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    Daniel Bikle, MD, PhD

    TitleProfessor in Residence
    SchoolUCSF School of Medicine
    DepartmentMedicine
    AddressVAMC 6
    Phone415-221-4810x3338

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca(2+) and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100.
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      2. Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013; 4:6.
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      3. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8.
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      4. Bikle DD. Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci. 2012 Nov 19; 11(12):1808-16.
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      5. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: Part II. J Am Acad Dermatol. 2012 Nov; 67(5):817.e1-817.e11.
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      6. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: Part I. J Am Acad Dermatol. 2012 Nov; 67(5):803.e1-803.e12.
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      7. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec; 303(11):E1354-62.
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      8. Bikle DD, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Curr Mol Pharmacol. 2012 Jun; 5(2):135-42.
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      9. Bikle DD. Vitamin D and bone. Curr Osteoporos Rep. 2012 Jun; 10(2):151-9.
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      10. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-9.
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      11. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66.
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      12. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92.
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      13. Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem. 2012 May 24; 55(10):4640-51.
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      14. Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH. Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes. J Invest Dermatol. 2012 Aug; 132(8):2097-100.
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      15. Bikle DD. Vitamin D and the skin: Physiology and pathophysiology. Rev Endocr Metab Disord. 2012 Mar; 13(1):3-19.
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      16. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95.
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      17. Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol. 2012 Apr; 132(4):1075-83.
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      18. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47.
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      19. Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res. 2011 Dec; 26(12):2948-58.
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      20. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 6; 287(2):1158-67.
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      21. Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD. Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. J Invest Dermatol. 2011 Nov; 131(11):2289-97.
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      22. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46.
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      23. Bikle DD. Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. 2011 Dec 5; 347(1-2):80-9.
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      24. Tang JY, Xiao TZ, Oda Y, Chang KS, Shpall E, Wu A, So PL, Hebert J, Bikle D, Epstein EH. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila). 2011 May; 4(5):744-51.
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      25. Tu CL, Chang W, Bikle DD. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28.
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      26. Bikle DD. Vitamin D: an ancient hormone. Exp Dermatol. 2011 Jan; 20(1):7-13.
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      27. Bikle DD. Vitamin D regulation of immune function. Vitam Horm. 2011; 86:1-21.
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      28. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Discov Med. 2011 Jan; 11(56):7-17.
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      29. Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM, Mauro TM. Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. Br J Dermatol. 2011 Jan; 164(1):16-25.
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      30. Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem. 2011 Jan 14; 286(2):997-1004.
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      31. Teichert A, Elalieh H, Bikle D. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice. J Cell Physiol. 2010 Nov; 225(2):482-9.
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      32. Oda Y, Chalkley RJ, Burlingame AL, Bikle DD. The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation. J Invest Dermatol. 2010 Oct; 130(10):2377-88.
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      33. Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y. Differential regulation of epidermal function by VDR coactivators. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):308-13.
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      34. Bikle DD. Vitamin D: newly discovered actions require reconsideration of physiologic requirements. Trends Endocrinol Metab. 2010 Jun; 21(6):375-84.
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      35. Bikle DD. Vitamin D and the skin. J Bone Miner Metab. 2010 Mar; 28(2):117-30.
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      36. Asgari MM, Tang J, Warton ME, Chren MM, Quesenberry CP, Bikle D, Horst RL, Orentreich N, Vogelman JH, Friedman GD. Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. J Invest Dermatol. 2010 May; 130(5):1438-43.
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      37. Bikle DD. Vitamin D and immune function: understanding common pathways. Curr Osteoporos Rep. 2009 Jul; 7(2):58-63.
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      38. Pao VY, Chang S, Shoback DM, Bikle DD. Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review. J Bone Miner Res. 2009 Jun; 24(6):1135-9.
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      39. Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Quantification of the vitamin D receptor-coregulator interaction. Biochemistry. 2009 Feb 24; 48(7):1454-61.
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      40. Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD. Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. Mol Biol Cell. 2009 Mar; 20(6):1695-704.
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      41. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol. 2009 Jun; 129(6):1367-78.
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      42. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009 Jan; 94(1):26-34.
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      43. Bikle DD. Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism. J Invest Dermatol. 2008 Oct; 128(10):2357-61.
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      44. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008; 1(35):ra1.
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      45. Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008 Jul; 17(4):348-52.
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      46. Bikle DD. Growth hormone/insulin-like growth factor-1/PTH axis in bone. J Bone Miner Res. 2008 May; 23(5):581-3.
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      47. Bikle DD. Integrins, insulin like growth factors, and the skeletal response to load. Osteoporos Int. 2008 Sep; 19(9):1237-46.
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      48. Tu CL, Chang W, Xie Z, Bikle DD. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 8; 283(6):3519-28.
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      49. Bikle DD. Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V50-4.
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      50. Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL. Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2008 Apr; 128(4):816-24.
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      51. Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007 Sep; 22(9):1329-37.
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      52. Bikle DD. What is new in vitamin D: 2006-2007. Curr Opin Rheumatol. 2007 Jul; 19(4):383-8.
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      53. Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol. 2007 Jul; 103(1):125-31.
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      54. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007 Jul; 148(7):3156-63.
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      55. Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 2007 Mar; 117(3):803-11.
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      56. Xie Z, Bikle DD. The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation. J Biol Chem. 2007 Mar 23; 282(12):8695-703.
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      57. Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD. Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):776-80.
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      58. Bikle D, Teichert A, Hawker N, Xie Z, Oda Y. Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):396-404.
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      59. Tu CL, Chang W, Bikle DD. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1074-83.
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      60. Hawker NP, Pennypacker SD, Chang SM, Bikle DD. Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J Invest Dermatol. 2007 Apr; 127(4):874-80.
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      61. Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res. 2006 Sep; 21(9):1350-8.
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      62. Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S. Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone. 2007 Jan; 40(1):160-8.
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      63. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61.
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      64. Bikle DD, Elalieh H, Chang S, Xie Z, Sundberg JP. Development and progression of alopecia in the vitamin D receptor null mouse. J Cell Physiol. 2006 May; 207(2):340-53.
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      65. Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol. 2006 May; 189(2):279-87.
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      66. Xie Z, Chang S, Oda Y, Bikle DD. Hairless suppresses vitamin D receptor transactivation in human keratinocytes. Endocrinology. 2006 Jan; 147(1):314-23.
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      67. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005 Dec; 146(12):5294-303.
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      68. Bikle DD, Oda Y, Xie Z. Vitamin D and skin cancer: a problem in gene regulation. J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):83-91.
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      69. Xie Z, Singleton PA, Bourguignon LY, Bikle DD. Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell. 2005 Jul; 16(7):3236-46.
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      70. Tu CL, Chang W, Bikle DD. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97.
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      71. Bikle DD. Vitamin D and skin cancer. J Nutr. 2004 Dec; 134(12 Suppl):3472S-3478S.
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      72. Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR. The effect of LXR activators on AP-1 proteins in keratinocytes. J Invest Dermatol. 2004 Jul; 123(1):41-8.
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      73. Bikle DD. Vitamin D regulated keratinocyte differentiation. J Cell Biochem. 2004 Jun 1; 92(3):436-44.
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      74. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):347-53.
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      75. Bikle DD, Oda Y, Xie Z. Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):355-60.
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      76. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):273-6.
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      77. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol. 2004 Apr; 122(4):984-92.
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      78. Tu CL, Oda Y, Komuves L, Bikle DD. The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium. 2004 Mar; 35(3):265-73.
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      79. Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res. 2004 Mar; 19(3):436-46.
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      80. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44.
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      81. Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM. Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J Invest Dermatol. 2003 Oct; 121(4):688-94.
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      82. Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calcif Tissue Int. 2003 Aug; 73(2):147-52.
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      83. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Mol Endocrinol. 2003 Nov; 17(11):2329-39.
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      84. Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD. Skeletal unloading induces resistance to insulin-like growth factor I on bone formation. Bone. 2003 Jun; 32(6):669-80.
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      85. Bikle DD, Sakata T, Halloran BP. The impact of skeletal unloading on bone formation. Gravit Space Biol Bull. 2003 Jun; 16(2):45-54.
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      86. Yang LC, Ng DC, Bikle DD. Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. J Cell Physiol. 2003 May; 195(2):249-59.
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      87. Dolezalova H, Shankar G, Huang MC, Bikle DD, Goetzl EJ. Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. J Cell Biochem. 2003 Mar 1; 88(4):732-43.
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      88. Bikle DD, Tu CL, Xie Z, Oda Y. Vitamin D regulated keratinocyte differentiation: role of coactivators. J Cell Biochem. 2003 Feb 1; 88(2):290-5.
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      89. Bikle DD, Xie Z, Ng D, Tu CL, Oda Y. Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why? Recent Results Cancer Res. 2003; 164:111-22.
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      90. Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM. Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro. Tissue Eng. 2002 Dec; 8(6):931-9.
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      91. Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z. The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2002 Nov; 119(5):1109-13.
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      92. Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res. 2002 Sep; 17(9):1570-8.
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      93. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54.
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      94. Xie Z, Munson SJ, Huang N, Portale AA, Miller WL, Bikle DD. The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem. 2002 Oct 4; 277(40):36987-90.
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      95. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002 Jan; 118(1):11-6.
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      96. Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B. The skeletal structure of insulin-like growth factor I-deficient mice. J Bone Miner Res. 2001 Dec; 16(12):2320-9.
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      97. Xie Z, Bikle DD. Inhibition of 1,25-dihydroxyvitamin-D-induced keratinocyte differentiation by blocking the expression of phospholipase C-gamma1. J Invest Dermatol. 2001 Nov; 117(5):1250-4.
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      98. Tu CL, Chang W, Bikle DD. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem. 2001 Nov 2; 276(44):41079-85.
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      99. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z. Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol. 2001 May 25; 177(1-2):161-71.
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      100. Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD. Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization. J Appl Physiol. 2001 May; 90(5):1849-54.
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      101. Xie Z, Bikle DD. The role of phospholipase C-gamma1 in 1alpha,25-dihydroxyvitamin D(3) regulated keratinocyte differentiation. Steroids. 2001 Mar-May; 66(3-5):339-45.
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      102. Schuster I, Egger H, Bikle D, Herzig G, Reddy GS, Stuetz A, Stuetz P, Vorisek G. Selective inhibition of vitamin D hydroxylases in human keratinocytes. Steroids. 2001 Mar-May; 66(3-5):409-22.
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      103. Hanley K, Wood L, Ng DC, He SS, Lau P, Moser A, Elias PM, Bikle DD, Williams ML, Feingold KR. Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. J Lipid Res. 2001 Mar; 42(3):390-8.
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      104. Kömüves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR. Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol. 2000 Sep; 115(3):353-60.
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      105. Ng DC, Shafaee S, Lee D, Bikle DD. Requirement of an AP-1 site in the calcium response region of the involucrin promoter. J Biol Chem. 2000 Aug 4; 275(31):24080-8.
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      106. Hanley K, Kömüves LG, Ng DC, Schoonjans K, He SS, Lau P, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. J Biol Chem. 2000 Apr 14; 275(15):11484-91.
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      107. Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J Invest Dermatol. 2000 Mar; 114(3):545-53.
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      108. Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14; 275(2):1183-90.
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      109. Tu CL, Oda Y, Bikle DD. Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes. J Invest Dermatol. 1999 Sep; 113(3):340-5.
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      112. Ratnam AV, Bikle DD, Cho JK. 1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes. J Cell Physiol. 1999 Feb; 178(2):188-96.
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      113. Bikle DD, Halloran BP. The response of bone to unloading. J Bone Miner Metab. 1999; 17(4):233-44.
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      115. Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. J Bone Miner Res. 1999 Jan; 14(1):21-31.
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      116. Khoroshev MI, Munson SJ, Bikle DD. Six putative IQ motifs of the recombinant chicken intestinal brush border myosin I are involved in calmodulin binding. Arch Biochem Biophys. 1999 Jan 1; 361(1):94-100.
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      117. Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem. 1998 Sep 4; 273(36):23344-52.
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      118. Xie Z, Bikle DD. Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes. J Invest Dermatol. 1998 May; 110(5):730-3.
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      119. Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR. Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. J Invest Dermatol. 1998 Apr; 110(4):368-75.
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      120. Gibson DF, Bikle DD, Harris J. All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes. J Cell Physiol. 1998 Jan; 174(1):1-8.
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      121. Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Am J Physiol. 1997 Dec; 273(6 Pt 1):E1133-9.
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      122. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec; 11(13):1961-70.
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      123. Bikle DD. Biochemical markers in the assessment of bone disease. Am J Med. 1997 Nov; 103(5):427-36.
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      124. Bikle DD. Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation. J Am Acad Dermatol. 1997 Sep; 37(3 Pt 2):S42-52.
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      125. Gibson DF, Bikle DD, Harris J, Goldberg GS. The expression of the gap junctional protein Cx43 is restricted to proliferating and non differentiated normal and transformed keratinocytes. Exp Dermatol. 1997 Aug; 6(4):167-74.
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      126. Cho JK, Bikle DD. Decrease of Ca(2+)-ATPase activity in human keratinocytes during calcium-induced differentiation. J Cell Physiol. 1997 Aug; 172(2):146-54.
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      127. Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E. Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res. 1997 Jul; 12(7):1068-74.
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      128. Bikle DD, Halloran BP, Morey-Holton E. Spaceflight and the skeleton: lessons for the earthbound. Gravit Space Biol Bull. 1997 Jun; 10(2):119-35.
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      129. Xie Z, Bikle DD. Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element. J Biol Chem. 1997 Mar 7; 272(10):6573-7.
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      130. Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P. Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. J Clin Endocrinol Metab. 1997 Feb; 82(2):429-34.
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      131. Bikle DD, Halloran BP, Morey-Holton E. Space flight and the skeleton: lessons for the earthbound. Endocrinologist. 1997 Jan-Feb; 7(1):10-22.
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      132. Love-Schimenti CD, Gibson DF, Ratnam AV, Bikle DD. Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells. Cancer Res. 1996 Jun 15; 56(12):2789-94.
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      133. Bikle DD, Munson S, Komuves L. Zipper protein, a B-G protein with the ability to regulate actin/myosin 1 interactions in the intestinal brush border. J Biol Chem. 1996 Apr 12; 271(15):9075-83.
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      134. Bikle DD. 1,25(OH)2D3-modulated calcium induced keratinocyte differentiation. J Investig Dermatol Symp Proc. 1996 Apr; 1(1):22-7.
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      135. Ratnam AV, Bikle DD, Su MJ, Pillai S. Squamous carcinoma cell lines fail to respond to 1,25-Dihydroxyvitamin D despite normal levels of the vitamin D receptor. J Invest Dermatol. 1996 Mar; 106(3):522-5.
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      136. Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest. 1996 Feb 15; 97(4):1085-93.
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      137. Gibson DF, Ratnam AV, Bikle DD. Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes. J Invest Dermatol. 1996 Jan; 106(1):154-61.
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      138. Ng DC, Su MJ, Kim R, Bikle DD. Regulation of involucrin gene expression by calcium in normal human keratinocytes. Front Biosci. 1996 Jan 1; 1:a16-24.
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      139. Bikle DD, Abe-Hashimoto J, Su MJ, Felt S, Gibson DF, Pillai S. 22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism. J Invest Dermatol. 1995 Nov; 105(5):693-8.
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      140. Halloran BP, Bikle DD, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, Morey-Holton E. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res. 1995 Aug; 10(8):1168-76.
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      141. Pillai S, Bikle DD, Su MJ, Ratnam A, Abe J. 1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels. J Clin Invest. 1995 Jul; 96(1):602-9.
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      142. Bikle DD. 1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: basic studies and their clinical application. J Nutr. 1995 Jun; 125(6 Suppl):1709S-1714S.
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      143. Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology. 1995 May; 136(5):2099-109.
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      144. Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Ann Intern Med. 1995 Apr 1; 122(7):511-3.
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      145. Bikle DD, Harris J, Halloran BP, Morey-Holton E. Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation. Am J Physiol. 1994 Dec; 267(6 Pt 1):E822-7.
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      146. Bikle DD, Harris J, Halloran BP, Morey-Holton ER. Skeletal unloading induces resistance to insulin-like growth factor I. J Bone Miner Res. 1994 Nov; 9(11):1789-96.
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      147. Bikle DD, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J Bone Miner Res. 1994 Nov; 9(11):1777-87.
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      148. Bikle DD. Role of vitamin D, its metabolites, and analogs in the management of osteoporosis. Rheum Dis Clin North Am. 1994 Aug; 20(3):759-75.
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      149. Bikle DD, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E. Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth. Am J Physiol. 1994 Aug; 267(2 Pt 1):E278-86.
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      150. Bikle DD, Halloran BP, Morey-Holton E. Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astronaut. 1994 Jul; 33:119-29.
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      151. Su MJ, Bikle DD, Mancianti ML, Pillai S. 1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium. J Biol Chem. 1994 May 20; 269(20):14723-9.
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      152. Bikle DD, Halloran BP, Riviere JE. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. J Invest Dermatol. 1994 May; 102(5):796-8.
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      153. Kaune R, Munson S, Bikle DD. Regulation of calmodulin binding to the ATP extractable 110 kDa protein (myosin I) from chicken duodenal brush border by 1,25-(OH)2D3. Biochim Biophys Acta. 1994 Mar 23; 1190(2):329-36.
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      154. Bikle DD, Gee E, Pillai S. Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol. 1993 Nov; 101(5):713-8.
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      155. Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R. Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. Alcohol Clin Exp Res. 1993 Jun; 17(3):690-5.
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      156. Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E. Skeletal unloading decreases production of 1,25-dihydroxyvitamin D. Am J Physiol. 1993 May; 264(5 Pt 1):E712-6.
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      157. Bikle DD, Pillai S. Vitamin D, calcium, and epidermal differentiation. Endocr Rev. 1993 Feb; 14(1):3-19.
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      158. Bikle DD, Halloran B, Fong L, Steinbach L, Shellito J. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone. J Clin Endocrinol Metab. 1993 Feb; 76(2):456-61.
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      159. Bikle DD, Munson S, Morrison N, Eisman J. Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border. J Biol Chem. 1993 Jan 5; 268(1):620-6.
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      160. Bikle DD. Alcohol-induced bone disease. World Rev Nutr Diet. 1993; 73:53-79.
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      161. Pillai S, Menon GK, Bikle DD, Elias PM. Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes. J Cell Physiol. 1993 Jan; 154(1):101-12.
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      162. Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. Am J Physiol. 1992 Dec; 263(6 Pt 1):E1164-70.
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      163. Bikle DD. Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential. Endocr Rev. 1992 Nov; 13(4):765-84.
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      164. Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H. Effects of dietary protein deficiency on mineral metabolism and bone mineral density. Am J Clin Nutr. 1992 Aug; 56(2):314-9.
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      165. Bikle DD, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992 Aug; 75(2):519-23.
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      166. Pillai S, Bikle DD. Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes. J Clin Invest. 1992 Jul; 90(1):42-51.
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      167. Pillai S, Bikle DD. Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation. J Cell Physiol. 1992 Jun; 151(3):623-9.
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      168. Bikle DD, Pillai S, Gee E. Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect. J Invest Dermatol. 1991 Sep; 97(3):435-41.
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      169. Bikle DD, Pillai S, Gee E, Hincenbergs M. Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology. 1991 Jul; 129(1):33-8.
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      170. Bikle DD, Munson S, Mancianti ML. Limited tissue distribution of the intestinal brush border myosin I protein. Gastroenterology. 1991 Feb; 100(2):395-402.
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      171. Pillai S, Bikle DD, Mancianti ML, Hincenbergs M. Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines. Exp Cell Res. 1991 Feb; 192(2):567-73.
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      172. Pillai S, Bikle DD. Epidermal vitamin D metabolism, function, and regulation. Adv Lipid Res. 1991; 24:321-41.
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      173. Pillai S, Bikle DD. Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3. J Cell Physiol. 1991 Jan; 146(1):94-100.
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      174. Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E. Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion. Am J Physiol. 1990 Nov; 259(5 Pt 1):E715-22.
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      175. Pillai S, Bikle DD, Mancianti ML, Cline P, Hincenbergs M. Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J Cell Physiol. 1990 May; 143(2):294-302.
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      176. Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S. Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease. J Clin Endocrinol Metab. 1989 Dec; 69(6):1234-9.
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      177. Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, Morey-Holton E. Effects of simulated weightlessness on rat osteocalcin and bone calcium. Am J Physiol. 1989 Nov; 257(5 Pt 2):R1103-9.
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      178. Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E. Bone response to normal weight bearing after a period of skeletal unloading. Am J Physiol. 1989 Oct; 257(4 Pt 1):E606-10.
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      179. Barnes PF, Modlin RL, Bikle DD, Adams JS. Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. J Clin Invest. 1989 May; 83(5):1527-32.
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      180. Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest. 1989 Mar; 83(3):816-21.
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      181. Halloran BP, Bikle DD, Castro ME, Gee E. Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism. Biochemistry. 1989 Feb 7; 28(3):1278-81.
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      182. Bikle DD, Gee E. Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology. 1989 Feb; 124(2):649-54.
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      183. Bikle DD, Pillai S, Gee E, Hincenbergs M. Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology. 1989 Feb; 124(2):655-60.
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      184. Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P. Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins. Biochim Biophys Acta. 1989 Jan 17; 1010(1):122-7.
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      185. Halloran BP, Bikle DD, Cone CM, Morey-Holton E. Glucocorticoids and inhibition of bone formation induced by skeletal unloading. Am J Physiol. 1988 Dec; 255(6 Pt 1):E875-9.
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      186. Taylor A, Bikle DD, Norman ME. Serum dihydrotachysterol levels and biological action in normal man. J Clin Endocrinol Metab. 1988 Jul; 67(1):198-202.
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      187. Pillai S, Bikle DD, Elias PM. 1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation. J Biol Chem. 1988 Apr 15; 263(11):5390-5.
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      188. Bikle DD. Effects of alcohol abuse on bone. Compr Ther. 1988 Feb; 14(2):16-20.
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      189. Pillai S, Bikle DD, Hincenbergs M, Elias PM. Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium. J Cell Physiol. 1988 Feb; 134(2):229-37.
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      190. Pillai S, Bikle DD, Elias PM. Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation. Skin Pharmacol. 1988; 1(3):149-60.
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      191. Bikle DD, Pillai S. Vitamin D metabolite production and function in keratinocytes. Ann N Y Acad Sci. 1988; 548:27-44.
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      192. Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle DD, Elias PM. The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro. Biochim Biophys Acta. 1987 Sep 14; 930(2):193-200.
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      193. Cunningham J, Bikle DD, Avioli LV. Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney. J Bone Miner Res. 1987 Aug; 2(4):289-96.
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      194. Bikle DD, Halloran BP, Cone CM, Globus RK, Morey-Holton E. The effects of simulated weightlessness on bone maturation. Endocrinology. 1987 Feb; 120(2):678-84.
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      195. Long RG, Bikle DD, Munson SJ. Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum. Endocrinology. 1986 Dec; 119(6):2568-73.
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      196. Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey-Holton ER. Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization. Endocrinology. 1986 Dec; 119(6):2580-5.
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      197. Bikle DD, Gee EA, Munson SJ. Effect of ethanol on intestinal calcium transport in chicks. Gastroenterology. 1986 Oct; 91(4):870-6.
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      198. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986 Oct; 63(4):954-9.
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      199. Halloran BP, Bikle DD, Levens MJ, Castro ME, Globus RK, Holton E. Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. J Clin Invest. 1986 Sep; 78(3):622-8.
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      200. Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J Clin Invest. 1986 Sep; 78(3):748-52.
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      201. Bikle DD, Nemanic MK, Gee E, Elias P. 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest. 1986 Aug; 78(2):557-66.
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      202. Bikle DD, Nemanic MK, Whitney JO, Elias PW. Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3. Biochemistry. 1986 Apr 8; 25(7):1545-8.
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      203. Globus RK, Bikle DD, Halloran B, Morey-Holton E. Skeletal response to dietary calcium in a rat model simulating weightlessness. J Bone Miner Res. 1986 Apr; 1(2):191-7.
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      204. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology. 1986 Mar; 118(3):948-54.
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      205. Globus RK, Bikle DD, Morey-Holton E. The temporal response of bone to unloading. Endocrinology. 1986 Feb; 118(2):733-42.
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      206. Bikle DD, Munson S. The villus gradient of brush border membrane calmodulin and the calcium-independent calmodulin-binding protein parallels that of calcium-accumulating ability. Endocrinology. 1986 Feb; 118(2):727-32.
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      207. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism. Physiologist. 1985 Dec; 28(6 Suppl):S127-8.
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      208. Bikle DD, Munson S. 1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane. J Clin Invest. 1985 Dec; 76(6):2312-6.
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      209. Bikle DD, Halloran BP, Cone CM, Morey-Holton E. Bone loss during simulated weightlessness: is it glucocorticoid mediated? Physiologist. 1985 Dec; 28(6 Suppl):S123-4.
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      210. Bikle DD, Siiteri PK, Ryzen E, Haddad JG. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab. 1985 Nov; 61(5):969-75.
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      211. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. Bone disease in alcohol abuse. Ann Intern Med. 1985 Jul; 103(1):42-8.
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      212. Bikle DD, Halloran BP, Whitney JO, Hollis BW. Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group. Biochemistry. 1984 Dec 18; 23(26):6920-5.
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      213. Bikle DD, Zolock DT, Munson S. Differential response of duodenal epithelial cells to 1,25-dihydroxyvitamin D3 according to position on the villus: a comparison of calcium uptake, calcium-binding protein, and alkaline phosphatase activity. Endocrinology. 1984 Dec; 115(6):2077-84.
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      214. Bikle DD, Gee E, Halloran B, Haddad JG. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest. 1984 Dec; 74(6):1966-71.
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      215. Halloran BP, Bikle DD, Whitney JO. Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography. J Chromatogr. 1984 Oct 26; 303(1):229-33.
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      216. Bikle DD, Munson S, Chafouleas J. Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport. FEBS Lett. 1984 Aug 20; 174(1):30-3.
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      217. Globus RK, Bikle DD, Morey-Holton E. Effects of simulated weightlessness on bone mineral metabolism. Endocrinology. 1984 Jun; 114(6):2264-70.
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      218. Bikle DD, Munson S, Chafouleas JG. The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane. Prog Clin Biol Res. 1984; 168:193-8.
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      219. Bikle DD, Whitney J, Munson S. The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes. Endocrinology. 1984 Jan; 114(1):260-7.
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      220. Cunningham J, Bikle DD, Avioli LV. Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism. Kidney Int. 1984 Jan; 25(1):47-52.
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      221. Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle DD, Morey ER. Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton. Aviat Space Environ Med. 1983 Dec; 54(12 Pt 1):1080-4.
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      222. Bikle DD, Munson S, Zolock DT. Calcium flux across chick duodenal brush border membrane vesicles: regulation by 1,25-dihydroxyvitamin D. Endocrinology. 1983 Dec; 113(6):2072-80.
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      223. Bikle DD. Fluoride treatment of osteoporosis: a new look at an old drug. Ann Intern Med. 1983 Jun; 98(6):1013-5.
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      224. Bikle DD. Calcium absorption and vitamin D metabolism. Clin Gastroenterol. 1983 May; 12(2):379-94.
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      225. Bikle DD, Herman RH, Hull S, Hagler L, Harris D, Halloran B. Adaptive response of humans to changes in dietary calcium: relationship between vitamin D regulated intestinal function and serum 1,25-dihydroxyvitamin D levels. Gastroenterology. 1983 Feb; 84(2):314-23.
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      226. Bikle DD, Herman RH. Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion. J Clin Endocrinol Metab. 1983 Jan; 56(1):11-7.
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      227. Bikle DD, Peck CC, Holford NH, Zolock DT, Morrissey RL. Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick. Endocrinology. 1982 Sep; 111(3):939-46.
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      228. Bikle DD. The vitamin D endocrine system. Adv Intern Med. 1982; 27:45-71.
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      229. Rost CR, Bikle DD, Kaplan RA. In vitro stimulation of 25-hydroxycholecalciferol 1 alpha-hydroxylation by parathyroid hormone in chick kidney slices: evidence for a role for adenosine 3',5'-monophosphate. Endocrinology. 1981 Mar; 108(3):1002-6.
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      230. Bikle DD, Morrissey RL, Zolock DT, Rasmussen H. The intestinal response to vitamin D. Rev Physiol Biochem Pharmacol. 1981; 89:63-142.
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      231. Bikle DD, Zolock DT, Morrissey RL. Action of vitamin D on intestinal calcium transport. Ann N Y Acad Sci. 1981; 372:481-501.
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      232. Bikle DD. Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase. Biochim Biophys Acta. 1980 Sep 9; 615(1):208-22.
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      233. Bikle DD, Spencer EM, Burke WH, Rost CR. Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro. Endocrinology. 1980 Jul; 107(1):81-4.
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      234. Bikle DD, Askew EW, Zolock DT, Morrissey RL, Herman RH. Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta. 1980 Jun 6; 598(3):561-74.
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      235. Bikle DD, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM. Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3. Calcif Tissue Int. 1980; 32(1):9-17.
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      236. Bikle DD, Morrissey RL, Zolock DT. The mechanism of action of vitamin D in the intestine. Am J Clin Nutr. 1979 Nov; 32(11):2322-8.
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      237. Bikle DD, Morrissey RL, Zolock DT, Herman RH. Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms. J Lab Clin Med. 1979 Jul; 94(1):88-94.
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      238. Bikle DD, Hagler L, Lollini LO, Hull SF, Herman RH. Work-induced muscle hypertrophy in vitamin D-deficient rats. Am J Clin Nutr. 1979 Mar; 32(3):515-6.
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      239. Morrissey RL, Zolock DT, Bucci TJ, Bikle DD. Immunoperoxidase localization of vitamin D dependent calcium binding protein. J Histochem Cytochem. 1978 Aug; 26(8):628-34.
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      240. Bikle DD, Rasmussen H. A biochemical model for the ionic control of 25-hydroxyvitamin D3 1alpha-hydroxylase. J Biol Chem. 1978 May 10; 253(9):3042-8.
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      241. Bikle DD, Zolock DT, Morrissey RL, Herman RH. Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis. J Biol Chem. 1978 Jan 25; 253(2):484-8.
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      242. Morrissey RL, Zolock DT, Bikle DD, Empson RN, Bucci TJ. Intestinal response to 1 alpha, 25-dihydroxycholecalciferol. I. RNA polymerase, alkaline phosphatase, calcium and phosphorus uptake in vitro, and in vivo calcium transport and accumulation. Biochim Biophys Acta. 1978 Jan 3; 538(1):23-33.
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      243. Morrissey RL, Empson RN, Zolock DT, Bikle DD, Bucci TJ. Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein. Biochim Biophys Acta. 1978 Jan 3; 538(1):34-41.
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      244. Bikle DD, Rasmussen H. Ionic control of 1,25-dihydroxy vitamin D-3 production by isolated chick renal mitochondria. Influence of anions and sucrose. Biochim Biophys Acta. 1978 Jan 3; 538(1):127-38.
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      245. Bikle DD, Empson RN, Herman RH, Morrissey RL, Zolock DR. The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus. Biochim Biophys Acta. 1977 Aug 25; 499(1):61-6.
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      246. Bikle DD, Murphy EW, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D-3 synthesis in isolated chick renal mitochondria. The role of potassium. Biochim Biophys Acta. 1976 Jul 21; 437(2):394-402.
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      247. Bikle DD, Murphy EW, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion. J Clin Invest. 1975 Feb; 55(2):299-304.
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      248. Bikle DD, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules. J Clin Invest. 1975 Feb; 55(2):292-8.
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      249. Bikle DD, Rasmussen H. A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria. Biochim Biophys Acta. 1974 Oct 8; 362(3):439-47.
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      250. Bikle DD, Rasmussen H. The metabolism of 25-hydroxycholecalciferol by isolated renal tubules in vitro as studied by a new chromatographic technique. Biochim Biophys Acta. 1974 Oct 8; 362(3):425-38.
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      251. Rasmussen H, Wong M, Bikle D, Goodman DB. Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. J Clin Invest. 1972 Sep; 51(9):2502-4.
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