Loading...

Roy Gerona, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentOb/Gyn, Reproductive Sciences
AddressLocation Required
Varies CA 00000
Phone415-514-5749
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    University of the PhilippinesBS Chemistry1990Institute of Chemistry
    University of the PhilippinesMS Biochemistry1998Institute of Chemistry
    University of Wisconsin, MadisonPhD Biochemistry2008Department of Biochemistry
    University of California San FranciscoPost-Doctoral Fellowship- Clinical Chemistry 2011Department of Laboratory Medicine

    Collapse Overview 
    Collapse overview
    My research focus is on the development of mass spectrometric techniques and their application to environmental biomonitoring, clinical toxicology, and therapeutic drug monitoring in HIV/AIDS patients. My laboratory primarily serves as an analytical core to the Program on Reproductive Health and the Environment (PRHE) as well as other biomonitoring groups within UCSF and other universities and research institutions in the United States and Europe. Under this capacity, my laboratory is pioneering the application of high resolution mass spectrometry to the general unknown screening of environmental chemicals in biological matrices. In working with various biomonitoring groups, my laboratory has also continuously developed innovative and sensitive liquid chromatography- mass spectrometry (LC-MS) methods for measuring environmental chemicals (e.g. environmental phenols such as BPA, BPS and triclosan; phthalate metabolites; perfluorinated compounds; and, flame retardants) in a variety of biological matrices including serum, urine, amniotic fluid, placenta, hair, and various other human tissues.

    My laboratory also specializes in the analysis of designer drugs using high resolution and tandem mass spectrometry to aid Poison Centers, Medical Examiner’s Offices, and various government agencies including the Drug Enforcement Administration, the Centers for Disease Control and Prevention, the National Institute of Occupational Safety and Health, and the National Transportation Safety Board in tracking down synthetic drug intoxications and epidemics. More recently, I have also started working with the Positive Health Program at San Francisco General Hospital to develop LC-MS methods for hair antiretroviral and TB drug monitoring in HIV/AIDS and related studies.


    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P. α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nat Med. 2017 Feb 06. PMID: 28165480.
      View in: PubMed
    2. Armenian P, Campagne D, Stroh G, Ives Tallman C, Zeng WZ, Lin T, Gerona R. Hot and Cold Drugs: National Park Service Medication Stability at the Extremes of Temperature. Prehosp Emerg Care. 2017 Jan 06; 1-8. PMID: 28059581.
      View in: PubMed
    3. Adams AJ, Banister SD, Irizarry L, Trecki J, Schwartz M, Gerona R. "Zombie" Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York. N Engl J Med. 2016 Dec 14. PMID: 27973993.
      View in: PubMed
    4. Noble MJ, Longstreet B, Hendrickson RG, Gerona R. Unintentional Pediatric Ingestion of Electronic Cigarette Nicotine Refill Liquid Necessitating Intubation. Ann Emerg Med. 2016 Dec 13. PMID: 27988056.
      View in: PubMed
    5. VandeVoort CA, Gerona RR, Vom Saal FS, Tarantal AF, Hunt PA, Hillenweck A, Zalko D. Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey. PLoS One. 2016; 11(12):e0165410. PMID: 27930651.
      View in: PubMed
    6. Springer YP, Gerona R, Scheunemann E, Shafer SL, Lin T, Banister SD, Cooper MP, Castrodale LJ, Levy M, Butler JC, McLaughlin JB. Increase in Adverse Reactions Associated with Use of Synthetic Cannabinoids - Anchorage, Alaska, 2015-2016. MMWR Morb Mortal Wkly Rep. 2016 Oct 14; 65(40):1108-1111. PMID: 27736839.
      View in: PubMed
    7. Darracq MA, Thornton SL, Minns AB, Gerona R, et al. A Case of 3,4-Dimethoxyamphetamine (3,4-DMA) and 3,4 Methylendioxymethamphetamine (MDMA) Toxicity with Possible Metabolic Interaction. J Psychoactive Drugs. 2016 Sep 16; 1-4. PMID: 27636207.
      View in: PubMed
    8. Banister S, Adams A, Gerona R . Fentanyl and other synthetic opioids sold as counterfeits in deadly new trend. The Conversation. 2016.
    9. Armenian P, Olson A, Anaya A, Kurtz A, Ruegner R, Gerona R, et al. Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street "Norco" in Central California: A Case Report. Ann Emerg Med. 2016 Jul 20. PMID: 27473610.
      View in: PubMed
    10. Gerona R, Wen A, Koss C, Bacchetti P, Gandhi M, Metcalfe J. A multi-analyte panel for non-invasive pharmacokinetic monitoring of second-line anti-tuberculosis drugs. Int J Tuberc Lung Dis. 2016 Jul; 20(7):991-2. PMID: 27287660.
      View in: PubMed
    11. Sutter ME, Gerona R, Davis MT, Roche BM, Colby DK, Chenoweth JA, Adams AJ, Owen KP, Ford JB, Black H, Albertson TE, Heard KJ, et al. Fatal Fentanyl: One Pill Can Kill. Acad Emerg Med. 2016 Jun 20. PMID: 27322591.
      View in: PubMed
    12. Gerona R, Wen A, Chin AT, Koss CA, Bacchetti P, Metcalfe J, Gandhi M. Quantifying Isoniazid Levels in Small Hair Samples: A Novel Method for Assessing Adherence during the Treatment of Latent and Active Tuberculosis. PLoS One. 2016; 11(5):e0155887. PMID: 27191185.
      View in: PubMed
    13. Gerona RR, Pan J, Zota AR, Schwartz JM, Friesen M, Taylor JA, Hunt PA, Woodruff TJ. Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health. 2016; 15(1):50. PMID: 27071747.
      View in: PubMed
    14. Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, Vom Saal FS. Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology". Environ Health Perspect. 2016 Apr 1; 124(4):A66. PMID: 27035054.
      View in: PubMed
    15. Lung D, Wilson N, Chatenet FT, LaCroix C, Gerona R. Non-targeted screening for novel psychoactive substances among agitated emergency department patients. Clin Toxicol (Phila). 2016 Apr; 54(4):319-23. PMID: 26846684.
      View in: PubMed
    16. Beauchamp GA, Lin T, Zeng WZ, Hendrickson RG, Gerona R. Quantitative analysis of powdered caffeine products purchased from the Internet using liquid chromatography-quadrupole time-of-flight mass spectrometry. Clin Toxicol (Phila). 2016 Apr; 54(4):339-43. PMID: 26837659.
      View in: PubMed
    17. Springer Y, Shafer S, Gerona R . Increase in Hospital Emergency Department Visits Related to Use of Synthetic Cannabinoids— Municipality of Anchorage, July to September, 2015. State of Alaska Epidemiology Bulletin. 2015; 17(2):1-19.
    18. Tyndall JA, Gerona R, De Portu G, Trecki J, Elie MC, Lucas J, Slish J, Rand K, Bazydlo L, Holder M, Ryan MF, Myers P, Iovine N, Plourde M, Weeks E, Hanley JR, Endres G, Germaine DS, Dobrowolski PJ, Schwartz M. An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA. Clin Toxicol (Phila). 2015 Dec; 53(10):950-6. PMID: 26555732.
      View in: PubMed
    19. Banister S, McGregor I, Gerona R . Labs make new, dangerous synthetic cannabinoid drugs faster than we can ban them. The Conversation. 2015.
    20. Kasper AM, Ridpath AD, Arnold JK, Chatham-Stephens K, Morrison M, Olayinka O, Parker C, Galli R, Cox R, Preacely N, Anderson J, Kyle PB, Gerona R, Martin C, Schier J, Wolkin A, Dobbs T. Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015. MMWR Morb Mortal Wkly Rep. 2015; 64(39):1121-2. PMID: 26447715.
      View in: PubMed
    21. Thornton SL, Akpunonu P, Glauner K, Hoehn KS, Gerona R. Unintentional Pediatric Exposure to a Synthetic Cannabinoid (AB-PINACA) Resulting in Coma and Intubation. Ann Emerg Med. 2015 Sep; 66(3):343-4. PMID: 26304261.
      View in: PubMed
    22. Trecki J, Gerona RR, Schwartz MD. Synthetic Cannabinoid-Related Illnesses and Deaths. N Engl J Med. 2015 Jul 9; 373(2):103-7. PMID: 26154784.
      View in: PubMed
    23. Albadareen R, Thornton S, Heshmati A, Gerona R, Lowry J. Unusually Prolonged Presentation of Designer Drug Encephalopathy Responsive to Steroids. Pediatrics. 2015 Jul; 136(1):e246-8. PMID: 26055852.
      View in: PubMed
    24. Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2016 Mar; 8(3-4):328-33. PMID: 25847603.
      View in: PubMed
    25. Chenoweth JA, Gerona RR, Ford JB, Sutter ME, Rose JS, Albertson TE, Clarke SO, Owen KP. Altered mental status and end organ damage associated with the use of gacyclidine: a case series. J Med Toxicol. 2015 Mar; 11(1):115-20. PMID: 25048606; PMCID: PMC4371039 [Available on 03/01/16].
    26. Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR. A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA. J Emerg Med. 2015 May; 48(5):573-80. PMID: 25726258.
      View in: PubMed
    27. O'Connell CW, Gerona RR, Friesen MW, Ly BT. Internet-purchased ibogaine toxicity confirmed with serum, urine, and product content levels. Am J Emerg Med. 2015 Jul; 33(7):985.e5-6. PMID: 25687617.
      View in: PubMed
    28. Cooks T, Davis TK, Hu J, Metheny R, Schwartz M, Gerona R. "Smoking" guns: Answers. Pediatr Nephrol. 2014 Oct 21. PMID: 25330880.
      View in: PubMed
    29. Cooks T, Davis TK, Hu J, Metheny R, Schwartz M, Gerona R. "Smoking" guns: Questions. Pediatr Nephrol. 2016 Jan; 31(1):61-2. PMID: 25330878.
      View in: PubMed
    30. Spiller HA, Russell JL, Casavant MJ, Ho RY, Gerona RR. Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. Clin Toxicol (Phila). 2014 Nov; 52(9):976-9. PMID: 25211007.
      View in: PubMed
    31. Hunt PA, VandeVoort C, Woodruff T, Gerona R. Invalid controls undermine conclusions of FDA studies. Toxicol Sci. 2014 Sep; 141(1):1-2. PMID: 25232149.
      View in: PubMed
    32. Buser GL, Gerona RR, Horowitz BZ, Vian KP, Troxell ML, Hendrickson RG, Houghton DC, Rozansky D, Su SW, Leman RF. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014 Aug; 52(7):664-73. PMID: 25089722.
      View in: PubMed
    33. Schneir A, Ly BT, Casagrande K, Darracq M, Offerman SR, Thornton S, Smollin C, Vohra R, Rangun C, Tomaszewski C, Gerona RR. Comprehensive analysis of "bath salts" purchased from California stores and the internet. Clin Toxicol (Phila). 2014 Aug; 52(7):651-8. PMID: 25089721.
      View in: PubMed
    34. MacIsaac JK, Gerona RR, Blanc PD, Apatira L, Friesen MW, Coppolino M, Janssen S. Health care worker exposures to the antibacterial agent triclosan. J Occup Environ Med. 2014 Aug; 56(8):834-9. PMID: 25099409; PMCID: PMC4133120.
    35. Lo JC, Gerona RR. A case of rivaroxaban associated intracranial hemorrhage. West J Emerg Med. 2014 Jul; 15(4):375-7. PMID: 25035736; PMCID: PMC4100836.
    36. Gugelmann H, Gerona R, Li C, Tsutaoka B, Olson KR, Lung D. 'Crazy Monkey' poisons man and dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid. Clin Toxicol (Phila). 2014 Jul; 52(6):635-8. PMID: 24905571.
      View in: PubMed
    37. Armenian P, Gerona RR. The electric Kool-Aid NBOMe test: LC-TOF/MS confirmed 2C-C-NBOMe (25C) intoxication at Burning Man. Am J Emerg Med. 2014 Nov; 32(11):1444.e3-5. PMID: 24908444.
      View in: PubMed
    38. Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health. 2014; 13(1):25. PMID: 24690217; PMCID: PMC4066311.
    39. Drenzek C, Geller R, Steck A, Arnold J, Lopez G, Gerona R, Edison L. Notes from the Field: Severe Illness Associated with Synthetic Cannabinoid Use — Brunswick, Georgia, 2013. MMWR. Morbidity and mortality weekly report. 2013; 62(46):939.
    40. Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA. Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environ Sci Technol. 2013; 47(21):12477-85. PMID: 23941471; PMCID: PMC3881559.
    41. Lung DD, Scott BJ, Wu AH, Gerona RR. Prolonged ventilatory failure and flaccid quadriparesis after ingestion of poison hemlock. Muscle Nerve. 2013 Nov; 48(5):823-7. PMID: 23733387.
      View in: PubMed
    42. Lung DD, Wu AH, Gerona RR. Cardiotoxicity in a citalopram and olanzapine overdose. J Emerg Med. 2013 Oct; 45(4):554-8. PMID: 23871479.
      View in: PubMed
    43. Cantrell L, Suchard J, Gerona R. Comment regarding the stability of active ingredients in long-expired prescription medications--reply. JAMA Intern Med. 2013 Jun 10; 173(11):1035. PMID: 23752969.
      View in: PubMed
    44. Alhadi S, Tiwari A, Vohra R, Gerona R, Acharya J, Bilello K. High times, low sats: diffuse pulmonary infiltrates associated with chronic synthetic cannabinoid use. J Med Toxicol. 2013 Jun; 9(2):199-206. PMID: 23539384; PMCID: PMC3657026.
    45. Thornton SL, Wood C, Friesen MW, Gerona RR. Synthetic cannabinoid use associated with acute kidney injury. Clin Toxicol (Phila). 2013 Mar; 51(3):189-90. PMID: 23473465.
      View in: PubMed
    46. Murphy T, Van Houten C, Gerona R, Moran J, Kirschner R, Marraffa J, Stork CM, Birkhead G, Newman A, Hendrickson R, Horowitz Z, Vian K, Lehman R, Thornton S, Wood C, Myers S, Orr E, Devlin J, Schwartz M. Morbidity and Mortality Weekly Report. Acute Kidney Injury Associated with Synthetic Cannabinoid Use — Multiple States, 2012. 2013; 62(6):93-98.
    47. Coralic Z, Lenhoff T, Kanzaria HK, Gerona R. A 120-hour case of priapism from an over-the-counter herbal supplement. Ann Pharmacother. 2013 Feb; 47(2):289-90. PMID: 23386071.
      View in: PubMed
    48. Cantrell L, Suchard JR, Wu A, Gerona RR. Stability of active ingredients in long-expired prescription medications. Arch Intern Med. 2012 Nov 26; 172(21):1685-7. PMID: 23045150.
      View in: PubMed
    49. Thornton SL, Lo J, Clark RF, Wu AH, Gerona RR. Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis. Clin Toxicol (Phila). 2012 Dec; 50(10):1165-8. PMID: 23163617.
      View in: PubMed
    50. Gerona RR, Wu AH. Bath salts. Clin Lab Med. 2012 Sep; 32(3):415-27. PMID: 22939300.
      View in: PubMed
    51. Thornton SL, Gerona RR, Tomaszewski CA. Psychosis from a bath salt product containing flephedrone and MDPV with serum, urine, and product quantification. J Med Toxicol. 2012 Sep; 8(3):310-3. PMID: 22528592; PMCID: PMC3550171.
    52. Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL. Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology. Clin Toxicol (Phila). 2012 Sep; 50(8):733-42. PMID: 22888997.
      View in: PubMed
    53. Diffley M, Armenian P, Gerona R, Reinhartz O, Avasarala K. Catecholaminergic polymorphic ventricular tachycardia found in an adolescent after a methylenedioxymethamphetamine and marijuana-induced cardiac arrest. Crit Care Med. 2012 Jul; 40(7):2223-6. PMID: 22584762.
      View in: PubMed
    54. Wu AH, Lorizio W, Tchu S, Lynch K, Gerona R, Ji W, Ruan W, Ruddy KJ, Desantis SD, Burstein HJ, Ziv E. Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score. Breast Cancer Res Treat. 2012 Jun; 133(2):677-83. PMID: 22294487.
      View in: PubMed
    55. Lung DD, Gerona RR, Wu AH, Smollin CG. Confirmed glyburide poisoning from ingestion of "street Valium". J Emerg Med. 2012 Aug; 43(2):276-8. PMID: 21978878.
      View in: PubMed
    56. Armenian P, Gerona RR, Blanc PD, Wu AH, Mookherjee S. 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use. J Emerg Med. 2012 Jul; 43(1):54-7. PMID: 21978879.
      View in: PubMed
    57. Lynch KL, Gerona RR, Kielar DM, Martens S, McMahon HT, Martin TF. Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol Biol Cell. 2008 Dec; 19(12):5093-103. PMID: 18799625; PMCID: PMC2592635.
    58. Lynch KL, Gerona RR, Larsen EC, Marcia RF, Mitchell JC, Martin TF. Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis. Mol Biol Cell. 2007 Dec; 18(12):4957-68. PMID: 17914059; PMCID: PMC2096586.
    59. Waselle L, Gerona RR, Vitale N, Martin TF, Bader MF, Regazzi R. Role of phosphoinositide signaling in the control of insulin exocytosis. Mol Endocrinol. 2005 Dec; 19(12):3097-106. PMID: 16081518.
      View in: PubMed
    60. Grishanin RN, Kowalchyk JA, Klenchin VA, Ann K, Earles CA, Chapman ER, Gerona RR, Martin TF. CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein. Neuron. 2004 Aug 19; 43(4):551-62. PMID: 15312653.
      View in: PubMed
    61. Gerona RR, Larsen EC, Kowalchyk JA, Martin TF. The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes. J Biol Chem. 2000 Mar 3; 275(9):6328-36. PMID: 10692432.
      View in: PubMed
    Roy's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP