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    Roy Gerona, PhD

    TitleADJ INSTR-HCOMP
    SchoolUCSF School of Medicine
    DepartmentOb/Gyn, Reproductive Sciences
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
    Phone415-514-5749
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      Collapse Biography 
      Collapse Education and Training
      University of the PhilippinesBS ChemistryInstitute of Chemistry1990
      University of the PhilippinesMS BiochemistryInstitute of Chemistry1998
      University of Wisconsin, MadisonPhD BiochemistryDepartment of Biochemistry2008
      University of California San FranciscoPost-Doctoral Fellowship- Clinical Chemistry Department of Laboratory Medicine2011

      Collapse Overview 
      Collapse Overview
      My research focus is on the development of mass spectrometric techniques and their application to environmental biomonitoring, clinical toxicology, and therapeutic drug monitoring in HIV/AIDS patients. My laboratory primarily serves as an analytical core to the Program on Reproductive Health and the Environment (PRHE) as well as other biomonitoring groups within UCSF and other universities and research institutions in the United States and Europe. Under this capacity, my laboratory is pioneering the application of high resolution mass spectrometry to the general unknown screening of environmental chemicals in biological matrices. In working with various biomonitoring groups, my laboratory has also continuously developed innovative and sensitive liquid chromatography- mass spectrometry (LC-MS) methods for measuring environmental chemicals (e.g. environmental phenols such as BPA, BPS and triclosan; phthalate metabolites; perfluorinated compounds; and, flame retardants) in a variety of biological matrices including serum, urine, amniotic fluid, placenta, hair, and various other human tissues.

      My laboratory also specializes in the analysis of designer drugs using high resolution and tandem mass spectrometry to aid Poison Centers, Medical Examiner’s Offices, and various government agencies including the Drug Enforcement Administration, the Centers for Disease Control and Prevention, the National Institute of Occupational Safety and Health, and the National Transportation Safety Board in tracking down synthetic drug intoxications and epidemics. More recently, I have also started working with the Positive Health Program at San Francisco General Hospital to develop LC-MS methods for hair antiretroviral and TB drug monitoring in HIV/AIDS and related studies.

      Collapse Interests
      Mass spectrometry, High Resolution Mass Spectrometry, General unknown screening, Environmental biomonitoring, Environmental health, Endocrine disruptors, Maternal-fetal toxin transport, Analytical Toxicology, Clinical Toxicology, Designer drugs, Synthetic cannabinoids, Synthetic cathinones, HIV/AIDS Therapeutic drug monitoring, Hair antiretroviral analysis, Hair TB drug analysis

      Collapse ORNG Applications 
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lung D, Wilson N, Chatenet FT, LaCroix C, Gerona R. Non-targeted screening for novel psychoactive substances among agitated emergency department patients. Clin Toxicol (Phila). 2016 Feb 5; 1-5. PMID: 26846684.
        View in: PubMed
      2. Beauchamp GA, Lin T, Zeng WZ, Hendrickson RG, Gerona R. Quantitative analysis of powdered caffeine products purchased from the Internet using liquid chromatography-quadrupole time-of-flight mass spectrometry. Clin Toxicol (Phila). 2016 Feb 3; 1-5. PMID: 26837659.
        View in: PubMed
      3. Springer Y, Shafer S, Gerona R. . Increase in Hospital Emergency Department Visits Related to Use of Synthetic Cannabinoids— Municipality of Anchorage, July to September, 2015. State of Alaska Epidemiology Bulletin. 2015; 17(2):1-19.
      4. Tyndall JA, Gerona R, De Portu G, Trecki J, Elie MC, Lucas J, Slish J, Rand K, Bazydlo L, Holder M, Ryan MF, Myers P, Iovine N, Plourde M, Weeks E, Hanley JR, Endres G, Germaine DS, Dobrowolski PJ, Schwartz M, et al. An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA. Clin Toxicol (Phila). 2015 Nov 10; 1-7. PMID: 26555732.
        View in: PubMed
      5. Banister S, McGregor I, Gerona R. . Labs make new, dangerous synthetic cannabinoid drugs faster than we can ban them. 2015.
      6. Kasper AM, Ridpath AD, Arnold JK, Chatham-Stephens K, Morrison M, Olayinka O, Parker C, Galli R, Cox R, Preacely N, Anderson J, Kyle PB, Gerona R, Martin C, Schier J, Wolkin A, Dobbs T. Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015. MMWR Morb Mortal Wkly Rep. 2015; 64(39):1121-2. PMID: 26447715.
        View in: PubMed
      7. Thornton SL, Akpunonu P, Glauner K, Hoehn KS, Gerona R. Unintentional Pediatric Exposure to a Synthetic Cannabinoid (AB-PINACA) Resulting in Coma and Intubation. Ann Emerg Med. 2015 Sep; 66(3):343-4. PMID: 26304261.
        View in: PubMed
      8. Trecki J, Gerona RR, Schwartz MD. Synthetic Cannabinoid-Related Illnesses and Deaths. N Engl J Med. 2015 Jul 9; 373(2):103-7. PMID: 26154784.
        View in: PubMed
      9. Albadareen R, Thornton S, Heshmati A, Gerona R, Lowry J. Unusually Prolonged Presentation of Designer Drug Encephalopathy Responsive to Steroids. Pediatrics. 2015 Jul; 136(1):e246-8. PMID: 26055852.
        View in: PubMed
      10. Cohen PA, Bloszies C, Yee C, Gerona R, et al. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PMID: 25847603.
        View in: PubMed
      11. Chenoweth JA, Gerona RR, Ford JB, Sutter ME, Rose JS, Albertson TE, Clarke SO, Owen KP. Altered Mental Status and End Organ Damage Associated with the use of Gacyclidine: A Case Series. J Med Toxicol. 2015 Mar; 11(1):115-20. PMID: 25048606.
        View in: PubMed
      12. Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR. A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA. J Emerg Med. 2015 May; 48(5):573-80. PMID: 25726258.
        View in: PubMed
      13. O'Connell CW, Gerona RR, Friesen MW, Ly BT. Internet-purchased ibogaine toxicity confirmed with serum, urine, and product content levels. Am J Emerg Med. 2015 Jul; 33(7):985.e5-6. PMID: 25687617.
        View in: PubMed
      14. Cooks T, Davis TK, Hu J, Metheny R, Schwartz M, Gerona R, et al. "Smoking" guns: Answers. Pediatr Nephrol. 2014 Oct 21. PMID: 25330880.
        View in: PubMed
      15. Cooks T, Davis TK, Hu J, Metheny R, Schwartz M, Gerona R, et al. "Smoking" guns: Questions. Pediatr Nephrol. 2014 Oct 21. PMID: 25330878.
        View in: PubMed
      16. Spiller HA, Russell JL, Casavant MJ, Ho RY, Gerona RR. Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. Clin Toxicol (Phila). 2014 Nov; 52(9):976-9. PMID: 25211007.
        View in: PubMed
      17. Buser GL, Gerona RR, Horowitz BZ, Vian KP, Troxell ML, Hendrickson RG, Houghton DC, Rozansky D, Su SW, Leman RF. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014 Aug; 52(7):664-73. PMID: 25089722.
        View in: PubMed
      18. Schneir A, Ly BT, Casagrande K, Darracq M, Offerman SR, Thornton S, Smollin C, Vohra R, Rangun C, Tomaszewski C, Gerona RR. Comprehensive analysis of "bath salts" purchased from California stores and the internet. Clin Toxicol (Phila). 2014 Aug; 52(7):651-8. PMID: 25089721.
        View in: PubMed
      19. MacIsaac JK, Gerona RR, Blanc PD, Apatira L, Friesen MW, Coppolino M, Janssen S. Health care worker exposures to the antibacterial agent triclosan. J Occup Environ Med. 2014 Aug; 56(8):834-9. PMID: 25099409; PMCID: PMC4133120 [Available on 08/01/15].
      20. Lo JC, Gerona RR. A case of rivaroxaban associated intracranial hemorrhage. West J Emerg Med. 2014 Jul; 15(4):375-7. PMID: 25035736; PMCID: PMC4100836.
      21. Gugelmann H, Gerona R, Li C, Tsutaoka B, Olson KR, Lung D. 'Crazy Monkey' poisons man and dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid. Clin Toxicol (Phila). 2014 Jul; 52(6):635-8. PMID: 24905571.
        View in: PubMed
      22. Hunt PA, VandeVoort C, Woodruff T, Gerona R, et al. Invalid Controls Undermine Conclusions of FDA Studies. Toxicol Sci. 2014 Jun 3. PMID: 24893712.
        View in: PubMed
      23. Armenian P, Gerona RR. The electric Kool-Aid NBOMe test: LC-TOF/MS confirmed 2C-C-NBOMe (25C) intoxication at Burning Man. Am J Emerg Med. 2014 Nov; 32(11):1444.e3-5. PMID: 24908444.
        View in: PubMed
      24. Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health. 2014; 13(1):25. PMID: 24690217; PMCID: PMC4066311.
      25. Drenzek C, Geller R, Steck A, Arnold J, Lopez G, Gerona R, Edison L. . Notes from the Field: Severe Illness Associated with Synthetic Cannabinoid Use — Brunswick, Georgia, 2013. MMWR. Morbidity and mortality weekly report. 2013; 62(46):939.
      26. Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA. Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environ Sci Technol. 2013 Nov 5; 47(21):12477-85. PMID: 23941471; PMCID: PMC3881559.
      27. Lung DD, Scott BJ, Wu AH, Gerona RR. Prolonged ventilatory failure and flaccid quadriparesis after ingestion of poison hemlock. Muscle Nerve. 2013 Nov; 48(5):823-7. PMID: 23733387.
        View in: PubMed
      28. Lung DD, Wu AH, Gerona RR. Cardiotoxicity in a citalopram and olanzapine overdose. J Emerg Med. 2013 Oct; 45(4):554-8. PMID: 23871479.
        View in: PubMed
      29. Cantrell L, Suchard J, Gerona R. Comment regarding the stability of active ingredients in long-expired prescription medications--reply. JAMA Intern Med. 2013 Jun 10; 173(11):1035. PMID: 23752969.
        View in: PubMed
      30. Alhadi S, Tiwari A, Vohra R, Gerona R, Acharya J, Bilello K. High times, low sats: diffuse pulmonary infiltrates associated with chronic synthetic cannabinoid use. J Med Toxicol. 2013 Jun; 9(2):199-206. PMID: 23539384; PMCID: PMC3657026.
      31. Thornton SL, Wood C, Friesen MW, Gerona RR. Synthetic cannabinoid use associated with acute kidney injury. Clin Toxicol (Phila). 2013 Mar; 51(3):189-90. PMID: 23473465.
        View in: PubMed
      32. Murphy T, Van Houten C, Gerona RR, Moran J, Kirschner R, Marraffa J, Stork CM, Birkhead G, Newman A, Hendrickson R, Horowitz Z, Vian K, Lehman R, Thornton S, Wood C, Myers S, Orr E, Devlin J, Schwartz M. . Morbidity and Mortality Weekly Report. Acute Kidney Injury Associated with Synthetic Cannabinoid Use — Multiple States, 2012. 2013; 62(6):93-98.
      33. Coralic Z, Lenhoff T, Kanzaria HK, Gerona R. A 120-hour case of priapism from an over-the-counter herbal supplement. Ann Pharmacother. 2013 Feb; 47(2):289-90. PMID: 23386071.
        View in: PubMed
      34. Cantrell L, Suchard JR, Wu A, Gerona RR. Stability of active ingredients in long-expired prescription medications. Arch Intern Med. 2012 Nov 26; 172(21):1685-7. PMID: 23045150.
        View in: PubMed
      35. Thornton SL, Lo J, Clark RF, Wu AH, Gerona RR. Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis. Clin Toxicol (Phila). 2012 Dec; 50(10):1165-8. PMID: 23163617.
        View in: PubMed
      36. Gerona RR, Wu AH. Bath salts. Clin Lab Med. 2012 Sep; 32(3):415-27. PMID: 22939300.
        View in: PubMed
      37. Thornton SL, Gerona RR, Tomaszewski CA. Psychosis from a bath salt product containing flephedrone and MDPV with serum, urine, and product quantification. J Med Toxicol. 2012 Sep; 8(3):310-3. PMID: 22528592; PMCID: PMC3550171.
      38. Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL. Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology. Clin Toxicol (Phila). 2012 Sep; 50(8):733-42. PMID: 22888997.
        View in: PubMed
      39. Diffley M, Armenian P, Gerona R, Reinhartz O, Avasarala K. Catecholaminergic polymorphic ventricular tachycardia found in an adolescent after a methylenedioxymethamphetamine and marijuana-induced cardiac arrest. Crit Care Med. 2012 Jul; 40(7):2223-6. PMID: 22584762.
        View in: PubMed
      40. Wu AH, Lorizio W, Tchu S, Lynch K, Gerona R, Ji W, Ruan W, Ruddy KJ, Desantis SD, Burstein HJ, Ziv E. Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score. Breast Cancer Res Treat. 2012 Jun; 133(2):677-83. PMID: 22294487.
        View in: PubMed
      41. Armenian P, Mamantov TM, Tsutaoka BT, Gerona RR, Silman EF, Wu AH, Olson KR. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med. 2013 Jul-Aug; 28(4):252-8. PMID: 22640978.
        View in: PubMed
      42. Lung DD, Gerona RR, Wu AH, Smollin CG. Confirmed glyburide poisoning from ingestion of "street Valium". J Emerg Med. 2012 Aug; 43(2):276-8. PMID: 21978878.
        View in: PubMed
      43. Armenian P, Gerona RR, Blanc PD, Wu AH, Mookherjee S. 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use. J Emerg Med. 2012 Jul; 43(1):54-7. PMID: 21978879.
        View in: PubMed
      44. Lynch KL, Gerona RR, Kielar DM, Martens S, McMahon HT, Martin TF. Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol Biol Cell. 2008 Dec; 19(12):5093-103. PMID: 18799625; PMCID: PMC2592635.
      45. Lynch KL, Gerona RR, Larsen EC, Marcia RF, Mitchell JC, Martin TF. Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis. Mol Biol Cell. 2007 Dec; 18(12):4957-68. PMID: 17914059; PMCID: PMC2096586.
      46. Waselle L, Gerona RR, Vitale N, Martin TF, Bader MF, Regazzi R. Role of phosphoinositide signaling in the control of insulin exocytosis. Mol Endocrinol. 2005 Dec; 19(12):3097-106. PMID: 16081518.
        View in: PubMed
      47. Grishanin RN, Kowalchyk JA, Klenchin VA, Ann K, Earles CA, Chapman ER, Gerona RR, Martin TF. CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein. Neuron. 2004 Aug 19; 43(4):551-62. PMID: 15312653.
        View in: PubMed
      48. Gerona RR, Larsen EC, Kowalchyk JA, Martin TF. The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes. J Biol Chem. 2000 Mar 3; 275(9):6328-36. PMID: 10692432.
        View in: PubMed
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