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    Kole Roybal, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology
    Address1700 4th Street
    San Francisco CA 94158
    Phone415-514-4137
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      Collapse Biography 
      Collapse Education and Training
      UT Southwestern Medical Center Ph.D.Immunology2013
      Austin CollegeB.A.Biology2005
      Collapse Awards and Honors
      Postdoctoral Fellowship2014 - 2017Jane Coffin Childs Memorial Fund (Yale University)
      Ruth L. Kirschstein National Research Service Award2007 - 2010NIH

      Collapse Overview 
      Collapse Overview
      I am principally interested in the development of synthetic biology approaches to control complex signaling networks and cellular behavior for cell-based cancer immunotherapy. As a component of this research, I am also focused on elucidating fundamental mechanisms by which immune cells utilize receptors and signaling networks to regulate natural immune responses to pathogens.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 6; 167(2):419-432.e16. PMID: 27693353.
        View in: PubMed
      2. Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016; 9(424):rs3. PMID: 27095595.
        View in: PubMed
      3. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. PMID: 26830879.
        View in: PubMed
      4. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. PMID: 26830878.
        View in: PubMed
      5. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. PMID: 26405231.
        View in: PubMed
      6. Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. PMID: 26237050; PMCID: PMC4523204.
      7. Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. PMID: 26237588; PMCID: PMC4523178.
      8. Wu CY, Rupp LJ, Roybal KT, Lim WA. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. PMID: 26218616; PMCID: PMC4553068 [Available on 08/01/16].
      9. Wülfing C, Roybal KT. . Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686.
      10. Huber JP, Gonzales-van Horn SR, Roybal KT, Gill MA, Farrar JD. IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. PMID: 24813204; PMCID: PMC4104489.
      11. Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. PMID: 24284965; PMCID: PMC3929435.
      12. Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. PMID: 24117818.
        View in: PubMed
      13. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA. Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. PMID: 23776671; PMCID: PMC3679086.
      14. Roybal KT, Wülfing C. New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. PMID: 23183270.
        View in: PubMed
      15. Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS. Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. PMID: 22820329; PMCID: PMC3457510.
      16. DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS. The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. PMID: 21543646; PMCID: PMC3110614.
      17. Sinai P, Roybal KT, Wülfing C. Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. PMID: 21331235; PMCID: PMC3038059.
      18. Roybal KT, Wülfing C. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010; 3(132):pe24. PMID: 20664063.
        View in: PubMed
      19. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009; 2(65):ra15. PMID: 19351954; PMCID: PMC2694444.
      20. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11. PMID: 17379666; PMCID: PMC1851061.
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