncotarget. 2017 Dec 22; 8(68):112236-112244.
PMID: 29348821.
View in: PubMed Mentions: 11 Fields:
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The Role of Age and Excess Body Mass Index in Progression to Type 1 Diabetes in At-Risk Adults. J Clin Endocrinol Metab. 2017 12 01; 102(12):4596-4603.
Ferrara CT, Geyer SM, Evans-Molina C, Libman IM, Becker DJ, Wentworth JM, Moran A, Gitelman SE, Redondo MJ. PMID: 29092051.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11. Channels (Austin). 2017 Nov 02; 11(6):636-647.
Yang YY, Long RK, Ferrara CT, Gitelman SE, German MS, Yang SB. PMID: 29087246.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Type 1 Diabetes and Celiac Disease: Causal Association or True, True, Unrelated? Pediatrics. 2017 11; 140(5).
Ferrara CT, Gitelman SE. PMID: 29018047.
View in: PubMed Mentions: Fields: Translation: Humans
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Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs. Transplantation. 2017 10; 101(10):2501-2507.
PMID: 28198767.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCTClinical Trials
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Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development? Diabetes Care. 2017 05; 40(5):698-701.
PMID: 28202550.
View in: PubMed Mentions: 16 Fields: Translation: Humans
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Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes. Diabetes Care. 2016 Dec; 39(12):2218-2224.
PMID: 27872156.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. Diabetes. 2016 Dec; 65(12):3765-3775.
PMID: 27669730.
View in: PubMed Mentions: 23 Fields: Translation: HumansCells
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Regulatory T cell therapy for type 1 diabetes: May the force be with you. J Autoimmun. 2016 07; 71:78-87.
PMID: 27133597.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Two- and Four-Hour Tests Differ in Capture of C-Peptide Responses to a Mixed Meal in Type 1 Diabetes. Diabetes Care. 2016 06; 39(6):e76-8.
PMID: 27208317.
View in: PubMed Mentions: 1 Fields:
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Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial. Diabetologia. 2016 06; 59(6):1153-61.
PMID: 27053235.
View in: PubMed Mentions: 20 Fields: Translation: HumansCells
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Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25; 7(315):315ra189.
PMID: 26606968.
View in: PubMed Mentions: 226 Fields: Translation: HumansCellsCTClinical Trials
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Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report. Diabetes Care. 2015 Oct; 38(10):1975-85.
PMID: 26404927.
View in: PubMed Mentions: 29 Fields: Translation: Humans
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Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest. 2015 Aug 03; 125(8):3285-96.
PMID: 26193635.
View in: PubMed Mentions: 81 Fields: Translation: HumansCellsCTClinical Trials
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Anti-thymocyte globulin/G-CSF treatment preserves ß cell function in patients with established type 1 diabetes. J Clin Invest. 2015 Jan; 125(1):448-55.
PMID: 25500887.
View in: PubMed Mentions: 60 Fields: Translation: HumansCellsCTClinical Trials
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Recommendations for the definition of clinical responder in insulin preservation studies. Diabetes. 2014 Sep; 63(9):3120-7.
PMID: 24722251.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes Care. 2014 Apr; 37(4):1069-75.
PMID: 24296850.
View in: PubMed Mentions: 59 Fields: Translation: Humans
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Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013 Dec; 1(4):284-94.
PMID: 24622414.
View in: PubMed Mentions: 67 Fields: Translation: HumansCellsCTClinical Trials
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B-lymphocyte depletion with rituximab and ß-cell function: two-year results. Diabetes Care. 2014 Feb; 37(2):453-9.
PMID: 24026563.
View in: PubMed Mentions: 63 Fields: Translation: HumansCellsCTClinical Trials
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Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2013 Dec; 1(4):306-16.
PMID: 24622416.
View in: PubMed Mentions: 52 Fields: Translation: HumansCTClinical Trials
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Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes. 2013 Nov; 62(11):3766-74.
PMID: 23835333.
View in: PubMed Mentions: 99 Fields: Translation: Humans
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Altering the course of type 1 diabetes: an update on prevention and new-onset clinical trials. Pediatr Diabetes. 2013 Aug; 14(5):311-21.
PMID: 23773203.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease. Am J Transplant. 2013 Aug; 13(8):2207-10.
PMID: 23763601.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry. J Diabetes. 2013 Jun; 5(2):216-23.
PMID: 23368514.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet. 2013 Jun 01; 381(9881):1905-15.
PMID: 23562090.
View in: PubMed Mentions: 118 Fields: Translation: HumansCells
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A cross-sectional study of osteocalcin and body fat measures among obese adolescents. Obesity (Silver Spring). 2013 Apr; 21(4):808-14.
PMID: 23712984.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Immune therapy and ß-cell death in type 1 diabetes. Diabetes. 2013 May; 62(5):1676-80.
PMID: 23423576.
View in: PubMed Mentions: 38 Fields: Translation: HumansCells
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Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb; 56(2):391-400.
PMID: 23086558.
View in: PubMed Mentions: 43 Fields: Translation: Humans
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Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data. Diabetes. 2012 Aug; 61(8):2066-73.
PMID: 22688329.
View in: PubMed Mentions: 112 Fields: Translation: HumansCells
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Persistent elevation of urine aquaporin-2 during water loading in a child with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) caused by a R137L mutation in the V2 vasopressin receptor. Int J Pediatr Endocrinol. 2012 Feb 10; 2012(1):3.
PMID: 22325688.
View in: PubMed Mentions:
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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet. 2011 Jul 30; 378(9789):412-9.
PMID: 21719096.
View in: PubMed Mentions: 205 Fields: Translation: HumansCellsCTClinical Trials
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Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet. 2011 Jul 23; 378(9788):319-27.
PMID: 21714999.
View in: PubMed Mentions: 126 Fields: Translation: Humans
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Detecting and treating hyperlipidemia in children with type 1 diabetes mellitus: are standard guidelines applicable to this special population? Pediatr Diabetes. 2011 Jun; 12(4 Pt 2):442-59.
Glaser NS, Geller DH, Haqq A, Gitelman S, Malloy M. PMID: 21054719.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Impact of an interactive online nursing educational module on insulin errors in hospitalized pediatric patients. Diabetes Care. 2010 Aug; 33(8):1744-6.
Sullivan MM, O'Brien CR, Gitelman SE, Shapiro SE, Rushakoff RJ. PMID: 20504898.
View in: PubMed Mentions: 7 Fields: Translation: Humans
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Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments. Mol Pharmacol. 2010 May; 77(5):836-45.
Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpré G, Chen S, Kovoor A, Gitelman SE, Rosenthal SM, von Zastrow M, Bouvier M. PMID: 20159941.
View in: PubMed Mentions: 24 Fields: Translation: HumansCells
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Long-term outcomes in a family with nephrogenic syndrome of inappropriate antidiuresis. Int J Pediatr Endocrinol. 2009; 2009:431527.
Cho YH, Gitelman S, Rosenthal S, Ambler G. PMID: 20148077.
View in: PubMed Mentions:
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Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med. 2009 Nov 26; 361(22):2143-52.
Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, McGee PF, Moran AM, Raskin P, Rodriguez H, Schatz DA, Wherrett D, Wilson DM, Lachin JM, Skyler JS. PMID: 19940299.
View in: PubMed Mentions: 349 Fields: Translation: HumansCells
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Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2009 Aug 12; 302(6):624; author reply 624-5.
Gitelman SE, Haller MJ, Schatz D. PMID: 19671901.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Relation of body fat indexes to vitamin D status and deficiency among obese adolescents. Am J Clin Nutr. 2009 Sep; 90(3):459-67.
Lenders CM, Feldman HA, Von Scheven E, Merewood A, Sweeney C, Wilson DM, Lee PD, Abrams SH, Gitelman SE, Wertz MS, Klish WJ, Taylor GA, Chen TC, Holick MF. PMID: 19640956.
View in: PubMed Mentions: 56 Fields: Translation: Humans
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Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin Immunol. 2009 Aug; 132(2):166-73.
Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA. PMID: 19443276.
View in: PubMed Mentions: 77 Fields: Translation: Humans
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The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr Diabetes. 2008 Jun; 9(3 Pt 2):69-73.
Huang EA, Gitelman SE. PMID: 18221433.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Congenital hyperinsulinism in an infant caused by a macroscopic insulin-producing lesion. J Pediatr Endocrinol Metab. 2007 Mar; 20(3):437-40.
Bremer AA, Nobuhara KK, Gitelman SE. PMID: 17451083.
View in: PubMed Mentions: Fields: Translation: Humans
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Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:66-70.
Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE. PMID: 17261972.
View in: PubMed Mentions: Fields: Translation: Humans
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Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes. 2006 Sep; 55(9):2588-94.
Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC. PMID: 16936208.
View in: PubMed Mentions: 37 Fields: Translation: HumansCells
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Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. Am J Med. 2006 Jul; 119(7 Suppl 1):S54-8.
Gitelman SE, Feldman BJ, Rosenthal SM. PMID: 16843086.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. J Pediatr. 2006 Jan; 148(1):128-31.
Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE. PMID: 16423613.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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Prevalence and characteristics of type 2 diabetes mellitus in 9-18 year-old children with diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2005 Sep; 18(9):865-72.
Sapru A, Gitelman SE, Bhatia S, Dubin RF, Newman TB, Flori H. PMID: 16279364.
View in: PubMed Mentions: 7 Fields: Translation: Humans
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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes. 2005 Jun; 54(6):1763-9.
Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA. PMID: 15919798.
View in: PubMed Mentions: 212 Fields: Translation: HumansCTClinical Trials
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Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 05; 352(18):1884-90.
Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. PMID: 15872203.
View in: PubMed Mentions: 68 Fields: Translation: HumansCells
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A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. Diabetes Care. 2005 Jan; 28(1):15-9.
Wilson DM, Buckingham BA, Kunselman EL, Sullivan MM, Paguntalan HU, Gitelman SE. PMID: 15616227.
View in: PubMed Mentions: 30 Fields: Translation: HumansCTClinical Trials
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The use of a continuous glucose monitoring system in hypoglycemic disorders. J Pediatr Endocrinol Metab. 2004 Mar; 17(3):281-8.
Conrad SC, Mastrototaro JJ, Gitelman SE. PMID: 15112904.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Insulin secretion in type 1 diabetes. Diabetes. 2004 Feb; 53(2):426-33.
Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC. PMID: 14747294.
View in: PubMed Mentions: 53 Fields: Translation: HumansCTClinical Trials
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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med. 2002 May 30; 346(22):1692-8.
Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA. PMID: 12037148.
View in: PubMed Mentions: 372 Fields: Translation: HumansCTClinical Trials
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Transition from multiple daily injections to continuous subcutaneous insulin infusion in type 1 diabetes mellitus. J Pediatr. 2002 Feb; 140(2):235-40.
Conrad SC, McGrath MT, Gitelman SE. PMID: 11865277.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Increased incidence in post-transplant diabetes mellitus in children: a case-control analysis. Pediatr Nephrol. 2002 Jan; 17(1):1-5.
Greenspan LC, Gitelman SE, Leung MA, Glidden DV, Mathias RS. PMID: 11793126.
View in: PubMed Mentions: 19 Fields: Translation: Humans
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Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients. Diabetologia. 2000 May; 43(5):598-608.
Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S. PMID: 10855535.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct; 126(19):4267-79.
Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. PMID: 10477295.
View in: PubMed Mentions: 69 Fields: Translation: AnimalsCells
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Smooth muscle expresses bone morphogenetic protein (Vgr-1/BMP-6) in human fetal intestine. Biol Neonate. 1999 Mar; 75(3):210-4.
Perr HA, Ye J, Gitelman SE. PMID: 9925908.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimals
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Neonatal hyperinsulinism. Clin Perinatol. 1998 Dec; 25(4):1015-38, viii.
Schwitzgebel VM, Gitelman SE. PMID: 9891627.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease. J Clin Endocrinol Metab. 1997 Oct; 82(10):3196-202.
Devoe DJ, Miller WL, Conte FA, Kaplan SL, Grumbach MM, Rosenthal SM, Wilson CB, Gitelman SE. PMID: 9329338.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimals
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Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents. J Clin Endocrinol Metab. 1997 May; 82(5):1362-7.
Mootha SL, Barkovich AJ, Grumbach MM, Edwards MS, Gitelman SE, Kaplan SL, Conte FA. PMID: 9141516.
View in: PubMed Mentions: 25 Fields: Translation: Humans
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Structure and sequence of the mouse Bmp6 gene. Mamm Genome. 1997 Mar; 8(3):212-4.
Gitelman SE, Kobrin M, Lee A, Fet V, Lyons K, Hogan BL, Derynck R. PMID: 9069123.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Immunoreactive inhibin, müllerian inhibitory substance, and activin as biochemical markers for juvenile granulosa cell tumors. J Pediatr. 1996 Dec; 129(6):918-21.
Silverman LA, Gitelman SE. PMID: 8969738.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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A promoter within intron 35 of the human C4A gene initiates abundant adrenal-specific transcription of a 1 kb RNA: location of a cryptic CYP21 promoter element? Hum Mol Genet. 1995 Nov; 4(11):2109-16.
Tee MK, Babalola GO, Aza-Blanc P, Speek M, Gitelman SE, Miller WL. PMID: 8589688.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth Differ. 1995 Jul; 6(7):827-36.
Gitelman SE, Kirk M, Ye JQ, Filvaroff EH, Kahn AJ, Derynck R. PMID: 7547504.
View in: PubMed Mentions: 10 Fields: Translation: Cells
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Toward a molecular understanding of skeletal development. Cell. 1995 Feb 10; 80(3):371-8.
Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. PMID: 7859279.
View in: PubMed Mentions: 113 Fields: Translation: HumansAnimals
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Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol. 1994 Sep; 126(6):1595-609.
Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R. PMID: 8089189.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. J Cell Biol. 1993 Jul; 122(1):265-78.
Bristow J, Tee MK, Gitelman SE, Mellon SH, Miller WL. PMID: 7686164.
View in: PubMed Mentions: 42 Fields: Translation: HumansCells
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Abundant adrenal-specific transcription of the human P450c21A "pseudogene". J Biol Chem. 1993 Jun 15; 268(17):12919-24.
Bristow J, Gitelman SE, Tee MK, Staels B, Miller WL. PMID: 7685353.
View in: PubMed Mentions: 17 Fields: Translation: HumansCells
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Mental retardation locus in Xp21 chromosome microdeletion. Am J Med Genet. 1993 Jun 01; 46(4):363-8.
Fries MH, Lebo RV, Schonberg SA, Golabi M, Seltzer WK, Gitelman SE, Golbus MS. PMID: 8357005.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Congenital lipoid adrenal hyperplasia--genes for P450scc, side chain cleavage enzyme, are normal. J Steroid Biochem Mol Biol. 1993 Apr; 45(1-3):87-97.
Saenger P, Lin D, Gitelman SE, Miller WL. PMID: 8481356.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Analysis of the duplicated human C4/P450c21/X gene cluster. J Steroid Biochem Mol Biol. 1992 Dec; 43(8):961-71.
PMID: 22217841.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus. Mol Cell Biol. 1992 Jul; 12(7):3313-4.
Gitelman SE, Bristow J, Miller WL. PMID: 1620134.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus. Mol Cell Biol. 1992 May; 12(5):2124-34.
Gitelman SE, Bristow J, Miller WL. PMID: 1373808.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
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Normal genes for the cholesterol side chain cleavage enzyme, P450scc, in congenital lipoid adrenal hyperplasia. J Clin Invest. 1991 Dec; 88(6):1955-62.
Lin D, Gitelman SE, Saenger P, Miller WL. PMID: 1661294.
View in: PubMed Mentions: 18 Fields: Translation: HumansCells
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Cloning of the LH/CG receptor: implications for a unique G-protein coupled receptor. Trends Endocrinol Metab. 1990 Mar-Apr; 1(4):181-4.
Gitelman SE. PMID: 18411115.
View in: PubMed Mentions: Fields:
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Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6582-6.
Morel Y, Bristow J, Gitelman SE, Miller WL. PMID: 2475872.
View in: PubMed Mentions: 36 Fields: Translation: HumansCells
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Purification of calmodulin from Chlamydomonas: calmodulin occurs in cell bodies and flagella. J Cell Biol. 1980 Dec; 87(3 Pt 1):764-70.
Gitelman SE, Witman GB. PMID: 6257728.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
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Year | Publications |
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1991 | 1 | 1992 | 3 | 1993 | 4 | 1994 | 1 | 1995 | 3 | 1996 | 1 | 1997 | 3 | 1998 | 1 | 1999 | 2 | 2000 | 1 | 2002 | 3 | 2004 | 2 | 2005 | 4 | 2006 | 4 | 2007 | 1 | 2008 | 1 | 2009 | 4 | 2010 | 4 | 2011 | 2 | 2012 | 3 | 2013 | 11 | 2014 | 2 | 2015 | 3 | 2016 | 5 | 2017 | 6 | 2018 | 2 | 2019 | 5 | 2020 | 4 | 2021 | 2 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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