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    David Pearce, MD

    SchoolUCSF School of Medicine
    Address1001 Potrero Ave, SFGH 100
    San Francisco CA 94110
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPost-Doc Fellow/Scholar Medicine1989
      University of California, San FranciscoResidency

      Collapse Overview 
      Collapse Overview
      College: University of California, Berkeley BA (Mathematics)
      Medical School: University of Chicago, Pritzker School of Medicine, MD
      Internal Medicine Residency: Harbor-UCLA Medical Center
      Nephrology Fellowship: University of California, San Francisco

      Dr. Pearce's research focuses on understanding the cellular and molecular mechanisms underlying hormone-regulated ion transport in the kidney tubules. His lab has cloned and characterized several key regulatory proteins involved in the control of epithelial Na+ and K+ transport. Notably, SGK1 is a serine-threonine signaling kinase, which mediates the effects of multiple hormones, and is necessary for normal Na+ and K+ homeostasis. Defects in SGK1 result in pseudohypoaldosteronism (Na+ wasting and inability to excrete K+ despite high aldosterone levels).

      His group has made seminal contributions to our understanding of how the effects of SGK1 and other signaling proteins are integrated to achieve specific regulation of ion transport. Recently, his lab identified a large multiprotein complex, which integrates manifold inputs that impact on Na+ transport in kidney tubule cells. The principal goal of this basic research is to identify points of entry for treatment of diseases such as hypertension and metabolic syndrome. Already, SGK1 inhibitors are in preclinical testing for the treatment of salt sensitive hypertension.

      Dr. Pearce's research is funded by two R01's from the NIDDK, and several Foundation awards.

      Dr. Pearce is Professor of Medicine and Cellular & Molecular Pharmacology at UCSF, and Chief of Nephrology at San Francisco General Hospital, one of the core teaching hospitals affiliated with UCSF.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D. mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity. J Clin Invest. 2015 Jan 2; 125(1):117-28.
        View in: PubMed
      2. Miller JN, Kovács AD, Pearce DA. The novel Cln1R151X mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015 Jan 1; 24(1):185-96.
        View in: PubMed
      3. Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE. Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol. 2015 Jan 7; 10(1):135-46.
        View in: PubMed
      4. Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W. Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase aENaC transcription. Am J Physiol Renal Physiol. 2013 Nov 15; 305(10):F1436-44.
        View in: PubMed PMC3840248
      5. Getty A, Kovács AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH, Pearce DA. Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3. PLoS One. 2013; 8(6):e66203.
        View in: PubMed PMC3688782
      6. Miller JN, Chan CH, Pearce DA. The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Jul 1; 22(13):2723-34.
        View in: PubMed
      7. Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH. Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24; 199(7):1145-58.
        View in: PubMed PMC3529522
      8. Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cell Physiol Biochem. 2012; 30(6):1423-35.
        View in: PubMed
      9. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25.
        View in: PubMed PMC3463358
      10. Kovács AD, Saje A, Wong A, Ramji S, Cooper JD, Pearce DA. Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease. Neuropharmacology. 2012 Oct; 63(5):769-75.
        View in: PubMed PMC3408822
      11. Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S. The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis. Sex Dev. 2012; 6(4):169-77.
        View in: PubMed
      12. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun; 26(6):1000-13.
        View in: PubMed
      13. Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012 Jul-Aug; 47(4):349-59.
        View in: PubMed
      14. Soundararajan R, Pearce D, Ziera T. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012 Mar 24; 350(2):242-7.
        View in: PubMed PMC3270213
      15. Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 2011 Dec; 25(12):2106-18.
        View in: PubMed PMC3231839
      16. Finn R, Kovács AD, Pearce DA. Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis. J Neurosci Res. 2012 Feb; 90(2):367-75.
        View in: PubMed PMC3237775
      17. Lu M, Wang J, Ives HE, Pearce D. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011 Sep 2; 286(35):30647-54.
        View in: PubMed PMC3162425
      18. Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 2011 Jul; 80(1):61-7.
        View in: PubMed
      19. Humphreys MH, Ni XP, Pearce D. Cardiovascular effects of melanocortins. Eur J Pharmacol. 2011 Jun 11; 660(1):43-52.
        View in: PubMed PMC3086937
      20. Pasham V, Rotte A, Bhandaru M, Eichenmüller M, Fröhlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F. Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3. J Gastroenterol. 2011 Mar; 46(3):305-17.
        View in: PubMed
      21. Kovács AD, Saje A, Wong A, Szénási G, Kiricsi P, Szabó E, Cooper JD, Pearce DA. Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease. Neuropharmacology. 2011 Feb-Mar; 60(2-3):405-9.
        View in: PubMed PMC3174473
      22. Soundararajan R, Wang J, Melters D, Pearce D. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem. 2010 Dec 17; 285(51):39905-13.
        View in: PubMed PMC3000972
      23. Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1496-506.
        View in: PubMed PMC3006302
      24. Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1007-14.
        View in: PubMed PMC3774517
      25. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem. 2010 Oct 1; 285(40):30363-9.
        View in: PubMed PMC2945528
      26. Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F. Regulation of gastric acid secretion by PKB/Akt2. Cell Physiol Biochem. 2010; 25(6):695-704.
        View in: PubMed PMC3709192
      27. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 9; 285(28):21671-8.
        View in: PubMed PMC2898378
      28. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8.
        View in: PubMed PMC2865740
      29. Kempe DS, Ackermann TF, Boini KM, Klaus F, Umbach AT, Dërmaku-Sopjani M, Judenhofer MS, Pichler BJ, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F. Akt2/PKBbeta-sensitive regulation of renal phosphate transport. Acta Physiol (Oxf). 2010 Sep; 200(1):75-85.
        View in: PubMed
      30. Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F. Regulation of renal tubular glucose reabsorption by Akt2/PKBß. Am J Physiol Renal Physiol. 2010 May; 298(5):F1113-7.
        View in: PubMed PMC4116394
      31. Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D. Akt2 and SGK3 are both determinants of postnatal hair follicle development. FASEB J. 2009 Sep; 23(9):3193-202.
        View in: PubMed PMC2735357
      32. Ni XP, van Dijk C, Pearce D, Humphreys MH. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone. Exp Physiol. 2009 Aug; 94(8):867-76.
        View in: PubMed PMC2853237
      33. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7804-9.
        View in: PubMed PMC2683131
      34. Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 3; 7(3):e60.
        View in: PubMed PMC2650726
      35. Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50.
        View in: PubMed PMC2536874
      36. Soundararajan R, Wang J, Melters D, Pearce D. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem. 2007 Dec 14; 282(50):36303-13.
        View in: PubMed
      37. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1741-50.
        View in: PubMed
      38. Pearce D, Kleyman TR. Salt, sodium channels, and SGK1. J Clin Invest. 2007 Mar; 117(3):592-5.
        View in: PubMed PMC1804371
      39. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 8; 281(36):26159-69.
        View in: PubMed
      40. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F714-21.
        View in: PubMed
      41. Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F. Renal function of gene-targeted mice lacking both SGK1 and SGK3. Am J Physiol Regul Integr Comp Physiol. 2006 Apr; 290(4):R945-50.
        View in: PubMed
      42. Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F. Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse. Behav Brain Res. 2006 Feb 15; 167(1):75-86.
        View in: PubMed
      43. Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D. A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport. J Biol Chem. 2005 Dec 2; 280(48):39970-81.
        View in: PubMed
      44. Ni XP, Bhargava A, Pearce D, Humphreys MH. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R560-7.
        View in: PubMed
      45. Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol. 2005 Dec; 19(12):3073-84.
        View in: PubMed
      46. Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F. Decreased intestinal glucose transport in the sgk3-knockout mouse. Pflugers Arch. 2005 Dec; 451(3):437-44.
        View in: PubMed
      47. McCormick JA, Bhalla V, Pao AC, Pearce D. SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology (Bethesda). 2005 Apr; 20:134-9.
        View in: PubMed
      48. Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol. 2005 Jun 1; 565(Pt 2):381-90.
        View in: PubMed PMC1464516
      49. Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, de Kloet ER. Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling. Endocrinology. 2005 Mar; 146(3):1438-48.
        View in: PubMed
      50. McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell. 2004 Sep; 15(9):4278-88.
        View in: PubMed PMC515358
      51. Bhargava A, Dallman MF, Pearce D, Choi S. Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides. Brain Res Brain Res Protoc. 2004 Jun; 13(2):115-25.
        View in: PubMed
      52. Bhargava A, Pearce D. Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products. Trends Endocrinol Metab. 2004 May-Jun; 15(4):147-53.
        View in: PubMed
      53. Bhargava A, Wang J, Pearce D. Regulation of epithelial ion transport by aldosterone through changes in gene expression. Mol Cell Endocrinol. 2004 Mar 31; 217(1-2):189-96.
        View in: PubMed
      54. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71.
        View in: PubMed
      55. Adams M, Meijer OC, Wang J, Bhargava A, Pearce D. Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants. Mol Endocrinol. 2003 Dec; 17(12):2583-92.
        View in: PubMed
      56. Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD. Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities. Endocrinology. 2003 Oct; 144(10):4226-36.
        View in: PubMed
      57. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest. 2003 Apr; 111(8):1251-8.
        View in: PubMed PMC152936
      58. Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Pflugers Arch. 2003 Mar; 445(6):693-6.
        View in: PubMed
      59. Pearce D, Bhargava A, Cole TJ. Aldosterone: its receptor, target genes, and actions. Vitam Horm. 2003; 66:29-76.
        View in: PubMed
      60. Pearce D. SGK1 regulation of epithelial sodium transport. Cell Physiol Biochem. 2003; 13(1):13-20.
        View in: PubMed
      61. Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F. The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J Am Soc Nephrol. 2002 Dec; 13(12):2823-30.
        View in: PubMed
      62. Edinger RS, Watkins SC, Pearce D, Johnson JP. Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F254-61.
        View in: PubMed
      63. Bhargava A, Mathias RS, McCormick JA, Dallman MF, Pearce D. Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1. Mol Endocrinol. 2002 Jul; 16(7):1629-37.
        View in: PubMed
      64. Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D. Hypotonic induction of SGK1 and Na+ transport in A6 cells. Am J Physiol Renal Physiol. 2002 Jul; 283(1):F105-13.
        View in: PubMed
      65. Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J. 2001 Dec 17; 20(24):7052-9.
        View in: PubMed PMC125341
      66. Pearce D, Náray-Fejes-Tóth A, Fejes-Tóth G. Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors. J Biol Chem. 2002 Jan 11; 277(2):1451-6.
        View in: PubMed
      67. Pearce D. The role of SGK1 in hormone-regulated sodium transport. Trends Endocrinol Metab. 2001 Oct; 12(8):341-7.
        View in: PubMed
      68. Bhargava A, Fullerton MJ, Myles K, Purdy TM, Funder JW, Pearce D, Cole TJ. The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Endocrinology. 2001 Apr; 142(4):1587-94.
        View in: PubMed
      69. Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol. 2001 Apr; 280(4):F675-82.
        View in: PubMed
      70. Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol. 2001 Feb; 280(2):F303-13.
        View in: PubMed
      71. Sherman MP, de Noronha CM, Pearce D, Greene WC. Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest. J Virol. 2000 Sep; 74(17):8159-65.
        View in: PubMed PMC112350
      72. Iñiguez-Lluhí JA, Pearce D. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol. 2000 Aug; 20(16):6040-50.
        View in: PubMed PMC86080
      73. Bhargava A, Meijer OC, Dallman MF, Pearce D. Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus. J Neurosci. 2000 May 1; 20(9):3129-38.
        View in: PubMed
      74. Pearce D, Verrey F, Chen SY, Mastroberardino L, Meijer OC, Wang J, Bhargava A. Role of SGK in mineralocorticoid-regulated sodium transport. Kidney Int. 2000 Apr; 57(4):1283-9.
        View in: PubMed
      75. Verrey F, Pearce D, Pfeiffer R, Spindler B, Mastroberardino L, Summa V, Zecevic M. Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms. Kidney Int. 2000 Apr; 57(4):1277-82.
        View in: PubMed
      76. Meijer OC, Williamson A, Dallman MF, Pearce D. Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context. J Neuroendocrinol. 2000 Mar; 12(3):245-54.
        View in: PubMed
      77. Wissink S, Meijer O, Pearce D, van Der Burg B, van Der Saag PT. Regulation of the rat serotonin-1A receptor gene by corticosteroids. J Biol Chem. 2000 Jan 14; 275(2):1321-6.
        View in: PubMed
      78. Rogatsky I, Hittelman AB, Pearce D, Garabedian MJ. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Mol Cell Biol. 1999 Jul; 19(7):5036-49.
        View in: PubMed PMC84339
      79. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2514-9.
        View in: PubMed PMC26816
      80. Pearce D, Matsui W, Miner JN, Yamamoto KR. Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites. J Biol Chem. 1998 Nov 13; 273(46):30081-5.
        View in: PubMed
      81. Fejes-Tóth G, Pearce D, Náray-Fejes-Tóth A. Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2973-8.
        View in: PubMed PMC19679
      82. Chen SY, Wang J, Liu W, Pearce D. Aldosterone responsiveness of A6 cells is restored by cloned rat mineralocorticoid receptor. Am J Physiol. 1998 Jan; 274(1 Pt 1):C39-46.
        View in: PubMed
      83. Chen Sy, Wang J, Yu Gq, Liu W, Pearce D. Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity. J Biol Chem. 1997 May 30; 272(22):14087-92.
        View in: PubMed
      84. Page MD, Pearce DA, Norris HA, Ferguson SJ. The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter. Microbiology. 1997 Feb; 143 ( Pt 2):563-76.
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      85. Liu W, Wang J, Yu G, Pearce D. Steroid receptor transcriptional synergy is potentiated by disruption of the DNA-binding domain dimer interface. Mol Endocrinol. 1996 Nov; 10(11):1399-406.
        View in: PubMed
      86. Liu W, Wang J, Sauter NK, Pearce D. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12480-4.
        View in: PubMed PMC40381
      87. Pearce D. A mechanistic basis for distinct mineralocorticoid and glucocorticoid receptor transcriptional specificities. Steroids. 1994 Feb; 59(2):153-9.
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      88. Pearce D, Yamamoto KR. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science. 1993 Feb 19; 259(5098):1161-5.
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      89. Krapf R, Pearce D, Lynch C, Xi XP, Reudelhuber TL, Pouysségur J, Rector FC. Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis. J Clin Invest. 1991 Feb; 87(2):747-51.
        View in: PubMed PMC296370
      90. Pearce D, Verkman AS. NaCl reflection coefficients in proximal tubule apical and basolateral membrane vesicles. Measurement by induced osmosis and solvent drag. Biophys J. 1989 Jun; 55(6):1251-9.
        View in: PubMed PMC1330589
      91. Chen PY, Pearce D, Verkman AS. Membrane water and solute permeability determined quantitatively by self-quenching of an entrapped fluorophore. Biochemistry. 1988 Jul 26; 27(15):5713-8.
        View in: PubMed
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