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    Roberta Keller

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address533 Parnassus Ave, UC Hall
    San Francisco CA 94143
    Phone415-514-3192

       Biography 
       Awards and Honors
      UCSF T1 Translational Catalyst Award Program2012Consultation Award
      2012US News and World Report Top Doctor
      UCSF2009Academic Senate Travel Grant
      Western Society for Pediatric Research2009Mead Johnson Travel Award Winner
      2007The Ivan Gold and Trudi Morrison Volunteer Leadership Award
      Perinatal Research Society2007NIH/NICHD Young Investigator
      Society for Pediatric Research2006Member
      NHLBI2005 - 2010K23 Career Development Award
      UCSF Roadmap K12 Clinical Research Development Award2005NIH Multidisciplinary Clinical Research Scholar
      Pulmonary Hypertension Association2005 - 2010Supplemental Career Development Award
      Western Society for Pediatric Research2004Member

       Overview 
       Overview
      My research program is in developmental lung disease. I am interested in the evaluation of prognostic factors, biomarkers and consequences of lung disease related to extreme prematurity or birth defects (specifically, congenital diaphragmatic hernia).

       Interests
      developmental lung disease, lung hypoplasia, pulmonary hypertension, congenital diaphragmatic hernia, bronchopulmonary dysplasia, lung injury and remodeling, vascular injury and remodeling, respiratory failure, extracorporeal life support, follow up of infant lung disease, clinical trials, clinical-translational research

       ORNG Applications 
       Websites
       Faculty Mentoring
       Awarded Grants
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Keller RL, Steinhorn RH. Extracorporeal membrane oxygenation in resource-limited countries*. Pediatr Crit Care Med. 2013 Nov; 14(9):900-2.
        View in: PubMed
      2. Oishi PE, Klein OD, Keller RL. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1.
        View in: PubMed
      3. Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatr Res. 2013 Sep; 74(3):290-8.
        View in: PubMed
      4. Amirnovin R, Oishi P, Fineman JR, Keller RL. Reply to the editor. J Thorac Cardiovasc Surg. 2013 May; 145(5):1416.
        View in: PubMed
      5. Radman M, Mack R, Barnoya J, CastaƱeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50.
        View in: PubMed
      6. Keller RL, Merrill JD, Black DM, Steinhorn RH, Eichenwald EC, Durand DJ, Ryan RM, Truog WE, Courtney SE, Ballard PL, Ballard RA. Late administration of surfactant replacement therapy increases surfactant protein-B content: a randomized pilot study. Pediatr Res. 2012 Dec; 72(6):613-9.
        View in: PubMed
      7. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5.
        View in: PubMed
      8. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87.
        View in: PubMed
      9. Oishi PE, Keller RL. When persistent pulmonary hypertension of the newborn persists. Pediatr Crit Care Med. 2012 Mar; 13(2):224-5.
        View in: PubMed
      10. Jancelewicz T, Vu LT, Keller RL, Jelin EB, Bratton BJ, Townsend TC, Nobuhara KK. Outcomes of multigestational pregnancies affected by congenital diaphragmatic hernia. J Pediatr Surg. 2010 Sep; 45(9):1753-8.
        View in: PubMed
      11. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug 15; 182(4):555-61.
        View in: PubMed
      12. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ, Truog WE, Ballard PL, Zadell A, Wadlinger SR, Coburn CE, Ballard RA. Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxide. J Pediatr. 2010 Apr; 156(4):556-61.e1.
        View in: PubMed
      13. Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution. J Pediatr Surg. 2010 Jan; 45(1):155-60; discussion 160.
        View in: PubMed
      14. Sherlock RL, McQuillen PS, Miller SP. Preventing brain injury in newborns with congenital heart disease: brain imaging and innovative trial designs. Stroke. 2009 Jan; 40(1):327-32.
        View in: PubMed
      15. Grethel EJ, Farrell J, Ball RH, Keller RL, Goldstein RB, Lee H, Farmer DL, Harrison MR, Nobuhara KK. Does congenital diaphragmatic hernia associated with bronchopulmonary sequestration portend a better prognosis? Fetal Diagn Ther. 2008; 23(4):250-3.
        View in: PubMed
      16. Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman JR. Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection. J Thorac Cardiovasc Surg. 2008 Apr; 135(4):746-53.
        View in: PubMed
      17. Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. J Thorac Cardiovasc Surg. 2007 Nov; 134(5):1179-87.
        View in: PubMed
      18. Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):939-45.
        View in: PubMed
      19. Jani J, Nicolaides KH, Keller RL, Benachi A, Peralta CF, Favre R, Moreno O, Tibboel D, Lipitz S, Eggink A, Vaast P, Allegaert K, Harrison M, Deprest J. Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia. Ultrasound Obstet Gynecol. 2007 Jul; 30(1):67-71.
        View in: PubMed
      20. Yang SH, Nobuhara KK, Keller RL, Ball RH, Goldstein RB, Feldstein VA, Callen PW, Filly RA, Farmer DL, Harrison MR, Lee H. Reliability of the lung-to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeks. Am J Obstet Gynecol. 2007 Jul; 197(1):30.e1-7.
        View in: PubMed
      21. Keller RL. Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management. Am J Med Genet C Semin Med Genet. 2007 May 15; 145C(2):184-200.
        View in: PubMed
      22. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94.
        View in: PubMed
      23. Jegatheesan P, Keller RL, Hawgood S. Early variable-flow nasal continuous positive airway pressure in infants < or =1000 grams at birth. J Perinatol. 2006 Mar; 26(3):189-96.
        View in: PubMed
      24. Jani J, Keller RL, Benachi A, Nicolaides KH, Favre R, Gratacos E, Laudy J, Eisenberg V, Eggink A, Vaast P, Deprest J. Prenatal prediction of survival in isolated left-sided diaphragmatic hernia. Ultrasound Obstet Gynecol. 2006 Jan; 27(1):18-22.
        View in: PubMed
      25. Grethel EJ, Cortes RA, Wagner AJ, Clifton MS, Lee H, Farmer DL, Harrison MR, Keller RL, Nobuhara KK. Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex. J Pediatr Surg. 2006 Jan; 41(1):29-33; discussion 29-33.
        View in: PubMed
      26. Keller RL, Tacy TA, Fields S, Ofenstein JP, Aranda JV, Clyman RI. Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns. Pediatr Res. 2005 Dec; 58(6):1216-21.
        View in: PubMed
      27. Slavotinek AM, Schauer G, Machin G, Dasouki M, Rueda-Pedraza ME, Chiricosta F, Keller R. Fryns syndrome: report of eight new cases. Genet Med. 2005 Jan; 7(1):74-6.
        View in: PubMed
      28. Cortes RA, Keller RL, Townsend T, Harrison MR, Farmer DL, Lee H, Piecuch RE, Leonard CH, Hetherton M, Bisgaard R, Nobuhara KK. Survival of severe congenital diaphragmatic hernia has morbid consequences. J Pediatr Surg. 2005 Jan; 40(1):36-45; discussion 45-6.
        View in: PubMed
      29. Keller RL, Hawgood S, Neuhaus JM, Farmer DL, Lee H, Albanese CT, Harrison MR, Kitterman JA. Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia. Pediatr Res. 2004 Nov; 56(5):818-25.
        View in: PubMed
      30. Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7.
        View in: PubMed
      31. Harrison MR, Keller RL, Hawgood SB, Kitterman JA, Sandberg PL, Farmer DL, Lee H, Filly RA, Farrell JA, Albanese CT. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med. 2003 Nov 13; 349(20):1916-24.
        View in: PubMed
      32. Keller RL, Clyman RI. Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus. Pediatrics. 2003 Sep; 112(3 Pt 1):583-7.
        View in: PubMed
      33. Keller RL, Glidden DV, Paek BW, Goldstein RB, Feldstein VA, Callen PW, Filly RA, Albanese CT. The lung-to-head ratio and fetoscopic temporary tracheal occlusion: prediction of survival in severe left congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2003 Mar; 21(3):244-9.
        View in: PubMed
      34. Keller RL, Aaroz PA, Hawgood S, Higgins CB. MR imaging of hepatic pulmonary fusion in neonates. AJR Am J Roentgenol. 2003 Feb; 180(2):438-40.
        View in: PubMed
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