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    Galateia Kazakia, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address185 Berry Street
    San Francisco CA 94143
    Phone415-353-4534
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
      Collapse Awards and Honors
      National Institutes of Health2009Mentored Career Development Award
      Musculoskeletal Quantitative Imaging Research Group2006Excellence in Research Award
      International Sun Valley Workshop of Skeletal Biology2006Young Investigator Award
      National Science Foundation1999Graduate Research Fellowship

      Collapse Overview 
      Collapse Overview
      Galateia J. Kazakia, PhD, is an Assistant Professor in Residence and Director of Bone Quality Research Laboratory in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Kazakia received her BS in Mechanical Engineering from Cornell University in Ithaca, New York in 1995. She completed her MS in Mechanical Engineering from the University of California, Berkeley in 2001, followed by a PhD in Mechanical Engineering from Berkeley in 2004. Dr. Kazakia was awarded an NIH postdoctoral fellowship to develop bone imaging techniques, performing this work in the Musculoskeletal Quantitative Imaging Research group at UCSF. Dr. Kazakia joined the UCSF Department of Radiology and Biomedical Imaging as an Assistant Professor in Residence in 2009.

      Dr. Kazakia’s research is focused on the development of quantitative bone quality characterization techniques. This includes ex vivo tools such as micro computed tomography (microCT), Fourier Transform Infrared (FTIR) imaging, in vivo systems such as high-resolution peripheral quantitative CT (HR-pQCT), and the evaluation of their clinical utility in the study of aging and musculoskeletal diseases. Dr. Kazakia’s major areas of research include: 1) tissue-level mineral characterization, which provides critical information in understanding mineralization processes and bone biomechanics in health and diseases, and 2) HR-pQCT assessment of structure parameters, which evaluates the accuracy, reproducibility, and clinical significance of high-resolution CT technology to in vivo imaging.

      Dr. Kazakia is an active member of the American Society for Bone and Mineral Research, the American Association for the Advancement of Science, and the Orthopaedic Research Society. Dr. Kazakia serves as a reviewer for 10 scientific journals, and she has 26 published articles. She has written 27 peer-reviewed articles and 50 abstracts.

      Expertise:
      Musculoskeletal Radiology

      Specialty:
      Musculoskeletal imaging, musculoskeletal diseases, microCT, FTIR

      Professional Interests:
      Mineralization, bone quality, bone architecture, bone micro-damage, biomechanics, mechanical properties, fourier transform infrared (FTIR) spectroscopy, high-resolution computed tomography (CT), fluorescence imaging

      Education and Training:
      • Bachelor of Science: Cornell University, Ithaca, New York - Mechanical Engineering
      • Masters of Science: University of California, Berkeley - Mechanical Engineering
      • Doctor of Philosophy: University of California, Berkeley - Mechanical Engineering

      Collapse Interests
      Mineralization, bone quality, bone architecture, bone micro-damage, biomechanics, mechanical properties, Fourier transform infrared (FTIR) spectroscopy, high-resolution computed tomography (CT), fluorescence imaging.

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      Collapse Websites
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G. Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int. 2016 May 6. PMID: 27154435.
        View in: PubMed
      2. Wang J, Kazakia GJ, Zhou B, Shi XT, Guo XE. Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone. J Bone Miner Res. 2015 Sep; 30(9):1641-50. PMID: 25736715; PMCID: PMC4540699 [Available on 09/01/16].
      3. Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ. Spatial distribution of intracortical porosity varies across age and sex. Bone. 2015 Jun; 75:88-95. PMID: 25701139; PMCID: PMC4454740.
      4. Kaynia N, Soohoo E, Keaveny TM, Kazakia GJ. Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone. J Biomech Eng. 2015 Jan; 137(1). PMID: 25412197; PMCID: PMC4290509 [Available on 01/01/16].
      5. Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44. PMID: 25425074; PMCID: PMC4442769 [Available on 08/01/16].
      6. Carriero A, Zimmermann EA, Paluszny A, Tang SY, Bale H, Busse B, Alliston T, Kazakia G, Ritchie RO, Shefelbine SJ. How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res. 2014 Jun; 29(6):1392-401. PMID: 24420672; PMCID: PMC4477967.
      7. Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB. The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT. Bone. 2014 Jun; 63:132-40. PMID: 24603002; PMCID: PMC4041600.
      8. Hesse B, Langer M, Varga P, Pacureanu A, Dong P, Schrof S, Männicke N, Suhonen H, Olivier C, Maurer P, Kazakia GJ, Raum K, Peyrin F. Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron µCT study. PLoS One. 2014; 9(2):e88481. PMID: 24586331; PMCID: PMC3931622.
      9. Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ. Structural analysis of cortical porosity applied to HR-pQCT data. Med Phys. 2014 Jan; 41(1):013701. PMID: 24387533; PMCID: PMC3895089.
      10. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36. PMID: 23074145; PMCID: PMC3577969.
      11. Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S. Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb; 52(2):623-31. PMID: 23142360; PMCID: PMC3564644.
      12. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS. The role of oxygen during fracture healing. Bone. 2013 Jan; 52(1):220-9. PMID: 23063782.
        View in: PubMed
      13. Kazakia GJ, Kuo D, Schooler J, Siddiqui S, Shanbhag S, Bernstein G, Horvai A, Majumdar S, Ries M, Li X. Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees. Osteoarthritis Cartilage. 2013 Jan; 21(1):94-101. PMID: 23025926; PMCID: PMC3538951.
      14. Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr; 39(4):1893-903. PMID: 22482611; PMCID: PMC3316694.
      15. Patsch JM, Burghardt AJ, Kazakia G, Majumdar S. Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci. 2011 Dec; 1240:77-87. PMID: 22172043; PMCID: PMC4461066.
      16. Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011 Jul; 89(1):10-20. PMID: 21526395; PMCID: PMC3110278.
      17. Kazakia GJ, Burghardt AJ, Link TM, Majumdar S. Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. J Biomech. 2011 Jan 11; 44(2):257-66. PMID: 21071031; PMCID: PMC3019283.
      18. Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 1; 48(3):611-21. PMID: 21059422; PMCID: PMC4461063.
      19. Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S. A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010 Dec; 25(12):2558-71. PMID: 20564242; PMCID: PMC3179276.
      20. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May; 25(5):983-93. PMID: 19888900; PMCID: PMC3153365.
      21. Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone. 2010 Jun; 46(6):1652-60. PMID: 20188877; PMCID: PMC2875319.
      22. Goldenstein J, Kazakia G, Majumdar S. In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women. Ann Biomed Eng. 2010 Feb; 38(2):235-46. PMID: 19953321; PMCID: PMC2815796.
      23. Slyfield CR, Niemeyer KE, Tkachenko EV, Tomlinson RE, Steyer GG, Patthanacharoenphon CG, Kazakia GJ, Wilson DL, Hernandez CJ. Three-dimensional surface texture visualization of bone tissue through epifluorescence-based serial block face imaging. J Microsc. 2009 Oct; 236(1):52-9. PMID: 19772536; PMCID: PMC2978811.
      24. Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G. Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard. Eur Radiol. 2010 Feb; 20(2):458-68. PMID: 19711081; PMCID: PMC2814042.
      25. Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S. Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009 Sep; 45(3):473-9. PMID: 19501201; PMCID: PMC4454742.
      26. Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2009 Dec; 20(12):2017-24. PMID: 19330422.
        View in: PubMed
      27. Burghardt AJ, Kazakia GJ, Laib A, Majumdar S. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int. 2008 Aug; 83(2):129-38. PMID: 18685797; PMCID: PMC2801565.
      28. Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008 Jul; 35(7):3170-9. PMID: 18697542; PMCID: PMC2673562.
      29. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74. PMID: 18052756.
        View in: PubMed
      30. Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61. PMID: 17992467.
        View in: PubMed
      31. Bigley RF, Singh M, Hernandez CJ, Kazakia GJ, Martin RB, Keaveny TM. Validity of serial milling-based imaging system for microdamage quantification. Bone. 2008 Jan; 42(1):212-5. PMID: 17951125.
        View in: PubMed
      32. Burghardt AJ, Kazakia GJ, Majumdar S. A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007 Oct; 35(10):1678-86. PMID: 17602299.
        View in: PubMed
      33. Kazakia GJ, Lee JJ, Singh M, Bigley RF, Martin RB, Keaveny TM. Automated high-resolution three-dimensional fluorescence imaging of large biological specimens. J Microsc. 2007 Feb; 225(Pt 2):109-17. PMID: 17359245.
        View in: PubMed
      34. Kazakia GJ, Nauman EA, Ebenstein DM, Halloran BP, Keaveny TM. Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone substitute. J Biomed Mater Res A. 2006 Jun 15; 77(4):688-99. PMID: 16514602.
        View in: PubMed
      35. Kazakia GJ, Majumdar S. New imaging technologies in the diagnosis of osteoporosis. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):67-74. PMID: 17043763.
        View in: PubMed
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