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    John Feiner, MD

    TitleProfessor of Clinical
    SchoolUCSF School of Medicine
    DepartmentAnesthesia/Perioperative Care
    Address521 Parnassus Ave, Clinic Sci
    San Francisco CA 94143
    Phone415-476-8624

       Overview 
       Overview
      All my current research involvement addresses clinical questions by studying human subjects or patients. I collaborate with other faculty in the department on all my research and provide expertise in the following areas: data analysis and statistics; mathematical modeling; data acquisition programming; human studies; respiratory physiology. Recent projects include the development of a model of Propofol and Remifentanyl induced apnea in order to identify factors that affect the risk of apnea and hypoxemia. Another recent study tested the accuracy of multi-wavelength pulse oximeter to detect methemoglobin. Current transfusion studies include a volunteer study examining the effects of transfusing stored vs. fresh autologous blood on lung function and inflammatory mediators. Clinical studies in the operating room and hospital track all patients who develop TRALI.


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Menda SK, Gregory GA, Feiner JR, Zwass MS, Ferschl MB. The effect of deep and awake tracheal extubation on turnover times and postoperative respiratory complications post adenoid-tonsillectomy. Can J Anaesth. 2012 Dec; 59(12):1158-9.
        View in: PubMed
      2. Stefanutto TB, Feiner J, Krombach J, Brown R, Caldwell JE. Hemoglobin desaturation after propofol/remifentanil-induced apnea: a study of the recovery of spontaneous ventilation in healthy volunteers. Anesth Analg. 2012 May; 114(5):980-6.
        View in: PubMed
      3. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9.
        View in: PubMed
      4. Heier T, Feiner JR, Wright PM, Ward T, Caldwell JE. Sex-related differences in the relationship between acceleromyographic adductor pollicis train-of-four ratio and clinical manifestations of residual neuromuscular block: a study in healthy volunteers during near steady-state infusion of mivacurium. Br J Anaesth. 2012 Mar; 108(3):444-51.
        View in: PubMed
      5. Feiner JR, Finlay-Morreale HE, Toy P, Lieberman JA, Viele MK, Hopf HW, Weiskopf RB. High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion. Anesthesiology. 2011 Sep; 115(3):492-8.
        View in: PubMed
      6. Liu S, Shah SJ, Wilmes LJ, Feiner J, Kodibagkar VD, Wendland MF, Mason RP, Hylton N, Hopf HW, Rollins MD. Quantitative tissue oxygen measurement in multiple organs using 19F MRI in a rat model. Magn Reson Med. 2011 Dec; 66(6):1722-30.
        View in: PubMed
      7. Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU. Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model. Nephrol Dial Transplant. 2011 Jun; 26(6):1813-20.
        View in: PubMed
      8. Heier T, Caldwell JE, Feiner JR, Liu L, Ward T, Wright PM. Relationship between normalized adductor pollicis train-of-four ratio and manifestations of residual neuromuscular block: a study using acceleromyography during near steady-state concentrations of mivacurium. Anesthesiology. 2010 Oct; 113(4):825-32.
        View in: PubMed
      9. Feiner JR, Bickler PE. Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg. 2010 Nov; 111(5):1160-7.
        View in: PubMed
      10. Vagefi PA, Klein I, Gelb B, Hameed B, Moff SL, Simko JP, Fix OK, Eilers H, Feiner JR, Ascher NL, Freise CE, Bass NM. Emergent orthotopic liver transplantation for hemorrhage from a giant cavernous hepatic hemangioma: case report and review. J Gastrointest Surg. 2011 Jan; 15(1):209-14.
        View in: PubMed
      11. Niemann CU, Feiner J. Quality improvement in transplant anesthesia: which way forward? Curr Opin Organ Transplant. 2010 Jun; 15(3):374-6.
        View in: PubMed
      12. Feiner JR, Bickler PE, Mannheimer PD. Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg. 2010 Jul; 111(1):143-8.
        View in: PubMed
      13. Niemann CU, Walia A, Waldman J, Davio M, Roberts JP, Hirose R, Feiner J. Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin. Liver Transpl. 2009 Dec; 15(12):1852-60.
        View in: PubMed
      14. Lyon R, Lieberman JA, Feiner J, Burch S. Relative efficacy of transcranial motor evoked potentials, mechanically-elicited electromyography, and evoked EMG to assess nerve root function during sustained retraction in a porcine model. Spine (Phila Pa 1976). 2009 Jul 15; 34(16):E558-64.
        View in: PubMed
      15. Blasi-Ibanez A, Hirose R, Feiner J, Freise C, Stock PG, Roberts JP, Niemann CU. Predictors associated with terminal renal function in deceased organ donors in the intensive care unit. Anesthesiology. 2009 Feb; 110(2):333-41.
        View in: PubMed
      16. Weiskopf RB, Feiner J, Toy P. Red blood cell age and function. Transfusion. 2008 Sep; 48(9):2026.
        View in: PubMed
      17. Lieberman JA, Lyon R, Feiner J, Hu SS, Berven SH. The efficacy of motor evoked potentials in fixed sagittal imbalance deformity correction surgery. Spine (Phila Pa 1976). 2008 Jun 1; 33(13):E414-24.
        View in: PubMed
      18. Feiner JR, Severinghaus JW, Bickler PE. Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender. Anesth Analg. 2007 Dec; 105(6 Suppl):S18-23, tables of contents.
        View in: PubMed
      19. Weiskopf RB, Feiner J, Lieberman J, Hu SS. Visual loss after spinal surgery. Anesthesiology. 2007 Jun; 106(6):1250-1; author reply 1251-2.
        View in: PubMed
      20. Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP. Central venous pressure monitoring during living right donor hepatectomy. Liver Transpl. 2007 Feb; 13(2):266-71.
        View in: PubMed
      21. Lieberman JA, Lyon R, Feiner J, Diab M, Gregory GA. The effect of age on motor evoked potentials in children under propofol/isoflurane anesthesia. Anesth Analg. 2006 Aug; 103(2):316-21, table of contents.
        View in: PubMed
      22. Weiskopf RB, Feiner J, Hopf H, Lieberman J, Finlay HE, Quah C, Kramer JH, Bostrom A, Toy P. Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans. Anesthesiology. 2006 May; 104(5):911-20.
        View in: PubMed
      23. Finlay HE, Cassorla L, Feiner J, Toy P. Designing and testing a computer-based screening system for transfusion-related acute lung injury. Am J Clin Pathol. 2005 Oct; 124(4):601-9.
        View in: PubMed
      24. Bickler PE, Feiner JR, Severinghaus JW. Effects of skin pigmentation on pulse oximeter accuracy at low saturation. Anesthesiology. 2005 Apr; 102(4):715-9.
        View in: PubMed
      25. Weiskopf RB, Toy P, Hopf HW, Feiner J, Finlay HE, Takahashi M, Bostrom A, Songster C, Aminoff MJ. Acute isovolemic anemia impairs central processing as determined by P300 latency. Clin Neurophysiol. 2005 May; 116(5):1028-32.
        View in: PubMed
      26. Feiner JR, Bickler PE, Estrada S, Donohoe PH, Fahlman CS, Schuyler JA. Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg. 2005 Jan; 100(1):215-25.
        View in: PubMed
      27. Lyon R, Feiner J, Lieberman JA. Progressive suppression of motor evoked potentials during general anesthesia: the phenomenon of "anesthetic fade". J Neurosurg Anesthesiol. 2005 Jan; 17(1):13-9.
        View in: PubMed
      28. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98.
        View in: PubMed
      29. Weiskopf RB, Aminoff MJ, Hopf HW, Feiner J, Viele MK, Watson JJ, Ho R, Songster C, Toy P. Acute isovolemic anemia does not impair peripheral or central nerve conduction. Anesthesiology. 2003 Sep; 99(3):546-51.
        View in: PubMed
      30. Weiskopf RB, Feiner J, Hopf H, Viele MK, Watson JJ, Lieberman J, Kelley S, Toy P. Heart rate increases linearly in response to acute isovolemic anemia. Transfusion. 2003 Feb; 43(2):235-40.
        View in: PubMed
      31. Weiskopf RB, Feiner J, Hopf HW, Viele MK, Watson JJ, Kramer JH, Ho R, Toy P. Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia. Anesthesiology. 2002 Apr; 96(4):871-7.
        View in: PubMed
      32. Feiner JR, Miller RD, Hickey RF. Productivity versus availability as a measure of faculty clinical responsibility. Anesth Analg. 2001 Aug; 93(2):313-8, 2nd contents page.
        View in: PubMed
      33. Heier T, Feiner JR, Lin J, Brown R, Caldwell JE. Hemoglobin desaturation after succinylcholine-induced apnea: a study of the recovery of spontaneous ventilation in healthy volunteers. Anesthesiology. 2001 May; 94(5):754-9.
        View in: PubMed
      34. Hashimoto K, Hampl KF, Nakamura Y, Bollen AW, Feiner J, Drasner K. Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat. Anesthesiology. 2001 May; 94(5):876-81.
        View in: PubMed
      35. Hopf HW, Viele M, Watson JJ, Feiner J, Weiskopf R, Hunt TK, Noorani M, Yeap H, Ho R, Toy P. Subcutaneous perfusion and oxygen during acute severe isovolemic hemodilution in healthy volunteers. Arch Surg. 2000 Dec; 135(12):1443-9.
        View in: PubMed
      36. Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P. Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Anesthesiology. 2000 Oct; 93(4):1004-10.
        View in: PubMed
      37. Weiskopf RB, Kramer JH, Viele M, Neumann M, Feiner JR, Watson JJ, Hopf HW, Toy P. Acute severe isovolemic anemia impairs cognitive function and memory in humans. Anesthesiology. 2000 Jun; 92(6):1646-52.
        View in: PubMed
      38. Toy P, Feiner J, Viele MK, Watson J, Yeap H, Weiskopf RB. Fatigue during acute isovolemic anemiain healthy, resting humans. Transfusion. 2000 Apr; 40(4):457-60.
        View in: PubMed
      39. Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M. Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1). Anesthesiology. 2000 Feb; 92(2):407-13.
        View in: PubMed
      40. Gregory GA, Feiner J, Severinghaus JW. Tidal volume, PaCO2, and lung injury. Crit Care Med. 1998 Oct; 26(10):1632-3.
        View in: PubMed
      41. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998 Jan 21; 279(3):217-21.
        View in: PubMed
      42. Gray AT, Buck LT, Feiner JR, Bickler PE. Interactive effects of pH and temperature on N-methyl-D-aspartate receptor activity in rat cortical brain slices. J Neurosurg Anesthesiol. 1997 Apr; 9(2):180-7.
        View in: PubMed
      43. Podolsky A, Eldridge MW, Richardson RS, Knight DR, Johnson EC, Hopkins SR, Johnson DH, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Severinghaus JW, Wagner PD. Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema. J Appl Physiol. 1996 Aug; 81(2):922-32.
        View in: PubMed
      44. Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Wagner PD, Severinghaus JW. Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J Appl Physiol. 1996 Aug; 81(2):911-21.
        View in: PubMed
      45. Bickler PE, Buck LT, Feiner JR. Volatile and intravenous anesthetics decrease glutamate release from cortical brain slices during anoxia. Anesthesiology. 1995 Dec; 83(6):1233-40.
        View in: PubMed
      46. Feiner JR, Bickler PE, Severinghaus JW. Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Respir Physiol. 1995 Jun; 100(3):213-22.
        View in: PubMed
      47. Unger RJ, Feiner JR. Hemodynamic effects of intermittent pneumatic compression of the legs. Anesthesiology. 1987 Aug; 67(2):266-8.
        View in: PubMed
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