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    Daniel Bikle, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address4150 Clement St
    San Francisco CA 94121
    Phone415-575-0557
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      HarvardABHarvard1965
      University of PennsylvaniaSchool of Medicine1969
      University of PennsylvaniaPhDGraduate School of Arts and Sciences1974

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bikle DD. The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven. Endocrinology. 2016 May; 157(5):1717-8. PMID: 27014941.
        View in: PubMed
      2. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. J Biol Chem. 2016 Apr 8; 291(15):8140-9. PMID: 26865633.
        View in: PubMed
      3. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15; 109:238-46. PMID: 26774929.
        View in: PubMed
      4. Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72. PMID: 26782853.
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      5. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. PMID: 26453498.
        View in: PubMed
      6. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7. PMID: 26504023.
        View in: PubMed
      7. Bikle DD. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30. PMID: 26269123.
        View in: PubMed
      8. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. PMID: 25801198.
        View in: PubMed
      9. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Aug 8. PMID: 26253396.
        View in: PubMed
      10. Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. J Bone Miner Res. 2015 Dec; 30(12):2239-48. PMID: 26011431.
        View in: PubMed
      11. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6. PMID: 26097993.
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      12. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76. PMID: 25502173.
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      13. Bourguignon LY, Bikle D. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224. PMID: 26029210.
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      14. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6. PMID: 25739654.
        View in: PubMed
      15. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. PMID: 25757956.
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      16. Welsh J, Bikle DD, Lips P. Highlights from the 17th workshop on vitamin d, chicago, IL, june 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2. PMID: 25641118.
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      17. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54. PMID: 25559384.
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      18. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51. PMID: 25445917.
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      19. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98. PMID: 25107568; PMCID: PMC4177010 [Available on 10/01/15].
      20. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. PMID: 24677183; PMCID: PMC4108521 [Available on 08/01/15].
      21. Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One. 2014; 9(6):e99991. PMID: 24949995; PMCID: PMC4065011.
      22. Bikle DD, Mauro TM. Calcium, Orai1, and epidermal proliferation. J Invest Dermatol. 2014 Jun; 134(6):1506-8. PMID: 24825060; PMCID: PMC4023905 [Available on 12/01/14].
      23. Bikle D. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:1-4. PMID: 24793579.
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      24. Jiang YJ, Bikle DD. LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. Exp Dermatol. 2014 Mar; 23(3):147-50. PMID: 24499465; PMCID: PMC4103949.
      25. Hollis BW, Bikle DD. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014 Feb 27; 370(9):879-80. PMID: 24571766; PMCID: PMC4165606.
      26. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20; 21(3):319-29. PMID: 24529992; PMCID: PMC3968073 [Available on 03/20/15].
      27. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014 May; 99(5):1631-7. PMID: 24483159; PMCID: PMC4010704 [Available on 05/01/15].
      28. Bikle DD. Vitamin D and cancer: the promise not yet fulfilled. Endocrine. 2014 May; 46(1):29-38. PMID: 24402695; PMCID: PMC3976762 [Available on 05/01/15].
      29. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014; 810:282-302. PMID: 25207372.
        View in: PubMed
      30. Jiang YJ, Bikle DD. LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:87-90. PMID: 24342142.
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      31. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al. Front Neuroendocrinol. 2014 Jan; 35(1):2-5. PMID: 24268499.
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      32. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:156-8. PMID: 24240067; PMCID: PMC4022715 [Available on 10/01/15].
      33. Hu L, Bikle DD, Oda Y. Reciprocal role of vitamin D receptor on ß-catenin regulated keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:237-41. PMID: 24239508; PMCID: PMC4061268 [Available on 10/01/15].
      34. Bikle DD, Jiang Y. The protective role of vitamin d signaling in non-melanoma skin cancer. Cancers (Basel). 2013; 5(4):1426-38. PMID: 24202452; PMCID: PMC3875946.
      35. Wang Y, Bikle DD, Chang W. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59. PMID: 26273506.
        View in: PubMed
      36. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology. 2013 Nov; 154(11):3957-60. PMID: 24048095.
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      37. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J Clin Endocrinol Metab. 2013 Nov; 98(11):4400-9. PMID: 24030939; PMCID: PMC3816263.
      38. Norman AW, Bikle D, Bouillon R. Fifteenth vitamin D workshop. J Steroid Biochem Mol Biol. 2013 Jul; 136:1-2. PMID: 23768771; PMCID: PMC4102609.
      39. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. PMID: 23782944; PMCID: PMC3749485.
      40. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry. 2013 Jun 18; 52(24):4193-203. PMID: 23713684; PMCID: PMC3724348.
      41. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. PMID: 23682710; PMCID: PMC3717170.
      42. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100. PMID: 23239173; PMCID: PMC3617088.
      43. Tu CL, Bikle DD. Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):415-27. PMID: 23856269; PMCID: PMC3713412.
      44. Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013; 4:6. PMID: 23382729; PMCID: PMC3563099.
      45. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8. PMID: 23362869; PMCID: PMC4099380.
      46. Bikle DD. Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci. 2012 Dec; 11(12):1808-16. PMID: 22990497; PMCID: PMC3501582.
      47. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part II. J Am Acad Dermatol. 2012 Nov; 67(5):817.e1-11; quiz 827-8. PMID: 23062904; PMCID: PMC3706259.
      48. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part I. J Am Acad Dermatol. 2012 Nov; 67(5):803.e1-12, quiz 815-6. PMID: 23062903; PMCID: PMC3688468.
      49. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec 1; 303(11):E1354-62. PMID: 23047986; PMCID: PMC3774081.
      50. Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A. Protective role of vitamin D signaling in skin cancer formation. J Steroid Biochem Mol Biol. 2013 Jul; 136:271-9. PMID: 23059470; PMCID: PMC3596439.
      51. Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD. 1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the ß-catenin pathway. J Steroid Biochem Mol Biol. 2013 Jul; 136:229-32. PMID: 23026511; PMCID: PMC4102608.
      52. Bikle DD, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Curr Mol Pharmacol. 2012 Jun; 5(2):135-42. PMID: 21787292; PMCID: PMC3690777.
      53. Bikle DD. Vitamin D and bone. Curr Osteoporos Rep. 2012 Jun; 10(2):151-9. PMID: 22544628; PMCID: PMC3688475.
      54. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-9. PMID: 22622426; PMCID: PMC3434298.
      55. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66. PMID: 22623742; PMCID: PMC3725981.
      56. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92. PMID: 22596255; PMCID: PMC3365859.
      57. Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem. 2012 May 24; 55(10):4640-51. PMID: 22563729; PMCID: PMC3364162.
      58. Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH. Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes. J Invest Dermatol. 2012 Aug; 132(8):2097-100. PMID: 22495177; PMCID: PMC3396713.
      59. Bikle DD. Vitamin D and the skin: Physiology and pathophysiology. Rev Endocr Metab Disord. 2012 Mar; 13(1):3-19. PMID: 21845365; PMCID: PMC3687803.
      60. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95. PMID: 22277942; PMCID: PMC3305850.
      61. Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol. 2012 Apr; 132(4):1075-83. PMID: 22189783; PMCID: PMC3400544.
      62. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47. PMID: 21956637; PMCID: PMC3222747.
      63. Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res. 2011 Dec; 26(12):2948-58. PMID: 21932337; PMCID: PMC3222734.
      64. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 6; 287(2):1158-67. PMID: 22094462; PMCID: PMC3256874.
      65. Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD. Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. J Invest Dermatol. 2011 Nov; 131(11):2289-97. PMID: 21814234; PMCID: PMC3193543.
      66. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46. PMID: 21312270; PMCID: PMC3530140.
      67. Bikle DD. Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. 2011 Dec 5; 347(1-2):80-9. PMID: 21664236; PMCID: PMC3188673.
      68. Tang JY, Xiao TZ, Oda Y, Chang KS, Shpall E, Wu A, So PL, Hebert J, Bikle D, Epstein EH. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila). 2011 May; 4(5):744-51. PMID: 21436386; PMCID: PMC3088781.
      69. Tu CL, Chang W, Bikle DD. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28. PMID: 21209619; PMCID: PMC3078217.
      70. Bikle DD. Vitamin D: an ancient hormone. Exp Dermatol. 2011 Jan; 20(1):7-13. PMID: 21197695.
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      71. Bikle DD. Vitamin D regulation of immune function. Vitam Horm. 2011; 86:1-21. PMID: 21419265.
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      72. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Discov Med. 2011 Jan; 11(56):7-17. PMID: 21276406; PMCID: PMC4113511.
      73. Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM, Mauro TM. Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. Br J Dermatol. 2011 Jan; 164(1):16-25. PMID: 20846312; PMCID: PMC3010253.
      74. Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem. 2011 Jan 14; 286(2):997-1004. PMID: 21047796; PMCID: PMC3020784.
      75. Teichert A, Elalieh H, Bikle D. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice. J Cell Physiol. 2010 Nov; 225(2):482-9. PMID: 20458748; PMCID: PMC4103951.
      76. Oda Y, Chalkley RJ, Burlingame AL, Bikle DD. The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation. J Invest Dermatol. 2010 Oct; 130(10):2377-88. PMID: 20520624; PMCID: PMC4114506.
      77. Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y. Differential regulation of epidermal function by VDR coactivators. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):308-13. PMID: 20298785; PMCID: PMC2906691.
      78. Bikle DD. Vitamin D: newly discovered actions require reconsideration of physiologic requirements. Trends Endocrinol Metab. 2010 Jun; 21(6):375-84. PMID: 20149679; PMCID: PMC2880203.
      79. Bikle DD. Vitamin D and the skin. J Bone Miner Metab. 2010 Mar; 28(2):117-30. PMID: 20107849.
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      80. Asgari MM, Tang J, Warton ME, Chren MM, Quesenberry CP, Bikle D, Horst RL, Orentreich N, Vogelman JH, Friedman GD. Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. J Invest Dermatol. 2010 May; 130(5):1438-43. PMID: 20043012; PMCID: PMC2855394.
      81. Bikle DD. Vitamin D and immune function: understanding common pathways. Curr Osteoporos Rep. 2009 Jul; 7(2):58-63. PMID: 19631030.
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      82. Pao VY, Chang S, Shoback DM, Bikle DD. Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review. J Bone Miner Res. 2009 Jun; 24(6):1135-9. PMID: 19113910.
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      83. Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Quantification of the vitamin D receptor-coregulator interaction. Biochemistry. 2009 Feb 24; 48(7):1454-61. PMID: 19183053; PMCID: PMC2654718.
      84. Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD. Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. Mol Biol Cell. 2009 Mar; 20(6):1695-704. PMID: 19158393; PMCID: PMC2655244.
      85. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol. 2009 Jun; 129(6):1367-78. PMID: 19052561; PMCID: PMC2843519.
      86. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009 Jan; 94(1):26-34. PMID: 18854395; PMCID: PMC2630868.
      87. Bikle DD. Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism. J Invest Dermatol. 2008 Oct; 128(10):2357-61. PMID: 18787544.
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      88. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008; 1(35):ra1. PMID: 18765830; PMCID: PMC3538864.
      89. Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008 Jul; 17(4):348-52. PMID: 18660668.
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      90. Bikle DD. Growth hormone/insulin-like growth factor-1/PTH axis in bone. J Bone Miner Res. 2008 May; 23(5):581-3. PMID: 18433295.
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      91. Bikle DD. Integrins, insulin like growth factors, and the skeletal response to load. Osteoporos Int. 2008 Sep; 19(9):1237-46. PMID: 18373051.
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      92. Tu CL, Chang W, Xie Z, Bikle DD. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 8; 283(6):3519-28. PMID: 18065418.
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      93. Bikle DD. Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V50-4. PMID: 18290722.
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      194. Bikle DD, Halloran BP, Morey-Holton E. Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astronaut. 1994 Jul; 33:119-29. PMID: 11539511.
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      195. Su MJ, Bikle DD, Mancianti ML, Pillai S. 1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium. J Biol Chem. 1994 May 20; 269(20):14723-9. PMID: 7910167.
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      196. Bikle DD, Halloran BP, Riviere JE. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. J Invest Dermatol. 1994 May; 102(5):796-8. PMID: 8176265.
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      197. Kaune R, Munson S, Bikle DD. Regulation of calmodulin binding to the ATP extractable 110 kDa protein (myosin I) from chicken duodenal brush border by 1,25-(OH)2D3. Biochim Biophys Acta. 1994 Mar 23; 1190(2):329-36. PMID: 8142433.
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      198. Bikle DD, Gee E, Pillai S. Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol. 1993 Nov; 101(5):713-8. PMID: 8228333.
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      199. Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R. Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. Alcohol Clin Exp Res. 1993 Jun; 17(3):690-5. PMID: 8333602.
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      200. Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E. Skeletal unloading decreases production of 1,25-dihydroxyvitamin D. Am J Physiol. 1993 May; 264(5 Pt 1):E712-6. PMID: 8498493.
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      201. Bikle DD, Halloran B, Fong L, Steinbach L, Shellito J. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone. J Clin Endocrinol Metab. 1993 Feb; 76(2):456-61. PMID: 8432789.
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      202. Bikle DD, Pillai S. Vitamin D, calcium, and epidermal differentiation. Endocr Rev. 1993 Feb; 14(1):3-19. PMID: 8491153.
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      203. Bikle DD, Munson S, Morrison N, Eisman J. Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border. J Biol Chem. 1993 Jan 5; 268(1):620-6. PMID: 7678004.
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      204. Bikle DD. Alcohol-induced bone disease. World Rev Nutr Diet. 1993; 73:53-79. PMID: 8367983.
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      205. Pillai S, Menon GK, Bikle DD, Elias PM. Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes. J Cell Physiol. 1993 Jan; 154(1):101-12. PMID: 8419397.
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      206. Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. Am J Physiol. 1992 Dec; 263(6 Pt 1):E1164-70. PMID: 1476189.
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      207. Bikle DD. Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential. Endocr Rev. 1992 Nov; 13(4):765-84. PMID: 1459048.
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      208. Bikle DD, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992 Aug; 75(2):519-23. PMID: 1639954.
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      209. Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H. Effects of dietary protein deficiency on mineral metabolism and bone mineral density. Am J Clin Nutr. 1992 Aug; 56(2):314-9. PMID: 1636610.
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      210. Pillai S, Bikle DD. Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes. J Clin Invest. 1992 Jul; 90(1):42-51. PMID: 1321844; PMCID: PMC443061.
      211. Pillai S, Bikle DD. Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation. J Cell Physiol. 1992 Jun; 151(3):623-9. PMID: 1363554.
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      212. Bikle DD, Pillai S, Gee E. Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect. J Invest Dermatol. 1991 Sep; 97(3):435-41. PMID: 1875043.
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      213. Bikle DD, Pillai S, Gee E, Hincenbergs M. Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology. 1991 Jul; 129(1):33-8. PMID: 1675987.
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      214. Bikle DD, Munson S, Mancianti ML. Limited tissue distribution of the intestinal brush border myosin I protein. Gastroenterology. 1991 Feb; 100(2):395-402. PMID: 1985037.
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      215. Pillai S, Bikle DD, Mancianti ML, Hincenbergs M. Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines. Exp Cell Res. 1991 Feb; 192(2):567-73. PMID: 1988295.
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      216. Pillai S, Bikle DD. Epidermal vitamin D metabolism, function, and regulation. Adv Lipid Res. 1991; 24:321-41. PMID: 1763717.
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      217. Pillai S, Bikle DD. Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3. J Cell Physiol. 1991 Jan; 146(1):94-100. PMID: 1990023.
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      218. Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E. Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion. Am J Physiol. 1990 Nov; 259(5 Pt 1):E715-22. PMID: 2240210.
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      219. Pillai S, Bikle DD, Mancianti ML, Cline P, Hincenbergs M. Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J Cell Physiol. 1990 May; 143(2):294-302. PMID: 1970572.
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      220. Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S. Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease. J Clin Endocrinol Metab. 1989 Dec; 69(6):1234-9. PMID: 2584358.
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      221. Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, Morey-Holton E. Effects of simulated weightlessness on rat osteocalcin and bone calcium. Am J Physiol. 1989 Nov; 257(5 Pt 2):R1103-9. PMID: 2589536.
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      222. Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E. Bone response to normal weight bearing after a period of skeletal unloading. Am J Physiol. 1989 Oct; 257(4 Pt 1):E606-10. PMID: 2801939.
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      223. Barnes PF, Modlin RL, Bikle DD, Adams JS. Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. J Clin Invest. 1989 May; 83(5):1527-32. PMID: 2540219; PMCID: PMC303857.
      224. Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest. 1989 Mar; 83(3):816-21. PMID: 2466051; PMCID: PMC303753.
      225. Halloran BP, Bikle DD, Castro ME, Gee E. Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism. Biochemistry. 1989 Feb 7; 28(3):1278-81. PMID: 2713363.
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      226. Bikle DD, Gee E. Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology. 1989 Feb; 124(2):649-54. PMID: 2463902.
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      227. Bikle DD, Pillai S, Gee E, Hincenbergs M. Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology. 1989 Feb; 124(2):655-60. PMID: 2463903.
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      228. Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P. Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins. Biochim Biophys Acta. 1989 Jan 17; 1010(1):122-7. PMID: 2909247.
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      229. Halloran BP, Bikle DD, Cone CM, Morey-Holton E. Glucocorticoids and inhibition of bone formation induced by skeletal unloading. Am J Physiol. 1988 Dec; 255(6 Pt 1):E875-9. PMID: 3202163.
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      230. Taylor A, Bikle DD, Norman ME. Serum dihydrotachysterol levels and biological action in normal man. J Clin Endocrinol Metab. 1988 Jul; 67(1):198-202. PMID: 3379133.
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      231. Pillai S, Bikle DD, Elias PM. 1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation. J Biol Chem. 1988 Apr 15; 263(11):5390-5. PMID: 2451669.
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      232. Bikle DD. Effects of alcohol abuse on bone. Compr Ther. 1988 Feb; 14(2):16-20. PMID: 3278834.
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      233. Pillai S, Bikle DD, Hincenbergs M, Elias PM. Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium. J Cell Physiol. 1988 Feb; 134(2):229-37. PMID: 2450102.
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      234. Pillai S, Bikle DD, Elias PM. Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation. Skin Pharmacol. 1988; 1(3):149-60. PMID: 3078531.
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      235. Bikle DD, Pillai S. Vitamin D metabolite production and function in keratinocytes. Ann N Y Acad Sci. 1988; 548:27-44. PMID: 2470300.
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      236. Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle DD, Elias PM. The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro. Biochim Biophys Acta. 1987 Sep 14; 930(2):193-200. PMID: 3040120.
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      237. Cunningham J, Bikle DD, Avioli LV. Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney. J Bone Miner Res. 1987 Aug; 2(4):289-96. PMID: 3455615.
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      238. Bikle DD, Halloran BP, Cone CM, Globus RK, Morey-Holton E. The effects of simulated weightlessness on bone maturation. Endocrinology. 1987 Feb; 120(2):678-84. PMID: 3803298.
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      239. Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey-Holton ER. Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization. Endocrinology. 1986 Dec; 119(6):2580-5. PMID: 3780540.
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      240. Long RG, Bikle DD, Munson SJ. Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum. Endocrinology. 1986 Dec; 119(6):2568-73. PMID: 3780539.
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      241. Bikle DD, Gee EA, Munson SJ. Effect of ethanol on intestinal calcium transport in chicks. Gastroenterology. 1986 Oct; 91(4):870-6. PMID: 3743964.
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      242. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986 Oct; 63(4):954-9. PMID: 3745408.
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      243. Halloran BP, Bikle DD, Levens MJ, Castro ME, Globus RK, Holton E. Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. J Clin Invest. 1986 Sep; 78(3):622-8. PMID: 3489007; PMCID: PMC423635.
      244. Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J Clin Invest. 1986 Sep; 78(3):748-52. PMID: 3745436; PMCID: PMC423667.
      245. Bikle DD, Nemanic MK, Gee E, Elias P. 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest. 1986 Aug; 78(2):557-66. PMID: 2426308; PMCID: PMC423594.
      246. Bikle DD, Nemanic MK, Whitney JO, Elias PW. Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3. Biochemistry. 1986 Apr 8; 25(7):1545-8. PMID: 2423114.
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      247. Globus RK, Bikle DD, Halloran B, Morey-Holton E. Skeletal response to dietary calcium in a rat model simulating weightlessness. J Bone Miner Res. 1986 Apr; 1(2):191-7. PMID: 3503537.
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      248. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology. 1986 Mar; 118(3):948-54. PMID: 3485043.
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      249. Globus RK, Bikle DD, Morey-Holton E. The temporal response of bone to unloading. Endocrinology. 1986 Feb; 118(2):733-42. PMID: 3943489.
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      250. Bikle DD, Munson S. The villus gradient of brush border membrane calmodulin and the calcium-independent calmodulin-binding protein parallels that of calcium-accumulating ability. Endocrinology. 1986 Feb; 118(2):727-32. PMID: 3753677.
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      251. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism. Physiologist. 1985 Dec; 28(6 Suppl):S127-8. PMID: 3841737.
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      252. Bikle DD, Munson S. 1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane. J Clin Invest. 1985 Dec; 76(6):2312-6. PMID: 3841129; PMCID: PMC424356.
      253. Bikle DD, Halloran BP, Cone CM, Morey-Holton E. Bone loss during simulated weightlessness: is it glucocorticoid mediated? Physiologist. 1985 Dec; 28(6 Suppl):S123-4. PMID: 3834430.
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      254. Bikle DD, Siiteri PK, Ryzen E, Haddad JG. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab. 1985 Nov; 61(5):969-75. PMID: 3840175.
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      255. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. Bone disease in alcohol abuse. Ann Intern Med. 1985 Jul; 103(1):42-8. PMID: 2988390.
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      256. Bikle DD, Halloran BP, Whitney JO, Hollis BW. Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group. Biochemistry. 1984 Dec 18; 23(26):6920-5. PMID: 6543324.
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      257. Bikle DD, Zolock DT, Munson S. Differential response of duodenal epithelial cells to 1,25-dihydroxyvitamin D3 according to position on the villus: a comparison of calcium uptake, calcium-binding protein, and alkaline phosphatase activity. Endocrinology. 1984 Dec; 115(6):2077-84. PMID: 6548695.
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      258. Bikle DD, Gee E, Halloran B, Haddad JG. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest. 1984 Dec; 74(6):1966-71. PMID: 6549014; PMCID: PMC425383.
      259. Halloran BP, Bikle DD, Whitney JO. Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography. J Chromatogr. 1984 Oct 26; 303(1):229-33. PMID: 6511833.
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      260. Bikle DD, Munson S, Chafouleas J. Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport. FEBS Lett. 1984 Aug 20; 174(1):30-3. PMID: 6547914.
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      261. Globus RK, Bikle DD, Morey-Holton E. Effects of simulated weightlessness on bone mineral metabolism. Endocrinology. 1984 Jun; 114(6):2264-70. PMID: 6723581.
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      262. Bikle DD, Munson S, Chafouleas JG. The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane. Prog Clin Biol Res. 1984; 168:193-8. PMID: 6549067.
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      263. Bikle DD, Whitney J, Munson S. The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes. Endocrinology. 1984 Jan; 114(1):260-7. PMID: 6546306.
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      264. Cunningham J, Bikle DD, Avioli LV. Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism. Kidney Int. 1984 Jan; 25(1):47-52. PMID: 6610073.
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      265. Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle DD, Morey ER. Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton. Aviat Space Environ Med. 1983 Dec; 54(12 Pt 1):1080-4. PMID: 6661121.
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      266. Bikle DD, Munson S, Zolock DT. Calcium flux across chick duodenal brush border membrane vesicles: regulation by 1,25-dihydroxyvitamin D. Endocrinology. 1983 Dec; 113(6):2072-80. PMID: 6416812.
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      267. Bikle DD. Fluoride treatment of osteoporosis: a new look at an old drug. Ann Intern Med. 1983 Jun; 98(6):1013-5. PMID: 6859684.
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      268. Bikle DD. Calcium absorption and vitamin D metabolism. Clin Gastroenterol. 1983 May; 12(2):379-94. PMID: 6347462.
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      269. Bikle DD, Herman RH, Hull S, Hagler L, Harris D, Halloran B. Adaptive response of humans to changes in dietary calcium: relationship between vitamin D regulated intestinal function and serum 1,25-dihydroxyvitamin D levels. Gastroenterology. 1983 Feb; 84(2):314-23. PMID: 6687358.
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      270. Bikle DD, Herman RH. Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion. J Clin Endocrinol Metab. 1983 Jan; 56(1):11-7. PMID: 6292254.
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      271. Bikle DD, Peck CC, Holford NH, Zolock DT, Morrissey RL. Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick. Endocrinology. 1982 Sep; 111(3):939-46. PMID: 6896685.
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      272. Bikle DD. The vitamin D endocrine system. Adv Intern Med. 1982; 27:45-71. PMID: 7041549.
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      273. Rost CR, Bikle DD, Kaplan RA. In vitro stimulation of 25-hydroxycholecalciferol 1 alpha-hydroxylation by parathyroid hormone in chick kidney slices: evidence for a role for adenosine 3',5'-monophosphate. Endocrinology. 1981 Mar; 108(3):1002-6. PMID: 6257493.
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      274. Bikle DD, Zolock DT, Morrissey RL. Action of vitamin D on intestinal calcium transport. Ann N Y Acad Sci. 1981; 372:481-501. PMID: 6951425.
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      275. Bikle DD, Morrissey RL, Zolock DT, Rasmussen H. The intestinal response to vitamin D. Rev Physiol Biochem Pharmacol. 1981; 89:63-142. PMID: 7015459.
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      276. Bikle DD. Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase. Biochim Biophys Acta. 1980 Sep 9; 615(1):208-22. PMID: 6775702.
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      277. Bikle DD, Spencer EM, Burke WH, Rost CR. Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro. Endocrinology. 1980 Jul; 107(1):81-4. PMID: 6892897.
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      278. Bikle DD, Askew EW, Zolock DT, Morrissey RL, Herman RH. Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta. 1980 Jun 6; 598(3):561-74. PMID: 6155944.
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      279. Bikle DD, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM. Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3. Calcif Tissue Int. 1980; 32(1):9-17. PMID: 6775785.
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      280. Bikle DD, Morrissey RL, Zolock DT. The mechanism of action of vitamin D in the intestine. Am J Clin Nutr. 1979 Nov; 32(11):2322-8. PMID: 158978.
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      281. Bikle DD, Morrissey RL, Zolock DT, Herman RH. Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms. J Lab Clin Med. 1979 Jul; 94(1):88-94. PMID: 313969.
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      282. Bikle DD, Hagler L, Lollini LO, Hull SF, Herman RH. Work-induced muscle hypertrophy in vitamin D-deficient rats. Am J Clin Nutr. 1979 Mar; 32(3):515-6. PMID: 420144.
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      283. Morrissey RL, Zolock DT, Bucci TJ, Bikle DD. Immunoperoxidase localization of vitamin D dependent calcium binding protein. J Histochem Cytochem. 1978 Aug; 26(8):628-34. PMID: 357647.
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      284. Bikle DD, Rasmussen H. A biochemical model for the ionic control of 25-hydroxyvitamin D3 1alpha-hydroxylase. J Biol Chem. 1978 May 10; 253(9):3042-8. PMID: 25278.
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      285. Bikle DD, Zolock DT, Morrissey RL, Herman RH. Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis. J Biol Chem. 1978 Jan 25; 253(2):484-8. PMID: 618881.
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      286. Morrissey RL, Zolock DT, Bikle DD, Empson RN, Bucci TJ. Intestinal response to 1 alpha, 25-dihydroxycholecalciferol. I. RNA polymerase, alkaline phosphatase, calcium and phosphorus uptake in vitro, and in vivo calcium transport and accumulation. Biochim Biophys Acta. 1978 Jan 3; 538(1):23-33. PMID: 620061.
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      287. Bikle DD, Rasmussen H. Ionic control of 1,25-dihydroxy vitamin D-3 production by isolated chick renal mitochondria. Influence of anions and sucrose. Biochim Biophys Acta. 1978 Jan 3; 538(1):127-38. PMID: 413585.
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      288. Morrissey RL, Empson RN, Zolock DT, Bikle DD, Bucci TJ. Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein. Biochim Biophys Acta. 1978 Jan 3; 538(1):34-41. PMID: 620062.
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      289. Bikle DD, Empson RN, Herman RH, Morrissey RL, Zolock DR. The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus. Biochim Biophys Acta. 1977 Aug 25; 499(1):61-6. PMID: 889896.
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      290. Bikle DD, Murphy EW, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D-3 synthesis in isolated chick renal mitochondria. The role of potassium. Biochim Biophys Acta. 1976 Jul 21; 437(2):394-402. PMID: 8103.
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      291. Bikle DD, Murphy EW, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion. J Clin Invest. 1975 Feb; 55(2):299-304. PMID: 236327; PMCID: PMC301748.
      292. Bikle DD, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules. J Clin Invest. 1975 Feb; 55(2):292-8. PMID: 236326; PMCID: PMC301747.
      293. Bikle DD, Rasmussen H. A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria. Biochim Biophys Acta. 1974 Oct 8; 362(3):439-47. PMID: 4411605.
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      294. Bikle DD, Rasmussen H. The metabolism of 25-hydroxycholecalciferol by isolated renal tubules in vitro as studied by a new chromatographic technique. Biochim Biophys Acta. 1974 Oct 8; 362(3):425-38. PMID: 4370485.
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      295. Rasmussen H, Wong M, Bikle D, Goodman DB. Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. J Clin Invest. 1972 Sep; 51(9):2502-4. PMID: 4344734; PMCID: PMC292420.
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