John Newman, MD, PhD
|School||UCSF School of Medicine|
|Address||1650 Owens St|
San Francisco CA 94107
|Yale University||BS/MS||2000||Molecular Biophysics and Biochemistry|
|University of Washington||MD/PhD||2008||Biochemistry|
|National Institute on Aging and American Federation for Aging Research||2014
|Larry L. Hillblom Foundation||2012
|Larry L. Hillblom Foundation||2014||John S. Spice Award in Aging|
|Paul F. Glenn Foundation||2013||Glenn Award for Research in Biological Mechanisms of Aging|
|Gladstone Institute of Virology and Immunology||2013||Award of Excellence in Scientific Leadership|
|John A. Hartford Foundation||2011
Dr. Newman is a geriatrician, basic science researcher, and educator in the Division of Geriatrics at UCSF. As a physician-scientist, Dr. Newman hopes to translate what we are learning of the pathways that control fundamental mechanisms of aging into therapies that will improve the health and preserve the independence of older adults.
His research work is in the laboratory of Eric Verdin at the Gladstone Institutes, and focuses on how ketone bodies, small molecules that our bodies make for energy when we fast or exercise, also act as molecular signals to control inflammation and gene expression. The signaling functions of ketone bodies may be translational targets for protecting cognition and improving resilience in older adults. This is one example how environmental cues like diet and fasting signal through small metabolites in our cells to regulate the genes and pathways that in turn control aging. Dr. Newman is particularly interested in testing if harnessing these signals can protect older adults from the risks of hospitalization like delirium and functional decline.
Dr. Newman attends on the inpatient medicine service and the acute care of elders unit at the San Francisco VA Medical Center, with a clinical focus on delirium and functional decline. He teaches students, residents, and fellows about geriatric clinical problems, as well as about the biology of aging and emerging translational science in geriatrics. He works as a part of the national Geroscience Network to develop frameworks and resources for testing interventions that target fundamental mechanisms of aging in clinical trials. He seeks to bridge the community of basic scientists that study aging to geriatricians and other clinicians who study the clinical problems of aging in order to develop innovative translational therapies.
Dr. Newman completed an MD/PhD at the University of Washington in Seattle, then residency training in Internal Medicine and a fellowship in Geriatrics at UCSF before joining the faculty in 2014. Dr. Newman is a 2014 Beeson Scholar from the National Institute on Aging and the American Federation of Aging Research. His work has also been supported by generous funding from the Larry L. Hillblom Foundation and the Glenn Foundation for Medical Research.
Assistant Professor, Division of Geriatrics at UCSF
Visiting Scientist, Gladstone Institutes
Geriatrician, San Francisco VA Medical Center
Geriatrics, aging, acute care of elders, frailty, longevity, metabolism, dietary restriction, ketone bodies, gene expression, epigenetics
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