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    Paul Garcia, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address400 Parnassus Ave, UC Clinics
    San Francisco CA 94143
    Phone415-353-2437

       Overview 
       Overview
      As the director of clinical epilepsy services, my focus has been on building a premiere clinical program. Over the past 5 years, our program has expanded to include pediatric subspecialty care, a VA Center of Excellence, dedicated dietary treatment and specialized epilepsy counseling. We have become one of the most active surgical programs in the US and we are one of the few programs to have around-the-clock EEG monitoring capability for optimal diagnosis and treatment of status epilepticus. My research is aimed at improving the diagnosis and treatment of people with hard-to-treat epilepsy. My teaching is centered on clinical epilepsy education for fellows, residents and students. My university service has been focused on the recruitment of outstanding medical students (especially from under-represented backgrounds) and on the diversification of faculty leadership on the UCSF campus.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO. Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study. Anesthesiology. 2014 May; 120(5):1118-25.
        View in: PubMed
      2. Englot DJ, Lee AT, Tsai C, Halabi C, Barbaro NM, Auguste KI, Garcia PA, Chang EF. Seizure types and frequency in patients who "fail" temporal lobectomy for intractable epilepsy. Neurosurgery. 2013 Nov; 73(5):838-44; quiz 844.
        View in: PubMed
      3. Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL. Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease. Neurology. 2013 Dec 3; 81(23):2015-23.
        View in: PubMed
      4. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 1; 70(9):1158-66.
        View in: PubMed
      5. Betjemann JP, Thompson AC, Santos-Sánchez C, Garcia PA, Ivey SL. Distinguishing language and race disparities in epilepsy surgery. Epilepsy Behav. 2013 Sep; 28(3):444-9.
        View in: PubMed
      6. Hensley-Judge H, Quigg M, Barbaro NM, Newman SA, Ward MM, Chang EF, Broshek DK, Lamborn KR, Laxer KD, Garcia P, Heck CN, Kondziolka D, Beach R, Salanova V, Goodman R. Visual field defects after radiosurgery for mesial temporal lobe epilepsy. Epilepsia. 2013 Aug; 54(8):1376-80.
        View in: PubMed
      7. de Hemptinne C, Ryapolova-Webb ES, Air EL, Garcia PA, Miller KJ, Ojemann JG, Ostrem JL, Galifianakis NB, Starr PA. Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4780-5.
        View in: PubMed
      8. Mueller SG, Young K, Hartig M, Barakos J, Garcia P, Laxer KD. A two-level multimodality imaging Bayesian network approach for classification of partial epilepsy: preliminary data. Neuroimage. 2013 May 1; 71:224-32.
        View in: PubMed
      9. Wang DD, Deans AE, Barkovich AJ, Tihan T, Barbaro NM, Garcia PA, Chang EF. Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control. J Neurosurg. 2013 Feb; 118(2):337-44.
        View in: PubMed
      10. Paterson RW, Torres-Chae CC, Kuo AL, Ando T, Nguyen EA, Wong K, Dearmond SJ, Haman A, Garcia P, Johnson DY, Miller BL, Geschwind MD. Differential diagnosis of jakob-creutzfeldt disease. Arch Neurol. 2012 Dec; 69(12):1578-82.
        View in: PubMed
      11. Hegde M, Santos-Sanchez C, Hess CP, Kabir AA, Garcia PA. Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. Epilepsy Behav. 2012 Dec; 25(4):563-6.
        View in: PubMed
      12. Englot DJ, Ouyang D, Wang DD, Rolston JD, Garcia PA, Chang EF. Relationship between hospital surgical volume, lobectomy rates, and adverse perioperative events at US epilepsy centers. J Neurosurg. 2013 Jan; 118(1):169-74.
        View in: PubMed
      13. Southwell DG, Garcia PA, Berger MS, Barbaro NM, Chang EF. Long-term seizure control outcomes after resection of gangliogliomas. Neurosurgery. 2012 Jun; 70(6):1406-13; discussion 1413-4.
        View in: PubMed
      14. Wang DD, Englot DJ, Garcia PA, Lawton MT, Young WL. Minocycline- and tetracycline-class antibiotics are protective against partial seizures in vivo. Epilepsy Behav. 2012 Jul; 24(3):314-8.
        View in: PubMed
      15. Tartaglia MC, Johnson DY, Thai JN, Cattaruzza T, Wong K, Garcia P, Dearmond SJ, Miller BL, Geschwind MD. Clinical overlap between Jakob-Creutzfeldt disease and Lewy body disease. Can J Neurol Sci. 2012 May; 39(3):304-10.
        View in: PubMed
      16. Englot DJ, Berger MS, Chang EF, Garcia PA. Characteristics and treatment of seizures in patients with high-grade glioma: a review. Neurosurg Clin N Am. 2012 Apr; 23(2):227-35, vii-viii.
        View in: PubMed
      17. Englot DJ, Ouyang D, Garcia PA, Barbaro NM, Chang EF. Epilepsy surgery trends in the United States, 1990-2008. Neurology. 2012 Apr 17; 78(16):1200-6.
        View in: PubMed
      18. Scanlon C, Mueller SG, Tosun D, Cheong I, Garcia P, Barakos J, Weiner MW, Laxer KD. Impact of methodologic choice for automatic detection of different aspects of brain atrophy by using temporal lobe epilepsy as a model. AJNR Am J Neuroradiol. 2011 Oct; 32(9):1669-76.
        View in: PubMed
      19. Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Predictors of seizure freedom after surgery for malformations of cortical development. Ann Neurol. 2011 Jul; 70(1):151-62.
        View in: PubMed
      20. Mueller SG, Laxer KD, Scanlon C, Garcia P, McMullen WJ, Loring DW, Meador KJ, Weiner MW. Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis. Hum Brain Mapp. 2012 Feb; 33(2):489-99.
        View in: PubMed
      21. Quigg M, Broshek DK, Barbaro NM, Ward MM, Laxer KD, Yan G, Lamborn K. Neuropsychological outcomes after Gamma Knife radiosurgery for mesial temporal lobe epilepsy: a prospective multicenter study. Epilepsia. 2011 May; 52(5):909-16.
        View in: PubMed
      22. Mueller SG, Ebel A, Barakos J, Scanlon C, Cheong I, Finlay D, Garcia P, Weiner MW, Laxer KD. Widespread extrahippocampal NAA/(Cr+Cho) abnormalities in TLE with and without mesial temporal sclerosis. J Neurol. 2011 Apr; 258(4):603-12.
        View in: PubMed
      23. Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010 May; 51(5):899-908.
        View in: PubMed
      24. Chang EF, Quigg M, Oh MC, Dillon WP, Ward MM, Laxer KD, Broshek DK, Barbaro NM. Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology. 2010 Jan 12; 74(2):165-72.
        View in: PubMed
      25. Chang EF, Christie C, Sullivan JE, Garcia PA, Tihan T, Gupta N, Berger MS, Barbaro NM. Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. J Neurosurg Pediatr. 2010 Jan; 5(1):123-30.
        View in: PubMed
      26. Binder DK, Garcia PA, Elangovan GK, Barbaro NM. Characteristics of auras in patients undergoing temporal lobectomy. J Neurosurg. 2009 Dec; 111(6):1283-9.
        View in: PubMed
      27. Mueller SG, Laxer KD, Barakos J, Cheong I, Finlay D, Garcia P, Cardenas-Nicolson V, Weiner MW. Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis. Epilepsia. 2010 Aug; 51(8):1436-45.
        View in: PubMed
      28. Taylor AM, Cahn-Weiner DA, Garcia PA. Examination of volunteer bias in research involving patients diagnosed with psychogenic nonepileptic seizures. Epilepsy Behav. 2009 Aug; 15(4):524-6.
        View in: PubMed
      29. Chang EF, Gabriel RA, Potts MB, Garcia PA, Barbaro NM, Lawton MT. Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations. Neurosurgery. 2009 Jul; 65(1):31-7; discussion 37-8.
        View in: PubMed
      30. Mueller SG, Laxer KD, Barakos J, Cheong I, Garcia P, Weiner MW. Subfield atrophy pattern in temporal lobe epilepsy with and without mesial sclerosis detected by high-resolution MRI at 4 Tesla: preliminary results. Epilepsia. 2009 Jun; 50(6):1474-83.
        View in: PubMed
      31. Mueller SG, Laxer KD, Barakos J, Cheong I, Garcia P, Weiner MW. Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis. Neuroimage. 2009 Jun; 46(2):353-9.
        View in: PubMed
      32. Barbaro NM, Quigg M, Broshek DK, Ward MM, Lamborn KR, Laxer KD, Larson DA, Dillon W, Verhey L, Garcia P, Steiner L, Heck C, Kondziolka D, Beach R, Olivero W, Witt TC, Salanova V, Goodman R. A multicenter, prospective pilot study of gamma knife radiosurgery for mesial temporal lobe epilepsy: seizure response, adverse events, and verbal memory. Ann Neurol. 2009 Feb; 65(2):167-75.
        View in: PubMed
      33. Geschwind MD, Potter CA, Sattavat M, Garcia PA, Rosen HJ, Miller BL, DeArmond SJ. Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease. Alzheimer Dis Assoc Disord. 2009 Jan-Mar; 23(1):82-87.
        View in: PubMed
      34. Garcia P. Patients with seizure clusters--identification of a high-risk group. Epilepsy Curr. 2009 Jan-Feb; 9(1):12-3.
        View in: PubMed
      35. Garcia P. Is seizure surgery an option for patients with very low IQ? Epilepsy Curr. 2008 Nov-Dec; 8(6):150-1.
        View in: PubMed
      36. Garcia P. Seizure remission in adults with intractable epilepsy: not just a pipe dream. Epilepsy Curr. 2008 Jul-Aug; 8(4):95-6.
        View in: PubMed
      37. Garcia PA. Imaging depression in epilepsy: hints at the biology of despair. Epilepsy Curr. 2007 Sep-Oct; 7(5):129-31.
        View in: PubMed
      38. Talke P, Stapelfeldt C, Garcia P. Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. J Neurosurg Anesthesiol. 2007 Jul; 19(3):195-9.
        View in: PubMed
      39. Garcia P. Nonconvulsive seizures in the pediatric intensive care unit: out of sight, out of mind? Epilepsy Curr. 2007 May-Jun; 7(3):70-2.
        View in: PubMed
      40. Garcia P. Brain stimulation for epilepsy: stimulating results? Epilepsy Curr. 2006 Nov-Dec; 6(6):192-4.
        View in: PubMed
      41. Garcia P. Medical intractability and imaging: can MRI predict the future? Epilepsy Curr. 2006 Sep-Oct; 6(5):155-6.
        View in: PubMed
      42. Kaiboriboon K, Parent JM, Barbaro NM, Walker JA, Garcia PA. Speech preservation during language-dominant, left temporal lobe seizures: report of a rare, potentially misleading finding. Epilepsia. 2006 Aug; 47(8):1343-6.
        View in: PubMed
      43. Garcia PA. Mood disorders and epilepsy surgery: lightening the burden in more ways than one? Epilepsy Curr. 2006 Jul-Aug; 6(4):112-3.
        View in: PubMed
      44. Garcia PA. Impact of epilepsy surgery on developing minds: how do we weigh the consequences? Epilepsy Curr. 2006 Jan-Feb; 6(1):25-6.
        View in: PubMed
      45. Kirsch HE, Walker JA, Winstanley FS, Hendrickson R, Wong ST, Barbaro NM, Laxer KD, Garcia PA. Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy. Neurology. 2005 Sep 13; 65(5):676-80.
        View in: PubMed
      46. Garcia PA. Surgery for heterotopia: a second look. Epilepsy Curr. 2005 Sep-Oct; 5(5):197-9.
        View in: PubMed
      47. Lee KC, Garcia PA, Alldredge BK. Clinical features of status epilepticus in patients with HIV infection. Neurology. 2005 Jul 26; 65(2):314-6.
        View in: PubMed
      48. Assaf BA, Karkar KM, Laxer KD, Garcia PA, Austin EJ, Barbaro NM, Aminoff MJ. Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy. Clin Neurophysiol. 2004 Sep; 115(9):2066-76.
        View in: PubMed
      49. Assaf BA, Karkar KM, Laxer KD, Garcia PA, Austin EJ, Barbaro NM, Aminoff MJ. Ictal magnetoencephalography in temporal and extratemporal lobe epilepsy. Epilepsia. 2003 Oct; 44(10):1320-7.
        View in: PubMed
      50. Meador KJ, Loring DW, Hulihan JF, Kamin M, Karim R. Differential cognitive and behavioral effects of topiramate and valproate. Neurology. 2003 May 13; 60(9):1483-8.
        View in: PubMed
      51. Alsaadi TM, Bateman LM, Laxer KD, Barbaro NM, Austin EJ, Garcia PA. Potentially misleading extratemporal lobe lesions in patients with temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2003 May; 74(5):566-9.
        View in: PubMed
      52. Chen JT, Garcia PA, Alldredge BK. Zonisamide-induced restless legs syndrome. Neurology. 2003 Jan 14; 60(1):147.
        View in: PubMed
      53. Karkar KM, Garcia PA, Bateman LM, Smyth MD, Barbaro NM, Berger M. Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. Epilepsia. 2002 Aug; 43(8):932-5.
        View in: PubMed
      54. Wu YW, Shek DW, Garcia PA, Zhao S, Johnston SC. Incidence and mortality of generalized convulsive status epilepticus in California. Neurology. 2002 Apr 9; 58(7):1070-6.
        View in: PubMed
      55. Alsaadi TM, Laxer KD, Barbaro NM, Marks WJ, Garcia PA. False lateralization by subdural electrodes in two patients with temporal lobe epilepsy. Neurology. 2001 Aug 14; 57(3):532-4.
        View in: PubMed
      56. Alsaadi TM, Laxer KD, Barbaro NM, Marks WJ, Garcia PA. Vagus nerve stimulation for the treatment of bilateral independent temporal lobe epilepsy. Epilepsia. 2001 Jul; 42(7):954-6.
        View in: PubMed
      57. Marks WJ, Garcia PA. Management of seizures and epilepsy. Am Fam Physician. 1998 Apr 1; 57(7):1589-600, 1603-4.
        View in: PubMed
      58. Garcia PA, Laxer KD, van der Grond J, Hugg JW, Matson GB, Weiner MW. Correlation of seizure frequency with N-acetyl-aspartate levels determined by 1H magnetic resonance spectroscopic imaging. Magn Reson Imaging. 1997; 15(4):475-8.
        View in: PubMed
      59. Garcia PA, Laxer KD. Magnetic resonance spectroscopy. Neuroimaging Clin N Am. 1995 Nov; 5(4):675-82.
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      60. Garcia PA, Aminoff MJ, Goodin DS. The frontal N30 component of the median-derived SEP in patients with predominantly unilateral Parkinson's disease. Neurology. 1995 May; 45(5):989-92.
        View in: PubMed
      61. Garcia PA, Laxer KD, van der Grond J, Hugg JW, Matson GB, Weiner MW. Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy. Ann Neurol. 1995 Feb; 37(2):279-81.
        View in: PubMed
      62. Garcia PA, Laxer KD, Ng T. Application of spectroscopic imaging in epilepsy. Magn Reson Imaging. 1995; 13(8):1181-5.
        View in: PubMed
      63. Garcia PA, Laxer KD, Barbaro NM, Dillon WP. Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients undergoing temporal lobectomy for medically refractory seizures. Epilepsia. 1994 May-Jun; 35(3):520-4.
        View in: PubMed
      64. Garcia PA, Laxer KD, van der Grond J, Hugg JW, Matson GB, Weiner MW. Phosphorus magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy. Ann Neurol. 1994 Feb; 35(2):217-21.
        View in: PubMed
      65. Garcia PA, Alldredge BK. Drug-induced seizures. Neurol Clin. 1994 Feb; 12(1):85-99.
        View in: PubMed
      66. Garcia PA, Bredesen DE, Vinters HV, Graefin von Einsiedel R, Williams RL, Kahn JO, Byers VS, Levin AS, Waites LA, Messing RO. Neurological reactions in HIV-infected patients treated with trichosanthin. Neuropathol Appl Neurobiol. 1993 Oct; 19(5):402-5.
        View in: PubMed
      67. Laxer KD, Garcia PA. Imaging criteria to identify the epileptic focus. Magnetic resonance imaging, magnetic resonance spectroscopy, positron emission tomography scanning, and single photon emission computed tomography. Neurosurg Clin N Am. 1993 Apr; 4(2):199-209.
        View in: PubMed
      68. Garcia PA, Barbaro NM, Laxer KD. The prognostic value of postoperative seizures following epilepsy surgery. Neurology. 1991 Sep; 41(9):1511-2.
        View in: PubMed
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