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    John Kane, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
    Phone415-476-1517
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPh.D. Graduate Division (Biochemistry)1971

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kane JP. Infectious basophilia? Am J Hematol. 2016 Feb; 91(2):E8. PMID: 26572775.
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      2. Kane JP, Malloy MJ. Emerging molecular strategies for management of dyslipidemias. Curr Opin Lipidol. 2015 Dec; 26(6):601-2. PMID: 26780015.
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      3. Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17; 66(20):2201-10. PMID: 26564598.
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      4. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015; 4. PMID: 26473617.
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      5. Pullinger CR, Stock EO, Movsesyan I, Malloy MJ, Frost PH, Tripuraneni R, Quinn AG, Ishida BY, Schaefer EJ, Asztalos BF, Kane JP. Identification and metabolic profiling of patients with lysosomal acid lipase deficiency. J Clin Lipidol. 2015 Sep-Oct; 9(5):716-726.e1. PMID: 26350820.
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      6. Kane JP, Malloy MJ, Pullinger CR. HDL Cholesterol Efflux Capacity and Cardiovascular Events. N Engl J Med. 2015 May 7; 372(19):1869-72. PMID: 25946301.
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      7. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50. PMID: 25632026.
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      8. Malloy MJ, Kane JP. Congenital absence of apolipoprotein e and neurological function-reply. JAMA Neurol. 2014 Dec 1; 71(12):1579. PMID: 25486213.
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      9. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. PMID: 25111166.
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      10. Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM, Ryan RO. Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2254-60. PMID: 25127531; PMCID: PMC4178935 [Available on 10/01/15].
      11. Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG. Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency. J Hepatol. 2014 Nov; 61(5):1135-42. PMID: 24993530; PMCID: PMC4203712 [Available on 11/01/15].
      12. Arndt C, Leclercq I, Nazeyrollas P, Durlach A, Ducasse A, Movesayan I, Socquard E, Clavel C, Malloy MM, Pullinger CR, Kane JP, Durlach V. Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients. Diabetes Metab. 2014 Dec; 40(6):452-8. PMID: 24852509.
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      13. Rowland CM, Pullinger CR, Luke MM, Shiffman D, Green L, Movsesyan I, Devlin JJ, Malloy MJ, Kane JP, Undas A. Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties. Thromb Res. 2014 May; 133(5):863-7. PMID: 24502962.
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      14. Roberts JD, Hsu JC, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Olgin JE, Marcus GM. Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation. J Cardiovasc Electrophysiol. 2014 Mar; 25(3):271-7. PMID: 24237655; PMCID: PMC3947706 [Available on 03/01/15].
      15. Pullinger CR, Goldfine ID, Tanyolaç S, Movsesyan I, Faynboym M, Durlach V, Chiefari E, Foti DP, Frost PH, Malloy MJ, Brunetti A, Kane JP. Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population. Metab Syndr Relat Disord. 2014 Feb; 12(1):25-30. PMID: 24148075.
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      16. Kane JP, Malloy MJ. Needed: a better understanding of the antiatherogenic properties of HDL. Curr Opin Lipidol. 2013 Oct; 24(5):453-4. PMID: 24005220.
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      17. Kane JP. New horizons in lipid management. J Am Coll Cardiol. 2013 Sep 24; 62(13):1163-4. PMID: 23770169.
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      18. Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC. Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression. J Am Heart Assoc. 2013 Jun; 2(3):e000134. PMID: 23686369; PMCID: PMC3698773.
      19. Balwani M, Breen C, Enns GM, Deegan PB, Honzík T, Jones S, Kane JP, Malinova V, Sharma R, Stock EO, Valayannopoulos V, Wraith JE, Burg J, Eckert S, Schneider E, Quinn AG. Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease. Hepatology. 2013 Sep; 58(3):950-7. PMID: 23348766; PMCID: PMC3728169.
      20. Malloy MJ, Kane JP. Hyperlipidemia and cardiovascular disease. Curr Opin Lipidol. 2012 Dec; 23(6):591-2. PMID: 23160407.
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      21. Kane JP, Malloy MJ. Prebeta-1 HDL and coronary heart disease. Curr Opin Lipidol. 2012 Aug; 23(4):367-71. PMID: 22517613.
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      22. Charles MA, Kane JP. New molecular insights into CETP structure and function: a review. J Lipid Res. 2012 Aug; 53(8):1451-8. PMID: 22679067; PMCID: PMC3540851.
      23. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 2012 May 4; 90(5):796-808. PMID: 22521419; PMCID: PMC3376540.
      24. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):961-7. PMID: 22300662; PMCID: PMC3349006.
      25. Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C. Polymorphisms and noncardioembolic stroke in three case-control studies. Cerebrovasc Dis. 2012; 33(1):80-5. PMID: 22134093.
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      26. Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A. Association between regulator of G protein signaling 9-2 and body weight. PLoS One. 2011; 6(11):e27984. PMID: 22132185; PMCID: PMC3223194.
      27. Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ. Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease. Am J Cardiol. 2011 Aug 1; 108(3):360-6. PMID: 21757044.
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      28. DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC. Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2012 Jul 15; 59(1):52-6. PMID: 21793187; PMCID: PMC3204324.
      29. Ruaño G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD. Mechanisms of statin-induced myalgia assessed by physiogenomic associations. Atherosclerosis. 2011 Oct; 218(2):451-6. PMID: 21868014; PMCID: PMC3224998.
      30. Francone OL, Ishida BY, de la Llera-Moya M, Royer L, Happe C, Zhu J, Chalkey RJ, Schaefer P, Cox C, Burlingame A, Kane JP, Rothblat GH. Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels. J Lipid Res. 2011 Nov; 52(11):1974-83. PMID: 21771977; PMCID: PMC3196229.
      31. Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA. 2011 Mar 2; 305(9):903-12. PMID: 21364139.
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      32. Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE. Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients. Diabetes Metab. 2011 Feb; 37(1):64-71. PMID: 21145773.
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      33. Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. J Lipid Res. 2011 Jan; 52(1):175-84. PMID: 20978167; PMCID: PMC2999936.
      34. Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pharmacogenomics. 2010 Jul; 11(7):959-71. PMID: 20602615; PMCID: PMC2921920.
      35. Pullinger CR, Aouizerat BE, Gay C, Coggins T, Movsesyan I, Davis H, Kane JP, Portillo C, Lee KA. Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults. Metab Syndr Relat Disord. 2010 Jun; 8(3):279-86. PMID: 20235745; PMCID: PMC3085320.
      36. Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ. Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. Atherosclerosis. 2010 Sep; 212(1):193-6. PMID: 20605575.
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      37. Pan J, Shilian P, Ishida B, Wu X, Kane JP, Malloy MJ, Charles MA. Effect of niacin on preß-1 high-density lipoprotein levels in diabetes. Metabolism. 2011 Feb; 60(2):292-7. PMID: 20303127.
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      38. Fujimoto VY, Kane JP, Ishida BY, Bloom MS, Browne RW. High-density lipoprotein metabolism and the human embryo. Hum Reprod Update. 2010 Jan-Feb; 16(1):20-38. PMID: 19700490.
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      39. Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID. Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects. Metab Syndr Relat Disord. 2009 Dec; 7(6):543-8. PMID: 19656007; PMCID: PMC3139525.
      40. Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 2010 Apr; 209(2):498-503. PMID: 19880117.
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      41. Ortiz-Muñoz G, Houard X, Martín-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O. HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property. FASEB J. 2009 Sep; 23(9):3129-39. PMID: 19417089; PMCID: PMC2735359.
      42. Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL. Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. Br J Ophthalmol. 2009 Aug; 93(8):1116-20. PMID: 19304587; PMCID: PMC3541028.
      43. Zhu J, Gardner J, Pullinger CR, Kane JP, Thompson JF, Francone OL. Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. J Lipid Res. 2009 Jul; 50(7):1330-9. PMID: 19237735; PMCID: PMC2694332.
      44. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7. PMID: 19091795; PMCID: PMC2649015.
      45. Meyer TE, Shiffman D, Morrison AC, Rowland CM, Louie JZ, Bare LA, Ross DA, Arellano AR, Chasman DI, Ridker PM, Pankow JS, Coresh J, Malloy MJ, Kane JP, Ellis SG, Devlin JJ, Boerwinkle E. GOSR2 Lys67Arg is associated with hypertension in whites. Am J Hypertens. 2009 Feb; 22(2):163-8. PMID: 19057520.
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      46. Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L, Ramírez-Jiménez S, de Bruin TW, Tusié-Luna T, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. Galanin preproprotein is associated with elevated plasma triglycerides. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):147-52. PMID: 18988886; PMCID: PMC2650822.
      47. Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. PLoS One. 2008; 3(8):e2895. PMID: 18682748; PMCID: PMC2483345.
      48. van der Net JB, Versmissen J, Oosterveer DM, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kane JP, Kastelein JJ, Sijbrands EJ. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. Atherosclerosis. 2009 Apr; 203(2):472-8. PMID: 18775537.
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      49. Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P. WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. Am J Hum Genet. 2008 Aug; 83(2):180-92. PMID: 18674750; PMCID: PMC2495060.
      50. van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJ, Kane JP, Sijbrands EJ. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. Eur Heart J. 2008 Sep; 29(18):2195-201. PMID: 18599554; PMCID: PMC2733738.
      51. Pullinger CR, Aouizerat BE, Movsesyan I, Durlach V, Sijbrands EJ, Nakajima K, Poon A, Dallinga-Thie GM, Hattori H, Green LL, Kwok PY, Havel RJ, Frost PH, Malloy MJ, Kane JP. An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. J Lipid Res. 2008 Aug; 49(8):1846-54. PMID: 18441017; PMCID: PMC2444008.
      52. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet. 2008 Mar; 4(3):e1000041. PMID: 18369459; PMCID: PMC2274885.
      53. Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet. 2007 Dec; 39(12):1483-7. PMID: 17994020.
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      54. Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):173-9. PMID: 17975119; PMCID: PMC2636623.
      55. Bare LA, Morrison AC, Rowland CM, Shiffman D, Luke MM, Iakoubova OA, Kane JP, Malloy MJ, Ellis SG, Pankow JS, Willerson JT, Devlin JJ, Boerwinkle E. Five common gene variants identify elevated genetic risk for coronary heart disease. Genet Med. 2007 Oct; 9(10):682-9. PMID: 18073581.
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      56. Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology. 2007 Sep; 107(3):406-11. PMID: 17721242.
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      57. Davidson MH, Smith J, Scott R, Small R, Choi J, Ishida BY, Kane JP. Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067. J Clin Lipidol. 2007 Aug; 1(4):271-9. PMID: 21291691.
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      58. Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky ML, Devlin JJ, Ellis SG. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):2030-6. PMID: 17569884.
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      59. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, Pankow JS, Devlin JJ, Willerson JT, Boerwinkle E. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2007 Jul 1; 166(1):28-35. PMID: 17443022.
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      60. Wung SF, Kulkarni MV, Pullinger CR, Malloy MJ, Kane JP, Aouizerat BE. The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion. Lipids Health Dis. 2006; 5:19. PMID: 16822320; PMCID: PMC1538992.
      61. Shiffman D, Rowland CM, Louie JZ, Luke MM, Bare LA, Bolonick JI, Young BA, Catanese JJ, Stiggins CF, Pullinger CR, Topol EJ, Malloy MJ, Kane JP, Ellis SG, Devlin JJ. Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. Arterioscler Thromb Vasc Biol. 2006 Jul; 26(7):1613-8. PMID: 16690874.
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      62. Ishida BY, Duncan KG, Bailey KR, Kane JP, Schwartz DM. High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture. Br J Ophthalmol. 2006 May; 90(5):616-20. PMID: 16622093; PMCID: PMC1857047.
      63. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C. Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol. 2005 Sep; 3(9):e315. PMID: 16122350; PMCID: PMC1193520.
      64. Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP. Identification of four gene variants associated with myocardial infarction. Am J Hum Genet. 2005 Oct; 77(4):596-605. PMID: 16175505; PMCID: PMC1275608.
      65. Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C. Parotid secretory protein is an HDL-associated protein with anticandidal activity. Am J Physiol Regul Integr Comp Physiol. 2005 May; 288(5):R1306-15. PMID: 15637169.
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      66. Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP. Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors. Hum Mutat. 2005 Jan; 25(1):18-21. PMID: 15580557.
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      67. Albert TS, Duchateau PN, Deeb SS, Pullinger CR, Cho MH, Heilbron DC, Malloy MJ, Kane JP, Brown BG. Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL. J Lipid Res. 2005 Mar; 46(3):469-74. PMID: 15604524.
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      68. Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR. Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL. Atherosclerosis. 2004 Sep; 176(1):37-44. PMID: 15306172.
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      69. Stoller ML, Meng MV, Abrahams HM, Kane JP. The primary stone event: a new hypothesis involving a vascular etiology. J Urol. 2004 May; 171(5):1920-4. PMID: 15076312.
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      70. Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. J Lipid Res. 2004 Feb; 45(2):263-71. PMID: 14594998.
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      71. Huuskonen J, Abedin M, Vishnu M, Pullinger CR, Baranzini SE, Kane JP, Fielding PE, Fielding CJ. Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts. Biochem Biophys Res Commun. 2003 Jun 27; 306(2):463-8. PMID: 12804586.
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      72. Aouizerat BE, Kane JP. Apolipoprotein A-II: active or passive role in familial combined hyperlipidemia. Circ Res. 2003 Jun 13; 92(11):1179-81. PMID: 12805235.
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      73. Pullinger CR, Kane JP, Malloy MJ. Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders. Expert Rev Cardiovasc Ther. 2003 May; 1(1):107-19. PMID: 15030301.
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      74. Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, Malloy MJ, Kane JP. Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. J Lipid Res. 2003 Jun; 44(6):1167-73. PMID: 12671030.
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      75. Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP. The effects of physical exercise on plasma prebeta-1 high-density lipoprotein. Metabolism. 2003 Apr; 52(4):437-42. PMID: 12701055.
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      76. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E. Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature. 2003 Mar 6; 422(6927):83-7. PMID: 12621437.
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      77. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest. 2002 Jul; 110(1):109-17. PMID: 12093894; PMCID: PMC151029.
      78. Gaffney D, Pullinger CR, O'Reilly DS, Hoffs MS, Cameron I, Vass JK, Kulkarni MV, Kane JP, Schumaker VN, Watts GF, Packard CJ. Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding. Clin Chim Acta. 2002 Jul; 321(1-2):113-21. PMID: 12031600.
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      79. Duncan KG, Bailey KR, Kane JP, Schwartz DM. Human retinal pigment epithelial cells express scavenger receptors BI and BII. Biochem Biophys Res Commun. 2002 Apr 12; 292(4):1017-22. PMID: 11944916.
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      80. Kane JP. Does hypertriglyceridemia present an indication for pioglitazone therapy in diabetes? Diabetes Technol Ther. 2002; 4(2):153-5. PMID: 12079618.
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      81. Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. J Lipid Res. 2001 Apr; 42(4):620-30. PMID: 11290834.
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      82. Malloy MJ, Kane JP. A risk factor for atherosclerosis: triglyceride-rich lipoproteins. Adv Intern Med. 2001; 47:111-36. PMID: 11795072.
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      83. Frossard PM, Malloy MJ, Lestringant GG, Kane JP. Haplotypes of the human renin gene associated with essential hypertension and stroke. J Hum Hypertens. 2001 Jan; 15(1):49-55. PMID: 11224002.
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      84. Drmanac S, Heilbron DC, Pullinger CR, Jafari M, Gietzen D, Ukrainczyk T, Cho MH, Frost PH, Siradze K, Drmanac RT, Kane JP, Malloy MJ. Elevated baseline triglyceride levels modulate effects of HMGCoA reductase inhibitors on plasma lipoproteins. J Cardiovasc Pharmacol Ther. 2001 Jan; 6(1):47-56. PMID: 11452336.
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      85. Mahley RW, Pépin J, Palaoglu KE, Malloy MJ, Kane JP, Bersot TP. Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype. J Lipid Res. 2000 Aug; 41(8):1290-301. PMID: 10946017.
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      86. Duchateau PN, Movsesyan I, Yamashita S, Sakai N, Hirano K, Schoenhaus SA, O'Connor-Kearns PM, Spencer SJ, Jaffe RB, Redberg RF, Ishida BY, Matsuzawa Y, Kane JP, Malloy MJ. Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects. J Lipid Res. 2000 Aug; 41(8):1231-6. PMID: 10946010.
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      87. Pullinger CR, Hakamata H, Duchateau PN, Eng C, Aouizerat BE, Cho MH, Fielding CJ, Kane JP. Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms. Biochem Biophys Res Commun. 2000 May 10; 271(2):451-5. PMID: 10799318.
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      88. Nishino M, Malloy MJ, Naya-Vigne J, Russell J, Kane JP, Redberg RF. Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women. J Am Coll Cardiol. 2000 Feb; 35(2):314-20. PMID: 10676675.
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      89. Frossard PM, Lestringant GG, Malloy MJ, Kane JP. Human renin gene BglI dimorphism associated with hypertension in two independent populations. Clin Genet. 1999 Dec; 56(6):428-33. PMID: 10665661.
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      90. Frossard PM, Kane JP, Malloy MJ, Bener A. Renin gene MboI dimorphism is a discriminator for hypertension in hyperlipidaemic subjects. Hypertens Res. 1999 Nov; 22(4):285-9. PMID: 10580395.
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      91. Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res. 1999 Oct; 9(10):936-49. PMID: 10523522; PMCID: PMC310821.
      92. Connor JP, Ferrer K, Kane JP, Goldberg JM. Evaluation of Langerhans' cells in the cervical epithelium of women with cervical intraepithelial neoplasia. Gynecol Oncol. 1999 Oct; 75(1):130-5. PMID: 10502439.
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      93. Kane JP, Havel RJ. Polymorphism of the lipopolysaccharide receptor (CD14) and myocardial infarction. New evidence for a role of gram-negative bacterial infection? Circulation. 1999 Jun 29; 99(25):3210-2. PMID: 10385489.
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      94. Pullinger CR, Gaffney D, Gutierrez MM, Malloy MJ, Schumaker VN, Packard CJ, Kane JP. The apolipoprotein B R3531C mutation. Characteristics of 24 subjects from 9 kindreds. J Lipid Res. 1999 Feb; 40(2):318-27. PMID: 9925662.
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      95. Cheng S, Pallaud C, Grow MA, Scharf SJ, Erlich HA, Klitz W, Pullinger CR, Malloy MJ, Kane JP, Siest G, Visvikis S. A multilocus genotyping assay for cardiovascular disease. Clin Chem Lab Med. 1998 Aug; 36(8):561-6. PMID: 9806460.
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      96. O'Connor PM, Zysow BR, Schoenhaus SA, Ishida BY, Kunitake ST, Naya-Vigne JM, Duchateau PN, Redberg RF, Spencer SJ, Mark S, Mazur M, Heilbron DC, Jaffe RB, Malloy MJ, Kane JP. Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender. J Lipid Res. 1998 Mar; 39(3):670-8. PMID: 9548598.
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      97. Schwartz GG, Oliver MF, Ezekowitz MD, Ganz P, Waters D, Kane JP, Texter M, Pressler ML, Black D, Chaitman BR, Olsson AG. Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study that evaluates atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction. Am J Cardiol. 1998 Mar 1; 81(5):578-81. PMID: 9514453.
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      98. Malloy MJ, Kane JP. Aggressive medical therapy for the prevention and treatment of coronary artery disease. Dis Mon. 1998 Jan; 44(1):1-40. PMID: 9457050.
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      99. Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, Malloy MJ, Korach KS, Rubanyi GM. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation. 1997 Nov 18; 96(10):3774-7. PMID: 9396482.
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      100. Duchateau PN, Pullinger CR, Orellana RE, Kunitake ST, Naya-Vigne J, O'Connor PM, Malloy MJ, Kane JP. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. J Biol Chem. 1997 Oct 10; 272(41):25576-82. PMID: 9325276.
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      101. O'Connor PM, Naya-Vigne JM, Duchateau PN, Ishida BY, Mazur M, Schoenhaus SA, Zysow BR, Malloy MJ, Kunitake ST, Kane JP. Measurement of prebeta-1 HDL in human plasma by an ultrafiltration-isotope dilution technique. Anal Biochem. 1997 Sep 5; 251(2):234-40. PMID: 9299021.
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      102. Pullinger CR, Malloy MJ, Shahidi AK, Ghassemzadeh M, Duchateau P, Villagomez J, Allaart J, Kane JP. A novel apolipoprotein C-III variant, apoC-III(Gln38-->Lys), associated with moderate hypertriglyceridemia in a large kindred of Mexican origin. J Lipid Res. 1997 Sep; 38(9):1833-40. PMID: 9323592.
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      103. Hennessy LK, Kunitake ST, Jarvis M, Hamilton RL, Endeman G, Protter A, Kane JP. Isolation of subpopulations of high density lipoproteins: three particle species containing apoE and two species devoid of apoE that have affinity for heparin. J Lipid Res. 1997 Sep; 38(9):1859-68. PMID: 9323595.
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      104. Phillips ML, Pullinger C, Kroes I, Kroes J, Hardman DA, Chen G, Curtiss LK, Gutierrez MM, Kane JP, Schumaker VN. A single copy of apolipoprotein B-48 is present on the human chylomicron remnant. J Lipid Res. 1997 Jun; 38(6):1170-7. PMID: 9215545.
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      105. van Antwerpen R, Chen GC, Pullinger CR, Kane JP, LaBelle M, Krauss RM, Luna-Chavez C, Forte TM, Gilkey JC. Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety. J Lipid Res. 1997 Apr; 38(4):659-69. PMID: 9144081.
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      106. Malloy MJ, Kane JP. Aggressive medical therapy for the prevention and treatment of coronary artery disease. Adv Intern Med. 1997; 42:1-38. PMID: 9048115.
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      107. Pullinger CR, Love JA, Liu W, Hennessy LK, Ghassemzadeh M, Newcomb KC, Illingworth DR, Kane JP. The apolipoprotein B Q3405E polymorphism has no effect on its low-density-lipoprotein receptor binding affinity. Hum Genet. 1996 Dec; 98(6):678-80. PMID: 8931699.
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      108. Hausmann D, Johnson JA, Sudhir K, Mullen WL, Friedrich G, Fitzgerald PJ, Chou TM, Ports TA, Kane JP, Malloy MJ, Yock PG. Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: correlation with high density lipoproteins. J Am Coll Cardiol. 1996 Jun; 27(7):1562-70. PMID: 8636537.
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      109. Chatterton JE, Schlapfer P, Bütler E, Gutierrez MM, Puppione DL, Pullinger CR, Kane JP, Curtiss LK, Schumaker VN. Identification of apolipoprotein B100 polymorphisms that affect low-density lipoprotein metabolism: description of a new approach involving monoclonal antibodies and dynamic light scattering. Biochemistry. 1995 Jul 25; 34(29):9571-80. PMID: 7626627.
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      110. Read TE, Grunfeld C, Kumwenda ZL, Calhoun MC, Kane JP, Feingold KR, Rapp JH. Triglyceride-rich lipoproteins prevent septic death in rats. J Exp Med. 1995 Jul 1; 182(1):267-72. PMID: 7790821; PMCID: PMC2192094.
      111. Pullinger CR, Hennessy LK, Chatterton JE, Liu W, Love JA, Mendel CM, Frost PH, Malloy MJ, Schumaker VN, Kane JP. Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity. J Clin Invest. 1995 Mar; 95(3):1225-34. PMID: 7883971; PMCID: PMC441461.
      112. Sudhir K, Ports TA, Amidon TM, Goldberger JJ, Bhushan V, Kane JP, Yock P, Malloy MJ. Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia. Circulation. 1995 Mar 1; 91(5):1375-80. PMID: 7867176.
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      113. Insull W, Davidson MH, Demke DM, Dujovne CA, Eckert SM, Ginsberg D, Goldberg AC, Hodis HN, Hughes TA, Kane JP, et al. The effects of colestipol tablets compared with colestipol granules on plasma cholesterol and other lipids in moderately hypercholesterolemic patients. Atherosclerosis. 1995 Jan 20; 112(2):223-35. PMID: 7772081.
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      114. Read TE, Grunfeld C, Kumwenda Z, Calhoun MC, Kane JP, Feingold KR, Rapp JH. Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats. Surgery. 1995 Jan; 117(1):62-7. PMID: 7809838.
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      115. Rapp JH, Lespine A, Hamilton RL, Colyvas N, Chaumeton AH, Tweedie-Hardman J, Kotite L, Kunitake ST, Havel RJ, Kane JP. Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arterioscler Thromb. 1994 Nov; 14(11):1767-74. PMID: 7947602.
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      116. Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med. 1994 Sep 1; 180(3):1025-35. PMID: 8064223; PMCID: PMC2191628.
      117. Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP. The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred. Clin Genet. 1994 Jun; 45(6):292-7. PMID: 7923858.
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      118. Kunitake ST, Carilli CT, Lau K, Protter AA, Naya-Vigne J, Kane JP. Identification of proteins associated with apolipoprotein A-I-containing lipoproteins purified by selected-affinity immunosorption. Biochemistry. 1994 Mar 1; 33(8):1988-93. PMID: 8117655.
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      119. Malloy MJ, Kane JP. Medical management of hyperlipidemic states. Adv Intern Med. 1994; 39:603-31. PMID: 8140966.
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      120. Read TE, Harris HW, Grunfeld C, Feingold KR, Kane JP, Rapp JH. The protective effect of serum lipoproteins against bacterial lipopolysaccharide. Eur Heart J. 1993 Dec; 14 Suppl K:125-9. PMID: 8131781.
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      121. Read TE, Harris HW, Grunfeld C, Feingold KR, Calhoun MC, Kane JP, Rapp JH. Chylomicrons enhance endotoxin excretion in bile. Infect Immun. 1993 Aug; 61(8):3496-502. PMID: 8335381; PMCID: PMC281028.
      122. Bhushan V, Malloy MJ, Engler MM, Engler MB, Drown D, Kane JP. Exploratory data analysis of hyperlipidemia on the Macintosh: software tools for analysis of biochemical, clinical, and genetic variables in 1677 consecutive lipid clinic patients. J Med Syst. 1993 Aug; 17(3-4):187-93. PMID: 8254263.
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      123. Hennessy LK, Kunitake ST, Kane JP. Apolipoprotein A-I-containing lipoproteins, with or without apolipoprotein A-II, as progenitors of pre-beta high-density lipoprotein particles. Biochemistry. 1993 Jun 8; 32(22):5759-65. PMID: 8504094.
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      124. Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF, Rapp JH. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest. 1993 Mar; 91(3):1028-34. PMID: 8450032; PMCID: PMC288056.
      125. Pullinger CR, Zysow BR, Hennessy LK, Frost PH, Malloy MJ, Kane JP. Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. Hum Mol Genet. 1993 Jan; 2(1):69-74. PMID: 8490626.
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      126. Kunitake ST, Jarvis MR, Hamilton RL, Kane JP. Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins. Proc Natl Acad Sci U S A. 1992 Aug 1; 89(15):6993-7. PMID: 1495991; PMCID: PMC49631.
      127. Pullinger CR, Hillas E, Hardman DA, Chen GC, Naya-Vigne JM, Iwasa JA, Hamilton RL, Lalouel JM, Williams RR, Kane JP. Two apolipoprotein B gene defects in a kindred with hypobetalipoproteinemia, one of which results in a truncated variant, apoB-61, in VLDL and LDL. J Lipid Res. 1992 May; 33(5):699-710. PMID: 1619363.
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      128. Zysow BR, Pullinger CR, Kane JP. A polymorphic PstI site in intron 2 of the human apolipoprotein C-II gene detected by polymerase chain reaction. Hum Genet. 1992 May; 89(3):361. PMID: 1351041.
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      129. Colyvas N, Rapp JH, Phillips NR, Stoney R, Perez S, Kane JP, Havel RJ. Relation of plasma lipid and apoprotein levels to progressive intimal hyperplasia after arterial endarterectomy. Circulation. 1992 Apr; 85(4):1286-92. PMID: 1555272.
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      130. Malloy MJ, Kane JP. Drs malloy and kane respond. West J Med. 1992 Feb; 156(2):209. PMID: 18750862.
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      131. Hardman DA, Pullinger CR, Hamilton RL, Kane JP, Malloy MJ. Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia. J Clin Invest. 1991 Nov; 88(5):1722-9. PMID: 1939657; PMCID: PMC295713.
      132. Eichbaum EB, Harris HW, Kane JP, Rapp JH. Chylomicrons can inhibit endotoxin activity in vitro. J Surg Res. 1991 Nov; 51(5):413-6. PMID: 1758174.
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      133. Malloy MJ, Frost PH, Kane JP. Niacin--the long and the short of it. West J Med. 1991 Oct; 155(4):424-6. PMID: 1771892; PMCID: PMC1003039.
      134. Harris HW, Eichbaum EB, Kane JP, Rapp JH. Detection of endotoxin in triglyceride-rich lipoproteins in vitro. J Lab Clin Med. 1991 Aug; 118(2):186-93. PMID: 1856581.
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      135. Chen GC, Lau K, Hamilton RL, Kane JP. Differences in local conformation in human apolipoprotein B-100 of plasma low density and very low density lipoproteins as identified by cathepsin D. J Biol Chem. 1991 Jul 5; 266(19):12581-7. PMID: 2061328.
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      136. Ameis D, Kobayashi J, Davis RC, Ben-Zeev O, Malloy MJ, Kane JP, Lee G, Wong H, Havel RJ, Schotz MC. Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene. J Clin Invest. 1991 Apr; 87(4):1165-70. PMID: 2010533; PMCID: PMC295125.
      137. Wardell MR, Rall SC, Schaefer EJ, Kane JP, Weisgraber KH. Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity. J Lipid Res. 1991 Mar; 32(3):521-8. PMID: 1648586.
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      138. Kane JP, Malloy MJ, Ports TA, Phillips NR, Diehl JC, Havel RJ. Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens. JAMA. 1990 Dec 19; 264(23):3007-12. PMID: 2243428.
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      139. Kunitake ST, Young SG, Chen GC, Pullinger CR, Zhu S, Pease RJ, Scott J, Hass P, Schilling J, Kane JP. Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content. J Biol Chem. 1990 Dec 5; 265(34):20739-46. PMID: 1701170.
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      140. Kane JP, Malloy MJ. Treatment of hyperlipidemia. Annu Rev Med. 1990; 41:471-82. PMID: 2184745.
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      141. Kunitake ST, Chen GC, Kung SF, Schilling JW, Hardman DA, Kane JP. Pre-beta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis. Arteriosclerosis. 1990 Jan-Feb; 10(1):25-30. PMID: 2136993.
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      142. Chen GC, Zhu S, Hardman DA, Schilling JW, Lau K, Kane JP. Structural domains of human apolipoprotein B-100. Differential accessibility to limited proteolysis of B-100 in low density and very low density lipoproteins. J Biol Chem. 1989 Aug 25; 264(24):14369-75. PMID: 2668286.
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      143. Chen GC, Hardman DA, Hamilton RL, Mendel CM, Schilling JW, Zhu S, Lau K, Wong JS, Kane JP. Distribution of lipid-binding regions in human apolipoprotein B-100. Biochemistry. 1989 Mar 21; 28(6):2477-84. PMID: 2730877.
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      144. Rapp JH, Harris HW, Hamilton RL, Krupski WC, Reilly LM, Ehrenfeld WK, Stoney RJ, Goldstone J, Kane JP. Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report. J Vasc Surg. 1989 Jan; 9(1):81-8. PMID: 2911145.
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      145. Sernatinger J, Hoffman A, Hardman D, Kane JP, Levy JA. Neutralization of mouse xenotropic virus by lipoproteins involves binding to the virions. J Gen Virol. 1988 Oct; 69 ( Pt 10):2657-61. PMID: 2844973.
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      146. Mendel CM, Kunitake ST, Hong K, Erickson SK, Kane JP, Kempner ES. Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes. Biochim Biophys Acta. 1988 Jul 22; 961(2):188-93. PMID: 2839235.
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      147. Coleman RT, Cawthon RM, Malloy MJ, Kane JP, Nakashima PF, Frossard PM. Bsm I RFLP at the human apolipoprotein AI-CIII gene complex locus. Nucleic Acids Res. 1988 Mar 25; 16(5):2364. PMID: 2895918; PMCID: PMC338250.
      148. Coleman RT, Malloy MJ, Kane JP, Frossard PM. NcoI dimorphic site located 8kb 3' to the human apolipoprotein AIV (APOA4) gene. Nucleic Acids Res. 1988 Feb 11; 16(3):1222. PMID: 2894008; PMCID: PMC334771.
      149. Gustafson A, Kane JP, Havel RJ. Determinants of kallikrein proteolysis of apolipoprotein B-100 in human blood plasma. Eur J Clin Invest. 1988 Feb; 18(1):75-80. PMID: 3130263.
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      150. Mendel CM, Kunitake ST, Kane JP, Kempner ES. Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes. J Biol Chem. 1988 Jan 25; 263(3):1314-9. PMID: 2826475.
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      151. Kane JP, Malloy MJ. When to treat hyperlipidemia. Adv Intern Med. 1988; 33:143-63. PMID: 3278503.
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      152. Hardman DA, Protter AA, Schilling JW, Kane JP. Carboxyl terminal analysis of human B-48 protein confirms the novel mechanism proposed for chain termination. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):1214-9. PMID: 3426612.
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      153. Malloy MJ, Kane JP, Kunitake ST, Tun P. Complementarity of colestipol, niacin, and lovastatin in treatment of severe familial hypercholesterolemia. Ann Intern Med. 1987 Nov; 107(5):616-23. PMID: 3662275.
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      154. Frossard PM, Coleman RT, Malloy MJ, Kane JP, Levy-Wilson B, Appleby VA. Human apolipoprotein CI (apoC1) gene locus: DraI dimorphic site. Nucleic Acids Res. 1987 Feb 25; 15(4):1884. PMID: 2881281; PMCID: PMC340600.
      155. Frossard PM, Lim DW, Coleman RT, Funke H, Assmann G, Malloy MJ, Kane JP. Human apolipoprotein CI (ApoC1) gene locus: BglI dimorphic site. Nucleic Acids Res. 1987 Feb 11; 15(3):1344. PMID: 2881271; PMCID: PMC340542.
      156. Frossard PM, Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Funke H, Assmann G. DraI RFLP in the human apolipoprotein AI-CIII-AIV gene complex. Nucleic Acids Res. 1986 Nov 11; 14(21):8699. PMID: 2878415; PMCID: PMC311899.
      157. Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Frossard PM. TaqI and XbaI RFLPs detected with a human apo IV (Apo4) cDNA probe. Nucleic Acids Res. 1986 Oct 10; 14(19):7818. PMID: 2877436; PMCID: PMC311808.
      158. Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ. Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia. J Clin Invest. 1986 Sep; 78(3):722-8. PMID: 3745433; PMCID: PMC423660.
      159. Protter AA, Hardman DA, Sato KY, Schilling JW, Yamanaka M, Hort YJ, Hjerrild KA, Chen GC, Kane JP. Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5678-82. PMID: 3461454; PMCID: PMC386352.
      160. Hardman DA, Gustafson A, Schilling JW, Donaldson VH, Kane JP. Scission of human apolipoprotein B-100 by kallikrein: characterization of the cleavage site. Biochem Biophys Res Commun. 1986 Jun 13; 137(2):821-5. PMID: 3637099.
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      161. Menzel HJ, Kane JP, Malloy MJ, Havel RJ. A variant primary structure of apolipoprotein C-II in individuals of African descent. J Clin Invest. 1986 Feb; 77(2):595-601. PMID: 3944271; PMCID: PMC423392.
      162. Kane JP. Speciation of HDL. Adv Exp Med Biol. 1986; 201:29-35. PMID: 3541521.
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      163. Kane JP, Havel RJ. Treatment of hypercholesterolemia. Annu Rev Med. 1986; 37:427-35. PMID: 3518611.
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      164. Kunitake ST, La Sala KJ, Kane JP. Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility. J Lipid Res. 1985 May; 26(5):549-55. PMID: 3926924.
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      165. Chen GC, Guo LS, Hamilton RL, Gordon V, Richards EG, Kane JP. Circular dichroic spectra of apolipoprotein E in model complexes and cholesterol-rich lipoproteins: lipid contribution. Biochemistry. 1984 Dec 18; 23(26):6530-8. PMID: 6529567.
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      166. McVicar JP, Kunitake ST, Hamilton RL, Kane JP. Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1356-60. PMID: 6424116; PMCID: PMC344832.
      167. Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ. Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans. Proc Natl Acad Sci U S A. 1984 Mar; 81(6):1839-43. PMID: 6584917; PMCID: PMC345017.
      168. Phillips NR, Havel RJ, Kane JP. Sex-related differences in the concentrations of apolipoprotein E in human blood plasma and plasma lipoproteins. J Lipid Res. 1983 Nov; 24(11):1525-31. PMID: 6655368.
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      169. Hornick CA, Kita T, Hamilton RL, Kane JP, Havel RJ. Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits. Proc Natl Acad Sci U S A. 1983 Oct; 80(19):6096-100. PMID: 6577469; PMCID: PMC534367.
      170. Davis PA, Forte TM, Kane JP, Hardman DA, Krauss RM, Blum CB. Apolipoprotein and size heterogeneity in human umbilical cord blood low density lipoproteins. Biochim Biophys Acta. 1983 Sep 20; 753(2):186-94. PMID: 6615856.
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      171. Havel RJ, Kotite L, Kane JP, Tun P, Bersot T. Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3. J Clin Invest. 1983 Jul; 72(1):379-87. PMID: 6860421; PMCID: PMC1129193.
      172. Fielding PE, Fielding CJ, Havel RJ, Kane JP, Tun P. Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma. J Clin Invest. 1983 Mar; 71(3):449-60. PMID: 6826717; PMCID: PMC436892.
      173. Kane JP, Chen GC, Hamilton RL, Hardman DA, Malloy MJ, Havel RJ. Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia. Arteriosclerosis. 1983 Jan-Feb; 3(1):47-56. PMID: 6824496.
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      174. Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS. Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia. Arteriosclerosis. 1982 Nov-Dec; 2(6):467-74. PMID: 6960858.
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      175. Phillips NR, Havel RJ, Kane JP. Serum apolipoprotein A-I levels: relationship to lipoprotein lipid levels and selected demographic variables. Am J Epidemiol. 1982 Aug; 116(2):302-13. PMID: 6810694.
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      176. Kunitake ST, Kane JP. Factors affecting the integrity of high density lipoproteins in the ultracentrifuge. J Lipid Res. 1982 Aug; 23(6):936-40. PMID: 6813413.
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      177. Guo LS, Hamilton RL, Kane JP, Fielding CJ, Chen GC. Characterization and quantitation of apolipoproteins A-I and E of normal and cholesterol-fed guinea pigs. J Lipid Res. 1982 May; 23(4):531-42. PMID: 7182951.
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      178. Malloy MJ, Kane JP. Hypolipidemia. Med Clin North Am. 1982 Mar; 66(2):469-84. PMID: 7040848.
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      179. Kane JP, Malloy MJ. Treatment of hypercholesterolemia. Med Clin North Am. 1982 Mar; 66(2):537-50. PMID: 7040850.
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      180. Havel RJ, Kane JP. Therapy of hyperlipidemic states. Annu Rev Med. 1982; 33:417-33. PMID: 7044276.
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      181. Van't Hooft FM, Hardman DA, Kane JP, Havel RJ. Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins. Proc Natl Acad Sci U S A. 1982 Jan; 79(1):179-82. PMID: 6948299; PMCID: PMC345686.
      182. Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. J Clin Invest. 1981 Oct; 68(4):1075-85. PMID: 6270194; PMCID: PMC370895.
      183. Malloy MJ, Kane JP, Hardman DA, Hamilton RL, Dalal KB. Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein. J Clin Invest. 1981 May; 67(5):1441-50. PMID: 7229035; PMCID: PMC370711.
      184. Kane JP, Malloy MJ, Tun P, Phillips NR, Freedman DD, Williams ML, Rowe JS, Havel RJ. Normalization of low-density-lipoprotein levels in heterozygous familial hypercholesterolemia with a combined drug regimen. N Engl J Med. 1981 Jan 29; 304(5):251-8. PMID: 7003391.
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      185. Phillips NR, Havel RJ, Kane JP. Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides. Association with adiposity and the consumption of ethanol, tobacco, and beverages containing caffeine. Arteriosclerosis. 1981 Jan-Feb; 1(1):13-24. PMID: 7295182.
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      186. Havel RJ, Kotite L, Vigne JL, Kane JP, Tun P, Phillips N, Chen GC. Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency. J Clin Invest. 1980 Dec; 66(6):1351-62. PMID: 7440719; PMCID: PMC371621.
      187. Polz E, Kotite L, Havel RJ, Kane JP, Sata T. Human apolipoprotein C-I: concentration in blood serum and lipoproteins. Biochem Med. 1980 Dec; 24(3):229-37. PMID: 7283981.
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      188. Tan MH, Havel RJ, Gerich JE, Soeldner JS, Kane JP. Pancreatic alpha and beta cell function in familial dysbetalipoproteinemia. Horm Metab Res. 1980 Sep; 12(9):421-5. PMID: 7000652.
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      189. Kane JP, Hardman DA, Dimpfl JC, Levy JA. Apolipoprotein is responsible for neutralization of xenotropic type C virus by mouse serum. Proc Natl Acad Sci U S A. 1979 Nov; 76(11):5957-61. PMID: 230495; PMCID: PMC411772.
      190. Chen GC, Kane JP. Secondary structure in very low density and intermediate density lipoproteins of human serum. J Lipid Res. 1979 May; 20(4):481-8. PMID: 222856.
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      191. Abrams JJ, Grundy SM, Kane JP, Chang CM. Normocholesterolemic dysbetalipoproteinemia with xanthomatosis. Metabolism. 1979 Feb; 28(2):113-24. PMID: 216881.
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      192. Havel RJ, Kotite L, Kane JP. Isoelectric heterogeneity of the cofactor protein for lipoprotein lipase in human blood plasma. Biochem Med. 1979 Feb; 21(1):121-38. PMID: 222259.
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      193. Lie-Injo LE, Randhawa ZI, Kane JP, Ganesan J, George R. Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia. Am J Hematol. 1979; 6(1):17-25. PMID: 453194.
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      194. Kunitake ST, Loh E, Schumaker VN, Ma SK, Knobler CM, Kane JP, Hamilton RL. Molecular weight distributions of polydisperse systems: application to very low density lipoproteins. Biochemistry. 1978 May 16; 17(10):1936-42. PMID: 207303.
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      195. Malloy MJ, Kane JP, Rowe JS. Familial hypercholesterolemia in children: treatment with p-aminosalicylic acid. Pediatrics. 1978 Mar; 61(3):365-72. PMID: 205828.
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      196. Kaufman JM, Fam B, Jacobs SC, Gabilondo F, Yalla S, Kane JP, Rossier AB. Bladder cancer and squamous metaplasia in spinal cord injury patients. J Urol. 1977 Dec; 118(6):967-71. PMID: 926277.
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      197. Pagnan A, Havel RJ, Kane JP, Kotite L. Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia. J Lipid Res. 1977 Sep; 18(5):613-22. PMID: 198504.
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      198. Lie-Injo LE, Ganesan J, Randhawa ZI, Peterson D, Kane JP. Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia. Am J Hematol. 1977; 2(4):335-42. PMID: 602924.
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      199. Sata T, Havel RJ, Kotite L, Kane JP. New protein in human blood plasma, rich in proline, with lipid-binding properties. Proc Natl Acad Sci U S A. 1976 Apr; 73(4):1063-7. PMID: 1063389; PMCID: PMC430200.
      200. Wolfe BM, Havel JR, Marliss EB, Kane JP, Seymour J, Ahuja SP. Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men. J Clin Invest. 1976 Feb; 57(2):329-40. PMID: 176179; PMCID: PMC436657.
      201. Kane JP, Sata T, Hamilton RL, Havel RJ. Apoprotein composition of very low density lipoproteins of human serum. J Clin Invest. 1975 Dec; 56(6):1622-34. PMID: 172534; PMCID: PMC333142.
      202. Havel RJ, Kane JP. Quantification of triglyceride transport in blood plasma: a critical analysis. Fed Proc. 1975 Dec; 34(13):2250-7. PMID: 172371.
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      203. Faergeman O, Sata T, Kane JP, Havel RJ. Metabolism of apoprotein B of plasma very low density lipoproteins in the rat. J Clin Invest. 1975 Dec; 56(6):1396-1403. PMID: 172530; PMCID: PMC333117.
      204. Chapman MJ, Kane JP. Stability of the apoprotein of human serum low density lipoprotein: absence of endogenous endopeptidase activity. Biochem Biophys Res Commun. 1975 Oct 6; 66(3):1030-6. PMID: 170935.
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      205. Chen GC, Kane JP. Temperature dependence of the optical activity of human serum low density lipoprotein. The role of lipids. Biochemistry. 1975 Jul 29; 14(15):3357-62. PMID: 167825.
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      206. Kane JP, Malloy MJ. Editorial: Early prevention of atherosclerosis. West J Med. 1975 Apr; 122(4):328-9. PMID: 1154774; PMCID: PMC1129734.
      207. Chen GC, Kane JP. Contribution of carotenoids to the optical activity of human serum low-density lipoprotein. Biochemistry. 1974 Jul 30; 13(16):3330-5. PMID: 4366472.
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      208. Wolfe BM, Kane JP, Havel RJ, Brewster HP. Mechanism of the hypolipemic effect of clofibrate in postabsorptive man. J Clin Invest. 1973 Sep; 52(9):2146-59. PMID: 4353773; PMCID: PMC333015.
      209. Havel RJ, Kane JP. Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins. Proc Natl Acad Sci U S A. 1973 Jul; 70(7):2015-9. PMID: 4352966; PMCID: PMC433655.
      210. Kane JP. A rapid electrophoretic technique for identification of subunit species of apoproteins in serum lipoproteins. Anal Biochem. 1973 Jun; 53(2):350-64. PMID: 4351944.
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      211. Havel RJ, Kane JP, Kashyap ML. Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. J Clin Invest. 1973 Jan; 52(1):32-8. PMID: 4345202; PMCID: PMC302224.
      212. Havel RJ, Kane JP. Drugs and lipid metabolism. Annu Rev Pharmacol. 1973; 13:287-308. PMID: 4576891.
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      213. Hamilton RL, Havel RJ, Kane JP, Blaurock AE, Sata T. Cholestasis: lamellar structure of the abnormal human serum lipoprotein. Science. 1971 Apr 30; 172(3982):475-8. PMID: 5550502.
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      214. Havel RJ, Kane JP, Balasse EO, Segel N, Basso LV. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J Clin Invest. 1970 Nov; 49(11):2017-35. PMID: 5475985; PMCID: PMC535780.
      215. Kane JP, Richards EG, Havel RJ. Subunit heterogeneity in human serum beta lipoprotein. Proc Natl Acad Sci U S A. 1970 Aug; 66(4):1075-82. PMID: 4990876; PMCID: PMC335788.
      216. Havel RJ, Balasse EO, Williams HE, Kane JP, Segel N. Splanchnic metabolism in von Gierke's disease (glycogenosis type I). Trans Assoc Am Physicians. 1969; 82:305-23. PMID: 5375154.
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      217. KANE JP, LONGCOPE C, PAVLATOS FC, GRODSKY GM. STUDIES OF CARBOHYDRATE METABOLISM IN IDIOPATHIC HYPERTRIGLYCERIDEMIA. Metabolism. 1965 Apr; 14:471-86. PMID: 14288605.
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      218. KANE JP, FORSHAM PH. Sterol biosynthesis under the influence of a thyroxine analog (3,5-diiodothyroacetic acid). Metabolism. 1962 Dec; 11:1310-4. PMID: 13962187.
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