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    Harold Collard

    TitleAssociate Professor of Clinical
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address505 Parnassus Ave, Moffitt
    San Francisco CA 94143
    Phone415-353-1043

       Overview 
       Overview
      Dr. Harold R. Collard is an associate professor of medicine in UCSF's Division of Pulmonary and Critical Care Medicine and the Director of the Interstitial Lung Disease Program at UCSF. His primary interest is in the management of patients with interstitial lung disease, including how best to diagnose and treat interstitial lung disease and how the condition impacts a patient's quality of life and survival.

      Dr. Collard earned a medical degree at Duke University. He completed an internship, residency and chief residency in internal medicine at UCSF as well as a fellowship in pulmonary and critical care medicine at the University of Colorado. Prior to joining UCSF, Dr. Collard was a member of the Interstitial Lung Disease Program at the National Jewish Medical and Research Center in Denver. Dr. Collard regularly sees patients with interstitial lung disease as part of the UCSF Interstitial Lung Disease Clinic (415-353-2577 (phone), http://www.ucsfhealth.org/ild).

      Research Interests

      Dr. Collard is a clinical and translational researcher focused on patients and populations of patients with interstitial lung disease. Dr. Collard is currently conducting projects investigating: (1) acute exacerbations of idiopathic pulmonary fibrosis (acute events that cause significant worsening of disease for many patients); (2) predicting disease progression (3) factors contributing to patients’ symptoms of shortness of breath and ways to improve patients’ quality of life; (4) clinical trials of promising but unproven therapies for patients with interstitial lung disease. Dr. Collard also supervises the UCSF ILD Program clinical database which contains data from over 1500 patients with various forms of interstitial lung disease.


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Raghu G, Behr J, Brown KK, Egan JJ, Kawut SM, Flaherty KR, Martinez FJ, Nathan SD, Wells AU, Collard HR, Costabel U, Richeldi L, de Andrade J, Khalil N, Morrison LD, Lederer DJ, Shao L, Li X, Pedersen PS, Montgomery AB, Chien JW, O'Riordan TG. Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med. 2013 May 7; 158(9):641-9.
        View in: PubMed
      2. Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, Hays S, Golden JA, Hoopes C, Kukreja J, Singer JP. Outcomes in systemic sclerosis-related lung disease after lung transplantation. Transplantation. 2013 Apr 15; 95(7):975-80.
        View in: PubMed
      3. Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Respir Med. 2013 Feb; 107(2):249-55.
        View in: PubMed
      4. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012; 13:105.
        View in: PubMed
      5. Collard HR, Morris A, Daley CL, Humbert M, Meyer KC. Clinical year in review IV: HIV, mycobacterial disease, pulmonary hypertension, and interstitial lung disease. Proc Am Thorac Soc. 2012 Oct; 9(4):204-9.
        View in: PubMed
      6. Adkins JM, Collard HR. Idiopathic pulmonary fibrosis. Semin Respir Crit Care Med. 2012 Oct; 33(5):433-9.
        View in: PubMed
      7. Ley B, Ryerson CJ, Vittinghoff E, Ryu JH, Tomassetti S, Lee JS, Poletti V, Buccioli M, Elicker BM, Jones KD, King TE, Collard HR. A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann Intern Med. 2012 May 15; 156(10):684-91.
        View in: PubMed
      8. Collard HR, Ward AJ, Lanes S, Cortney Hayflinger D, Rosenberg DM, Hunsche E. Burden of illness in idiopathic pulmonary fibrosis. J Med Econ. 2012; 15(5):829-35.
        View in: PubMed
      9. Raghu G, Collard HR, Anstrom KJ, Flaherty KR, Fleming TR, King TE, Martinez FJ, Brown KK. Idiopathic pulmonary fibrosis: clinically meaningful primary endpoints in phase 3 clinical trials. Am J Respir Crit Care Med. 2012 May 15; 185(10):1044-8.
        View in: PubMed
      10. Ryerson CJ, Arean PA, Berkeley J, Carrieri-Kohlman VL, Pantilat SZ, Landefeld CS, Collard HR. Depression is a common and chronic comorbidity in patients with interstitial lung disease. Respirology. 2012 Apr; 17(3):525-32.
        View in: PubMed
      11. Klein OL, Jones M, Lee J, Collard HR, Smith LJ. Reduced lung diffusion capacity in type 2 diabetes is independent of heart failure. Diabetes Res Clin Pract. 2012 Jun; 96(3):e73-5.
        View in: PubMed
      12. Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR. Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis. Thorax. 2012 May; 67(5):407-11.
        View in: PubMed
      13. Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ. Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Histopathology. 2012 Jul; 61(1):98-106.
        View in: PubMed
      14. King TE, Collard HR, Richeldi L. Interstitial lung diseases. Preface. Clin Chest Med. 2012 Mar; 33(1):xiii.
        View in: PubMed
      15. Ley B, Collard HR. Risk prediction in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012 Jan 1; 185(1):6-7.
        View in: PubMed
      16. Lee JS, Song JW, Wolters PJ, Elicker BM, King TE, Kim DS, Collard HR. Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis. Eur Respir J. 2012 Feb; 39(2):352-8.
        View in: PubMed
      17. Ryerson CJ, Collard HR. How to build a biomarker: IL-7 and acute exacerbation of IPF. Sarcoidosis Vasc Diffuse Lung Dis. 2011 Oct; 28(2):83-4.
        View in: PubMed
      18. Lee JS, McLaughlin S, Collard HR. Comprehensive care of the patient with idiopathic pulmonary fibrosis. Curr Opin Pulm Med. 2011 Sep; 17(5):348-54.
        View in: PubMed
      19. Ryerson CJ, Abbritti M, Ley B, Elicker BM, Jones KD, Collard HR. Cough predicts prognosis in idiopathic pulmonary fibrosis. Respirology. 2011 Aug; 16(6):969-75.
        View in: PubMed
      20. Lee JS, Collard HR. Primum non nocere: safety in clinical trials for IPF. Respirology. 2011 Jul; 16(5):723-4.
        View in: PubMed
      21. Lee JS, Ryu JH, Elicker BM, Lydell CP, Jones KD, Wolters PJ, King TE, Collard HR. Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1390-4.
        View in: PubMed
      22. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE, Kondoh Y, Myers J, Müller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schünemann HJ. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011 Mar 15; 183(6):788-824.
        View in: PubMed
      23. Wootton SC, Kim DS, Kondoh Y, Chen E, Lee JS, Song JW, Huh JW, Taniguchi H, Chiu C, Boushey H, Lancaster LH, Wolters PJ, DeRisi J, Ganem D, Collard HR. Viral infection in acute exacerbation of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1698-702.
        View in: PubMed
      24. Ley B, Collard HR, King TE. Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Feb 15; 183(4):431-40.
        View in: PubMed
      25. Ryerson CJ, Berkeley J, Carrieri-Kohlman VL, Pantilat SZ, Landefeld CS, Collard HR. Depression and functional status are strongly associated with dyspnea in interstitial lung disease. Chest. 2011 Mar; 139(3):609-16.
        View in: PubMed
      26. Ryerson CJ, Garvey C, Collard HR. Pulmonary rehabilitation for interstitial lung disease. Chest. 2010 Jul; 138(1):240-1; author reply 241-2.
        View in: PubMed
      27. Ryerson CJ, Collard HR, Pantilat SZ. Management of dyspnea in interstitial lung disease. Curr Opin Support Palliat Care. 2010 Jun; 4(2):69-75.
        View in: PubMed
      28. A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis. N Engl J Med. 2010 Aug 12; 363(7):620-8.
        View in: PubMed
      29. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7.
        View in: PubMed
      30. Collard HR. The age of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2010 Apr 15; 181(8):771-2.
        View in: PubMed
      31. Lee JS, Collard HR, Raghu G, Sweet MP, Hays SR, Campos GM, Golden JA, King TE. Does chronic microaspiration cause idiopathic pulmonary fibrosis? Am J Med. 2010 Apr; 123(4):304-11.
        View in: PubMed
      32. Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE. Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. Lung. 2010 Apr; 188(2):143-9.
        View in: PubMed
      33. Collard HR. Idiopathic pulmonary fibrosis and pirfenidone. Eur Respir J. 2010 Apr; 35(4):728-9.
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      34. Kim EJ, Elicker BM, Maldonado F, Webb WR, Ryu JH, Van Uden JH, Lee JS, King TE, Collard HR. Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J. 2010 Jun; 35(6):1322-8.
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      35. Kim EJ, Collard HR, King TE. Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern. Chest. 2009 Nov; 136(5):1397-405.
        View in: PubMed
      36. Chen H, Gomez A, Shum A, Collard HR. Longitudinal lung function in idiopathic NSIP: what are we missing? Eur Respir J. 2009 Oct; 34(4):1004; author reply 1004-5.
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      37. Lancaster LH, Mason WR, Parnell JA, Rice TW, Loyd JE, Milstone AP, Collard HR, Malow BA. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest. 2009 Sep; 136(3):772-8.
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      38. Zamora AC, Collard HR, Barrera L, Mendoza F, Webb WR, Carrillo G. Silicone injection causing acute pneumonitis: a case series. Lung. 2009 Aug; 187(4):241-4.
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      39. Ferreira A, Garvey C, Connors GL, Hilling L, Rigler J, Farrell S, Cayou C, Shariat C, Collard HR. Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response. Chest. 2009 Feb; 135(2):442-7.
        View in: PubMed
      40. Collard HR, Pantilat SZ. Dyspnea in interstitial lung disease. Curr Opin Support Palliat Care. 2008 Jun; 2(2):100-4.
        View in: PubMed
      41. Collard HR, King TE. Idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia should stay separate. Eur Respir J. 2008 May; 31(5):1141-2; author reply 1142-3.
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      42. Zamora AC, Wolters PJ, Collard HR, Connolly MK, Elicker BM, Webb WR, King TE, Golden JA. Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease. Respir Med. 2008 Jan; 102(1):150-5.
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      43. Goldschlager N, Epstein AE, Naccarelli GV, Olshansky B, Singh B, Collard HR, Murphy E. A practical guide for clinicians who treat patients with amiodarone: 2007. Heart Rhythm. 2007 Sep; 4(9):1250-9.
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      44. Collard HR, Moore BB, Flaherty KR, Brown KK, Kaner RJ, King TE, Lasky JA, Loyd JE, Noth I, Olman MA, Raghu G, Roman J, Ryu JH, Zisman DA, Hunninghake GW, Colby TV, Egan JJ, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kondoh Y, Lynch DA, Müller-Quernheim J, Myers JL, Nicholson AG, Selman M, Toews GB, Wells AU, Martinez FJ. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2007 Oct 1; 176(7):636-43.
        View in: PubMed
      45. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Am J Respir Crit Care Med. 2007 Oct 1; 176(7):691-7.
        View in: PubMed
      46. Collard HR, Loyd JE, King TE, Lancaster LH. Current diagnosis and management of idiopathic pulmonary fibrosis: a survey of academic physicians. Respir Med. 2007 Sep; 101(9):2011-6.
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      47. Flanders SA, Saint S, Collard HR. In response to Silvestri. Am J Infect Control. 2007 May; 35(4):284-5.
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      48. Collard HR. On beyond zebra: understanding rare diseases. Chest. 2007 Mar; 131(3):644-6.
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      49. Collard HR, Anstrom KJ, Schwarz MI, Zisman DA. Sildenafil improves walk distance in idiopathic pulmonary fibrosis. Chest. 2007 Mar; 131(3):897-9.
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      50. Collard HR, Cool CD, Leslie KO, Curran-Everett D, Groshong S, Brown KK. Organizing pneumonia and lymphoplasmacytic inflammation predict treatment response in idiopathic pulmonary fibrosis. Histopathology. 2007 Jan; 50(2):258-65.
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      51. Collard HR, Tino G, Noble PW, Shreve MA, Michaels M, Carlson B, Schwarz MI. Patient experiences with pulmonary fibrosis. Respir Med. 2007 Jun; 101(6):1350-4.
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      52. Zamora AC, Collard HR, Wolters PJ, Webb WR, King TE. Neurofibromatosis-associated lung disease: a case series and literature review. Eur Respir J. 2007 Jan; 29(1):210-4.
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      53. Kinder BW, Collard HR, King TE. Anticoagulant therapy and idiopathic pulmonary fibrosis. Chest. 2006 Jul; 130(1):302-3.
        View in: PubMed
      54. Kim DS, Collard HR, King TE. Classification and natural history of the idiopathic interstitial pneumonias. Proc Am Thorac Soc. 2006 Jun; 3(4):285-92.
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      55. Walter N, Collard HR, King TE. Current perspectives on the treatment of idiopathic pulmonary fibrosis. Proc Am Thorac Soc. 2006 Jun; 3(4):330-8.
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      56. Flanders SA, Collard HR, Saint S. Nosocomial pneumonia: state of the science. Am J Infect Control. 2006 Mar; 34(2):84-93.
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      57. Janssen WJ, Collard HR, Saint S, Weinberger SE. Clinical problem-solving. A perfect storm. N Engl J Med. 2005 Nov 3; 353(18):1956-61.
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      58. Safdar N, Dezfulian C, Collard HR, Saint S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med. 2005 Oct; 33(10):2184-93.
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      59. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005 Jan; 118(1):11-8.
        View in: PubMed
      60. Janssen WJ, Dhaliwal G, Collard HR, Saint S. Clinical problem-solving. Why "why" matters. N Engl J Med. 2004 Dec 2; 351(23):2429-34.
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      61. Collard HR, Schwarz MI. Diffuse alveolar hemorrhage. Clin Chest Med. 2004 Sep; 25(3):583-92, vii.
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      62. Collard HR, Ryu JH, Douglas WW, Schwarz MI, Curran-Everett D, King TE, Brown KK. Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis. Chest. 2004 Jun; 125(6):2169-74.
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      63. Thabut G, Fournier M, Collard HR, Brown KK. Prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2004 May 1; 169(9):1075-6; author reply 1076.
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      64. Collard HR, Gruber MP, Weinberger SE, Saint S. Clinical problem-solving. Anatomy of a diagnosis. N Engl J Med. 2003 Sep 4; 349(10):987-92.
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      65. Collard HR, King TE, Bartelson BB, Vourlekis JS, Schwarz MI, Brown KK. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003 Sep 1; 168(5):538-42.
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      66. Collard HR, Saint S, Matthay MA. Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Ann Intern Med. 2003 Mar 18; 138(6):494-501.
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      67. Collard HR, King TE. Demystifying idiopathic interstitial pneumonia. Arch Intern Med. 2003 Jan 13; 163(1):17-29.
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      68. Jha AK, Collard HR, Tierney LM. Clinical problem-solving. Diagnosis still in question. N Engl J Med. 2002 Jun 6; 346(23):1813-6.
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      69. Collard HR, King TE. Lung biopsy in patients with usual interstitial pneumonia. Eur Respir J. 2001 Nov; 18(5):895-8.
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      70. Collard HR, King TE. The clinical significance of histopathologic subgroups in idiopathic interstitial pneumonia: is surgical lung biopsy essential? Semin Respir Crit Care Med. 2001 Aug; 22(4):347-56.
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      71. Collard HR, King TE. Treatment of idiopathic pulmonary fibrosis: the rise and fall of corticosteroids. Am J Med. 2001 Mar; 110(4):326-8.
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      72. Collard HR, Boeck A, Mc Laughlin TM, Watson TJ, Schiff SE, Hale LP, Markert ML. Possible extrathymic development of nonfunctional T cells in a patient with complete DiGeorge syndrome. Clin Immunol. 1999 May; 91(2):156-62.
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      73. Markert ML, Finkel BD, McLaughlin TM, Watson TJ, Collard HR, McMahon CP, Andrews LG, Barrett MJ, Ward FE. Mutations in purine nucleoside phosphorylase deficiency. Hum Mutat. 1997; 9(2):118-21.
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      74. Mehta BA, Collard HR, Negrin RS. The role of N-linked carbohydrate residues in lymphokine-activated killer cell-mediated cytolysis. Cell Immunol. 1994 Apr 15; 155(1):95-110.
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      75. Ambrosino DM, Bolon D, Collard H, Van Etten R, Kanchana MV, Finberg RW. Effect of Haemophilus influenzae polysaccharide outer membrane protein complex conjugate vaccine on macrophages. J Immunol. 1992 Dec 15; 149(12):3978-83.
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      76. Ambrosino DM, Sood SK, Lee MC, Chen D, Collard HR, Bolon DL, Johnson C, Daum RS. IgG1, IgG2 and IgM responses to two Haemophilus influenzae type b conjugate vaccines in young infants. Pediatr Infect Dis J. 1992 Oct; 11(10):855-9.
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