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Hua Su, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-3162
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Fellow1992Medicine

    Collapse Overview 
    Collapse Overview
    My research interests include: (1) adeno-associated viral vector (AAV)-mediated tissue specific gene transfer and gene expression; (2) the pathogenesis of cerebrovascular malformation; (3) development of new therapies for ischemic stroke and arteriovenous malformation; and (4) the impact of aging, peripheral injury (such as bone fracture), and innate immune response on stroke recovery.


    Collapse Research 
    Collapse Research Activities and Funding
    Cell type-specific influences on HHT pathogenesis
    NIH/NHLBI R01HL122774Jan 16, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Soluble VEGF receptor therapy for brain arteriovenous malformation
    NIH/NINDS R21NS083788Apr 15, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Targeted Gene Expression in Ischemic Brain by Intravenous Delivery
    NIH/NINDS R21NS070153Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH/NINDS P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Co-Investigator
    Hemodynamics of Cerebral Arteriovenous Malformations
    NIH/NINDS R01NS027713Aug 1, 1990 - Dec 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Transl Stroke Res. 2017 Sep 13. PMID: 28900857.
      View in: PubMed
    2. Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H. Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Stroke. 2017 Oct; 48(10):2881-2884. PMID: 28855391.
      View in: PubMed
    3. Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H. Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Stroke. 2017 May; 48(5):1420-1423. PMID: 28325846.
      View in: PubMed
    4. Ma L, Kim H, Chen XL, Wu CX, Ma J, Su H, Zhao Y. Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation. Cerebrovasc Dis. 2017; 43(5-6):231-241. PMID: 28241126.
      View in: PubMed
    5. Zou D, Luo M, Han Z, Zhan L, Zhu W, Kang S, Bao C, Li Z, Nelson J, Zhang R, Su H. Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. Mol Neurobiol. 2016 Dec 02. PMID: 27914011.
      View in: PubMed
    6. Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H. Integrin ß8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice. Transl Stroke Res. 2016 Dec; 7(6):488-496. PMID: 27352867.
      View in: PubMed
    7. Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H, et al. Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation. Angiogenesis. 2016 Oct; 19(4):451-461. PMID: 27325285.
      View in: PubMed
    8. Liu J, Su H, Qu QM, et al. Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy. Neurochem Res. 2016 Sep; 41(9):2311-23. PMID: 27168327.
      View in: PubMed
    9. Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T. Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages. Clin Neuropathol. 2016 May-Jun; 35(3):114-21. PMID: 27049066; PMCID: PMC4910647.
    10. Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H. Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. PLoS One. 2016; 11(4):e0153835. PMID: 27089041; PMCID: PMC4835054.
    11. Zhang JY, Deng YN, Zhang M, Su H, Qu QM. SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model. Neurochem Res. 2016 Jul; 41(7):1761-73. PMID: 27053302.
      View in: PubMed
    12. Deng YN, Zeng JY, Su H, Qu QM. Recombinant VLP-Z of JC Polyomavirus: A Novel Vector for Targeting Gene Delivery. Intervirology. 2015; 58(6):363-8. PMID: 26909539.
      View in: PubMed
    13. Huo K, Hashim SI, Yong KL, Su H, Qu QM. Impact and risk factors of post-stroke bone fracture. World J Exp Med. 2016 Feb 20; 6(1):1-8. PMID: 26929915; PMCID: PMC4759351.
    14. Zhang R, Zhu W, Su H. Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. Acta Neurochir Suppl. 2016; 121:29-35. PMID: 26463919; PMCID: PMC4654926.
    15. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    16. Ma L, Guo Y, Zhao YL, Su H . Review. The role of macrophage in the pathogenesis of brain arteriovenous malformation. 2015; 1(2):52-56.
    17. Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H. Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1. Gene Ther. 2015 Nov; 22(11):893-900. PMID: 26090874; PMCID: PMC4636448.
    18. Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J. Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells. Transl Stroke Res.2015 Feb;6(1):50-59. 2015; 1(6):50-59.
    19. Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb; 21(1):120-8. PMID: 25934786; PMCID: PMC4757193.
    20. Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT. Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis. J Vis Exp. 2015 Jan 27; (95):50472. PMID: 25650793; PMCID: PMC4354570.
    21. Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015; 1(22):195-198.
    22. Ma L, Guo Y, Zhao YL, Su H. The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation. Int J Hematol Res. 2015 Jan 01; 1(2):52-56. PMID: 26495437.
      View in: PubMed
    23. Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9. PMID: 25450638; PMCID: PMC4654108.
    24. Guo Y, Tihan T, Lawton MT, Kim H, Young WL, Zhao Y, Su H . Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation. Neuroimmunology and Neuroinflammation. 2014; 1(3):147-152.
    25. Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Lawton MT. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015 Jan; 22(1):195-8. PMID: 25443091; PMCID: PMC4657565.
    26. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H. Activation of a-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PLoS One. 2014; 9(8):e105711. PMID: 25157794; PMCID: PMC4144901.
    27. Han Z, Li L, Wang L, Degos V, Maze M, Su H. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov; 131(4):498-508. PMID: 25040630; PMCID: PMC4221541.
    28. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H. Endoglin deficiency impairs stroke recovery. Stroke. 2014 Jul; 45(7):2101-6. PMID: 24876084; PMCID: PMC4118747.
    29. Chen W, Choi EJ, McDougall CM, Su H. Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets. Transl Stroke Res. 2014 Jun; 5(3):316-29. PMID: 24723256; PMCID: PMC4081044.
    30. Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS One. 2014; 9(2):e88511. PMID: 24520391; PMCID: PMC3919779.
    31. Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H. De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation. Stroke. 2014 Mar; 45(3):900-2. PMID: 24457293; PMCID: PMC4117234.
    32. Chen W, Young WL, Su H. Induction of brain arteriovenous malformation in the adult mouse. Methods Mol Biol. 2014; 1135:309-16. PMID: 24510874; PMCID: PMC3988785.
    33. Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunol Neuroinflamm. 2014; 1(3):147-152. PMID: 25568888.
      View in: PubMed
    34. Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec; 19(4):399-408. PMID: 24355142; PMCID: PMC3902737.
    35. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H. Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology. 2013 Jun; 118(6):1362-72. PMID: 23438676; PMCID: PMC3987811.
    36. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013 Mar; 118(3):527-36. PMID: 23426204; PMCID: PMC3779063.
    37. Choi EJ, Walker EJ, Degos V, Jun K, Kuo R, Pile-Spellman J, Su H, Young WL. Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation. Stroke. 2013 Mar; 44(3):795-8. PMID: 23306322; PMCID: PMC3582755.
    38. Shen F, Kuo R, Milon-Camus M, Han Z, Jiang L, Young WL, Su H. Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci. Stroke. 2013 Jan; 44(1):252-4. PMID: 23250995; PMCID: PMC3531817.
    39. Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):305-10. PMID: 23241407; PMCID: PMC3569037.
    40. Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Neuroreport. 2012 Jul 11; 23(10):627-30. PMID: 22643235; PMCID: PMC3535489.
    41. Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin AJ, Lawton MT, Neuwelt EA, Saloner DA, Young WL. Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Transl Stroke Res. 2012 Jul; 3(Suppl 1):166-73. PMID: 23002401; PMCID: PMC3445332.
    42. Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc Dis. 2012; 33(6):540-7. PMID: 22571958; PMCID: PMC3569027.
    43. Walker EJ, Su H, Shen F, Degos V, Amend G, Jun K, Young WL. Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain. Stroke. 2012 Jul; 43(7):1925-30. PMID: 22569934; PMCID: PMC3404823.
    44. Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL. Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Stroke. 2012 May; 43(5):1240-6. PMID: 22308253; PMCID: PMC3335931.
    45. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329. PMID: 22272337; PMCID: PMC3260268.
    46. Walker EJ, Shen F, Young WL, Su H. Cerebrovascular casting of the adult mouse for 3D imaging and morphological analysis. J Vis Exp. 2011 Nov 30; (57):e2958. PMID: 22143104; PMCID: PMC3235703.
    47. Walker EJ, Shen F, Young WL, Su H. Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis. J Vis Exp. 2011 Nov 30; (57). PMID: 22439017.
      View in: PubMed
    48. Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H. Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res. 2011 Sep; 2(3):366-75. PMID: 22022343; PMCID: PMC3196661.
    49. Shen F, Walker EJ, Jiang L, Degos V, Li J, Sun B, Heriyanto F, Young WL, Su H. Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2343-51. PMID: 21772310; PMCID: PMC3323197.
    50. Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL. Arteriovenous malformation in the adult mouse brain resembling the human disease. Ann Neurol. 2011 Jun; 69(6):954-62. PMID: 21437931; PMCID: PMC3117949.
    51. Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl. 2011; 111:83-92. PMID: 21725736; PMCID: PMC3187860.
    52. Su H, Yang GY. Treatment of focal brain ischemia with viral vector-mediated gene transfer. Methods Mol Biol. 2011; 686:429-46. PMID: 21082386.
      View in: PubMed
    53. Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, Young WL. Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9. Stroke. 2011 Feb; 42(2):453-8. PMID: 21164138; PMCID: PMC3026909.
    54. Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12; 330(6006):985-9. PMID: 21071672; PMCID: PMC3099479.
    55. Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL. Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery. 2010 Oct; 67(4):1029-35. PMID: 20881566; PMCID: PMC2949301.
    56. Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL. VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Transl Stroke Res. 2010 Sep 01; 1(3):197-201. PMID: 20640035.
      View in: PubMed
    57. Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB. MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell. 2010 Apr 02; 6(4):323-35. PMID: 20362537; PMCID: PMC2851637.
    58. Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 2010 Apr; 67(4):488-97. PMID: 20437584; PMCID: PMC3026588.
    59. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27. PMID: 20019187; PMCID: PMC2808104.
    60. Gao P, Shen F, Gabriel RA, Law D, Yang E, Yang GY, Young WL, Su H. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke. 2009 Nov; 40(11):3596-600. PMID: 19745179; PMCID: PMC2783321.
    61. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53. PMID: 19554624.
      View in: PubMed
    62. Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 2009 Jul; 66(1):19-27. PMID: 19670444; PMCID: PMC2773229.
    63. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. PMID: 19458547; PMCID: PMC2728585.
    64. Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL. Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab. 2009 Aug; 29(8):1482-90. PMID: 19471278; PMCID: PMC2745831.
    65. Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Stroke. 2009 Mar; 40(3 Suppl):S95-7. PMID: 19064791; PMCID: PMC2677752.
    66. Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY. Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2250-6. PMID: 18835925; PMCID: PMC2614529.
    67. Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY. Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2151-7. PMID: 18802012; PMCID: PMC2610019.
    68. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):419-22. PMID: 18789891.
      View in: PubMed
    69. Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB. Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Radiology. 2008 Nov; 249(2):560-71. PMID: 18780824; PMCID: PMC2657866.
    70. Fan Y, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY. Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1543-51. PMID: 18461079; PMCID: PMC2581494.
    71. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 03; 133(2):191-7. PMID: 18295361; PMCID: PMC2692365.
    72. Beiter T, Zimmermann M, Fragasso A, Armeanu S, Lauer UM, Bitzer M, Su H, Young WL, Niess AM, Simon P. Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping. Exerc Immunol Rev. 2008; 14:73-85. PMID: 19203085.
      View in: PubMed
    73. Su H, Hao Q, Shen F, Zhu Y, Lee CZ, Young WL, Yang GY. Development of a cerebral microvascular dysplasia model in rodents. Acta Neurochir Suppl. 2008; 105:185-9. PMID: 19066107; PMCID: PMC2677755.
    74. Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl. 2008; 105:199-206. PMID: 19066109; PMCID: PMC2640934.
    75. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. 2008 Jan; 10(1):33-41. PMID: 18044793.
      View in: PubMed
    76. Shen F, Fan Y, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther. 2008 Jan; 15(1):30-9. PMID: 17960159; PMCID: PMC2586392.
    77. Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1853-60. PMID: 17392691.
      View in: PubMed
    78. Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol. 2007; 366:331-42. PMID: 17568134.
      View in: PubMed
    79. Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci. 2006 Sep 01; 11:3190-8. PMID: 16720385.
      View in: PubMed
    80. Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 2006 Oct; 37(10):2601-6. PMID: 16946160.
      View in: PubMed
    81. Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW. AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect. Gene Ther. 2006 Nov; 13(21):1495-502. PMID: 16775632.
      View in: PubMed
    82. Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16280-5. PMID: 15534198; PMCID: PMC527136.
    83. Chang DS, Su H, Tang GL, Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM. Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther. 2003 Jan; 7(1):44-51. PMID: 12573617.
      View in: PubMed
    84. Su H, Arakawa-Hoyt J, Kan YW. Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9480-5. PMID: 12084814; PMCID: PMC123166.
    85. Su H, Lu R, Kan YW. Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13801-6. PMID: 11095751; PMCID: PMC17656.
    86. Su H, Lu R, Ding R, Kan YW. Adeno-associated viral-mediated gene transfer to hepatoma: thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated than in GCV-treated animals. Mol Ther. 2000 Jun; 1(6):509-15. PMID: 10933975.
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    87. Su H, Lu R, Chang JC, Kan YW. Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13891-6. PMID: 9391123; PMCID: PMC28403.
    88. Kypta RM, Su H, Reichardt LF. Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. J Cell Biol. 1996 Sep; 134(6):1519-29. PMID: 8830779; PMCID: PMC2121007.
    89. Su H, Chang JC, Xu SM, Kan YW. Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther. 1996 Mar 01; 7(4):463-70. PMID: 8800740.
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    90. Su H, Lau YF. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. Am J Hum Genet. 1993 Jan; 52(1):24-38. PMID: 8434602; PMCID: PMC1682107.
    91. Su H, Lau YF. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Mol Reprod Dev. 1992 Nov; 33(3):252-8. PMID: 1449792.
      View in: PubMed
    92. Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. J Reprod Immunol. 1992 Apr; 21(3):275-91. PMID: 1522559.
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