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    Dyche Mullins, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentCMP (Cellular Molecular Pha)
    Address600 16th Street
    San Francisco CA 94158
    Phone415-502-4838

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       Global Health
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       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. J Am Chem Soc. 2014 Sep 10; 136(36):12624-30.
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      2. Polka JK, Kollman JM, Mullins RD. Accessory factors promote AlfA-dependent plasmid segregation by regulating filament nucleation, disassembly, and bundling. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2176-81.
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      3. Petek NA, Mullins RD. Bacterial actin-like proteins: purification and characterization of self-assembly properties. Methods Enzymol. 2014; 540:19-34.
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      4. Hansen SD, Kwiatkowski AV, Ouyang CY, Liu H, Pokutta S, Watkins SC, Volkmann N, Hanein D, Weis WI, Mullins RD, Nelson WJ. aE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors. Mol Biol Cell. 2013 Dec; 24(23):3710-20.
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      5. Belin BJ, Mullins RD. What we talk about when we talk about nuclear actin. Nucleus. 2013 Jul-Aug; 4(4):291-7.
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      6. Belin BJ, Cimini BA, Blackburn EH, Mullins RD. Visualization of actin filaments and monomers in somatic cell nuclei. Mol Biol Cell. 2013 Apr; 24(7):982-94.
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      7. Ingerman E, Hsiao JY, Mullins RD. Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly. J Cell Biol. 2013 Mar 4; 200(5):619-33.
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      8. Hansen SD, Zuchero JB, Mullins RD. Cytoplasmic actin: purification and single molecule assembly assays. Methods Mol Biol. 2013; 1046:145-70.
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      9. Mullins RD, Hansen SD. In vitro studies of actin filament and network dynamics. Curr Opin Cell Biol. 2013 Feb; 25(1):6-13.
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      10. Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3.
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      11. Mullins RD. The instability of stabilization. Proc Natl Acad Sci U S A. 2012 Jul 3; 109(27):10743-4.
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      12. Zuchero JB, Belin B, Mullins RD. Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY. Mol Biol Cell. 2012 Mar; 23(5):853-63.
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      13. Mullins D. Pulling together and pulling apart: collective cargo movement in eukaryotic cells. Nat Cell Biol. 2011 Dec; 13(12):1391-2.
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      14. Mullins D. Cytoskeleton dynamics. Mol Biol Cell. 2011 Mar 15; 22(6):718.
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      15. Rivera CR, Kollman JM, Polka JK, Agard DA, Mullins RD. Architecture and assembly of a divergent member of the ParM family of bacterial actin-like proteins. J Biol Chem. 2011 Apr 22; 286(16):14282-90.
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      16. Hansen SD, Mullins RD. VASP is a processive actin polymerase that requires monomeric actin for barbed end association. J Cell Biol. 2010 Nov 1; 191(3):571-84.
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      17. Fletcher DA, Mullins RD. Cell mechanics and the cytoskeleton. Nature. 2010 Jan 28; 463(7280):485-92.
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      18. Mullins RD. Cytoskeletal mechanisms for breaking cellular symmetry. Cold Spring Harb Perspect Biol. 2010 Jan; 2(1):a003392.
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      19. Dayel MJ, Akin O, Landeryou M, Risca V, Mogilner A, Mullins RD. In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol. 2009 Sep; 7(9):e1000201.
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      20. Galkin VE, Orlova A, Rivera C, Mullins RD, Egelman EH. Structural polymorphism of the ParM filament and dynamic instability. Structure. 2009 Sep 9; 17(9):1253-64.
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      21. Polka JK, Kollman JM, Agard DA, Mullins RD. The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation. J Bacteriol. 2009 Oct; 191(20):6219-30.
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      22. Zuchero JB, Coutts AS, Quinlan ME, Thangue NB, Mullins RD. p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol. 2009 Apr; 11(4):451-9.
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      23. Mullins RD. Bacterial Chromosome Segregation. Annu Rev Cell Dev Biol. 2009 Jan 12.
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      24. Mullins D. Q and A: Dyche Mullins. Curr Biol. 2008 Oct 14; 18(19):R895-6.
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      25. LeClaire LL, Baumgartner M, Iwasa JH, Mullins RD, Barber DL. Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. J Cell Biol. 2008 Aug 25; 182(4):647-54.
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      26. Choi CL, Claridge SA, Garner EC, Alivisatos AP, Mullins RD. Protein-nanocrystal conjugates support a single filament polymerization model in R1 plasmid segregation. J Biol Chem. 2008 Oct 17; 283(42):28081-6.
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      27. Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature. 2008 Aug 21; 454(7207):1005-8.
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      28. Akin O, Mullins RD. Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex. Cell. 2008 May 30; 133(5):841-51.
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      29. Mullins RD. Trapping fugitive filament formers. Structure. 2008 May; 16(5):661-3.
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      30. Campbell CS, Mullins RD. In vivo visualization of type II plasmid segregation: bacterial actin filaments pushing plasmids. J Cell Biol. 2007 Dec 3; 179(5):1059-66.
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      31. Quinlan ME, Hilgert S, Bedrossian A, Mullins RD, Kerkhoff E. Regulatory interactions between two actin nucleators, Spire and Cappuccino. J Cell Biol. 2007 Oct 8; 179(1):117-28.
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      32. Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH. The structure of bacterial ParM filaments. Nat Struct Mol Biol. 2007 Oct; 14(10):921-6.
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      33. Iwasa JH, Mullins RD. Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol. 2007 Mar 6; 17(5):395-406.
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      34. Garner EC, Campbell CS, Weibel DB, Mullins RD. Reconstitution of DNA segregation driven by assembly of a prokaryotic actin homolog. Science. 2007 Mar 2; 315(5816):1270-4.
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      35. Loomis PA, Kelly AE, Zheng L, Changyaleket B, Sekerková G, Mugnaini E, Ferreira A, Mullins RD, Bartles JR. Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells. J Cell Sci. 2006 Apr 15; 119(Pt 8):1655-65.
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      36. Kelly AE, Kranitz H, Dötsch V, Mullins RD. Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. J Biol Chem. 2006 Apr 14; 281(15):10589-97.
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      37. Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD. Drosophila Spire is an actin nucleation factor. Nature. 2005 Jan 27; 433(7024):382-8.
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      38. Garner EC, Campbell CS, Mullins RD. Dynamic instability in a DNA-segregating prokaryotic actin homolog. Science. 2004 Nov 5; 306(5698):1021-5.
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      39. Dayel MJ, Mullins RD. Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2. PLoS Biol. 2004 Apr; 2(4):E91.
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      40. Welch MD, Mullins RD. Cellular control of actin nucleation. Annu Rev Cell Dev Biol. 2002; 18:247-88.
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      41. Dayel MJ, Holleran EA, Mullins RD. Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):14871-6.
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      42. Zalevsky J, Lempert L, Kranitz H, Mullins RD. Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities. Curr Biol. 2001 Dec 11; 11(24):1903-13.
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      43. Shahidain R, Mullins RD, Sisken JE. Calcium spiking activity and baseline calcium levels in ROS 17/2.8 cells exposed to extremely low frequency electromagnetic fields (ELF EMF). Int J Radiat Biol. 2001 Feb; 77(2):241-8.
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      44. Pollard TD, Blanchoin L, Mullins RD. Actin dynamics. J Cell Sci. 2001 Jan; 114(Pt 1):3-4.
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      45. Prehoda KE, Scott JA, Mullins RD, Lim WA. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science. 2000 Oct 27; 290(5492):801-6.
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      46. Blanchoin L, Pollard TD, Mullins RD. Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks. Curr Biol. 2000 Oct 19; 10(20):1273-82.
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      47. Zalevsky J, Grigorova I, Mullins RD. Activation of the Arp2/3 complex by the Listeria acta protein. Acta binds two actin monomers and three subunits of the Arp2/3 complex. J Biol Chem. 2001 Feb 2; 276(5):3468-75.
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      48. Mullins RD, Sisken JE. Mechanisms underlying spontaneous calcium spiking in aequorin-loaded ROS 17/2.8 cells. Bioelectromagnetics. 2000 Jul; 21(5):329-37.
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      49. DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol. 2000 Mar 20; 148(6):1267-81.
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      50. Mullins RD. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures. Curr Opin Cell Biol. 2000 Feb; 12(1):91-6.
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      51. Pollard TD, Blanchoin L, Mullins RD. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct. 2000; 29:545-76.
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      52. Mullins RD, Machesky LM. Actin assembly mediated by Arp2/3 complex and WASP family proteins. Methods Enzymol. 2000; 325:214-37.
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      53. Mullins RD, Pollard TD. Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts. Curr Biol. 1999 Apr 22; 9(8):405-15.
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      54. Mullins RD, Pollard TD. Structure and function of the Arp2/3 complex. Curr Opin Struct Biol. 1999 Apr; 9(2):244-9.
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      55. Machesky LM, Mullins RD, Higgs HN, Kaiser DA, Blanchoin L, May RC, Hall ME, Pollard TD. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3739-44.
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      56. Mullins RD, Heuser JA, Pollard TD. The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6181-6.
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      57. Mullins RD, Kelleher JF, Xu J, Pollard TD. Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filaments. Mol Biol Cell. 1998 Apr; 9(4):841-52.
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      58. Kelleher JF, Mullins RD, Pollard TD. Purification and assay of the Arp2/3 complex from Acanthamoeba castellanii. Methods Enzymol. 1998; 298:42-51.
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      59. Mullins RD, Stafford WF, Pollard TD. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. J Cell Biol. 1997 Jan 27; 136(2):331-43.
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      60. Mullins RD, Kelleher JF, Pollard TD. Actin' like actin? Trends Cell Biol. 1996 Jun; 6(6):208-12.
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      61. McCoy KR, Mullins RD, Newcomb TG, Ng GM, Pavlínková G, Polinsky RJ, Nee LE, Sisken JE. Serum- and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts. Neurobiol Aging. 1993 Sep-Oct; 14(5):447-55.
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      62. Newcomb TG, Mullins RD, Sisken JE. Altered calcium regulation in SV40-transformed Swiss 3T3 fibroblasts. Cell Calcium. 1993 Jul; 14(7):539-49.
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      63. Mullins RD, Sisken JE, Hejase HA, Sisken BF. Design and characterization of a system for exposure of cultured cells to extremely low frequency electric and magnetic fields over a wide range of field strengths. Bioelectromagnetics. 1993; 14(2):173-86.
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