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Alan Verkman, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-8530
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    Collapse Biography 
    Collapse Education and Training
    M.I.T.S.B., S.B.Physics, Biology
    Harvard UniversityM.A., Ph.D.Physics
    Harvard Medical School / HSTM.D.
    Brigham & Womens HospitalResidency Medicine
    University of California, San FranciscoFellowship Nephrology

    Collapse Research 
    Collapse Research Activities and Funding
    Urea transport inhibitors as a new class of diuretics
    NIH/NIDDK R01DK101373Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH/NIBIB R37EB000415Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Novel Small-Molecule Therapies for CF
    NIH/NIDDK P30DK072517Aug 7, 2010 - May 31, 2020
    Role: Principal Investigator
    CFTR inhibitors for therapy of polycystic kidney disease
    NIH/NIDDK RC1DK086125Sep 25, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Role of airway submucosal glands in CF lung disease
    NIH/NHLBI R01HL073856Sep 1, 2003 - Aug 31, 2013
    Role: Principal Investigator
    Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New Therapies
    NIH/NEI R01EY013574Sep 1, 2002 - Aug 31, 2012
    Role: Principal Investigator
    Physiology and Molecular Biology of Lung Water Transport
    NIH/NHLBI R01HL059198Sep 1, 1998 - Jul 31, 2009
    Role: Principal Investigator
    ALTERATIONS IN AIRWAY SURFACE LIQUID IN CYSTIC FIBROSIS
    NIH P50HL060288Sep 1, 1998 - Aug 31, 2003
    Role: Co-Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH/NIBIB R01EB000415Jul 1, 1997 - Mar 31, 2007
    Role: Principal Investigator
    MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    NIH/FIC R03TW000704Sep 1, 1996 - Aug 31, 2000
    Role: Principal Investigator
    APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    NIH/NIDDK R01DK043840Feb 1, 1993 - Jun 30, 1998
    Role: Principal Investigator
    DEVELOPMENT OF CHLORIDE-SENSITIVE FLUORESCENT INDICATORS
    NIH/NIDDK R01DK039354Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    NIH/NIDDK R37DK035124Jan 1, 1986 - May 31, 2010
    Role: Principal Investigator
    Mechanisms of water transport in renal epithelia
    NIH/NIDDK R01DK035124Jan 1, 1986 - Mar 31, 1999
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CF pathogenesis mechanisms and therapies
    Cystic Fibrosis Foundation
    Role: PI
    Neuromyelitis Optica: Disease Mechanisms & New Therapies
    Guthy-Jackson Charitable Foundation
    Role: PI

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation. J Cyst Fibros. 2020 Jul 14. Phuan PW, Haggie PM, Tan JA, Rivera AA, Finkbeiner WE, Nielson DW, Thomas MM, Janahi IA, Verkman AS. PMID: 32674984.
      View in: PubMed   Mentions:    Fields:    
    2. Current and potential future applications of human stem cell models in drug development. J Clin Invest. 2020 May 26. Donowitz M, Turner JR, Verkman AS, Zachos NC. PMID: 32452833.
      View in: PubMed   Mentions:    Fields:    
    3. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 Apr 01; 130(4):2041-2053. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. PMID: 31961827.
      View in: PubMed   Mentions:    Fields:    
    4. Emerging therapeutic targets for neuromyelitis optica spectrum disorder. Expert Opin Ther Targets. 2020 Mar; 24(3):219-229. Tradtrantip L, Asavapanumas N, Verkman AS. PMID: 32070155.
      View in: PubMed   Mentions:    Fields:    
    5. Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye. J Ocul Pharmacol Ther. 2020 Apr; 36(3):147-153. Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS. PMID: 31934802.
      View in: PubMed   Mentions:    Fields:    
    6. Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. Sci Rep. 2019 11 27; 9(1):17640. Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS. PMID: 31776420.
      View in: PubMed   Mentions: 1     Fields:    
    7. Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders. Neuropharmacology. 2020 01 01; 162:107827. Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS. PMID: 31654702.
      View in: PubMed   Mentions: 2     Fields:    
    8. Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings. Brain Pathol. 2020 01; 30(1):13-25. Duan T, Verkman AS. PMID: 31587392.
      View in: PubMed   Mentions: 1     Fields:    
    9. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem. 2019 09 12; 62(17):8330-8337. Lee S, Cil O, Haggie PM, Verkman AS. PMID: 31389695.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Diabetes insipidus. Nat Rev Dis Primers. 2019 08 08; 5(1):54. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS. PMID: 31395885.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Rebuttal from Alex J. Smith and Alan S. Verkman. J Physiol. 2019 09; 597(17):4427-4428. Smith AJ, Verkman AS. PMID: 31389015.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin-4 independent. J Physiol. 2019 09; 597(17):4421-4424. Smith AJ, Verkman AS. PMID: 31389038.
      View in: PubMed   Mentions: 1     Fields:    
    13. Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. Sci Rep. 2019 07 16; 9(1):10310. Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. PMID: 31311979.
      View in: PubMed   Mentions:    Fields:    
    14. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB J. 2019 10; 33(10):11247-11257. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. PMID: 31299174.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity. Acta Neuropathol Commun. 2019 07 11; 7(1):112. Duan T, Smith AJ, Verkman AS. PMID: 31296268.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorg Med Chem Lett. 2019 08 15; 29(16):2119-2123. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. PMID: 31281021.
      View in: PubMed   Mentions:    Fields:    
    17. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. FASEB J. 2019 10; 33(10):10924-10934. Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. PMID: 31268738.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta Neuropathol Commun. 2019 05 08; 7(1):74. Smith AJ, Duan T, Verkman AS. PMID: 31068220.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2019 Mar 09; 16(1):57. Tradtrantip L, Duan T, Yeaman MR, Verkman AS. PMID: 30851734.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 02 21; 4(4). Duan T, Cil O, Thiagarajah JR, Verkman AS. PMID: 30668547.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. FASEB J. 2019 05; 33(5):6185-6196. Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B. PMID: 30768374.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cell Mol Gastroenterol Hepatol. 2019; 7(3):641-653. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. PMID: 30659943.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. J Neuropathol Exp Neurol. 2019 01 01; 78(1):47-56. Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS. PMID: 30500945.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2018 Oct 22; 15(1):294. Duan T, Smith AJ, Verkman AS. PMID: 30348195.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    25. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight. 2018 07 26; 3(14). Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. PMID: 30046015.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. J Cyst Fibros. 2018 09; 17(5):595-606. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. PMID: 29903467.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Anal Chem. 2018 06 19; 90(12):7675-7681. Jin BJ, Lee S, Verkman AS. PMID: 29779372.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis. JCI Insight. 2018 05 17; 3(10). Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW. PMID: 29769447.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 04 12; 61(7):3209-3217. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. PMID: 29589443.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov. 2018 09; 23(8):823-831. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. PMID: 29533733.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    31. Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica. Neuropharmacology. 2018 05 01; 133:345-353. Tradtrantip L, Felix CM, Spirig R, Morelli AB, Verkman AS. PMID: 29428821.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. J Cell Mol Med. 2018 03; 22(3):2039-2040. Verkman AS, Yao X, Smith AJ. PMID: 29363875.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB J. 2018 02; 32(2):543-551. Smith AJ, Verkman AS. PMID: 29101220.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert Opin Ther Targets. 2017 12; 21(12):1161-1170. Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO. PMID: 29072508.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4506-4513. Felix CM, Lee S, Levin MH, Verkman AS. PMID: 28873176.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. Elife. 2017 08 21; 6. Smith AJ, Yao X, Dix JA, Jin BJ, Verkman AS. PMID: 28826498.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    37. Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 07 27; 5(1):57. Yao X, Verkman AS. PMID: 28750658.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    38. Mechanisms of Autoantibody-Induced Pathology. Front Immunol. 2017; 8:603. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. PMID: 28620373.
      View in: PubMed   Mentions: 67     Fields:    
    39. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta Neuropathol. 2017 07; 134(1):35-44. Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS. PMID: 28567523.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    40. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 06 08; 60(11):4626-4635. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. PMID: 28493701.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    41. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochim Biophys Acta Biomembr. 2017 Aug; 1859(8):1326-1334. Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O. PMID: 28477975.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    42. Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1231-1241. Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B. PMID: 28344130.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    43. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 03 23; 60(6):2401-2410. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. PMID: 28230981.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    44. Microfluidic platform for rapid measurement of transepithelial water transport. Lab Chip. 2017 02 28; 17(5):887-895. Jin BJ, Verkman AS. PMID: 28184395.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    45. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 Feb 17; 5(1):15. Yao X, Verkman AS. PMID: 28212662.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    46. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. J Med Chem. 2017 02 09; 60(3):1210-1218. Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS. PMID: 28099811.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    47. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. PMID: 28049834.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    48. Aquaporin-Targeted Therapeutics: State-of-the-Field. Adv Exp Med Biol. 2017; 969:239-250. Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS. PMID: 28258578.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    49. Aquaporin Water Channels and Hydrocephalus. Pediatr Neurosurg. 2017; 52(6):409-416. Verkman AS, Tradtrantip L, Smith AJ, Yao X. PMID: 27978530.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    50. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14781-14786. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. PMID: 27940915.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    51. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. J Biol Chem. 2017 01 20; 292(3):771-785. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 27895116.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. J Gen Physiol. 2016 12; 148(6):489-501. Jin BJ, Smith AJ, Verkman AS. PMID: 27836940.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    53. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 02; 31(2):751-760. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. PMID: 27871064.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    54. Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. J Neuroinflammation. 2016 10 20; 13(1):275. Felix CM, Levin MH, Verkman AS. PMID: 27765056.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    55. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. PMID: 27815136.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    56. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. PMID: 27570835.
      View in: PubMed   Mentions: 7     Fields:    
    57. Aquaporin gene therapy for disorders of cholestasis? Hepatology. 2016 08; 64(2):344-6. Tradtrantip L, Verkman AS. PMID: 27115396.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    58. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Sci Rep. 2016 05 11; 6:25781. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K. PMID: 27165276.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    59. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. PMID: 27153921.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    60. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun. 2016 04 26; 4(1):42. Yao X, Su T, Verkman AS. PMID: 27117475.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    61. Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1. Mol Pharmacol. 2016 06; 89(6):686-93. Esteva-Font C, Jin BJ, Lee S, Phuan PW, Anderson MO, Verkman AS. PMID: 26993802.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    62. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J. 2016 06; 30(6):2187-97. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. PMID: 26932931.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    63. Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease. FASEB J. 2016 05; 30(5):1789-97. Flores AM, Casey SD, Felix CM, Phuan PW, Verkman AS, Levin MH. PMID: 26842854.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    64. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. J Enzyme Inhib Med Chem. 2016 Dec; 31(6):1362-8. Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO. PMID: 26796863.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    65. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. J Cereb Blood Flow Metab. 2017 01; 37(1):277-290. Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J. PMID: 26767580.
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    66. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. PMID: 27127798.
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    67. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophys J. 2015 Dec 15; 109(12):2511-2522. Smith AJ, Verkman AS. PMID: 26682810.
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    68. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. J Cyst Fibros. 2015 Nov; 14(6):700-5. Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. PMID: 26474804.
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    69. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci. 2015 Sep 30; 35(39):13525-37. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D. PMID: 26424896.
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    70. Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab Chip. 2015 Aug 21; 15(16):3380-90. Jin BJ, Esteva-Font C, Verkman AS. PMID: 26159099.
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    71. Potentiators of Defective ?F508-CFTR Gating that Do Not Interfere with Corrector Action. Mol Pharmacol. 2015 Oct; 88(4):791-9. Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 26245207.
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    72. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct; 88(4):689-96. Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. PMID: 26174774.
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    73. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):446-57. Thiagarajah JR, Donowitz M, Verkman AS. PMID: 26122478.
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    74. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-?B signalling in keratinocytes and development of psoriasis. Nat Commun. 2015 Jun 23; 6:7454. Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS. PMID: 26100668.
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    75. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. J Neurotrauma. 2015 Oct 01; 32(19):1458-64. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS. PMID: 25790314.
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    76. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015 Aug; 88(2):311-20. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. PMID: 25993324.
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    77. Muddying the water in brain edema? Trends Neurosci. 2015 Jun; 38(6):331-2. Smith AJ, Jin BJ, Verkman AS. PMID: 25980601.
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    78. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia. 2015 Oct; 63(10):1860-9. Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS. PMID: 25944186.
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    79. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. J Biol Chem. 2015 May 08; 290(19):12123-34. Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. PMID: 25792738.
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    80. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochim Biophys Acta. 2015 May; 1848(5):1075-80. Esteva-Font C, Phuan PW, Lee S, Su T, Anderson MO, Verkman AS. PMID: 25613743.
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    81. Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons. Exp Neurol. 2015 Mar; 265:152-9. Zhang H, Verkman AS. PMID: 25585012.
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    82. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. FASEB J. 2015 Apr; 29(4):1551-63. Wang W, Li F, Sun Y, Lei L, Zhou H, Lei T, Xia Y, Verkman AS, Yang B. PMID: 25573755.
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    83. Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors. Medchemcomm. 2015; 6:1278-1284. Lee S, Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. PMID: 26191399.
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    84. Urea transporter proteins as targets for small-molecule diuretics. Nat Rev Nephrol. 2015 Feb; 11(2):113-23. Esteva-Font C, Anderson MO, Verkman AS. PMID: 25488859.
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    85. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neurosci Lett. 2015 Jan 01; 584:368-72. Yao X, Derugin N, Manley GT, Verkman AS. PMID: 25449874.
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    86. ?F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5840-5844. Ye L, Hu B, El-Badri F, Hudson BM, Phuan PW, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25452003.
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    87. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle Nerve. 2014 Nov; 50(5):859-62. Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman AS, Bollen AW, Ralph JW. PMID: 24862586.
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    88. Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. PLoS One. 2014; 9(9):e106824. Tradtrantip L, Asavapanumas N, Phuan PW, Verkman AS. PMID: 25191939.
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    89. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nat Rev Neurol. 2014 Sep; 10(9):493-506. Papadopoulos MC, Bennett JL, Verkman AS. PMID: 25112508.
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    90. Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking. J Med Chem. 2014 Aug 14; 57(15):6729-38. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25061695.
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    91. Some gating potentiators, including VX-770, diminish ?F508-CFTR functional expression. Sci Transl Med. 2014 Jul 23; 6(246):246ra97. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. PMID: 25101887.
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    92. Inhibitor(s) of the classical complement pathway in mouse serum limit the utility of mice as experimental models of neuromyelitis optica. Mol Immunol. 2014 Nov; 62(1):104-13. Ratelade J, Verkman AS. PMID: 24980869.
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    93. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors. FASEB J. 2014 Sep; 28(9):3878-90. Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. PMID: 24843071.
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    94. Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury. Acta Neuropathol Commun. 2014 Apr 24; 2:48. Asavapanumas N, Verkman AS. PMID: 24758159.
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    95. Synergy-based small-molecule screen using a human lung epithelial cell line yields ?F508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul; 86(1):42-51. Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 24737137.
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    96. Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neurosci Lett. 2014 Jun 27; 574:70-5. Akdemir G, Ratelade J, Asavapanumas N, Verkman AS. PMID: 24717641.
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    97. Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids. Biomicrofluidics. 2014 Mar; 8(2):024106. Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS. PMID: 24738013.
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    99. Aquaporins: important but elusive drug targets. Nat Rev Drug Discov. 2014 Apr; 13(4):259-77. Verkman AS, Anderson MO, Papadopoulos MC. PMID: 24625825.
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    100. Human immunoglobulin G reduces the pathogenicity of aquaporin-4 autoantibodies in neuromyelitis optica. Exp Neurol. 2014 May; 255:145-53. Ratelade J, Smith AJ, Verkman AS. PMID: 24636863.
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    101. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2674. Tradtrantip L, Ko EA, Verkman AS. PMID: 24551253.
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    102. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. J Cell Biol. 2014 Feb 17; 204(4):559-73. Smith AJ, Jin BJ, Ratelade J, Verkman AS. PMID: 24515349.
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    103. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. J Neuroinflammation. 2014 Jan 27; 11:16. Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS. PMID: 24468108.
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    104. Small-molecule inhibitors of urea transporters. Subcell Biochem. 2014; 73:165-77. Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. PMID: 25298345.
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    105. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J. 2014 Mar; 28(3):1446-53. Esteva-Font C, Jin BJ, Verkman AS. PMID: 24334548.
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    106. Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure. Neurobiol Dis. 2014 Mar; 63:222-8. Rama Rao KV, Verkman AS, Curtis KM, Norenberg MD. PMID: 24321433.
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    107. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clin Gastroenterol Hepatol. 2014 Feb; 12(2):204-9. Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. PMID: 24316107.
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    108. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB J. 2014 Feb; 28(2):791-801. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. PMID: 24200884.
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    109. Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG. Acta Neuropathol. 2014 Apr; 127(4):539-51. Asavapanumas N, Ratelade J, Verkman AS. PMID: 24190619.
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    110. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB J. 2014 Feb; 28(2):705-14. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS. PMID: 24186965.
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    111. Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO. Brain Pathol. 2013 Nov; 23(6):684-95. Verkman AS, Phuan PW, Asavapanumas N, Tradtrantip L. PMID: 24118484.
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    112. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clin Gastroenterol Hepatol. 2014 Jan; 12(1):27-31. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. PMID: 24184676.
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    113. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds. Lab Chip. 2013 Oct 07; 13(19):3862-7. Jin BJ, Ko EA, Namkung W, Verkman AS. PMID: 23907501.
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    114. A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol. 2013 Oct 24; 20(10):1235-44. Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. PMID: 24055006.
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    115. Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014 Jul; 63(7):1120-9. Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS. PMID: 24052273.
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    116. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Acta Neuropathol. 2013 Nov; 126(5):699-709. Ratelade J, Asavapanumas N, Ritchie AM, Wemlinger S, Bennett JL, Verkman AS. PMID: 23995423.
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    117. Chloride channel-targeted therapy for secretory diarrheas. Curr Opin Pharmacol. 2013 Dec; 13(6):888-94. Thiagarajah JR, Verkman AS. PMID: 23992767.
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    118. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2014 Jan; 16(1):1-14. Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM. PMID: 23910799.
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    119. Diffusion in the extracellular space in brain and tumors. Phys Biol. 2013 08; 10(4):045003. Verkman AS. PMID: 23913007.
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    121. Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harb Perspect Med. 2013 Jul 01; 3(7). Rowe SM, Verkman AS. PMID: 23818513.
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    122. Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ?F508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist. Mol Pharmacol. 2013 Sep; 84(3):384-92. Namkung W, Park J, Seo Y, Verkman AS. PMID: 23788656.
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    123. Response to "When can AQP4 assist transporter-mediated K? uptake?". J Gen Physiol. 2013 Jul; 142(1):91-2. Jin BJ, Zhang H, Binder DK, Verkman AS. PMID: 23752331.
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    124. C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica. Acta Neuropathol. 2013 Jun; 125(6):829-40. Phuan PW, Zhang H, Asavapanumas N, Leviten M, Rosenthal A, Tradtrantip L, Verkman AS. PMID: 23677375.
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    125. Mechanism-based corrector combination restores ?F508-CFTR folding and function. Nat Chem Biol. 2013 Jul; 9(7):444-54. Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. PMID: 23666117.
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    126. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 09; 4(5):456-459. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. PMID: 23814642.
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    128. Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. J Clin Invest. 2013 May; 123(5):2306-16. Zhang H, Verkman AS. PMID: 23563310.
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    129. 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorg Med Chem Lett. 2013 Jun 01; 23(11):3338-41. Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS, Anderson MO. PMID: 23597791.
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    130. Optic neuritis in neuromyelitis optica. Prog Retin Eye Res. 2013 Sep; 36:159-71. Levin MH, Bennett JL, Verkman AS. PMID: 23545439.
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    131. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013 Apr; 14(4):265-77. Papadopoulos MC, Verkman AS. PMID: 23481483.
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    132. Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. J Gen Physiol. 2013 Feb; 141(2):261-72. Jin BJ, Thiagarajah JR, Verkman AS. PMID: 23359285.
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    133. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol. 2013 Feb; 168(3):773-84. Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA. PMID: 22946562.
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    134. Aquaporins. Curr Biol. 2013 Jan 21; 23(2):R52-5. Verkman AS. PMID: 23347934.
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    136. Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. J Gen Physiol. 2013 Jan; 141(1):119-32. Jin BJ, Zhang H, Binder DK, Verkman AS. PMID: 23277478.
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    137. Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions. Neuroreport. 2012 Dec 19; 23(18):1044-7. Saadoun S, Bridges LR, Verkman AS, Papadopoulos MC. PMID: 23108041.
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    138. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. J Biol Chem. 2012 Dec 21; 287(52):43630-8. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. PMID: 23115232.
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    139. Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody. Ann Neurol. 2013 Jan; 73(1):77-85. Tradtrantip L, Ratelade J, Zhang H, Verkman AS. PMID: 23055279.
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    142. Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Mol Biol Cell. 2012 Nov; 23(21):4188-202. Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL. PMID: 22973054.
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    143. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med. 2012 Sep 24; 209(10):1743-52. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y. PMID: 22927550.
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    144. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep; 92(3):287-90. Thiagarajah JR, Verkman AS. PMID: 22850599.
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    145. Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis. Bioorg Med Chem. 2012 Sep 01; 20(17):5247-53. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. PMID: 22841006.
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    146. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes. J Cell Sci. 2012 Sep 15; 125(Pt 18):4405-12. Rossi A, Moritz TJ, Ratelade J, Verkman AS. PMID: 22718347.
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    147. Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. J Med Chem. 2012 Jun 28; 55(12):5942-50. Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS. PMID: 22694147.
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    148. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. Int J Biochem Cell Biol. 2012 Sep; 44(9):1519-30. Ratelade J, Verkman AS. PMID: 22713791.
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    149. Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem. 2012 Jul 15; 20(14):4237-44. Kumar S, Namkung W, Verkman AS, Sharma PK. PMID: 22739085.
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    150. Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. PLoS One. 2012; 7(5):e38030. Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS. PMID: 22666439.
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    151. Aquaporin 4 and neuromyelitis optica. Lancet Neurol. 2012 Jun; 11(6):535-44. Papadopoulos MC, Verkman AS. PMID: 22608667.
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    152. Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):E1511; author reply E1512. Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22589299.
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    153. Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss. Acta Neuropathol. 2012 Jun; 123(6):861-72. Ratelade J, Zhang H, Saadoun S, Bennett JL, Papadopoulos MC, Verkman AS. PMID: 22526022.
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    154. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul; 23(7):1210-20. Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS. PMID: 22491419.
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    155. Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays. J Biol Chem. 2012 Apr 20; 287(17):13829-39. Phuan PW, Ratelade J, Rossi A, Tradtrantip L, Verkman AS. PMID: 22393049.
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    156. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol. 2012 Mar; 71(3):323-33. Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. PMID: 22374891.
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    157. Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB J. 2012 May; 26(5):2197-208. Tradtrantip L, Zhang H, Anderson MO, Saadoun S, Phuan PW, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22319008.
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    158. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol. 2012 Mar; 71(3):314-22. Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22271321.
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    159. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein. J Med Chem. 2012 Feb 09; 55(3):1242-51. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 22214395.
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    160. Fluorinated ?F508-CFTR correctors and potentiators for PET imaging. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1602-5. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. PMID: 22281185.
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    161. Aquaporins in clinical medicine. Annu Rev Med. 2012; 63:303-16. Verkman AS. PMID: 22248325.
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    162. Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion. Methods Enzymol. 2012; 504:341-54. Verkman AS, Rossi A, Crane JM. PMID: 22264543.
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    163. Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras. J Gen Physiol. 2012 Jan; 139(1):83-91. Baumgart F, Rossi A, Verkman AS. PMID: 22200949.
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    164. CFTR: folding, misfolding and correcting the ?F508 conformational defect. Trends Mol Med. 2012 Feb; 18(2):81-91. Lukacs GL, Verkman AS. PMID: 22138491.
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    165. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. PMID: 22034937.
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    166. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. Ann Neurol. 2011 Dec; 70(6):943-54. Zhang H, Bennett JL, Verkman AS. PMID: 22069219.
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    167. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. J Biol Chem. 2011 Dec 30; 286(52):45156-64. Ratelade J, Bennett JL, Verkman AS. PMID: 22069320.
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    168. Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays. Traffic. 2012 Jan; 13(1):43-53. Rossi A, Baumgart F, van Hoek AN, Verkman AS. PMID: 21981006.
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    169. Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema. PLoS One. 2011; 6(11):e27412. Ratelade J, Bennett JL, Verkman AS. PMID: 22076159.
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    170. Protein trafficking rates assessed by quantum dot quenching with bromocresol green. Traffic. 2012 Jan; 13(1):25-9. Valentine CD, Verkman AS, Haggie PM. PMID: 21951589.
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    171. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 2011 Nov; 25(11):4048-62. Namkung W, Yao Z, Finkbeiner WE, Verkman AS. PMID: 21836025.
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    172. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11; 54(15):5468-77. Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. PMID: 21707078.
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    173. Cyanoquinolines with independent corrector and potentiator activities restore ?Phe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis. Mol Pharmacol. 2011 Oct; 80(4):683-93. Phuan PW, Yang B, Knapp JM, Wood AB, Lukacs GL, Kurth MJ, Verkman AS. PMID: 21730204.
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    174. Aquaporins at a glance. J Cell Sci. 2011 Jul 01; 124(Pt 13):2107-12. Verkman AS. PMID: 21670197.
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    175. Model of aquaporin-4 supramolecular assembly in orthogonal arrays based on heterotetrameric association of M1-M23 isoforms. Biophys J. 2011 Jun 22; 100(12):2936-45. Jin BJ, Rossi A, Verkman AS. PMID: 21689527.
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    176. Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms. J Neuroimmunol. 2011 Jul; 236(1-2):93-8. Crane JM, Rossi A, Gupta T, Bennett JL, Verkman AS. PMID: 21621278.
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    177. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta Pharmacol Sin. 2011 Jun; 32(6):702-10. Verkman AS, Ratelade J, Rossi A, Zhang H, Tradtrantip L. PMID: 21552296.
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    178. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci. 2011 Apr 27; 31(17):6392-7. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. PMID: 21525279.
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    179. T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. J Neuroimmunol. 2011 Jun; 235(1-2):27-32. Saadoun S, Waters P, Macdonald C, Bridges LR, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. PMID: 21492943.
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    180. Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding. Glia. 2011 Jul; 59(7):1056-63. Rossi A, Crane JM, Verkman AS. PMID: 21491501.
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    181. Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB J. 2011 Jul; 25(7):2325-32. Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. PMID: 21427214.
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    182. Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. J Biol Chem. 2011 May 06; 286(18):16516-24. Crane JM, Lam C, Rossi A, Gupta T, Bennett JL, Verkman AS. PMID: 21454592.
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    183. Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing. European J Org Chem. 2011 Mar 01; 2011(7):1242-1248. Carpenter RD, Verkman AS. PMID: 23914138.
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    184. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J. 2011 May; 25(5):1556-66. Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS. PMID: 21257712.
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    185. Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. J Invest Dermatol. 2011 Apr; 131(4):865-73. Nakahigashi K, Kabashima K, Ikoma A, Verkman AS, Miyachi Y, Hara-Chikuma M. PMID: 21191421.
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    186. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21; 286(3):2365-74. Namkung W, Phuan PW, Verkman AS. PMID: 21084298.
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    187. Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. Mol Cell Neurosci. 2011 Jan; 46(1):318-24. Wang D, Nykanen M, Yang N, Winlaw D, North K, Verkman AS, Owler BK. PMID: 21040788.
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    188. Airway surface liquid depth imaged by surface laser reflectance microscopy. J Gen Physiol. 2010 Sep; 136(3):353-62. Thiagarajah JR, Song Y, Derichs N, Verkman AS. PMID: 20713545.
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    189. Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning. Biophys J. 2010 Aug 09; 99(4):1284-91. Zhang H, Verkman AS. PMID: 20713014.
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    190. Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J. 2010 Nov; 24(11):4178-86. Namkung W, Thiagarajah JR, Phuan PW, Verkman AS. PMID: 20581223.
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    191. CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. Mol Biol Cell. 2010 Aug 01; 21(15):2639-48. Namkung W, Finkbeiner WE, Verkman AS. PMID: 20554763.
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    192. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010 Jun; 67(6):794-801. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. PMID: 20517941.
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    193. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. J Med Chem. 2010 May 13; 53(9):3772-81. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. PMID: 20373765.
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    194. Isoxazolopyrimidines as Novel ?F508-CFTR Correctors. Synlett. 2010 Apr 01; 2010(7):1063-1066. Yu GJ, Yang B, Verkman AS, Kurth MJ. PMID: 23710112.
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    195. Synthesis of a sensitive and selective potassium-sensing fluoroionophore. Org Lett. 2010 Mar 19; 12(6):1160-3. Carpenter RD, Verkman AS. PMID: 20148571.
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    196. Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. Neuroscience. 2010 Apr 28; 167(1):60-7. Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. PMID: 20132873.
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    197. Aquaporin-4 (AQP4) associations and array dynamics probed by photobleaching and single-molecule analysis of green fluorescent protein-AQP4 chimeras. J Biol Chem. 2010 Mar 12; 285(11):8163-70. Tajima M, Crane JM, Verkman AS. PMID: 20071343.
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    198. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain. 2010 Feb; 133(Pt 2):349-61. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. PMID: 20047900.
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    199. Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells. J Biol Chem. 2009 Dec 18; 284(51):35850-60. Crane JM, Bennett JL, Verkman AS. PMID: 19843522.
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    200. Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. J Biol Chem. 2010 Feb 19; 285(8):5896-906. Zhang H, Verkman AS. PMID: 20018876.
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    201. Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes. Biophys J. 2009 Dec 02; 97(11):3010-8. Crane JM, Verkman AS. PMID: 19948131.
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    202. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):87-91. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ. PMID: 19954980.
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    203. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22; 52(20):6447-55. Tradtrantip L, Sonawane ND, Namkung W, Verkman AS. PMID: 19785436.
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    204. Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1131-40. Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS. PMID: 19820035.
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    205. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan; 77(1):69-78. Tradtrantip L, Namkung W, Verkman AS. PMID: 19808995.
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    206. Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles. Neuroscience. 2010 Jul 28; 168(4):892-902. Crane JM, Tajima M, Verkman AS. PMID: 19699275.
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    207. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. BMC Neurosci. 2009 Aug 06; 10:94. Li L, Zhang H, Verkman AS. PMID: 19660138.
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    208. Aquaporins: translating bench research to human disease. J Exp Biol. 2009 Jun; 212(Pt 11):1707-15. Verkman AS. PMID: 19448080.
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    209. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye. J Biol Chem. 2009 Jun 05; 284(23):15916-26. Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS. PMID: 19364771.
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    210. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. 2009 Jul 07; 161(3):764-72. Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC. PMID: 19345723.
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    211. Sporadic obstructive hydrocephalus in Aqp4 null mice. J Neurosci Res. 2009 Apr; 87(5):1150-5. Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T. PMID: 18951529.
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    212. Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L859-67. Haggie PM, Verkman AS. PMID: 19329540.
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    213. Extracellular space volume measured by two-color pulsed dye infusion with microfiberoptic fluorescence photodetection. Biophys J. 2009 Mar 18; 96(6):2382-90. Magzoub M, Zhang H, Dix JA, Verkman AS. PMID: 19289063.
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    214. Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Exp Eye Res. 2009 Aug; 89(2):159-65. Ruiz-Ederra J, Verkman AS. PMID: 19298815.
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    215. QUANTUM DOT SINGLE MOLECULE TRACKING REVEALS A WIDE RANGE OF DIFFUSIVE MOTIONS OF MEMBRANE TRANSPORT PROTEINS. Proc SPIE Int Soc Opt Eng. 2009 Mar 03; 7489. Crane JM, Haggie PM, Verkman AS. PMID: 24386532.
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    216. Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging. J Cell Sci. 2009 Mar 15; 122(Pt 6):813-21. Crane JM, Verkman AS. PMID: 19240114.
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    217. The expression of differentiation markers in aquaporin-3 deficient epidermis. Arch Dermatol Res. 2009 Mar; 301(3):245-52. Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, Miyachi Y. PMID: 19184071.
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    218. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G816-22. Li L, Zhang H, Ma T, Verkman AS. PMID: 19179619.
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    219. In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2132-8. Ruiz-Ederra J, Levin MH, Verkman AS. PMID: 19136711.
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    220. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem. 2009 Mar 20; 284(12):7681-6. Haggie PM, Verkman AS. PMID: 19136560.
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    221. Aquaporin water channels in transepithelial fluid transport. J Med Invest. 2009; 56 Suppl:179-84. Tradtrantip L, Tajima M, Li L, Verkman AS. PMID: 20224178.
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    222. Knock-out models reveal new aquaporin functions. Handb Exp Pharmacol. 2009; (190):359-81. Verkman AS. PMID: 19096787.
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    223. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J. 2009 Feb; 23(2):503-12. Yang B, Zhao D, Verkman AS. PMID: 18854434.
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    224. Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Mol Pharmacol. 2009 Jan; 75(1):134-42. Tradtrantip L, Yangthara B, Padmawar P, Morrison C, Verkman AS. PMID: 18824527.
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    225. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem. 2008 Oct 09; 51(19):6044-54. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 18788728.
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    226. Evidence against involvement of aquaporin-4 in cell-cell adhesion. J Mol Biol. 2008 Oct 24; 382(5):1136-43. Zhang H, Verkman AS. PMID: 18708067.
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    227. Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorg Med Chem. 2008 Sep 01; 16(17):8187-95. Sonawane ND, Verkman AS. PMID: 18691893.
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    228. Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chem Biol. 2008 Jul 21; 15(7):718-28. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 18635008.
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    229. Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. J Biol Chem. 2008 Aug 29; 283(35):23510-3. Haggie PM, Verkman AS. PMID: 18617526.
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    230. Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis. Biochem J. 2008 Jul 01; 413(1):135-42. Caci E, Caputo A, Hinzpeter A, Arous N, Fanen P, Sonawane N, Verkman AS, Ravazzolo R, Zegarra-Moran O, Galietta LJ. PMID: 18366345.
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    231. Roles of aquaporin-3 in the epidermis. J Invest Dermatol. 2008 Sep; 128(9):2145-51. Hara-Chikuma M, Verkman AS. PMID: 18548108.
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    232. Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorg Med Chem. 2008 Aug 01; 16(15):7489-93. Yang B, Zhang H, Verkman AS. PMID: 18572411.
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    233. Cell-based fluorescence screen for K+ channels and transporters using an extracellular triazacryptand-based K+ sensor. J Am Chem Soc. 2008 Jun 25; 130(25):7794-5. Namkung W, Padmawar P, Mills AD, Verkman AS. PMID: 18512924.
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    234. Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB J. 2008 Sep; 22(9):3216-23. Lu DC, Zhang H, Zador Z, Verkman AS. PMID: 18511552.
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    235. From the farm to the lab: the pig as a new model of cystic fibrosis lung disease. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L238-9. Verkman AS. PMID: 18502814.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    236. Functions of aquaporins in the eye. Prog Retin Eye Res. 2008 Jul; 27(4):420-33. Verkman AS, Ruiz-Ederra J, Levin MH. PMID: 18501660.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    237. Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking. Mol Biol Cell. 2008 Aug; 19(8):3369-78. Crane JM, Van Hoek AN, Skach WR, Verkman AS. PMID: 18495865.
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    238. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert Rev Mol Med. 2008 May 16; 10:e13. Verkman AS. PMID: 18482462.
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    239. Random-walk model of diffusion in three dimensions in brain extracellular space: comparison with microfiberoptic photobleaching measurements. Biophys J. 2008 Aug; 95(4):1785-94. Jin S, Zador Z, Verkman AS. PMID: 18469079.
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    240. Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Semin Nephrol. 2008 May; 28(3):217-26. Verkman AS. PMID: 18519083.
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    241. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol. 2008 Jul; 19(7):1300-10. Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS. PMID: 18385427.
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    242. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem. 2008 May 30; 283(22):15280-6. Yang B, Zador Z, Verkman AS. PMID: 18375385.
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    243. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett. 2008 Apr 15; 18(8):2610-4. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. PMID: 18394886.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    244. Aquaporins--new players in cancer biology. J Mol Med (Berl). 2008 May; 86(5):523-9. Verkman AS, Hara-Chikuma M, Papadopoulos MC. PMID: 18311471.
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    245. A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression. Exp Dermatol. 2008 Oct; 17(10):871-2. Verkman AS. PMID: 18312385.
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    246. Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity. J Pharmacol Exp Ther. 2008 May; 325(2):529-35. Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS. PMID: 18272811.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    247. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008 Apr; 131(Pt 4):1087-98. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. PMID: 18267965.
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    248. Chloride channels as drug targets. Nat Rev Drug Discov. 2009 Feb; 8(2):153-71. Verkman AS, Galietta LJ. PMID: 19153558.
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    249. Crowding effects on diffusion in solutions and cells. Annu Rev Biophys. 2008; 37:247-63. Dix JA, Verkman AS. PMID: 18573081.
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    250. Potential utility of aquaporin modulators for therapy of brain disorders. Prog Brain Res. 2008; 170:589-601. Papadopoulos MC, Verkman AS. PMID: 18655912.
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    251. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol. 2008 Mar; 73(3):758-68. De La Fuente R, Namkung W, Mills A, Verkman AS. PMID: 18083779.
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    252. Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. J Mol Med (Berl). 2008 Feb; 86(2):221-31. Hara-Chikuma M, Verkman AS. PMID: 17968524.
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    253. Aquaporins and cell migration. Pflugers Arch. 2008 Jul; 456(4):693-700. Papadopoulos MC, Saadoun S, Verkman AS. PMID: 17968585.
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    254. Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Mol Cell Biol. 2008 Jan; 28(1):326-32. Hara-Chikuma M, Verkman AS. PMID: 17967887.
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    255. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB J. 2008 Mar; 22(3):870-9. Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. PMID: 17965267.
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    256. Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4802-10. Ruiz-Ederra J, Verkman AS. PMID: 17898307.
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    257. Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane. Biophys J. 2008 Jan 15; 94(2):702-13. Crane JM, Verkman AS. PMID: 17890385.
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    258. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 2008 Jan; 22(1):276-84. Magzoub M, Jin S, Verkman AS. PMID: 17761521.
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    259. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem. 2007 Oct 26; 282(43):31422-8. Haggie PM, Verkman AS. PMID: 17724021.
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    260. Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells. Mol Cell Neurosci. 2008 Jan; 37(1):1-10. Zhang H, Verkman AS. PMID: 17869537.
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    261. Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut. 2007 Nov; 56(11):1529-35. Thiagarajah JR, Zhao D, Verkman AS. PMID: 17573386.
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    262. Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells. J Biol Chem. 2007 Jul 27; 282(30):21866-72. Ruiz-Ederra J, Zhang H, Verkman AS. PMID: 17525153.
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    263. Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels. Biophys J. 2007 Aug 01; 93(3):1079-88. Jin S, Haggie PM, Verkman AS. PMID: 17483157.
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    264. Small-molecule vasopressin-2 receptor antagonist identified by a g-protein coupled receptor "pathway" screen. Mol Pharmacol. 2007 Jul; 72(1):86-94. Yangthara B, Mills A, Chatsudthipong V, Tradtrantip L, Verkman AS. PMID: 17435162.
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    265. Single particle tracking of complex diffusion in membranes: simulation and detection of barrier, raft, and interaction phenomena. J Phys Chem B. 2007 Apr 12; 111(14):3625-32. Jin S, Verkman AS. PMID: 17388520.
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    266. Aquaporin-4 and brain edema. Pediatr Nephrol. 2007 Jun; 22(6):778-84. Papadopoulos MC, Verkman AS. PMID: 17347837.
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    267. Role of aquaporins in lung liquid physiology. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):324-30. Verkman AS. PMID: 17369110.
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    268. Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology. 2007 Apr; 132(4):1234-44. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 17408659.
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    269. Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B. FASEB J. 2007 Feb; 21(2):551-63. Levin MH, de la Fuente R, Verkman AS. PMID: 17202246.
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    270. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J. 2007 Jan; 21(1):108-16. Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS. PMID: 17135365.
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    271. Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide. FEBS Lett. 2006 Dec 11; 580(28-29):6679-84. Yang B, Kim JK, Verkman AS. PMID: 17126329.
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    272. Millisecond association kinetics of K+ with triazacryptand-based K+ indicators measured by fluorescence correlation spectroscopy. J Phys Chem B. 2006 Oct 26; 110(42):21216-21. Magzoub M, Padmawar P, Dix JA, Verkman AS. PMID: 17048948.
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    273. Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4365-72. Levin MH, Verkman AS. PMID: 17003427.
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    274. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell. 2006 Dec; 17(12):4937-45. Haggie PM, Kim JK, Lukacs GL, Verkman AS. PMID: 16987954.
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    275. Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening. Br J Pharmacol. 2006 Nov; 149(5):551-9. De La Fuente R, Sonawane ND, Arumainayagam D, Verkman AS. PMID: 16981005.
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    276. Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3960-7. Ruiz-Ederra J, Verkman AS. PMID: 16936111.
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    277. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L383-95. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. PMID: 16920886.
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    278. Aquaporins and CFTR in ocular epithelial fluid transport. J Membr Biol. 2006 Mar; 210(2):105-15. Levin MH, Verkman AS. PMID: 16868675.
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    279. Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins. J Biol Chem. 2006 Sep 01; 281(35):25803-12. Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS. PMID: 16829520.
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    280. Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J. 2006 Sep; 20(11):1892-4. Hu J, Verkman AS. PMID: 16818469.
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    281. Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins. Cell Mol Life Sci. 2006 Jun; 63(12):1386-92. Hara-Chikuma M, Verkman AS. PMID: 16715408.
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    282. Roles of aquaporins in kidney revealed by transgenic mice. Semin Nephrol. 2006 May; 26(3):200-8. Verkman AS. PMID: 16713493.
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    283. Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int. 2006 May; 69(9):1518-25. Ni J, Verbavatz JM, Rippe A, Boisdé I, Moulin P, Rippe B, Verkman AS, Devuyst O. PMID: 16508653.
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    284. Evidence against functionally significant aquaporin expression in mitochondria. J Biol Chem. 2006 Jun 16; 281(24):16202-6. Yang B, Zhao D, Verkman AS. PMID: 16624821.
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    285. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. Am J Physiol Cell Physiol. 2006 Sep; 291(3):C417-23. Yang B, Zhao D, Solenov E, Verkman AS. PMID: 16624991.
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    286. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia. 2006 Apr 15; 53(6):631-6. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT. PMID: 16470808.
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    287. Aquaporins in endothelia. Kidney Int. 2006 Apr; 69(7):1120-3. Verkman AS. PMID: 16508658.
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    288. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat Methods. 2006 Apr; 3(4):275-80. Thiagarajah JR, Kim JK, Magzoub M, Verkman AS. PMID: 16554832.
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    289. Cardiac aquaporin expression in humans, rats, and mice. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H705-13. Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, Winlaw DS. PMID: 16582023.
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    290. Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis. Transfus Clin Biol. 2006 Mar-Apr; 13(1-2):117-22. Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman AS, Cartron JP. PMID: 16574458.
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    291. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab. 2006 Dec; 26(12):1527-37. Bloch O, Auguste KI, Manley GT, Verkman AS. PMID: 16552421.
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    292. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochim Biophys Acta. 2006 Aug; 1758(8):1085-93. Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC. PMID: 16564496.
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    293. Fluorescence correlation spectroscopy simulations of photophysical phenomena and molecular interactions: a molecular dynamics/monte carlo approach. J Phys Chem B. 2006 Feb 02; 110(4):1896-906. Dix JA, Hom EF, Verkman AS. PMID: 16471761.
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    294. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1022-8. Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT. PMID: 16476579.
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    295. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F465-72. Yang B, Zhao D, Qian L, Verkman AS. PMID: 16434568.
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    296. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Curr Pharm Des. 2006; 12(18):2235-47. Verkman AS, Lukacs GL, Galietta LJ. PMID: 16787252.
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    297. Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):306-16. Levin MH, Kim JK, Hu J, Verkman AS. PMID: 16384978.
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    298. Increased seizure duration in mice lacking aquaporin-4 water channels. Acta Neurochir Suppl. 2006; 96:389-92. Binder DK, Yao X, Verkman AS, Manley GT. PMID: 16671491.
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    299. Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule. J Am Soc Nephrol. 2006 Jan; 17(1):39-45. Hara-Chikuma M, Verkman AS. PMID: 16319186.
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    300. Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB J. 2006 Jan; 20(1):130-2. Sonawane ND, Hu J, Muanprasat C, Verkman AS. PMID: 16317066.
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    301. Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Exp Eye Res. 2006 May; 82(5):879-84. Ruiz-Ederra J, Verkman AS. PMID: 16310189.
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    302. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005 Dec 15; 118(Pt 24):5691-8. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS. PMID: 16303850.
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    303. Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett. 2006 Feb; 16(3):537-40. Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ. PMID: 16288863.
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    304. K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods. 2005 Nov; 2(11):825-7. Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS. PMID: 16278651.
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    305. Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C741-9. Song Y, Salinas D, Nielson DW, Verkman AS. PMID: 16207791.
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    306. Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice. Biol Cell. 2005 Oct; 97(10):765-78. Kim SW, Gresz V, Rojek A, Wang W, Verkman AS, Frøkiaer J, Nielsen S. PMID: 15898956.
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    307. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem. 2005 Oct; 95(1):254-62. Bloch O, Papadopoulos MC, Manley GT, Verkman AS. PMID: 16181429.
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    308. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. PMID: 16143588.
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    309. Extracellular space diffusion in central nervous system: anisotropic diffusion measured by elliptical surface photobleaching. Biophys J. 2005 Nov; 89(5):3660-8. Papadopoulos MC, Kim JK, Verkman AS. PMID: 16143636.
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    310. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol. 2005 Sep; 25(17):7770-9. Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K. PMID: 16107722.
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    311. Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. J Clin Invest. 2005 Sep; 115(9):2564-71. Pedemonte N, Lukacs GL, Du K, Caci E, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 16127463.
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    312. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med. 2005 Aug 15; 202(4):473-7. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. PMID: 16087714.
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    313. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 2005 Aug 01; 118(Pt 15):3225-32. Verkman AS. PMID: 16079275.
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    314. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005 Dec; 289(6):F1195-200. Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S. PMID: 15998844.
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    315. Aquaporin-3 functions as a glycerol transporter in mammalian skin. Biol Cell. 2005 Jul; 97(7):479-86. Hara-Chikuma M, Verkman AS. PMID: 15966863.
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    316. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. Biochem J. 2005 May 01; 387(Pt 3):911-9. Schulz BL, Sloane AJ, Robinson LJ, Sebastian LT, Glanville AR, Song Y, Verkman AS, Harry JL, Packer NH, Karlsson NG. PMID: 15563276.
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    317. Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochem Biophys Res Commun. 2005 Apr 15; 329(3):941-6. Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS. PMID: 15752747.
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    318. Noninvasive early detection of brain edema in mice by near-infrared light scattering. J Neurosci Res. 2005 Apr 15; 80(2):293-9. Thiagarajah JR, Papadopoulos MC, Verkman AS. PMID: 15765520.
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    319. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005 Apr 07; 434(7034):786-92. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. PMID: 15815633.
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    320. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv Drug Deliv Rev. 2005 Apr 05; 57(5):755-67. Lechardeur D, Verkman AS, Lukacs GL. PMID: 15757759.
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    321. New drug targets for cholera therapy. Trends Pharmacol Sci. 2005 Apr; 26(4):172-5. Thiagarajah JR, Verkman AS. PMID: 15808339.
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    322. CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1428-34. Levin MH, Verkman AS. PMID: 15790911.
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    323. Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem. 2005 Apr 22; 280(16):15493-6. Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS. PMID: 15746100.
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    324. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May; 67(5):1797-807. Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS. PMID: 15722457.
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    325. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem. 2005 Apr 08; 280(14):13906-12. Papadopoulos MC, Verkman AS. PMID: 15695511.
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    326. Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol. 2005 May; 288(5):C1161-70. Yang B, Song Y, Zhao D, Verkman AS. PMID: 15647389.
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    327. Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery. J Biol Chem. 2005 Mar 04; 280(9):7823-8. Dauty E, Verkman AS. PMID: 15632160.
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    328. In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents. J Pharm Sci. 2005 Jan; 94(1):134-43. Sonawane ND, Muanprasat C, Nagatani R, Song Y, Verkman AS. PMID: 15761937.
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    329. Novel roles of aquaporins revealed by phenotype analysis of knockout mice. Rev Physiol Biochem Pharmacol. 2005; 155:31-55. Verkman AS. PMID: 16091927.
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    330. Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching. FASEB J. 2005 Mar; 19(3):425-7. Papadopoulos MC, Binder DK, Verkman AS. PMID: 15596484.
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    331. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. PMID: 15596485.
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    332. Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4477-83. Da T, Verkman AS. PMID: 15557457.
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    333. Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4423-32. Levin MH, Verkman AS. PMID: 15557451.
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    334. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J. 2005 Jan; 19(1):76-8. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT. PMID: 15533949.
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    335. ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem. 2005 Jan 14; 280(2):1241-7. Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS. PMID: 15504734.
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    336. In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci. 2004 Sep 15; 24(37):8049-56. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS. PMID: 15371505.
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    337. Drug discovery and epithelial physiology. Curr Opin Nephrol Hypertens. 2004 Sep; 13(5):563-8. Verkman AS. PMID: 15300164.
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    338. Molecular crowding reduces to a similar extent the diffusion of small solutes and macromolecules: measurement by fluorescence correlation spectroscopy. J Mol Recognit. 2004 Sep-Oct; 17(5):441-7. Dauty E, Verkman AS. PMID: 15362103.
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    339. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug; 124(2):125-37. Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. PMID: 15277574.
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    340. Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models. J Biol Chem. 2004 Sep 24; 279(39):40629-33. Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS. PMID: 15280357.
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    341. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L936-43. Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS. PMID: 15246976.
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    342. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004 Aug; 18(11):1291-3. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. PMID: 15208268.
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    343. Fluid transport across cultured layers of corneal endothelium from aquaporin-1 null mice. Exp Eye Res. 2004 Apr; 78(4):791-8. Kuang K, Yiming M, Wen Q, Li Y, Ma L, Iserovich P, Verkman AS, Fischbarg J. PMID: 15037113.
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    344. A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J. 2004 May; 18(7):875-7. Thiagarajah JR, Song Y, Haggie PM, Verkman AS. PMID: 15001557.
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    345. Drug discovery in academia. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C465-74. Verkman AS. PMID: 14761879.
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    346. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport. 2004 Feb 09; 15(2):259-62. Binder DK, Oshio K, Ma T, Verkman AS, Manley GT. PMID: 15076748.
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    347. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology. 2004 Feb; 126(2):511-9. Thiagarajah JR, Broadbent T, Hsieh E, Verkman AS. PMID: 14762788.
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    348. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30; 558(1-3):52-6. Taddei A, Folli C, Zegarra-Moran O, Fanen P, Verkman AS, Galietta LJ. PMID: 14759515.
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    349. Expression of aquaporin water channels in mouse spinal cord. Neuroscience. 2004; 127(3):685-93. Oshio K, Binder DK, Yang B, Schecter S, Verkman AS, Manley GT. PMID: 15283967.
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    350. New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience. 2004; 129(4):983-91. Manley GT, Binder DK, Papadopoulos MC, Verkman AS. PMID: 15561413.
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    351. Molecular mechanisms of brain tumor edema. Neuroscience. 2004; 129(4):1011-20. Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. PMID: 15561416.
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    352. Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif. J Biol Chem. 2004 Feb 13; 279(7):5494-500. Haggie PM, Stanton BA, Verkman AS. PMID: 14660592.
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    353. CFTR pharmacology and its role in intestinal fluid secretion. Curr Opin Pharmacol. 2003 Dec; 3(6):594-9. Thiagarajah JR, Verkman AS. PMID: 14644010.
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    354. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C426-32. Solenov E, Watanabe H, Manley GT, Verkman AS. PMID: 14576087.
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    355. Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. J Gen Physiol. 2003 Nov; 122(5):511-9. Song Y, Thiagarajah J, Verkman AS. PMID: 14557401.
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    356. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 01; 11(18):4113-20. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. PMID: 12927873.
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    357. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003 Nov 07; 278(45):44826-31. Sonawane ND, Szoka FC, Verkman AS. PMID: 12944394.
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    358. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett. 2003 Aug 04; 13(15):2509-12. Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. PMID: 12852954.
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    359. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem. 2003 Sep 12; 278(37):35079-85. Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. PMID: 12832418.
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    360. Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7360-5. Hara M, Verkman AS. PMID: 12771381.
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    361. Increased expression of H+-ATPase in inner medullary collecting duct of aquaporin-1-deficient mice. Am J Physiol Renal Physiol. 2003 Sep; 285(3):F550-7. Kim YH, Kim J, Verkman AS, Madsen KM. PMID: 12759225.
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    362. Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands. J Cell Biol. 2003 Mar 31; 160(7):1129-38. Sonawane ND, Verkman AS. PMID: 12668661.
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    363. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L180-8. Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. PMID: 12651632.
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    364. Role of aquaporin water channels in eye function. Exp Eye Res. 2003 Feb; 76(2):137-43. Verkman AS. PMID: 12565800.
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    365. Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C2-15. Verkman AS, Song Y, Thiagarajah JR. PMID: 12475759.
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    366. Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema. Acta Neurochir Suppl. 2003; 86:499-502. Oshio K, Binder DK, Bollen A, Verkman AS, Berger MS, Manley GT. PMID: 14753494.
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    367. Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production. Acta Neurochir Suppl. 2003; 86:525-8. Oshio K, Song Y, Verkman AS, Manley GT. PMID: 14753499.
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    368. Diffusion in cells measured by fluorescence recovery after photobleaching. Methods Enzymol. 2003; 360:635-48. Verkman AS. PMID: 12622172.
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    369. Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways. J Appl Physiol (1985). 2002 Dec; 93(6):2199-206. Borok Z, Verkman AS. PMID: 12433939.
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    370. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec; 110(11):1651-8. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. PMID: 12464670.
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    371. Expression and localization of aquaporin 1 and 3 in human fetal membranes. Am J Obstet Gynecol. 2002 Oct; 187(4):902-7. Mann SE, Ricke EA, Yang BA, Verkman AS, Taylor RN. PMID: 12388974.
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    372. Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery. J Biol Chem. 2002 Nov 29; 277(48):46616-21. Hara M, Ma T, Verkman AS. PMID: 12270942.
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    373. Aquaporin water channels and brain edema. Mt Sinai J Med. 2002 Sep; 69(4):242-8. Papadopoulos MC, Krishna S, Verkman AS. PMID: 12357265.
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    374. Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G739-46. Mennone A, Verkman AS, Boyer JL. PMID: 12181190.
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    375. Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J Appl Physiol (1985). 2003 Jan; 94(1):343-52. Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS. PMID: 12391048.
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    376. Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex. J Biol Chem. 2002 Oct 25; 277(43):40782-8. Haggie PM, Verkman AS. PMID: 12198136.
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    377. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem. 2002 Oct 04; 277(40):37235-41. Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 12161441.
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    378. Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J Biol Chem. 2002 Sep 27; 277(39):36782-6. Yang B, Verkman AS. PMID: 12133842.
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    379. Does aquaporin-1 pass gas? An opposing view. J Physiol. 2002 Jul 01; 542(Pt 1):31. Verkman AS. PMID: 12096046.
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    380. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. J Physiol. 2002 Jul 01; 542(Pt 1):63-9. Fang X, Yang B, Matthay MA, Verkman AS. PMID: 12096051.
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    381. Analysis of coupled bimolecular reaction kinetics and diffusion by two-color fluorescence correlation spectroscopy: enhanced resolution of kinetics by resonance energy transfer. Biophys J. 2002 Jul; 83(1):533-46. Hom EF, Verkman AS. PMID: 12080140.
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    382. Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production. J Gen Physiol. 2002 Jun; 119(6):561-9. Zhang D, Vetrivel L, Verkman AS. PMID: 12034763.
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    383. Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice. J Physiol. 2002 Jun 01; 541(Pt 2):561-8. Song Y, Sonawane N, Verkman AS. PMID: 12042359.
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    384. Aquaporin water channels and endothelial cell function. J Anat. 2002 Jun; 200(6):617-27. Verkman AS. PMID: 12162729.
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    385. Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J Biol Chem. 2002 May 24; 277(21):19139-44. Thiagarajah JR, Verkman AS. PMID: 11891232.
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    386. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J Biol Chem. 2002 May 10; 277(19):17147-53. Ma T, Hara M, Sougrat R, Verbavatz JM, Verkman AS. PMID: 11880378.
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    387. Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. J Biol Chem. 2002 May 10; 277(19):16419-25. Haggie PM, Stanton BA, Verkman AS. PMID: 11877404.
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    388. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol. 2002 Feb; 119(2):199-207. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. PMID: 11815669.
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    389. Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):573-9. Li J, Patil RV, Verkman AS. PMID: 11818406.
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    390. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J Neurosci Methods. 2002 Jan 15; 113(1):85-90. Solenov EI, Vetrivel L, Oshio K, Manley GT, Verkman AS. PMID: 11741725.
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    391. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem. 2002 Mar 22; 277(12):10633-7. Yang B, Bankir L, Gillespie A, Epstein CJ, Verkman AS. PMID: 11792714.
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    392. Solute and macromolecule diffusion in cellular aqueous compartments. Trends Biochem Sci. 2002 Jan; 27(1):27-33. Verkman AS. PMID: 11796221.
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    393. Aquaporin gene delivery to kidney. Kidney Int. 2002 Jan; 61(1 Suppl):S120-4. Verkman AS, Yang B. PMID: 11841625.
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    394. Physiological importance of aquaporin water channels. Ann Med. 2002; 34(3):192-200. Verkman AS. PMID: 12173689.
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    395. Renal concentrating and diluting function in deficiency of specific aquaporin genes. Exp Nephrol. 2002; 10(4):235-40. Verkman AS. PMID: 12097826.
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    396. Fluorescent indicator methods to assay functional CFTR expression in cells. Methods Mol Med. 2002; 70:187-96. Verkman AS, Jayaraman S. PMID: 11917522.
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    397. Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. J Biol Chem. 2002 Feb 15; 277(7):5506-13. Sonawane ND, Thiagarajah JR, Verkman AS. PMID: 11741919.
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    398. In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1898-903. Thiagarajah JR, Jayaraman S, Naftalin RJ, Verkman AS. PMID: 11698248.
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    399. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):14132-7. Zhou Q, Clarke L, Nie R, Carnes K, Lai LW, Lien YH, Verkman A, Lubahn D, Fisher JS, Katzenellenbogen BS, Hess RA. PMID: 11698654.
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    400. Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1504-11. Jayaraman S, Song Y, Verkman AS. PMID: 11600413.
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    401. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1734-42. Galietta LV, Jayaraman S, Verkman AS. PMID: 11600438.
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    402. Applications of aquaporin inhibitors. Drug News Perspect. 2001 Sep; 14(7):412-20. Verkman AS. PMID: 12813584.
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    403. Aquaporin-4 expression in adult and developing mouse and rat kidney. J Am Soc Nephrol. 2001 Sep; 12(9):1795-804. Kim YH, Earm JH, Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J. PMID: 11518772.
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    404. Aquaporin-5 dependent fluid secretion in airway submucosal glands. J Biol Chem. 2001 Nov 02; 276(44):41288-92. Song Y, Verkman AS. PMID: 11514581.
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    405. Lung disease in cystic fibrosis: is airway surface liquid composition abnormal? Am J Physiol Lung Cell Mol Physiol. 2001 Aug; 281(2):L306-8. Verkman AS. PMID: 11435202.
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    406. HCO3- transport in relation to mucus secretion from submucosal glands. JOP. 2001 Jul; 2(4 Suppl):280-4. Joo NS, Krouse ME, Wu JV, Saenz Y, Jayaraman S, Verkman AS, Wine JJ. PMID: 11875272.
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    407. Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na(+)] and pH but elevated viscosity. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):8119-23. Jayaraman S, Joo NS, Reitz B, Wine JJ, Verkman AS. PMID: 11427704.
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    408. Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Lett. 2001 Jun 22; 499(3):220-4. Galietta LJ, Haggie PM, Verkman AS. PMID: 11423120.
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    409. Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem. 2001 Aug 17; 276(33):31233-7. Li J, Verkman AS. PMID: 11406631.
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    410. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol. 2001 Jun; 117(6):573-82. Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS. PMID: 11382807.
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    411. Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes. J Gen Physiol. 2001 May; 117(5):423-30. Jayaraman S, Song Y, Verkman AS. PMID: 11331352.
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    412. Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. J Biol Chem. 2001 Jun 15; 276(24):21331-6. Levin MH, Haggie PM, Vetrivel L, Verkman AS. PMID: 11297561.
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    413. Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. J Biol Chem. 2001 Jun 08; 276(23):19723-8. Galietta LJ, Springsteel MF, Eda M, Niedzinski EJ, By K, Haddadin MJ, Kurth MJ, Nantz MH, Verkman AS. PMID: 11262417.
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    414. Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH. J Clin Invest. 2001 Feb; 107(3):317-24. Jayaraman S, Song Y, Vetrivel L, Shankar L, Verkman AS. PMID: 11160155.
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    415. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001 Jan 05; 276(1):624-8. Yang B, Ma T, Verkman AS. PMID: 11035042.
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    416. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C126-34. Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS. PMID: 11121384.
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    417. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50. Song Y, Yang B, Matthay MA, Ma T, Verkman AS. PMID: 11078688.
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    418. Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. J Biol Chem. 2000 Nov 03; 275(44):34157-65. Foster W, Helm A, Turnbull I, Gulati H, Yang B, Verkman AS, Skach WR. PMID: 10944517.
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    419. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001 Jan 26; 276(4):2775-9. Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. PMID: 11035038.
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    420. Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Mol Biol Cell. 2000 Sep; 11(9):2973-85. Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS, Skach WR. PMID: 10982394.
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    421. Physiological importance of aquaporins: lessons from knockout mice. Curr Opin Nephrol Hypertens. 2000 Sep; 9(5):517-22. Verkman AS. PMID: 10990371.
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    422. Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G448-53. Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA. PMID: 10915655.
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    423. Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G463-70. Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA. PMID: 10915657.
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    424. Analysis of organ physiology in transgenic mice. Am J Physiol Cell Physiol. 2000 Jul; 279(1):C1-C18. Rao S, Verkman AS. PMID: 10898711.
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    425. Mesoscopic surfactant organization and membrane protein crystallization. Protein Sci. 2000 Jul; 9(7):1407-9. Wiener MC, Verkman AS, Stroud RM, van Hoek AN. PMID: 10933509.
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    426. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000 Jun 15; 525 Pt 3:771-9. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS. PMID: 10856128.
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    427. Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. Am J Physiol Renal Physiol. 2000 Jun; 278(6):F1030-3. Vallon V, Verkman AS, Schnermann J. PMID: 10836992.
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    428. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000 Jun; 278(6):C1108-15. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS. PMID: 10837338.
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    429. Quenching mechanism of quinolinium-type chloride-sensitive fluorescent indicators. Biophys Chem. 2000 May 31; 85(1):49-57. Jayaraman S, Verkman AS. PMID: 10885398.
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    430. Aquaporin water channels and lung physiology. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L867-79. Verkman AS, Matthay MA, Song Y. PMID: 10781416.
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    431. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000 May; 70(5):557-62. Moore M, Ma T, Yang B, Verkman AS. PMID: 10870513.
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    432. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4386-91. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. PMID: 10737773.
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    433. Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J Biol Chem. 2000 Mar 03; 275(9):6047-50. Jayaraman S, Haggie P, Wachter RM, Remington SJ, Verkman AS. PMID: 10692389.
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    434. Altered gravity downregulates aquaporin-1 protein expression in choroid plexus. J Appl Physiol (1985). 2000 Mar; 88(3):843-50. Masseguin C, Corcoran M, Carcenac C, Daunton NG, Güell A, Verkman AS, Gabrion J. PMID: 10710377.
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    435. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000 Mar; 85 Spec No:233S-241S. Verkman AS, Yang B, Song Y, Manley GT, Ma T. PMID: 10795927.
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    436. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther. 2000 Mar 01; 11(4):567-75. Yang B, Ma T, Dong JY, Verkman AS. PMID: 10724035.
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    437. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol. 2000 Feb; 278(2):F310-6. van Hoek AN, Ma T, Yang B, Verkman AS, Brown D. PMID: 10662735.
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    438. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000 Feb; 6(2):159-63. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. PMID: 10655103.
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    439. cAMP regulated membrane diffusion of a green fluorescent protein-aquaporin 2 chimera. Biophys J. 2000 Feb; 78(2):1024-35. Umenishi F, Verbavatz JM, Verkman AS. PMID: 10653816.
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    440. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000 Jan 28; 275(4):2686-92. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS. PMID: 10644730.
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    441. Size-dependent DNA mobility in cytoplasm and nucleus. J Biol Chem. 2000 Jan 21; 275(3):1625-9. Lukacs GL, Haggie P, Seksek O, Lechardeur D, Freedman N, Verkman AS. PMID: 10636854.
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    442. Water permeability measurement in living cells and complex tissues. J Membr Biol. 2000 Jan 15; 173(2):73-87. Verkman AS. PMID: 10630923.
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    443. Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest. 2000 Jan; 105(1):93-100. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. PMID: 10619865.
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    444. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000 Jan; 115(1):17-27. Song Y, Ma T, Matthay MA, Verkman AS. PMID: 10613915.
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    445. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest. 2000 Jan; 105(2):215-22. Pallone TL, Edwards A, Ma T, Silldorff EP, Verkman AS. PMID: 10642600.
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    446. Structure and function of aquaporin water channels. Am J Physiol Renal Physiol. 2000 Jan; 278(1):F13-28. Verkman AS, Mitra AK. PMID: 10644652.
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    447. Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus. J Biol Chem. 1999 Dec 03; 274(49):34825-31. Tamarappoo BK, Yang B, Verkman AS. PMID: 10574954.
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    448. Long-wavelength iodide-sensitive fluorescent indicators for measurement of functional CFTR expression in cells. Am J Physiol. 1999 11; 277(5):C1008-18. Jayaraman S, Teitler L, Skalski B, Verkman AS. PMID: 10564094.
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    449. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999 Jul 16; 274(29):20071-4. Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. PMID: 10400615.
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    450. Aquaporin water channels in gastrointestinal physiology. J Physiol. 1999 Jun 01; 517 ( Pt 2):317-26. Ma T, Verkman AS. PMID: 10332084.
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    451. Lessons on renal physiology from transgenic mice lacking aquaporin water channels. J Am Soc Nephrol. 1999 May; 10(5):1126-35. Verkman AS. PMID: 10232700.
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    452. Diffusion of green fluorescent protein in the aqueous-phase lumen of endoplasmic reticulum. Biophys J. 1999 May; 76(5):2843-51. Dayel MJ, Hom EF, Verkman AS. PMID: 10233100.
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    453. Fluorescent chloride indicators to assess the efficacy of CFTR cDNA delivery. Hum Gene Ther. 1999 Apr 10; 10(6):861-75. Mansoura MK, Biwersi J, Ashlock MA, Verkman AS. PMID: 10223721.
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    454. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999 Apr 01; 57(1):79-83. Yang B, Ma T, Xu Z, Verkman AS. PMID: 10191086.
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    455. Receptor-mediated targeting of fluorescent probes in living cells. J Biol Chem. 1999 Mar 19; 274(12):7603-6. Farinas J, Verkman AS. PMID: 10075643.
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    456. Synthesis and characterization of dual-wavelength Cl--sensitive fluorescent indicators for ratio imaging. Am J Physiol. 1999 03; 276(3):C747-57. Jayaraman S, Biwersi J, Verkman AS. PMID: 10070003.
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    457. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999 Feb; 103(4):491-6. Chou CL, Knepper MA, Hoek AN, Brown D, Yang B, Ma T, Verkman AS. PMID: 10021457.
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    458. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999 Feb; 103(4):555-61. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS. PMID: 10021464.
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    459. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol. 1999 01; 276(1):C76-81. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS. PMID: 9886922.
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    460. Green fluorescent protein as a probe to study intracellular solute diffusion. Methods Enzymol. 1999; 302:250-64. Verkman AS. PMID: 12876777.
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    461. Role of aquaporin water channels in kidney and lung. Am J Med Sci. 1998 Nov; 316(5):310-20. Verkman AS. PMID: 9822113.
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    462. Vasopressin regulated trafficking of a green fluorescent protein-aquaporin 2 chimera in LLC-PK1 cells. Histochem Cell Biol. 1998 Oct; 110(4):377-86. Gustafson CE, Levine S, Katsura T, McLaughlin M, Aleixo MD, Tamarappoo BK, Verkman AS, Brown D. PMID: 9792416.
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    463. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9660-4. Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS. PMID: 9689137.
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    464. A mouse model to test the in vivo efficacy of chemical chaperones. J Pharmacol Toxicol Methods. 1998 Jul; 40(1):39-45. Bai C, Biwersi J, Verkman AS, Matthay MA. PMID: 9920533.
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    465. Analysis of fluorophore diffusion by continuous distributions of diffusion coefficients: application to photobleaching measurements of multicomponent and anomalous diffusion. Biophys J. 1998 Jul; 75(1):557-67. Periasamy N, Verkman AS. PMID: 9649418.
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    466. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):143-9. Ma T, Yang B, Matthay MA, Verkman AS. PMID: 9651190.
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    467. Isolation and functional analysis of alternative promoters in the human aquaporin-4 water channel gene. Genomics. 1998 Jun 15; 50(3):373-7. Umenishi F, Verkman AS. PMID: 9676432.
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    468. Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. J Clin Invest. 1998 May 15; 101(10):2257-67. Tamarappoo BK, Verkman AS. PMID: 9593782.
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    469. Monte Carlo analysis of obstructed diffusion in three dimensions: application to molecular diffusion in organelles. Biophys J. 1998 May; 74(5):2722-30. Olveczky BP, Verkman AS. PMID: 9591696.
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    470. Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway. J Biol Chem. 1998 Apr 17; 273(16):9369-72. Yang B, Verkman AS. PMID: 9545259.
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    471. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Biophys J. 1998 Apr; 74(4):2121-8. Carter EP, Olveczky BP, Matthay MA, Verkman AS. PMID: 9545071.
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