Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Harold Chapman

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-514-1210
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      National Institute of Health2001 - 2012Merit Award
      1998American Association of Physicians
      1987American Society for Clinical Investigation

      Collapse Overview 
      Collapse Overview
      The Chapman lab has had a longstanding interest and track record of innovation in the field of tissue remodeling, particularly as it relates to lung disease. For many years my work primarily focused on proteolytic enzymes. My group and I cloned and characterized several new members of the cathepsin family and elucidated their roles in bone, brain, lung, and immune disorders. I also pursued basic mechanisms by which proteases and adhesion receptors coordinate cell invasion and extracellular matrix remodeling and this has led to longstanding interest in integrin signaling. We were the first to recognize the physical and functional connections between integrins and the key cell surface protease, plasminogen activator. After moving from Harvard to UCSF 12 years ago I focused my lab on pulmonary fibrosis as a disorder of great unmet medical need and a logical extension of my prior work in matrix biology. I pioneered the in vivo investigation of the role of epithelial mesenchymal transition (EMT) in pulmonary fibrosis and uncovered mechanistic insight as to how integrins and hypoxia regulate epithelial cell plasticity. These studies have provided a roadmap for defining the role of EMT signaling in human fibrosis and lung cancer. More recently we have extended our studies of epithelial plasticity into the realm of lung stem/progenitor cells and are committed to defining the regenerative potential of the lung after injury.

      I have trained approximately twenty PhD and/or MD post-docs who now populate academic departments and pharmaceutical labs. As a physician scientist myself, I have particularly enjoyed the responsibility of motivating and training capable young physicians for careers in disease-oriented research. These now include Division and Department Chairs as well as several independent medicine faculty with successful NIH-funded research programs. My lab now is comprised of mainly PhD trainees and junior faculty and we are committed to understanding and targeting the emerging relationship between hypoxia, EMT, and tissue remodeling during fibrogenesis and cancer progression.


      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 Oct; 55(4):613-615. PMID: 27689795.
        View in: PubMed
      2. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958; PMCID: PMC4312207.
      3. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. PMID: 25526531; PMCID: PMC4273650 [Available on 12/18/15].
      4. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 7; 15(2):123-38. PMID: 25105578; PMCID: PMC4212493.
      5. Reiser J, Chapman H. Soluble urokinase-type plasminogen activator receptor in FSGS: stirred but not shaken. J Am Soc Nephrol. 2014 Aug; 25(8):1611-3. PMID: 24790180; PMCID: PMC4116074.
      6. Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. J Biol Chem. 2014 May 2; 289(18):12791-804. PMID: 24644284; PMCID: PMC4007467.
      7. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. PMID: 24160862; PMCID: PMC3983890.
      8. Xi Y, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline. Am J Respir Cell Mol Biol. 2014 Jan; 50(1):51-60. PMID: 23944988; PMCID: PMC3930932.
      9. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 9; 5(206):206ra139. PMID: 24107778; PMCID: PMC3882146.
      10. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-70. PMID: 24012677; PMCID: PMC3814683.
      11. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 1; 188(3):370-5. PMID: 23713908; PMCID: PMC3778734.
      12. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856; PMCID: PMC3955361.
      13. Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M. Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Apr 1; 22(7):1417-23. PMID: 23297359; PMCID: PMC3596852.
      14. Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA. Identification of pY654-ß-catenin as a critical co-factor in hypoxia-inducible factor-1a signaling and tumor responses to hypoxia. Oncogene. 2013 Oct 17; 32(42):5048-57. PMID: 23246962; PMCID: PMC3871884.
      15. Vaughan AE, Chapman HA. Regenerative activity of the lung after epithelial injury. Biochim Biophys Acta. 2013 Jul; 1832(7):922-30. PMID: 23219956.
        View in: PubMed
      16. Chapman HA. Epithelial responses to lung injury: role of the extracellular matrix. Proc Am Thorac Soc. 2012 Jul; 9(3):89-95. PMID: 22802280.
        View in: PubMed
      17. Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012 Mar; 2(3):270-87. PMID: 22585997; PMCID: PMC3354652.
      18. Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA. Axin pathway activity regulates in vivo pY654-ß-catenin accumulation and pulmonary fibrosis. J Biol Chem. 2012 Feb 10; 287(7):5164-72. PMID: 22203675; PMCID: PMC3281604.
      19. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62. PMID: 21701069; PMCID: PMC3223845.
      20. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. PMID: 21653526; PMCID: PMC3132783.
      21. Chapman HA. Toward lung regeneration. N Engl J Med. 2011 May 12; 364(19):1867-8. PMID: 21561353.
        View in: PubMed
      22. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L71-8. PMID: 21498628; PMCID: PMC3129898.
      23. Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol. 2011; 73:413-35. PMID: 21054168.
        View in: PubMed
      24. Zhu S, Gladson CL, White KE, Ding Q, Stewart J, Jin TH, Chapman HA, Olman MA. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L97-108. PMID: 19411312; PMCID: PMC2711805.
      25. Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009 Mar; 136(5):843-53. PMID: 19176588; PMCID: PMC2685949.
      26. Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol. 2009 Jan 26; 184(2):309-22. PMID: 19171760; PMCID: PMC2654298.
      27. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. PMID: 19104148.
        View in: PubMed
      28. Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. J Cell Sci. 2008 Nov 15; 121(Pt 22):3747-56. PMID: 18940913; PMCID: PMC3903460.
      29. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 2008 Dec 4; 456(7222):658-62. PMID: 18820679; PMCID: PMC2596276.
      30. Kim KK, Chapman HA. Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):1-2. PMID: 17575081.
        View in: PubMed
      31. Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem. 2007 Feb 9; 282(6):3929-39. PMID: 17145753.
        View in: PubMed
      32. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol. 2006 Nov 1; 177(9):5779-84. PMID: 17056501.
        View in: PubMed
      33. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5. PMID: 16924102; PMCID: PMC1551904.
      34. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502. PMID: 16921128.
        View in: PubMed
      35. Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem. 2006 Aug; 387(8):1143-6. PMID: 16895486; PMCID: PMC2271110.
      36. Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol. 2006 Mar; 26(6):2309-16. PMID: 16508006; PMCID: PMC1430281.
      37. Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem. 2006 May 12; 281(19):13021-9. PMID: 16510444.
        View in: PubMed
      38. Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 2006 Mar 3; 281(9):6020-9. PMID: 16365041.
        View in: PubMed
      39. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64. PMID: 16358219; PMCID: PMC1380249.
      40. Chapman HA. Endosomal proteases in antigen presentation. Curr Opin Immunol. 2006 Feb; 18(1):78-84. PMID: 16338127.
        View in: PubMed
      41. Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA. Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease. Immunology. 2005 Dec; 116(4):532-40. PMID: 16313367; PMCID: PMC1802445.
      42. Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):355-62. PMID: 16081882; PMCID: PMC2715343.
      43. Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol. 2005 Jun 15; 174(12):8106-15. PMID: 15944319.
        View in: PubMed
      44. Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. J Immunol. 2005 Feb 1; 174(3):1729-37. PMID: 15661938.
        View in: PubMed
      45. Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol. 2005 Jan 31; 168(3):501-11. PMID: 15684035; PMCID: PMC2171741.
      46. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75. PMID: 15653570.
        View in: PubMed
      47. Aslanian AM, Chapman HA, Charo IF. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):628-32. PMID: 15591216.
        View in: PubMed
      48. DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301. PMID: 15347563.
        View in: PubMed
      49. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53. PMID: 15197138.
        View in: PubMed
      50. Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 1; 13(15):1649-56. PMID: 15175276.
        View in: PubMed
      51. DeMeo DL, Carey VJ, Chapman HA, Reilly JJ, Ginns LC, Speizer FE, Weiss ST, Silverman EK. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax. 2004 May; 59(5):396-400. PMID: 15115866; PMCID: PMC1747013.
      52. Chapman HA. Cathepsins as transcriptional activators? Dev Cell. 2004 May; 6(5):610-1. PMID: 15130484.
        View in: PubMed
      53. DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol. 2004 Apr; 164(4):1131-9. PMID: 15039201; PMCID: PMC1615345.
      54. Chapman HA. Disorders of lung matrix remodeling. J Clin Invest. 2004 Jan; 113(2):148-57. PMID: 14722604; PMCID: PMC311438.
      55. Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol. 2003 Oct 13; 163(1):177-88. PMID: 14557254; PMCID: PMC2173444.
      56. Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem. 2003 Oct-Nov; 384(10-11):1527-31. PMID: 14669996.
        View in: PubMed
      57. Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ. Matrilysin-dependent elastolysis by human macrophages. J Exp Med. 2003 Sep 15; 198(6):925-35. PMID: 12963695; PMCID: PMC2194197.
      58. Palmer LJ, Celedón JC, Chapman HA, Speizer FE, Weiss ST, Silverman EK. Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease. Hum Mol Genet. 2003 May 15; 12(10):1199-210. PMID: 12719384.
        View in: PubMed
      59. Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 2003 Mar 21; 92(5):493-500. PMID: 12600886.
        View in: PubMed
      60. Kugler MC, Wei Y, Chapman HA. Urokinase receptor and integrin interactions. Curr Pharm Des. 2003; 9(19):1565-74. PMID: 12871068.
        View in: PubMed
      61. Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease. J Immunol. 2002 Dec 15; 169(12):6720-32. PMID: 12471103.
        View in: PubMed
      62. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):236-46. PMID: 12119236.
        View in: PubMed
      63. Wu ZQ, Shen Y, Khan AQ, Chu CL, Riese R, Chapman HA, Kanagawa O, Snapper CM. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. J Immunol. 2002 Jun 1; 168(11):5551-7. PMID: 12023350.
        View in: PubMed
      64. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. PMID: 11985866.
        View in: PubMed
      65. Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet. 2002 May; 70(5):1229-39. PMID: 11914989; PMCID: PMC447597.
      66. Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet. 2002 Mar 15; 11(6):623-32. PMID: 11912177.
        View in: PubMed
      67. Zhu S, Gladson CL, Stewart J, White KE, Chapman HA, Olman MA. Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts. Chest. 2002 Mar; 121(3 Suppl):34S-35S. PMID: 11893675.
        View in: PubMed
      68. Fong S, Doyle MV, Goodson RJ, Drummond RJ, Stratton JR, McGuire L, Doyle LV, Chapman HA, Rosenberg S. Random peptide bacteriophage display as a probe for urokinase receptor ligands. Biol Chem. 2002 Jan; 383(1):149-58. PMID: 11928809.
        View in: PubMed
      69. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 2001 Dec; 15(6):909-19. PMID: 11754813.
        View in: PubMed
      70. Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Mol Biol Cell. 2001 Oct; 12(10):2975-86. PMID: 11598185; PMCID: PMC60149.
      71. Chapman HA, Wei Y. Protease crosstalk with integrins: the urokinase receptor paradigm. Thromb Haemost. 2001 Jul; 86(1):124-9. PMID: 11486997.
        View in: PubMed
      72. Fernández PL, Farré X, Nadal A, Fernández E, Peiró N, Sloane BF, Shi GP, Chapman HA, Campo E, Cardesa A. Expression of cathepsins B and S in the progression of prostate carcinoma. Int J Cancer. 2001 Jan 20; 95(1):51-5. PMID: 11241311.
        View in: PubMed
      73. Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med. 2000 Dec 4; 192(11):1587-600. PMID: 11104801; PMCID: PMC2193095.
      74. Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 Dec; 162(6):2152-8. PMID: 11112130.
        View in: PubMed
      75. Wolters PJ, Chapman HA. Importance of lysosomal cysteine proteases in lung disease. Respir Res. 2000; 1(3):170-7. PMID: 11667982; PMCID: PMC59556.
      76. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest. 2000 Nov; 106(9):1081-93. PMID: 11067861; PMCID: PMC301418.
      77. Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. Biochemistry. 2000 Jun 20; 39(24):7081-91. PMID: 10852705.
        View in: PubMed
      78. Chapman HA, Shi GP. Protease injury in the development of COPD: Thomas A. Neff Lecture. Chest. 2000 May; 117(5 Suppl 1):295S-9S. PMID: 10843961.
        View in: PubMed
      79. Simon DI, Wei Y, Zhang L, Rao NK, Xu H, Chen Z, Liu Q, Rosenberg S, Chapman HA. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. J Biol Chem. 2000 Apr 7; 275(14):10228-34. PMID: 10744708.
        View in: PubMed
      80. Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J Exp Med. 2000 Apr 3; 191(7):1177-86. PMID: 10748235; PMCID: PMC2193169.
      81. Villadangos JA, Driessen C, Shi GP, Chapman HA, Ploegh HL. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM. EMBO J. 2000 Mar 1; 19(5):882-91. PMID: 10698930; PMCID: PMC305628.
      82. Waltz DA, Fujita RM, Yang X, Natkin L, Zhuo S, Gerard CJ, Rosenberg S, Chapman HA. Nonproteolytic role for the urokinase receptor in cellular migration in vivo. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):316-22. PMID: 10696068.
        View in: PubMed
      83. Riese RJ, Chapman HA. Cathepsins and compartmentalization in antigen presentation. Curr Opin Immunol. 2000 Feb; 12(1):107-13. PMID: 10679409.
        View in: PubMed
      84. Villadangos JA, Bryant RA, Deussing J, Driessen C, Lennon-Duménil AM, Riese RJ, Roth W, Saftig P, Shi GP, Chapman HA, Peters C, Ploegh HL. Proteases involved in MHC class II antigen presentation. Immunol Rev. 1999 Dec; 172:109-20. PMID: 10631941.
        View in: PubMed
      85. Driessen C, Bryant RA, Lennon-Duménil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol. 1999 Nov 15; 147(4):775-90. PMID: 10562280; PMCID: PMC2156161.
      86. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest. 1999 Nov; 104(9):1191-7. PMID: 10545518; PMCID: PMC409823.
      87. Chapman HA, Wei Y, Simon DI, Waltz DA. Role of urokinase receptor and caveolin in regulation of integrin signaling. Thromb Haemost. 1999 Aug; 82(2):291-7. PMID: 10605716.
        View in: PubMed
      88. Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, Pørksen N, Sturis J, Hollingdal M, Pincus S, Veldhuis J, Dejgaard A, Schmitz O, Kristensen JS, Frandsen KB, Bayer T, Müller P, Dunning BE, Paladini S, Gutierrez C, Deacon R, Valentin M, Grunberger G, Weston WM, Patwardhan R, Rappaport EB, Sargeant LA, Wareham NJ, Khaw KT, Zethelius B, Lithell H, Hales CN, Berne C, Lakka HM, Oksanen L, Tuomainen TP, Kontula K, Salonen JT, Dekker JM, de Boks P, de Vegt F, Stehouwer CD, Nijpels G, Bouter LM, Heine RJ, Bruno G, Cavallo-Perin P, Bargero G, D'Errico N, Borra M, Macchia G, Pagano G, Newton RW, Ruta DA, New JP, Wallace C, Roxburgh MA, Young RJ, Vaughan NJ, Elliott P, Brennan G, Devers M, MacAlpine R, Steinke D, Lawson DH, Decallonne B, Casteels K, Gysemans C, Bouillon R, Mathieu C, Linn T, Strate C, Schneider K, Funda DP, Jirsa M, Kozáková H, Kaas A, Kofronová O, Tlaskalová-Hogenová H, Buschard K, Wanka H, Hartmann A, Kuttler B, Rasmussen SB, Sørensen TS, Markholst H, Petersen JS, Karounos D, Dyrberg T, Mabley JG, Haskó G, Szabó C, Seissler J, Nguyen TB, Steinbrenner H, Scherbaum WA, Cipriani R, Gabriele A, Sensi M, Guidobaldi L, Pantellini F, Cerrito MG, Scarpa S, Di Mario U, Morano S, Ceolotto G, Iori E, Baritono E, Del Prato S, Semplicini A, Trevisan R, Zerbini G, Meregalli G, Asnaghi V, Tentori F, Maestroni A, Mangili R, Marescotti C, Vedovato M, Tiengo A, Tadjieva J, Mankovsky BN, Van Aken S, Raes A, Vande Walle J, Matthys D, Craen M, Hansen HP, Lund SS, Rossing P, Jensen T, Parving HH, Andersen S, Tarnow L, Hansen BV, Trautner C, Haastert B, Ennenbach N, Willich S, Tabák ÁG, Orchard TJ, Spranger J, Preissner KT, Schatz H, Pfeiffer A, Cantón A, Burgos R, Hernández C, Lecube A, Mesa J, Segura RM, Mateo C, Simó R, Fathallah L, Greene DA, Obrosova I, Gilbert RE, Kelly DJ, Cox AJ, Berka-Wilkinson JL, Taylor HR, Panagiotopoulos S, Lee V, Jerums G, Cooper ME, Hitman GA, Aganna E, Ogunkolade WB, Rema M, Deepa R, Shanthi-Rani CS, Barakat K, Kumarajeewa TR, Cassell PG, McDermott MF, Mohan V, Ways K, Bursell S, Devries T, Woodworth J, Alatorre C, King G, Aiello LP, Karisen AE, Pavlovic D, Nielsen K, Jensen J, Andersen HU, Pociot F, Mandrup-Poulsen T, Eizirik DL, Nerup J, Lortz S, Tiedge M, Lenzen S, Lally FJ, Bone AJ, Darville MI, Ho YS, Sternesjö J, Sandler S, Chen MC, Schuit F, Pipeleers DG, Merezak S, Hardikar A, Hoet JJ, Remacle C, Reusens B, Bréant B, Garofano A, Czernichow P, Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Nakano R, Komeda K, Eto K, Tobe K, Kimura S, Kadowaki T, Ide T, Murakami K, Tsunoda M, Mochizuki T, Ozanne SE, Nave BT, Wang CL, Dorling MW, Petry CJ, Koopmans SJ, van der Bent C, Que I, Radder JK, Sebokova E, Sana AK, Klimes I, Ruderman N, Morviducci L, Pastore L, Morelli S, Sagratella E, Zorretta D, Buongiomo A, Tamburrano G, Giaccari A, Martinenghi S, De Angelis GC, Ravasi F, Bifari F, Bordignon C, Falqui L, Kessler A, Dransfeld O, Sasson S, Tomas E, Zorzano A, Eckel J, Thorsby P, Rosenfalck AM, Kjems L, Hanssen KF, Madsbad S, Birkeland KI, Hamilton-Wessler M, Markussen J, Bergman RN, Melki V, Hanaire-Broutin H, Bessières-Lacombe S, Tauber JP, Home PD, Lindholm A, Riis A, Rosenstock J, Schwartz S, Clark C, Edwards M, Donley D, Swift P, Mortensen HB, Lynggaard H, Hougaard P, Cull CA, Neil HA, Frighi V, Manley SE, Holman RR, Turner RC, Steiner G, Davis WA, Weeraratna T, Bruce DG, Davis TM, Vergès B, Duvillard L, Pont F, Florentin E, Gambert P, Benko B, Ljubic S, Turk Z, Granic M, März W, Wollschläger H, Klein G, Neiss A, Wehling M, Huxtable SJ, Saker PJ, Walker M, Frayling TM, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI, Orecchio A, Giacchini A, Dominici R, Canettieri G, Trinti B, Zani M, Andreoli M, Sciacchitano S, de Silva AM, Whitecross K, Pasco J, Kotowicz M, Nicholson G, Zimmet P, Boyko EJ, Collier GR, Frittitta L, Pizzuti A, Argiolas A, Graci S, Goldfine ID, Bozzali M, Ercolino T, et al. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 1999 Aug; 42(Suppl 1):A1-A330. PMID: 27770183.
        View in: PubMed
      89. Chapman HA. A Fas pathway to pulmonary fibrosis. J Clin Invest. 1999 Jul; 104(1):1-2. PMID: 10393691; PMCID: PMC408410.
      90. Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol. 1999 Mar 22; 144(6):1285-94. PMID: 10087270; PMCID: PMC2150580.
      91. Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity. 1999 Feb; 10(2):197-206. PMID: 10072072.
        View in: PubMed
      92. Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Brömme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. 1998 Nov 27; 273(48):32000-8. PMID: 9822672.
        View in: PubMed
      93. Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol. 1998 Sep 15; 161(6):2731-9. PMID: 9743330.
        View in: PubMed
      94. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest. 1998 Aug 1; 102(3):576-83. PMID: 9691094; PMCID: PMC508918.
      95. Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest. 1998 Jun 1; 101(11):2351-63. PMID: 9616206; PMCID: PMC508824.
      96. Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 1998 Jun; 157(6 Pt 1):1770-8. PMID: 9620904.
        View in: PubMed
      97. Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Brömme D, Chapman HA, Silverman GA. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry. 1998 Apr 14; 37(15):5258-66. PMID: 9548757.
        View in: PubMed
      98. Chapman HA. Endosomal proteolysis and MHC class II function. Curr Opin Immunol. 1998 Feb; 10(1):93-102. PMID: 9523118.
        View in: PubMed
      99. Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. J Pharmacol Exp Ther. 1998 Feb; 284(2):751-9. PMID: 9454824.
        View in: PubMed
      100. Chapman HA. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr Opin Cell Biol. 1997 Oct; 9(5):714-24. PMID: 9330876.
        View in: PubMed
      101. Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med. 1997 Aug 18; 186(4):549-60. PMID: 9254653; PMCID: PMC2199027.
      102. Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest. 1997 Jul 1; 100(1):58-67. PMID: 9202057; PMCID: PMC508165.
      103. Gelb BD, Shi GP, Heller M, Weremowicz S, Morton C, Desnick RJ, Chapman HA. Structure and chromosomal assignment of the human cathepsin K gene. Genomics. 1997 Apr 15; 41(2):258-62. PMID: 9143502.
        View in: PubMed
      104. Chapman HA, Riese RJ, Shi GP. Emerging roles for cysteine proteases in human biology. Annu Rev Physiol. 1997; 59:63-88. PMID: 9074757.
        View in: PubMed
      105. Simon DI, Rao NK, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, Chapman HA. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood. 1996 Oct 15; 88(8):3185-94. PMID: 8874219.
        View in: PubMed
      106. Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. Regulation of integrin function by the urokinase receptor. Science. 1996 Sep 13; 273(5281):1551-5. PMID: 8703217.
        View in: PubMed
      107. Gelb BD, Shi GP, Chapman HA, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science. 1996 Aug 30; 273(5279):1236-8. PMID: 8703060.
        View in: PubMed
      108. Wong WS, Simon DI, Rosoff PM, Rao NK, Chapman HA. Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). Immunology. 1996 May; 88(1):90-7. PMID: 8707356; PMCID: PMC1456468.
      109. Riese RJ, Wolf PR, Brömme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity. 1996 Apr; 4(4):357-66. PMID: 8612130.
        View in: PubMed
      110. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J. 1995 Oct 1; 311 ( Pt 1):299-305. PMID: 7575468; PMCID: PMC1136152.
      111. Rao NK, Shi GP, Chapman HA. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J Clin Invest. 1995 Jul; 96(1):465-74. PMID: 7615819; PMCID: PMC185220.
      112. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol. 1995 Apr; 146(4):848-60. PMID: 7717452; PMCID: PMC1869262.
      113. Shi GP, Chapman HA, Bhairi SM, DeLeeuw C, Reddy VY, Weiss SJ. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. FEBS Lett. 1995 Jan 3; 357(2):129-34. PMID: 7805878.
        View in: PubMed
      114. Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem. 1994 Dec 23; 269(51):32380-8. PMID: 7528215.
        View in: PubMed
      115. Chapman HA, Munger JS, Shi GP. The role of thiol proteases in tissue injury and remodeling. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 2):S155-9. PMID: 7952652.
        View in: PubMed
      116. Waltz DA, Chapman HA. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J Biol Chem. 1994 May 20; 269(20):14746-50. PMID: 7514182.
        View in: PubMed
      117. Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15; 269(15):11530-6. PMID: 8157683.
        View in: PubMed
      118. Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest. 1993 Sep; 92(3):1572-9. PMID: 8376607; PMCID: PMC288306.
      119. Waltz DA, Sailor LZ, Chapman HA. Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors. J Clin Invest. 1993 Apr; 91(4):1541-52. PMID: 8386190; PMCID: PMC288130.
      120. Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J Biol Chem. 1992 Apr 15; 267(11):7258-62. PMID: 1373132.
        View in: PubMed
      121. Munger JS, Shi GP, Mark EA, Chin DT, Gerard C, Chapman HA. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. J Biol Chem. 1991 Oct 5; 266(28):18832-8. PMID: 1918003.
        View in: PubMed
      122. Reilly JJ, Chen P, Sailor LZ, Wilcox D, Mason RW, Chapman HA. Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L. Am J Physiol. 1991 Aug; 261(2 Pt 1):L41-8. PMID: 1872415.
        View in: PubMed
      123. Nusrat AR, Chapman HA. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J Clin Invest. 1991 Mar; 87(3):1091-7. PMID: 1847936; PMCID: PMC329905.
      124. Chapman HA. Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages. Ann N Y Acad Sci. 1991; 624:87-96. PMID: 1648325.
        View in: PubMed
      125. Chapman HA, Bertozzi P, Sailor LZ, Nusrat AR. Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface. Am J Physiol. 1990 Dec; 259(6 Pt 1):L432-8. PMID: 2175557.
        View in: PubMed
      126. Chapman HA, Yang XL, Sailor LZ, Sugarbaker DJ. Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in lung injury. J Immunol. 1990 Nov 15; 145(10):3398-405. PMID: 2230126.
        View in: PubMed
      127. Reilly JJ, Chen P, Sailor LZ, Mason RW, Chapman HA. Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages. J Clin Invest. 1990 Jul; 86(1):176-83. PMID: 2365815; PMCID: PMC296705.
      128. Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med. 1990 Mar 29; 322(13):890-7. PMID: 2314423.
        View in: PubMed
      129. Chapman HA, Reilly JJ, Yee R, Grubb A. Identification of cystatin C, a cysteine proteinase inhibitor, as a major secretory product of human alveolar macrophages in vitro. Am Rev Respir Dis. 1990 Mar; 141(3):698-705. PMID: 2310099.
        View in: PubMed
      130. Reilly JJ, Mason RW, Chen P, Joseph LJ, Sukhatme VP, Yee R, Chapman HA. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages. Biochem J. 1989 Jan 15; 257(2):493-8. PMID: 2930462; PMCID: PMC1135606.
      131. Reilly JJ, Chapman HA. Association between alveolar macrophage plasminogen activator activity and indices of lung function in young cigarette smokers. Am Rev Respir Dis. 1988 Dec; 138(6):1422-8. PMID: 3202497.
        View in: PubMed
      132. Chapman HA, Bertozzi P, Reilly JJ. Role of enzymes mediating thrombosis and thrombolysis in lung disease. Chest. 1988 Jun; 93(6):1256-63. PMID: 3131071.
        View in: PubMed
      133. Chapman HA, Ehrhardt MM, Crombie G, Duffy LK. In vitro assay of extracellular matrix elastin degradation. J Biochem Biophys Methods. 1988 Mar; 15(5):283-9. PMID: 3379243.
        View in: PubMed
      134. Chapman HA, Reilly JJ, Kobzik L. Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages. Am Rev Respir Dis. 1988 Feb; 137(2):412-9. PMID: 3341631.
        View in: PubMed
      135. Chapman HA, Allen CL, Stone OL. Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease. Am Rev Respir Dis. 1986 Mar; 133(3):437-43. PMID: 3954252.
        View in: PubMed
      136. Mason RW, Johnson DA, Barrett AJ, Chapman HA. Elastinolytic activity of human cathepsin L. Biochem J. 1986 Feb 1; 233(3):925-7. PMID: 3518704; PMCID: PMC1153120.
      137. Chapman HA, Stone OL. A fibrinolytic inhibitor of human alveolar macrophages. Induction with endotoxin. Am Rev Respir Dis. 1985 Sep; 132(3):569-75. PMID: 3898943.
        View in: PubMed
      138. Chapman HA, Stone OL. Characterization of a macrophage-derived plasminogen-activator inhibitor. Similarities with placental urokinase inhibitor. Biochem J. 1985 Aug 15; 230(1):109-16. PMID: 2932100; PMCID: PMC1152593.
      139. Chapman HA, Allen CL, Stone OL, Fair DS. Human alveolar macrophages synthesize factor VII in vitro. Possible role in interstitial lung disease. J Clin Invest. 1985 Jun; 75(6):2030-7. PMID: 4008651; PMCID: PMC425564.
      140. Chapman HA, Stone OL. Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors. J Clin Invest. 1984 Nov; 74(5):1693-700. PMID: 6568228; PMCID: PMC425347.
      141. Chapman HA, Stone OL. Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages. Biochem J. 1984 Sep 15; 222(3):721-8. PMID: 6237643; PMCID: PMC1144235.
      142. Chapman HA, Stone OL, Vavrin Z. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation. J Clin Invest. 1984 Mar; 73(3):806-15. PMID: 6368589; PMCID: PMC425084.
      143. Chapman HA, Vavrin Z, Hibbs JB. Coordinate expression of macrophage procoagulant and fibrinolytic activity in vitro and in vivo. J Immunol. 1983 Jan; 130(1):261-6. PMID: 6847882.
        View in: PubMed
      144. Chapman HA, Vavrin Z, Hibbs JB. Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor. Cell. 1982 Mar; 28(3):653-62. PMID: 6210439.
        View in: PubMed
      145. Chapman HA, Vavrin Z, Hibbs JB. Modulation of plasminogen activator secretion by activated macrophages: influence of serum factors and correlation with tumoricidal potential. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):3899-903. PMID: 291048; PMCID: PMC383943.
      146. Weinberg JB, Chapman HA, Hibbs JB. Characterization of the effects of endotoxin on macrophage tumor cell killing. J Immunol. 1978 Jul; 121(1):72-80. PMID: 27559.
        View in: PubMed
      147. Chapman HA, Hibbs JB. Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid. Science. 1977 Jul 15; 197(4300):282-5. PMID: 195338.
        View in: PubMed
      148. Chapman HA, Johnson JS, Cooper MD. Ontogeny of Peyer's patches and immunoglobulin-containing cells in pigs. J Immunol. 1974 Feb; 112(2):555-63. PMID: 4591974.
        View in: PubMed
      Harold's Networks
      Related Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Related Authors
      People who share related concepts with this person.
      _
      Back to TOP