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    Andrew Burghardt

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentRadiology and Biomedical Imaging
    AddressQB3 Bldg., 1700 4th Street
    San Francisco CA
    Phone415-514-9658
    Emailandrew.burghardt@ucsf.edu

       Overview 
       Overview
      Andrew Burghardt is a Research Specialist in the Department of Radiology & Biomedical Imaging at UCSF. He has more than 10 years of experience in the field of medical imaging, with a particular emphasis on micro-tomographic imaging (µCT) of musculoskeletal tissues. He serves as the Technical Director of the Quantitative Micro-Imaging Facility (QMIF) - a UCSF core facility associated with the California Institute for Quantitative Biosciences (QB3), the Clinical & Translational Science Institute, and the Department of Radiology & Biomedical Imaging. His research program is focused on the development of quantitative imaging techniques for assessing skeletal health, primarily related to Osteoporosis and Rheumatoid Arthritis. As a Principal Investigator he has been awarded research grants from the National Institutes of Health and the UCSF Clinical & Translational Science Institute. His research has involved a number of significant industry and academic collaborations, including those with Merck & Co, Scanco Medical, Mayo Clinic, INSERM (Lyon, France) Columbia University, MGH/Harvard, among others. Mr. Burghardt has published more than 50 original research papers, review articles, and book chapters, and has served as a Reviewer for a number of academic journals.


       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, Brown JP, Ste-Marie LG, Kremer R, Erlandson MC, Dian L, Burghardt AJ, Boyd SK. High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the canadian bone strength working group. Curr Osteoporos Rep. 2013 Jun; 11(2):136-46.
        View in: PubMed
      2. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36.
        View in: PubMed
      3. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and Semiquantitative Bone Erosion Assessment on High-resolution Peripheral Quantitative Computed Tomography in Rheumatoid Arthritis. J Rheumatol. 2013 Apr; 40(4):408-16.
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      4. Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013 Feb; 28(2):313-24.
        View in: PubMed
      5. Valentinitsch A, Patsch JM, Burghardt AJ, Link TM, Majumdar S, Fischer L, Schueller-Weidekamm C, Resch H, Kainberger F, Langs G. Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clustering. Bone. 2013 May; 54(1):133-40.
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      6. Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S. Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb; 52(2):623-31.
        View in: PubMed
      7. Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr; 39(4):1893-903.
        View in: PubMed
      8. Dafni H, Burghardt AJ, Majumdar S, Navone NM, Ronen SM. Vascular patterning and permeability in prostate cancer models with differing osteogenic properties. NMR Biomed. 2012 Jun; 25(6):843-51.
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      9. Patsch JM, Burghardt AJ, Kazakia G, Majumdar S. Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci. 2011 Dec; 1240:77-87.
        View in: PubMed
      10. Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S. Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis. Magn Reson Imaging. 2012 Feb; 30(2):271-82.
        View in: PubMed
      11. Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S. Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone. 2012 Jan; 50(1):111-8.
        View in: PubMed
      12. Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012 Jan; 35(1):117-24.
        View in: PubMed
      13. Jobke B, Burghardt AJ, Muche B, Hahn M, Semler J, Amling M, Majumdar S, Busse B. Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment. PLoS One. 2011; 6(8):e23638.
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      14. Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC. Morphology of the human vertebral endplate. J Orthop Res. 2012 Feb; 30(2):280-7.
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      15. Burghardt AJ, Link TM, Majumdar S. High-resolution computed tomography for clinical imaging of bone microarchitecture. Clin Orthop Relat Res. 2011 Aug; 469(8):2179-93.
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      16. Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5.
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      17. Jobke B, Muche B, Burghardt AJ, Semler J, Link TM, Majumdar S. Teriparatide in bisphosphonate-resistant osteoporosis: microarchitectural changes and clinical results after 6 and 18 months. Calcif Tissue Int. 2011 Aug; 89(2):130-9.
        View in: PubMed
      18. Burghardt AJ, Krug R, Majumdar S. Vitamin D, 3rd Edition, Feldman, Pike, and Adams. Chapter 50: High-Resolution Imaging Techniques for Bone Quality Assessment. 2011; I:891-925.
      19. Rodriguez AG, Slichter CK, Acosta FL, Rodriguez-Soto AE, Burghardt AJ, Majumdar S, Lotz JC. Human disc nucleus properties and vertebral endplate permeability. Spine (Phila Pa 1976). 2011 Apr 1; 36(7):512-20.
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      20. Sode M, Burghardt AJ, Pialat JB, Link TM, Majumdar S. Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia. Bone. 2011 Jun 1; 48(6):1291-7.
        View in: PubMed
      21. Kazakia GJ, Burghardt AJ, Link TM, Majumdar S. Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. J Biomech. 2011 Jan 11; 44(2):257-66.
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      22. Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 1; 48(3):611-21.
        View in: PubMed
      23. Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM. High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2010 Nov; 95(11):5045-55.
        View in: PubMed
      24. Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S. A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010 Dec; 25(12):2558-71.
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      25. Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK. Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone. 2010 Sep; 47(3):519-28.
        View in: PubMed
      26. Krug R, Burghardt AJ, Majumdar S, Link TM. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am. 2010 May; 48(3):601-21.
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      27. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May; 25(5):983-93.
        View in: PubMed
      28. Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone. 2010 Jun; 46(6):1652-60.
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      29. Easley SK, Jekir MG, Burghardt AJ, Li M, Keaveny TM. Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebrae. Bone. 2010 Apr; 46(4):1162-9.
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      30. Shahnazari M, Yao W, Dai W, Wang B, Ionova-Martin SS, Ritchie RO, Heeren D, Burghardt AJ, Nicolella DP, Kimiecik MG, Lane NE. Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats. Bone. 2010 May; 46(5):1267-74.
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      31. Issever AS, Link TM, Kentenich M, Rogalla P, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Diederichs G. Trabecular bone structure analysis in the osteoporotic spine using a clinical in vivo setup for 64-slice MDCT imaging: comparison to microCT imaging and microFE modeling. J Bone Miner Res. 2009 Sep; 24(9):1628-37.
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      32. Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G. Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard. Eur Radiol. 2010 Feb; 20(2):458-68.
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      33. Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S. Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009 Sep; 45(3):473-9.
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      34. Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2009 Dec; 20(12):2017-24.
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      35. Diederichs G, Link TM, Kentenich M, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Rogalla P, Issever AS. Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing. Bone. 2009 May; 44(5):976-83.
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      36. Diederichs G, Link T, Marie K, Huber M, Rogalla P, Burghardt A, Majumdar S, Issever A. Feasibility of measuring trabecular bone structure of the proximal femur using 64-slice multidetector computed tomography in a clinical setting. Calcif Tissue Int. 2008 Nov; 83(5):332-41.
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      37. Burghardt AJ, Kazakia GJ, Laib A, Majumdar S. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int. 2008 Aug; 83(2):129-38.
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      38. Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008 Jul; 35(7):3170-9.
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      39. Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S. In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T. J Magn Reson Imaging. 2008 Apr; 27(4):854-9.
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      40. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74.
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      41. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36.
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      42. Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar; 149(3):1329-37.
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      43. Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61.
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      44. Davis KA, Burghardt AJ, Link TM, Majumdar S. The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography. Calcif Tissue Int. 2007 Nov; 81(5):364-71.
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      45. Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007 Sep; 22(9):1329-37.
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      46. Burghardt AJ, Kazakia GJ, Majumdar S. A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007 Oct; 35(10):1678-86.
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      47. Bauer JS, Link TM, Burghardt A, Henning TD, Mueller D, Majumdar S, Prevrhal S. Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment. Calcif Tissue Int. 2007 Jun; 80(6):366-73.
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      48. Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol. 2007 Jul; 103(1):125-31.
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      49. Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S. Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. Magn Reson Imaging. 2007 Apr; 25(3):392-8.
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      50. Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S. Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone. 2007 Jan; 40(1):160-8.
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      51. Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol. 2006 May; 189(2):279-87.
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      52. David-Vaudey E, Burghardt A, Keshari K, Brouchet A, Ries M, Majumdar S. Fourier Transform Infrared Imaging of focal lesions in human osteoarthritic cartilage. Eur Cell Mater. 2005; 10:51-60; discussion 60.
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      53. Inceoglu S, Burghardt A, Akbay A, Majumdar S, McLain RF. Trabecular architecture of lumbar vertebral pedicle. Spine (Phila Pa 1976). 2005 Jul 1; 30(13):1485-90.
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      54. Sell CA, Masi JN, Burghardt A, Newitt D, Link TM, Majumdar S. Quantification of trabecular bone structure using magnetic resonance imaging at 3 Tesla--calibration studies using microcomputed tomography as a standard of reference. Calcif Tissue Int. 2005 May; 76(5):355-64.
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      55. Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S. Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements. Conf Proc IEEE Eng Med Biol Soc. 2005; 7:7040-3.
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      56. Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18111-6.
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      57. Cao JJ, Singleton PA, Majumdar S, Boudignon B, Burghardt A, Kurimoto P, Wronski TJ, Bourguignon LY, Halloran BP. Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44. J Bone Miner Res. 2005 Jan; 20(1):30-40.
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      58. Morgan EF, Bayraktar HH, Yeh OC, Majumdar S, Burghardt A, Keaveny TM. Contribution of inter-site variations in architecture to trabecular bone apparent yield strains. J Biomech. 2004 Sep; 37(9):1413-20.
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      59. Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk RH. Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure. Eur Radiol. 2004 Aug; 14(8):1440-8.
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      60. Bauer JS, Issever AS, Fischbeck M, Burghardt A, Eckstein F, Rummeny EJ, Majumdar S, Link TM. [Multislice-CT for structure analysis of trabecular bone - a comparison with micro-CT and biomechanical strength]. Rofo. 2004 May; 176(5):709-18.
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      61. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63.
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      62. Issever AS, Burghardt A, Patel V, Laib A, Lu Y, Ries M, Majumdar S. A micro-computed tomography study of the trabecular bone structure in the femoral head. J Musculoskelet Neuronal Interact. 2003 Jun; 3(2):176-84.
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      63. Issever AS, Walsh A, Lu Y, Burghardt A, Lotz JC, Majumdar S. Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae. Spine (Phila Pa 1976). 2003 Jan 15; 28(2):123-8.
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      64. Patel V, Issever AS, Burghardt A, Laib A, Ries M, Majumdar S. MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J Orthop Res. 2003 Jan; 21(1):6-13.
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      65. Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. 2002 Jun; 17(6):1044-50.
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      66. Niebur GL, Yuen JC, Burghardt AJ, Keaveny TM. Sensitivity of damage predictions to tissue level yield properties and apparent loading conditions. J Biomech. 2001 May; 34(5):699-706.
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