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Hua Su, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address1001 Potrero Ave, SFGH 1
San Francisco CA 94110
Phone415-206-3162
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Fellow1992Medicine

    Collapse Overview 
    Collapse Overview
    My research interests include: (1) adeno-associated viral vector (AAV)-mediated tissue specific gene transfer and gene expression; (2) the pathogenesis of cerebrovascular malformation; (3) development of new therapies for ischemic stroke and arteriovenous malformation; and (4) the impact of aging, peripheral injury (such as bone fracture), and innate immune response on stroke recovery.


    Collapse Research 
    Collapse Research Activities and Funding
    Cell type-specific influences on HHT pathogenesis
    NIH R01HL122774Jan 16, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Soluble VEGF receptor therapy for brain arteriovenous malformation
    NIH R21NS083788Apr 15, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Targeted Gene Expression in Ischemic Brain by Intravenous Delivery
    NIH R21NS070153Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Co-Investigator
    Hemodynamics of Cerebral Arteriovenous Malformations
    NIH R01NS027713Aug 1, 1990 - Dec 31, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zou D, Luo M, Han Z, Zhan L, Zhu W, Kang S, Bao C, Li Z, Nelson J, Zhang R, Su H. Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. Mol Neurobiol. 2016 Dec 02. PMID: 27914011.
      View in: PubMed
    2. Gorman JR, Whitcomb BW, Standridge D, Malcarne VL, Romero SA, Roberts SA, Su HI. Adoption consideration and concerns among young adult female cancer survivors. J Cancer Surviv. 2016 Sep 30. PMID: 27696249.
      View in: PubMed
    3. Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H, et al. Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation. Angiogenesis. 2016 Jun 20. PMID: 27325285.
      View in: PubMed
    4. Liu J, Su H, Qu QM, et al. Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy. Neurochem Res. 2016 May 11. PMID: 27168327.
      View in: PubMed
    5. Cook-Andersen H, Curnow KJ, Su HI, Chang RJ, Shimasaki S. Growth and differentiation factor 9 promotes oocyte growth at the primary but not the early secondary stage in three-dimensional follicle culture. J Assist Reprod Genet. 2016 Aug; 33(8):1067-77. PMID: 27155601; PMCID: PMC4974221 [Available on 08/01/17].
    6. Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H. Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. PLoS One. 2016; 11(4):e0153835. PMID: 27089041.
      View in: PubMed
    7. Zhang JY, Deng YN, Zhang M, Su H, Qu QM. SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model. Neurochem Res. 2016 Jul; 41(7):1761-73. PMID: 27053302.
      View in: PubMed
    8. Johns C, Seav SM, Dominick SA, Gorman JR, Li H, Natarajan L, Mao JJ, Su HI. Informing hot flash treatment decisions for breast cancer survivors: a systematic review of randomized trials comparing active interventions. Breast Cancer Res Treat. 2016 Apr; 156(3):415-26. PMID: 27015968; PMCID: PMC4838539 [Available on 04/01/17].
    9. Kim J, Mersereau JE, Su HI, Whitcomb BW, Malcarne VL, Gorman JR. Young female cancer survivors' use of fertility care after completing cancer treatment. Support Care Cancer. 2016 Jul; 24(7):3191-9. PMID: 26939923; PMCID: PMC4879047 [Available on 07/01/17].
    10. Deng YN, Zeng JY, Su H, Qu QM. Recombinant VLP-Z of JC Polyomavirus: A Novel Vector for Targeting Gene Delivery. Intervirology. 2015; 58(6):363-8. PMID: 26909539.
      View in: PubMed
    11. Huo K, Hashim SI, Yong KL, Su H, Qu QM. Impact and risk factors of post-stroke bone fracture. World J Exp Med. 2016 Feb 20; 6(1):1-8. PMID: 26929915.
      View in: PubMed
    12. Zhang R, Zhu W, Su H. Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. Acta Neurochir Suppl. 2016; 121:29-35. PMID: 26463919; PMCID: PMC4654926 [Available on 01/01/16].
    13. Dominick S, Hickey M, Chin J, Su HI. Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen. Cochrane Database Syst Rev. 2015; (12):CD007245. PMID: 26649916.
      View in: PubMed
    14. Dominick SA, McLean MR, Whitcomb BW, Gorman JR, Mersereau JE, Bouknight JM, Su HI. Contraceptive Practices Among Female Cancer Survivors of Reproductive Age. Obstet Gynecol. 2015 Sep; 126(3):498-507. PMID: 26181090; PMCID: PMC4545298.
    15. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels(?). Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    16. Brier MJ, Chambless D, Gross R, Su HI, DeMichele A, Mao JJ. Association between self-report adherence measures and oestrogen suppression among breast cancer survivors on aromatase inhibitors. Eur J Cancer. 2015 Sep; 51(14):1890-6. PMID: 26169018.
      View in: PubMed
    17. Ma L, Guo Y, Zhao YL, Su H . Review. The role of macrophage in the pathogenesis of brain arteriovenous malformation. 2015; 1(2):52-56.
    18. Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H. Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1. Gene Ther. 2015 Nov; 22(11):893-900. PMID: 26090874; PMCID: PMC4636448 [Available on 05/01/16].
    19. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe SE, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang JT. Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol. 2015 Mar 15; 194(6):2551-60. PMID: 25667416; PMCID: PMC4355235.
    20. Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J. Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells. Transl Stroke Res.2015 Feb;6(1):50-59. 2015; 1(6):50-59.
    21. Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb; 21(1):120-8. PMID: 25934786.
      View in: PubMed
    22. Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT. Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis. J Vis Exp. 2015; (95):50472. PMID: 25650793; PMCID: PMC4354570.
    23. Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015; 1(22):195-198.
    24. Ma L, Guo Y, Zhao YL, Su H. The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation. Int J Hematol Res. 2015 Jan 1; 1(2):52-56. PMID: 26495437.
      View in: PubMed
    25. Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9. PMID: 25450638.
      View in: PubMed
    26. Gorman JR, Su HI, Roberts SC, Dominick SA, Malcarne VL. Experiencing reproductive concerns as a female cancer survivor is associated with depression. Cancer. 2015 Mar 15; 121(6):935-42. PMID: 25377593; PMCID: PMC4352116.
    27. Guo Y, Tihan T, Lawton MT, Kim H, Young WL, Zhao Y, Su H . Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation. Neuroimmunology and Neuroinflammation. 2014; 1(3):147-152.
    28. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H. Activation of a-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PLoS One. 2014; 9(8):e105711. PMID: 25157794; PMCID: PMC4144901.
    29. Han Z, Li L, Wang L, Degos V, Maze M, Su H. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov; 131(4):498-508. PMID: 25040630; PMCID: PMC4221541.
    30. Gorman JR, Roberts SC, Dominick SA, Malcarne VL, Dietz AC, Su HI. A Diversified Recruitment Approach Incorporating Social Media Leads to Research Participation Among Young Adult-Aged Female Cancer Survivors. J Adolesc Young Adult Oncol. 2014 Jun 1; 3(2):59-65. PMID: 24940529.
      View in: PubMed
    31. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H. Endoglin deficiency impairs stroke recovery. Stroke. 2014 Jul; 45(7):2101-6. PMID: 24876084; PMCID: PMC4118747.
    32. Dominick SA, Whitcomb BW, Gorman JR, Mersereau JE, Chung K, Su HI. Factors associated with pregnancy attempts among female young adult cancer survivors. J Cancer Surviv. 2014 Dec; 8(4):571-9. PMID: 24859010; PMCID: PMC4221647.
    33. Chen W, Choi EJ, McDougall CM, Su H. Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets. Transl Stroke Res. 2014 Jun; 5(3):316-29. PMID: 24723256; PMCID: PMC4081044.
    34. Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS One. 2014; 9(2):e88511. PMID: 24520391; PMCID: PMC3919779.
    35. Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H. De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation. Stroke. 2014 Mar; 45(3):900-2. PMID: 24457293; PMCID: PMC4117234.
    36. Chen W, Young WL, Su H. Induction of brain arteriovenous malformation in the adult mouse. Methods Mol Biol. 2014; 1135:309-16. PMID: 24510874; PMCID: PMC3988785.
    37. Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunol Neuroinflamm. 2014; 1(3):147-152. PMID: 25568888.
      View in: PubMed
    38. Gorman JR, Su HI, Pierce JP, Roberts SC, Dominick SA, Malcarne VL. A multidimensional scale to measure the reproductive concerns of young adult female cancer survivors. J Cancer Surviv. 2014 Jun; 8(2):218-28. PMID: 24352870; PMCID: PMC4016119.
    39. Su HI, Sue LY, Flatt SW, Natarajan L, Patterson RE, Pierce JP. Endogenous estradiol is not associated with poor physical health in postmenopausal breast cancer survivors. J Womens Health (Larchmt). 2013 Dec; 22(12):1043-8. PMID: 24111813; PMCID: PMC3852607.
    40. Mersereau JE, Goodman LR, Deal AM, Gorman JR, Whitcomb BW, Su HI. To preserve or not to preserve: how difficult is the decision about fertility preservation? Cancer. 2013 Nov 15; 119(22):4044-50. PMID: 24037854; PMCID: PMC3935984.
    41. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H. Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology. 2013 Jun; 118(6):1362-72. PMID: 23438676; PMCID: PMC3987811.
    42. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013 Mar; 118(3):527-36. PMID: 23426204; PMCID: PMC3779063.
    43. Choi EJ, Walker EJ, Degos V, Jun K, Kuo R, Pile-Spellman J, Su H, Young WL. Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation. Stroke. 2013 Mar; 44(3):795-8. PMID: 23306322; PMCID: PMC3582755.
    44. Shen F, Kuo R, Milon-Camus M, Han Z, Jiang L, Young WL, Su H. Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci. Stroke. 2013 Jan; 44(1):252-4. PMID: 23250995; PMCID: PMC3531817.
    45. Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):305-10. PMID: 23241407; PMCID: PMC3569037.
    46. Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Neuroreport. 2012 Jul 11; 23(10):627-30. PMID: 22643235; PMCID: PMC3535489.
    47. Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc Dis. 2012; 33(6):540-7. PMID: 22571958; PMCID: PMC3569027.
    48. Walker EJ, Su H, Shen F, Degos V, Amend G, Jun K, Young WL. Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain. Stroke. 2012 Jul; 43(7):1925-30. PMID: 22569934; PMCID: PMC3404823.
    49. Caan BJ, Emond JA, Su HI, Patterson RE, Flatt SW, Gold EB, Newman VA, Rock CL, Thomson CA, Pierce JP. Effect of postdiagnosis weight change on hot flash status among early-stage breast cancer survivors. J Clin Oncol. 2012 May 1; 30(13):1492-7. PMID: 22430275; PMCID: PMC4874147.
    50. Friedman CF, DeMichele A, Su HI, Feng R, Kapoor S, Desai K, Mao JJ. Vitamin d deficiency in postmenopausal breast cancer survivors. J Womens Health (Larchmt). 2012 Apr; 21(4):456-62. PMID: 22385131; PMCID: PMC3321674.
    51. Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL. Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Stroke. 2012 May; 43(5):1240-6. PMID: 22308253; PMCID: PMC3335931.
    52. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329. PMID: 22272337; PMCID: PMC3260268.
    53. Gorman JR, Bailey S, Pierce JP, Su HI. How do you feel about fertility and parenthood? The voices of young female cancer survivors. J Cancer Surviv. 2012 Jun; 6(2):200-9. PMID: 22179785; PMCID: PMC3667153.
    54. Walker EJ, Shen F, Young WL, Su H. Cerebrovascular casting of the adult mouse for 3D imaging and morphological analysis. J Vis Exp. 2011; (57):e2958. PMID: 22143104; PMCID: PMC3235703.
    55. Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H. Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res. 2011 Sep; 2(3):366-75. PMID: 22022343; PMCID: PMC3196661.
    56. Shen F, Walker EJ, Jiang L, Degos V, Li J, Sun B, Heriyanto F, Young WL, Su H. Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2343-51. PMID: 21772310; PMCID: PMC3323197.
    57. Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL. Arteriovenous malformation in the adult mouse brain resembling the human disease. Ann Neurol. 2011 Jun; 69(6):954-62. PMID: 21437931; PMCID: PMC3117949.
    58. Mao JJ, Su HI, Feng R, Donelson ML, Aplenc R, Rebbeck TR, Stanczyk F, DeMichele A. Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors. Breast Cancer Res. 2011 Jan 20; 13(1):R8. PMID: 21251330; PMCID: PMC3109575.
    59. Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl. 2011; 111:83-92. PMID: 21725736; PMCID: PMC3187860.
    60. Su H, Yang GY. Treatment of focal brain ischemia with viral vector-mediated gene transfer. Methods Mol Biol. 2011; 686:429-46. PMID: 21082386.
      View in: PubMed
    61. Su HI, Chung K, Sammel MD, Gracia CR, DeMichele A. Antral follicle count provides additive information to hormone measures for determining ovarian function in breast cancer survivors. Fertil Steril. 2011 Apr; 95(5):1857-9. PMID: 21193192; PMCID: PMC3062716.
    62. Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, Young WL. Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9. Stroke. 2011 Feb; 42(2):453-8. PMID: 21164138; PMCID: PMC3026909.
    63. Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12; 330(6006):985-9. PMID: 21071672; PMCID: PMC3099479.
    64. Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL. Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery. 2010 Oct; 67(4):1029-35. PMID: 20881566; PMCID: PMC2949301.
    65. Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL. VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Transl Stroke Res. 2010 Sep 1; 1(3):197-201. PMID: 20640035.
      View in: PubMed
    66. Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB. MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell. 2010 Apr 2; 6(4):323-35. PMID: 20362537; PMCID: PMC2851637.
    67. Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 2010 Apr; 67(4):488-97. PMID: 20437584; PMCID: PMC3026588.
    68. Su HI, Sammel MD, Springer E, Freeman EW, DeMichele A, Mao JJ. Weight gain is associated with increased risk of hot flashes in breast cancer survivors on aromatase inhibitors. Breast Cancer Res Treat. 2010 Nov; 124(1):205-11. PMID: 20182796; PMCID: PMC3670946.
    69. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27. PMID: 20019187; PMCID: PMC2808104.
    70. Gao P, Shen F, Gabriel RA, Law D, Yang E, Yang GY, Young WL, Su H. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke. 2009 Nov; 40(11):3596-600. PMID: 19745179; PMCID: PMC2783321.
    71. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53. PMID: 19554624.
      View in: PubMed
    72. Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 2009 Jul; 66(1):19-27. PMID: 19670444; PMCID: PMC2773229.
    73. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. PMID: 19458547; PMCID: PMC2728585.
    74. Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL. Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab. 2009 Aug; 29(8):1482-90. PMID: 19471278; PMCID: PMC2745831.
    75. Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Stroke. 2009 Mar; 40(3 Suppl):S95-7. PMID: 19064791; PMCID: PMC2677752.
    76. Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY. Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2250-6. PMID: 18835925; PMCID: PMC2614529.
    77. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):419-22. PMID: 18789891.
      View in: PubMed
    78. Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY. Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2151-7. PMID: 18802012; PMCID: PMC2610019.
    79. Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB. Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Radiology. 2008 Nov; 249(2):560-71. PMID: 18780824; PMCID: PMC2657866.
    80. Fan Y, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY. Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1543-51. PMID: 18461079; PMCID: PMC2581494.
    81. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 3; 133(2):191-7. PMID: 18295361; PMCID: PMC2692365.
    82. Beiter T, Zimmermann M, Fragasso A, Armeanu S, Lauer UM, Bitzer M, Su H, Young WL, Niess AM, Simon P. Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping. Exerc Immunol Rev. 2008; 14:73-85. PMID: 19203085.
      View in: PubMed
    83. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. 2008 Jan; 10(1):33-41. PMID: 18044793.
      View in: PubMed
    84. Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl. 2008; 105:199-206. PMID: 19066109; PMCID: PMC2640934.
    85. Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1853-60. PMID: 17392691.
      View in: PubMed
    86. Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol. 2007; 366:331-42. PMID: 17568134.
      View in: PubMed
    87. Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci. 2006; 11:3190-8. PMID: 16720385.
      View in: PubMed
    88. Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 2006 Oct; 37(10):2601-6. PMID: 16946160.
      View in: PubMed
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